Abdolamir Allameh

Abdolamir Allameh
Tarbiat Modares University | TMU · Department of Clinical Biochemistry

PhD

About

195
Publications
34,085
Reads
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3,853
Citations
Citations since 2016
51 Research Items
1742 Citations
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
Introduction
Abdolamir Allameh is currently a fuculty member of the Department of Clinical Biochemistry, Tarbiat Modares University. Professor Allameh,s lab is involved in research on molecular markers of cancer as well as biochemical and molecular markers of adult stem cells and differentiation. The biochemical mechanisms underlying protection against neurodegenrative diseases (MS) is also a priority research in his lab. In collaboration with other labs Prof. Allameh is working on anti-aflatoxin agents with emphasis on natural anti-mycotoxin products.
Additional affiliations
March 2017 - February 2018
McGill University
Position
  • Researcher
Description
  • During this period we did induction of hepatocarcinogenesis in mouse models with aberrant Iron homeostasis. The research was carried out at Lady Davis Institute for Medical Research in Prof. K. Pantopolous's Lab.
September 2000 - February 2001
University of Dundee
Position
  • Research Associate
September 1990 - present
Tarbiat Modares University
Position
  • Professor of Biochemistry

Publications

Publications (195)
Article
Background Evidence show that the recommended dose of zinc may not be sufficient for controlling pathological conditions such as type 2 diabetes mellitus (T2DM). Aim This study aimed to evaluate the effects of zinc supplementation on the oxidative status in overweight T2DM. In addition, the routine glycaemic parameters were determined and compared...
Article
Autophagy is a very well-coordinated intracellular process that maintains cellular homeostasis under basal conditions by removing unnecessary or dysfunctional components through orderly degradation and recycling. Under pathological conditions, defects in autophagy have been linked to various human disorders, including neurodegenerative disorders an...
Article
Full-text available
Hemojuvelin (HJV) enhances signaling to the iron hormone hepcidin and its deficiency causes iron overload, a risk factor for hepatocellular carcinoma (HCC). We utilized Hjv−/− mice to dissect mechanisms for hepatocarcinogenesis. We show that suboptimal treatment with diethylnitrosamine (DEN) triggers HCC only in Hjv−/− but not wt mice. Liver proteo...
Article
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Background and objective: Oral squamous cell carcinoma (OSCC) is the most common head and neck malignancy. Expression patterns of microRNAs (miRNAs) can direct us in identifying valuable biomarkers for the prognosis of different neoplasms. Inappropriate regulation of miRNAs during physiological procedures can result in malignancies including OSCC....
Article
Full-text available
Background Identification of molecular markers, such as miRNAs is promising for the diagnosis of asthma and its clinical phenotypes. The aim of this study was to examine the changes in the expression of selected microRNAs in plasma exosomal fractions of severe asthma patients. The expression of miRNAs was determined in relation to the changes in in...
Article
The aim of this study was to examine the impact of intake of a lactic acid bacterium, Lactobacillus plantarum 299v (Lp299v) on aflatoxin-induced hepatotoxicity in broilers. For this, broilers were intoxicated with dietary aflatoxins and simultaneously treated with live Lp299v in drinking water. One-day-old male broilers were divided into eight grou...
Article
Aims Cell-based therapy is a promising approach for the treatment of type-1 diabetes mellitus. Identifying stem cells with differentiation potential to Insulin-producing cells (IPCs) and their application is an emerging issue. Different strategies have been used to support cell survival and their specific functions to control hyperglycemia conditio...
Article
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Background: Oral Squamous Cell Carcinoma (OSCC) is among the ten most common cancers worldwide. Hypermethylation of CpG sites in the promoter region and subsequent down-regulation of a tumor suppressor gene, TGM-3 has been proposed to be linked to different types of human cancers including OSCC. In this study, methylation status of CpG sites in th...
Book
Book: Biochemistry of Cancer (In Persian) Edited by: Professor Abdolamir Allameh Professor of Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, I.R. Iran The aim of the book “Biochemistry of cancer” is to review the events and molecular pathways in carcinogenesis and the development of malignancies in humans. In this b...
Article
AimDue to lipases’ regio-selectivity and ability to catalyze different reactions such as hydrolysis, esterification, and transesterification, the enzyme is attractive in biotransformation technology. Besides, another technology, namely enzyme immobilization, has attracted scientists/technologists’ attention to employ immobilized lipase in such a fi...
Article
Objectives: Chronic inflammation in urothelial tissues can lead to DNA damage and cancer formation. Inflammatory reactions in bladder cancer (BC) probably depend on the stages and grades of tumors. The aim of this research was to find out if there is a relationship between the serum levels of selected inflammatory factors and the pathological grade...
Preprint
Full-text available
Background Identification of molecular markers, such as miRNAs is promising for the diagnosis of asthma and its clinical phenotypes. The aim of this study was to examine the changes in the expression of selected microRNAs in plasma exosomal fractions severe asthma patients. The expression of the miRNAs was determined in relation to the changes in s...
Article
Full-text available
Objectives: Autophagy is an intracellular degradation system of damaged proteins and organelles; however, the role of autophagy in the progression of cancer remains unclear. In recent years, mesenchymal stem cell (MSC)-based approaches have attracted considerable attention for anti-cancer therapy. The present study aimed to examine the interaction...
Preprint
Full-text available
Background Cell-based therapy is a promising approach for the treatment of type 1 diabetes mellitus. Identification of stem cells as progenitor stem cells with differentiation potential to Insulin-producing cells (IPCs) and their application is an emerging issue. Different strategies have been used to support the cell survival and their specific fu...
Article
Full-text available
N-acetylcysteine (NAC) as a glutathione inducer is known for its anti-inflammatory effects in inflammatory conditions. The aim of the present study was to know if supplementation of the culture medium with NAC can improve anti-inflammatory activities of hepatocytes during their differentiation from mesenchymal stem cells (MSCs). For this, in vitro...
Article
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The association of haptoglobin (Hp) with various cancers has been reported and also it has been documented that the Hp phenotypes/genotypes have different functional ability. So, we examined phenotypes/genotypes of Hp in newly diagnosed, untreated non-muscle invasive bladder cancer (NMIBC) patients and investigated its prognos-tic value for risk st...
Article
Full-text available
Micro (mi)-RNAs are vital regulators of multiple processes including insulin signaling pathways and glucose metabolism. Pancreatic β-cells function is dependent on some miRNAs and their target mRNA which together form a complex regulative network. Several miRNAs are known to be directly involved in β-cells functions such as insulin expression and s...
Article
Concurrent exposure to styrene (ST) and noise is common especially in industrial environments. The present study aims to determine the related oxidant-induced changes as the result of combined exposure to ST and noise. For this purpose, 24 male Wistar rats were used in four experimental groups (n = 6/groups): (1) control group, (2) the group expose...
Article
Objective: Despite the current guidelines for the management of type 2 diabetes mellitus (T2DM), patients still struggle with the hyperglycemia consequences. Imbalance in zinc homeostasis, in particular, renders diabetic patients more susceptible to the damages of oxidative stress. This study aimed to evaluate the effects of zinc supplementation on...
Article
Purpose Sphingosine 1 phosphate (S1P), S1P receptors (S1PRs) and their signaling pathways play an important role in the fate of cancer cells. The expression pattern of S1PR subtypes (S1PR1–S1PR5) may alter in cancer development stages, depending on the origin and the pathologic features of tumors. The present study aimed to examine the relationship...
Article
The aim of this study was to investigate the relationship between p16 methylation and its expression in oral squamous cell carcinoma (OSCC). Also the contribution of clinicopathological factors, HPV infection and smoking in p16 expression and promoter methylation has been investigated. In this study 67 consecutive OSCC patients and 59 normal indivi...
Article
Growing broiler chicks on a diet contaminated with aflatoxins (200 or 2000 ppb) for entire growth period resulted in increased oxidative stress and liver damage markers. The toxicity was subsided in broilers received a specific aflatoxin-binding probiotic i.e., Lactobacillus plantarum 299v (Lp299v). There was a substantial (30–90%) increase in anti...
Article
The anti-inflammatory role of the active metabolite of vitamin D, namely 1, 25-dihydroxyvitamin D3 (calcitriol), has been reported in multiple sclerosis (MS). Moreover, recent studies have shown that fibroblast growth factor 23 (FGF23) is involved in the regulation of calcitriol biosynthesis. The probable changes of FGF23 and calcitriol concentrati...
Article
Background: Progression of human bladder cancer is associated with growth of side-populations of cancer stem cells (CSC). Expression of ABCG2 and CD44 as the CSC markers, could be associated with different pathological grades of bladder cancer. Material and methods: 67 bladder cancer patients (63 male; 4 female) diagnosed with urothelial cancer us...
Article
Bladder cancer is one of the most prevalent genitourinary cancers responsible for about 150,000 deaths per year worldwide. Currently, several treatments, such as endoscopic and open surgery, appended by local or systemic immunotherapy, chemotherapy, and radiotherapy are used to treat this malignancy. However, the differences in treatment outcome am...
Article
This study was carried out to examine the role of intracellular albumin in the modulation of oxidative damage induced by glutathione modifiers in HepG2 cells. Also, the relationship of albumin synthesis with the oxidative stress factors including antioxidants was studied. HepG2 cell culture was supplemented with glutathione modifiers; L‐Buthionine‐...
Article
In recent years, a lot of attention has been paid to quantum dot (QD) nanoparticles as fluorescent sensors for sensitive and accurate detection of cancer biomarkers. Here, using a homemade specific monoclonal antibody against CA125 and QD525- or FITC-labeled probes, expression of this marker in an ovarian cancer cell line and cancer tissues were tr...
Conference Paper
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Effect of mesenchymal stem cells administration on infiltration of Eosinophils in tumor tissue in mouse model of 4T1 breast cance
Article
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Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelination disease associated with inflammatory reactions and attenuation of antioxidant capacity. Several lines of evidence show that organs such as the liver and kidneys can share their antioxidant activity to protect the central nervous system (CNS) against neurodegenerative d...
Article
Full-text available
Multiple sclerosis (MS) is an inflammatory demyelinating disease, which is considered as a common autoimmune disorder in young adults. A growing number of evidences indicated that the impairment in non-neural tissues plays a significant role in pathology of MS disease. There are bidirectional relationship, metabolic activities and functional simila...
Article
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Recently, we reported a positive correlation between Klotho, as an anti-aging protein, and the total antioxidant capacity (TAC) in cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients. However, there is no information about the Klotho and TAC changes within the central nervous system (CNS). Thus, the current study aimed to employ an experi...
Article
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Background: One of the key questions in biochemistry is why cell becomes aged and what are the involved factors? Why cell growth is stopped after some divisions and cells become senescent? This occurs in a greater frame in the whole body and cells dye after a while. Androgenetic alopecia (AGA) is characterized by a loss or decrease in hair follicle...
Article
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Differentiation of mesenchyal stem cells (MSCs) into biologically active hepatocytes depends on several factors. Glutathione (GSH) and antioxidant enzymes play major role in maintaining the balance between oxidative damage factors and antioxidants during the differentiation. Therefore by adding GSH modifiers to the culture media, we examined the im...
Article
Background we recently showed that a hypothesized anti-aging and anti-inflammatory protein, namely Klotho, may contribute to the etiology and/or pathogenesis of multiple sclerosis (MS). In addition, Klotho function and its gene expression are dependent on inflammatory pathways. Accordingly, the aim of this study was to investigate the Klotho gene e...
Article
Introduction: High dose of acetaminophen (APAP) is known to have hepatotoxic and nephrotoxic effects and studies show that this toxicities are dependent on the function of phase I bioactivation enzymes- Cyp450- and phase II biotransformation enzymes especially glucuronosylation and sulfonation pathways. However, the role of cyclooxygenase (COX) as...
Article
Resistance to oxidative damages in undifferentiated mesenchymal stem cells (MSCs) in comparison with the undifferentiated progenitor cells may differ depending on several factors. This study was carried out to examine the impact of hepatogenic differentiation process of MSCs on oxidative DNA damage markers. Hepatic differentiation of MSCs was carri...
Article
Stem cell therapy for degenerative diseases has been established; however there are controversies over the treatment of solid tumors with stem cell transplantation. In the present study, the anti-tumor action of mesenchymal stem cells (MSCs) has been examined in a mouse model of breast cancer with emphasize on tumor growth, angiogenesis and c-Myc e...
Chapter
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Caraway (Carum carvi L.) is widely cultivated all over the world. It is among the widely used spices which are used as crude or essence in various food products for its pleasant flavor and antispoilage properties. The caraway seeds contain essential oils rich in nutraceutical compounds used as food supplements and plant-based medicine. Experimental...
Article
Background: A number of complex and rare mutations in epidermal growth factor receptor (EGFR) gene have been identified and the clinical implication of serum EGFR ligands has also been reported. However, the prognostic significance of these mutations and also the serum EGFR and its ligands in Non-Small Cell Lung Carcinoma (NSCLC) has remained a ch...
Article
Full-text available
The aim of this study was to investigate the relationship between the H-ras and Cox-2 gene expression in tumors from Iranian Oral Squamous Cell Carcinoma (OSCC) patients. Fresh tumor biopsies removed from oral cavity were collected from 67 new cases. Total RNA was extracted from biopsies and processed for quantification of H-ras and Cox-2 specific...
Article
Incorporation of endothelial cells or their progenitor cells into newly sprouting blood vessels can contribute to tissue vascularization after ischemic injury. However, the interaction of the stem cells-derived endothelial cells with angiogenesis within tumors is not well understood. The aim of this study was to examine the efficiency of endothelia...
Article
In recent years, targeted delivery systems have been used along with combinatorial therapy to decrease drug resistance and increase cancer therapy efficacy. The anti-proliferative effects of vitamin D3 (VD3) on cancerous cells, such as C6 glioma, with active hedgehog pathways raised the question as to whether pre-targeting C6 glioma cells with VD3-...
Article
Full-text available
Objective: In vivo and in vitro stem cell differentiation into endothelial cells is a promising area of research for tissue engineering and cell therapy. Materials and methods: We induced human mesenchymal stem cells (MSCs) to differentiate to endothelial cells that had the ability to form capillaries on an extracellular matrix (ECM) gel. Therea...
Article
Full-text available
Background: This study assessed the effect of supplementation of omega-3 fatty acids and ascorbic acid alone and in combination on the level of lipid peroxidation (malondialdehyde, MDA concentration), total antioxidant capacity (TAC) and depression scores in depressed rotational shift workers in the Tehran Shahid Tondgoyan Oil refinery. Material...
Poster
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this poster has accepted in 11th breast cancer international congress,shahid beheshti unv ,tehran,iran
Article
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Apolipoprotein E (APOE) with its extraordinary features is readily assembled with hydrophobic compounds via its compact hydrophobic units (CHUs). These assemblies can then be converted to stable particles by protein-protein interactions via coiled coil regions (CCRs) which exist in APOE structure. Applying these features of APOE, we prepared novel...
Article
Full-text available
Aflatoxin contamination of grains and agro-products is a serious food safety issue and a significant economic concern worldwide. In the present study, the effects of eugenol on Aspergillus parasiticus growth and aflatoxin production were studied in relation to the expression of some essential genes involved in aflatoxin biosynthetic pathway. The fu...
Article
Recent studies have been established high degree of genetic diversity in solid organ tumors among individuals and even between individual tumor cells. This intratumor and intertumor genetic diversity results in a heterogeneous tumor with unique characteristics which potentially allows effective drug therapy. The goal of pharmacogenomics is to eluci...
Article
Full-text available
Objective The aim of this study was to determine the oxidative stress; serum level of Total Antioxidant Capacity (TAC)and Malondialdehyde (MDA) level and the depression score among the depressed rotational shift workers in Shahid Tondgouyan Refinery in Tehran (Iran). Methods A cross-sectional study was conducted among all the 189 shift workers in...
Article
Full-text available
Differentiation of mesenchymal stem cells (MSCs) to hepatocytes-like cells is associated with alteration in the level of reactive oxygen species (ROS) and antioxidant defense system. Here, we report the role of glutathione in the functions of hepatocytes derived from MSCs. The stem cells undergoing differentiation were treated with glutathione modi...
Article
Full-text available
Differentiation of mesenchymal stem cells (MSCs) to hepatocyte-like cells is associated with morphological and biological changes. In this study, the effect of hepatogenic differentiation on fatty acid profile and the expression of proliferator-activated receptors-α (PPAR-α) have been studied. For this purpose, MSCs isolated from human umbilical co...
Article
A dimeric organophosphorus hydrolase (OPH; EC 3.1.8.1; 72 kDa) was isolated from wild-type bacteria, analyzed for its 16s rRNA sequence, purified, and immobilized on gold nanoparticles (AuNPs) to form the transducer part of a biosensor. The isolated strain was identified as Pseudomonas aeruginosa. The AuNPs were characterized by transmission electr...
Article
Full-text available
n this study the possible effects of stem cell factor treatment on acetaminophen renal toxicity via conjugate formation with cellular glutathione was investigated. Mice treated with Stem cell factor (40µg/kg B.W i.p) 30 min following acetaminophen (300 mg/kg B.W i.p.) and sacrificed at intervals of 6, 12 and 24 h. The levels of acetaminophen- glu...
Article
T-2 toxin is the most poisonous trichothecene produced by Fusarium species especially F.sporotrichioides. T-2 toxin is a biological contaminant in a number of agricultural commodities that can cause severe diseases among humans and animals and even lead to death. The aim of the current study is the analysis of T-2 mycotoxin in Fusarium species by h...
Article
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Implication for health policy / practice / research / medical education: The implication of this study is to know recent developments in the stem cell technology and applications. To briefly describe the importance of different types of stem cells with their differentiation potential in cell therapy and regeneration medicine.
Article
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Abstract Differentiation of human mesenchymal stem cells (MSCs) to metabolically active hepatocytes depends on different regulatory factors. Trans-differentiation of stem cells into specific cell lineage in the presence of specific stimuli is associated with the molecular and cellular damage. The aim of the present study was to examine the role of...