Abdolmajid Ghasemian

Abdolmajid Ghasemian
Fasa University of Medical Sciences

PhD of Medical Bacteriology
Biological and biomedical Sciences research

About

140
Publications
49,891
Reads
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1,131
Citations
Citations since 2017
98 Research Items
1056 Citations
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2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300
Introduction
Dr. Abdolmajid Ghasemian research on Biological and Biomedical sciences such as microbiology and cancer therapies.
Additional affiliations
January 2011 - March 2020
Tarbiat Modares University
Position
  • PhD

Publications

Publications (140)
Article
Background & Objective: Helicobacter pylori (H. pylori), carried by more than half of the world population, is a major cause of chronic duodenal and gastric ulcers, gastritis and carcinoma. Colonization and toxin production include major virulence traits of H. pylori. The aim of this study was to assess the existence of H. pylori and virulence fact...
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Staphylococcus aureus (S. aureus) causes a wide spectrum of clinical disorders with pathogenic factors such as various toxins. The aims of this study were analysis of the prevalence of pvl gene among MSSA, MRSA, HA-MRSA, CA-MRSA and MSSA+MRSA groups in Iran. The prevalence of Panton-valentine leukocidin in Iran was searched from searching engines s...
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Diabetes mellitus (DM) arises following poor capacity to generate or secrete insulin or insulin resistance; hence insulin production impairment creates the illness. Individuals can control their weight, impulsivity, blood pressure, and blood lipids at the commencement of the disease. A single genetic mutation affects nearly 3% of people with diabet...
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Background: Diarrhea caused by bacterial pathogens such as Shigella spp. is one of the prominent public health concerns. The evolution of vast antibiotic resistance by these pathogens, leading to failure in the infections eradication, has made an impetus to seek and develop novel approaches. Recently, some alternative therapies such as phage thera...
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Owing to non-responsiveness of a high number of patients to the common melanoma therapies, seeking novel approaches seem as an unmet requirement. Chimeric antigen receptor (CAR) T cells were initially employed against recurrent or refractory B cell malignancies. However, advanced stages or pretreated patients have insufficient T cells (lymphopenia)...
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Background Food-borne infections mainly due to Salmonella enterica serovar Enteritidis ( S . Enteritidis) are major concerns worldwide. S . Enteritidis isolates may serve as reservoirs for spreading antimicrobial drug resistance genes including carbapenemases. This study aimed to screen the occurrence of virulence factors, carbapenemases, and antib...
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Skin cancer is one of leading cancers globally, divided into two major categories including melanoma and nonmelanoma. Skin cancer is a global concern with an increasing trend, hence novel therapies are essential. The local treatment strategies play a key role in skin cancer therapy. Nanoparticles (NPs) exert potential applications in medicine with...
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Nanobiosensor platforms have emerged as convenient and promising approaches with remarkable efficacy for the diagnosis of infectious diseases. Gold nanoparticles (AuNPs) have been widely used due to numerous advantageous properties such as optical, electrical, physicochemical and great biomolecules binding capabilities. This study aimed to apply Au...
Article
Human norovirus (HuNoV) causes acute viral gastroenteritis in all age groups, and dehydration and severe diarrhea in the elderly. The World Health Organization reports ∼1.45 million deaths from acute gastroenteritis annually in the world. Rupintrivir, an inhibitory medicine against the human rhinovirus C3 protease, has been reported to inhibit HuNo...
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Objective: As an innate immune system component, antimicrobial peptides (AMPs) exert various effects, such as anticancer properties. This study aimed to evaluate the LL37 AMP anticancer effect against colorectal cancer (CRC) cells and the expression of FOXE1 and lncRNA PTCSC2 genes. Methods: The LL37 AMP was purchased from GenScript USA, Inc. Va...
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The continuing emergence or re-emergence of vector-borne zoonotic Q fever (caused by Coxiella burnetii) and Crimean Congo hemorrhagic fever (CCHF, caused by Orthonairovirus) include indispensable extraordinary threat around the world. Low infectious dose and long-term environmental residence are major risks. Wildlife and domestic livestock act as h...
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Methicillin-resistant Staphylococcus aureus (MRSA) has evolved vast antibiotic resistance. These strains contain numerous virulence factors facilitating the development of severe infections. Considering the costs, side effects, and time duration needed for the synthesis of novel drugs, seeking efficient alternative approaches for the eradication of...
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Hepatitis C virus (HCV) infects the liver and causes chronic infection. Several mutations in the viral genome have been associated with drug resistance development. Currently, there is no approved vaccine against the HCV. The employment of computational biology is the primary and crucial step for vaccine design or antiviral therapy which can substa...
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Background & objective: The spread and development of drug-resistant bacterial strains has prompted the hunt for novel antibacterial polypeptides undergoing conformational changes to confer rapid bactericidal effects. The aim of this study was to evaluate the effect of novel BMAP27-Melittin conjugated peptide- nanoparticle (NP) against Streptococc...
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As drug-resistant tuberculosis (TB) infections grow more widespread, antibiotics that inhibit Mycobacterium tuberculosis through a novel technique might be an important component of changing TB therapy. In M. tuberculosis, protein kinase A (PknA) and protein kinase B (PknB) are both essential serine-threonine kinases. These enzymes present an intri...
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Background & Objective: The spread and development of drug-resistant bacterial strains has prompted the hunt for novel antibacterial polypeptides undergoing conformational changes to confer rapid bactericidal effects. The aim of this study was to evaluate the effect of novel BMAP27-Melittin conjugated peptide-nanoparticle (NP) against Streptococcus...
Article
Background & Objectives: The purpose of the present study was to calibrate and analyze the effects of Helianthus annuus (H. annuus) seeds extract on body weight and blood parameters of type-2 diabetic-mellitus (T2DM) patients. Materials & Methods: Three-hundred cases of T2DM patients were involved in this study including 180 males and 120 females a...
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Chimeric antigen receptor T (CAR-T) cell therapy procedure includes taking personal T cells and processing or genetic engineering using specific antigens and in vitro expanding and eventually infusing into the patient’s body to unleash immune responses. Adoptive cell therapy (ACT) includes lymphocytes taking, in vitro selection and expansion and pr...
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Bacterial vaginosis pattern and antibiotic susceptibility testing in female patients using high vaginal swabs. Biodiversitas 23: 2838-2844. Bacterial species found in the vaginal environment encompass a wide variety of species. A common cause of vaginal discharge in women is bacterial vaginosis BV (BV). Various Gram-positive and Gram-negative rod s...
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Purpose Colorectal cancer (CRC) is among the leading causes of cancer death worldwide. Graphene oxide (GO) plus doxorubicin (DOX) have low toxicity and facilitate drug carriage and provide enough surface. The GO-DOX anticancer effects against HCT-116 human CRC cells were compared with that of pure GO and DOX compounds. Methods Different concentrat...
Article
Innate and acquired immunity responses are crucial for viral infections elimination. However, genetic variations in coding genes may exacerbate the inflammation or initiate devastating cytokine storm which pose severe respiratory conditions in coronavirus disease‐19 (COVID‐19). Host genetic variations in particular those related to the immune respo...
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Nutraceuticals has great health benefits, as it is used in the treatment of many diseases, in addition to acting as a preventative from many diseases. They are natural, biologically active compounds found in foods, nutritional supplements, and herbal plants. Their importance is due to the fact that they contain active chemical compounds. It is dist...
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Mutations are genetic sequence changes, and they are the principal cause of organism diversity. These changes occur at many different levels and can have far-reaching different consequences. These alterations occur due to genetic or epigenetic factors. These changes possibly cause phenotypic change in human which develop a disorder or evolution. No...
Article
Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) is an important causative agent of periodontitis acting by employment of a series of virulence factors. Our aim was to evaluate the virulence traits and plasmid-mediated quinolone resistance of A. actinomycetemcomitans isolates in Iraq. A total of 1580 samples were collected from dent...
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Introduction: The direct association between some microbial species and cancers, such as in colorectal cancer (CRC), has been disclosed. Objective: The aim of this study was to evaluate the changes in intestinal microbiota in subjects with CRC compared with healthy group. Methods: Three-hundred fecal specimens were gathered from patients with CRC a...
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Background E. coli is among the substantial agents of nosocomial infections. The aim of this study was detection of the aminoglycoside resistance genes and their expression among multidrug-resistant (MDR) E. coli isolates in intensive care units (ICUs). Methods Totally, 500 isolates of E. coli were collected from ICU centers in Baghdad, Iraq. The...
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An upward trend in the incidence of Parkinson’s disease (PD), known as one of the most prominent neurodegenerative maladies, has evoked great concerns among medical community over the past decades. Recently, studies have suggested the initiation of PD in the gastrointestinal tract decades before the advent of manifestations. Accumulating evidence s...
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The worldwide spread and high rate of viral transmission and related morbidity and mortality of Coronavirus disease-19 (COVID-19) is a crisis. Some epigenetic determinants predispose individuals to severe infection. Patients with prior chronic medical illnesses (hypertension, diabetes, lupus, and chronic obstructive lung disease) are highly suscept...
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Introduction: Escherichia coli is among major nosocomial pathogens causing urinary tract infections (UTIs). The emergence of carbapenem-resistant strains is a major concern regarding the UTI treatment. The subjective of this study included assessment of genetic relation and screening of virulence factors among carbapenemase producing E. coli from U...
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Background: Countries in the World Health Organization (WHO) Eastern Mediterranean Region (EMR) are predisposed to highly contagious, severe and fatal, emerging infectious diseases (EIDs), and re-emerging infectious diseases (RIDs). This paper reviews the epidemiological situation of EIDs and RIDs of global concern in the EMR between 2001 and 2018....
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Background: Countries in the World Health Organization (WHO) Eastern Mediterranean Region (EMR) are predisposed to highly contagious, severe and fatal, emerging infectious diseases (EIDs), and re-emerging infectious diseases (RIDs). This paper reviews the epidemiological situation of EIDs and RIDs of global concern in the EMR between 2001 and 2018....
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This study aimed to determine the effect of green bismuth oxide (BiO) NPs against multidrug-resistant (MDR) Pseudomonas aeruginosa (P. aeruginosa) from wound infections. Among 450 wound samples collected from patients admitted to the hospital, 200 P. aeruginosa isolates were identified. MDR strains of P. aeruginosa were detected by disc diffusion m...
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Purpose To evaluate bacterial agents as cancer biomarkers. Methods and Results Various bacterial species have been demonstrated to involve in human cancers. However, the data is not enough for better understanding of predominant specific species. Application of a rapid and early-diagnostic, cost-effective, non-invasive, and inclusive method is a c...
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IntroductionMany agents disrupt the cell cycle and its signaling circuits leading to cancer progress. Cancer therapy is performed by surgery, radiation, and chemical drugs remaining some side effects.Objective To evaluate the anticancer traits of herbal medicines.Methods We collected previously published data in searching engines (Web of Science, P...
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Objective: Owing to side effects, drug resistance and recurrence of Echinococcus granulosus infestation following conventional therapies, seeking novel therapeutic approaches such as herbal medicines seems necessary. The aim of this study was assessment the antiparasitic and immunomodulatory effects of Cinnamomum camphora and Ziziphora tenuior her...
Preprint
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The inhibitory effect of intestinal microflora against the colorectal cancer (CRC) development was proposed by observation of the changes in intestinal microbiota and determining their composition in subjects with CRC compared to that of healthy individuals. Microbiota was considered as a goal for the prevention and treatment of CRC. The relationsh...
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Purpose Vast therapeutic traits and very low toxicity of curcumin compound have made it and related formulations promising for treatment purposes. The aim of this study was the assessment of dendrosome curcumin (DNC) inhibitory effects on breast cancer therapy compared to single curcumin compound. Methods DNC was synthesized and MCF-7 cells were p...
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Background Colon cancer is a major cause of death around the world. The evaluation of novel approaches on corresponding genes would be a vital strategy toward eradication of cancer cells. In this study, the toxicity of silver nanoparticle on the colon cancer cell line (HT29) and expression of matrix metalloproteinase (MMP29) gene was investigated....
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Abstract Background Colorectal cancer (CRC) remains a major cause of death worldwide. Chemotherapy is associated with some side effects during CRC treatment. Hence, proper employment of lower toxic and approaches exerting lowest side effects are essential. The Citrullus colocynthis (C. colocynthis) seems a potential anticancerous herbal medicine (H...
Article
Leptospirosis is a neglected zoonotic disease with no particular or verified symptoms, which has been underreported as an occupational infection. Leptospira interrogans serovar Icterohaemorrhagiae and L. interrogans serovar Grippotyphosa are the two major pathogenic serovars. Professionals who are in constant contact with animals and their residues...
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Vancomycin is among last-resort drugs for the elimination of serious methicillin-resistant Staphylococcus aureus (MRSA) infections. Suboptimal or prolonged exposure to vancomycin is a major cause of decreased vancomycin susceptibility being a great concern toward the eradication of related infections. This arises from genetic and metabolic alterati...
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Background and aim Foeniculum vulgare (F. vulgare) Mill, commonly known as fennel, belongs to the Umbelliferae (Apiaceae) family, biennial or perennial herbs disseminated in Mediterranean region and central Europe. This herbal medicine (HM) is considered as a traditional HM, and its parts have been studied. Methods In this survey, essential oils f...
Article
Vancomycin is among last-resort drugs for the elimination of serious methicillinresistant Staphylococcus aureus (MRSA) infections. Suboptimal or prolonged exposure to vancomycin is a major cause of decreased vancomycin susceptibility being a great concern toward the eradication of related infections. This arises from genetic and metabolic alteratio...
Article
Acinetobacter baumannii (A. baumannii) is a miscellaneous bacterium with ability of extensive antibiotic resistance. A. baumannii strains have also been isolated from animal origins. The objective of our atudy was characterization of A. baumannii antibiotic resistance and virulence traits from turkey and chicken raw meat. Of 576 turkey and 424 chic...
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Objective: Thefindingsof amultitudeofbothanimal andhumanstudiescouldsubstantiate anadditiveroleofbothlocalandgeneralanestheticagentsininhibitingbacterialgrowth.The present study attempted to assess antimicrobial effects of local analgesics and general anesthetics including lidocaine,bupivacaine,pethidine,midazolam, and sufentanyl citrate. Methods:...
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Typhoid fever diseases menace the human health worldwide. This study assessed the prevalence of typhoid fever among children in Hilla City. A total of 217 samples were collected. Children were diagnosed with payrexia caused by S. typhi by records of medical used for statistical study tools considered. Most of patients aged 1-4 years and were male (...
Article
Hydatidosis caused by Echinococcus granulosus is a major zoonotic diseases. In addition to imposing heavy economic losses, the disease is a public health problem worldwide. The larval stage of the parasite (hydatid cyst) is formed in a wide range of domestic, wild and human beings as intermediate hosts. On the other, its recurrence has been reporte...
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Bacterial biofilms are multicellular aggregates enclosed in a self-created biopolymer matrix. Biofilm-producing bacteria have become a great public health problem worldwide because biofilms enable these microorganisms to evade several clearance mechanisms produced by host and synthetic sources. Over the past years, different flavonoids including qu...
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Eucalyptus camaldulensis (E. camaldulensis), called the eucalyptus has so many characteristics such as antimicrobial features. Common names include red gum, red chewing gum, river chewing gum, red chewing gum. Its class is Eucalyptus, which is comprised of 800 species worldwide, but three or four species are found in Australia. This tree generally...
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&NA; Glanders is a zoonotic infection, and because of recent outbreaks among Equidae family, the possibility of its reemergence among human populations is a crisis. The causative agent is Burkholderia mallei, a Gram-negative, aerobic and highly contagious bacterium causing severe impacts with low infectious dose transmitted via direct contact to re...
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Helicobacter pylori (H. pylori) is a resident bacterium in the stomach that accounts for 75% cases of gastric cancer. In this review, we comprehensively studied published papers on H. pylori vaccines using Google Scholar and NCBI databases to gather information about vaccines against H. pylori. Considering the pivotal roles of the enzyme urease (in...
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The role of efflux pumps in antibiotic resistance development among Escherichia coli may have been underappreciated. The objective of this study was assessment the association of AcrAB-TolC efflux pumps and qepA genes with resistance to common antibiotics among E. coli isolates. A total of 200 E. coli isolates were obtained from diverse samples of...
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Helicobacter pylori (H. pylori) is a gram-negative microaerophilic bacterium that has been introduced as a cause of mucosal inflammation and gastric cancer. The most important pathogenic factors are VacA and CagA, which are associated with increased disease severity in clinical strains. Autophagy is a protected lysosomal degradation pathway degradi...
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l‐Asparaginases hydrolyzing plasma l‐asparagine and l‐glutamine has attracted tremendous attention in recent years owing to remarkable anticancer properties. This enzyme is efficiently used for acute lymphoblastic leukemia (ALL) and lymphosarcoma and emerged against ALL in children, neoplasia, and some other malignancies. Cancer cells reduce the ex...
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Helicobacter pylori (H. pylori) causes gastric mucosa inflammation and gastric cancer mostly via several virulence factors. Induction of proinflammatory pathways plays a crucial role in chronic inflammation, gastric carcinoma, and H. pylori pathogenesis. Herbal medicines (HMs) are nontoxic, inexpensive, and mostly anti‐inflammatory reminding meticu...
Article
Helicobacter pylori (H. pylori) causes gastric mucosa inflammation and gastric cancer mostly via several virulence factors. Induction of proinflammatory pathways plays a crucial role in chronic inflammation, gastric carcinoma, and H. pylori pathogenesis. Herbal medicines (HMs) are nontoxic, inexpensive, and mostly anti‐inflammatory reminding meticu...
Article
Full-text available
Helicobacter pylori (H. pylori) is a Gram‐negative bacterium and causative agent of gastric cancer. H. pylori induce defective autophagy or inhibit it by means of CagA and vacuolating cytotoxin A (VacA) toxins leading to the gastric cancer induction. Impaired or defective autophagy leads to the accumulation of cytotoxic materials, such as ROS and P...
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Human immunodeficiency virus (HIV) is one of the critical infectious agents with thousands of newly infected people worldwide. High mutational capability and rapid diversification, inhibition of humoral and cellular immune responses, and thus inability for recognition of an immunogenic region in the viral envelope by the immune system are major cha...
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The characterization of virulent and drug-resistant Escherichia coli strains helps to control and provide more accurate information regarding infection and eradication. The aim of this study was to determine the relationship between antibiotic susceptibility, phylogroups and virulence factors of E. coli isolates from children with septicaemia. One...
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Mycobacterium avium complex (MAC) and Mycobacterium avium paratuberculosis (MAP) cause zoonotic infections transmitted by birds and livestock herds. These pathogens have remained as serious economic and health threats in most areas of the world. As zoonotic diseases, the risk of development of occupational disease and even death outcome necessitate...
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The aim of this study was investigation of blaCTX-M, blaSHV and blaTEM ESBLs among Escherichia coli (E. coli) isolates from meat products. Fifty sheep meat samples were prepared from some slaughter houses in Tehran, Iran. The isolates were also confirmed by conventional biochemical tests. The antibiotic susceptibility of isolates was performed by d...
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Silicotuberculosis is critical in community settings among workers and employees exposed to silica dust. Older age of entry (>30 years), male sex, infection with human immunodeficiency virus (HIV), exposure duration, smoking, chronic obstructive pulmonary disease, migration, the severity of the silicosis and the intensity of the exposure are potent...
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Mammalian intestine contains a large diversity of commensal microbiota, which is far more than the number of host cells. Probiotics play an insecure and protective role against the colonization of intestinal pathogenic microbes and increase mucosal integrity by stimulating epithelial cells. Probiotics have innate capabilities in many ways, includin...