Abderrahim BenmoussaUniversité de Montréal | UdeM · Department of Nutrition
Abderrahim Benmoussa
Postdoctoral Research Fellow
Investigating the link between diet, gut microbia/metabolites and cardiometabolic complications in pediatric leukemia
About
38
Publications
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Introduction
Abderrahim Benmoussa currently works at the Department of Nutrition of University of Montreal. Abderrahim does research in Molecular Biology, immunity modulation, molecular and Cell Biology, cardiometabolic diseases, cancer and nutrition. Their current project is evaluating the effect of cancer chemotherapy on the gut microbiota and metabolites and their relation to treatment side-effects and long term cardiometabolic complications in children with cancer.
Publications
Publications (38)
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many...
Significance:
The 5-year survival rate of childhood cancers is now reaching 84%. However, treatments cause numerous acute and long-term side effects. These include cardiometabolic complications, namely hypertension, dyslipidemia, hyperglycemia, insulin resistance and increased fat mass. Recent advances: Many antineoplastic treatments can induce ox...
Chondrosarcomas are malignant bone tumors. Their abundant cartilage-like extracellular matrix and their hypoxic microenvironment contribute to their resistance to chemotherapy and radiotherapy, and no effective therapy is currently available. MicroRNAs (miRNAs) may be an interesting alternative in the development of therapeutic options. Here, for t...
Rationale and objectives: Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. Despite a 90% five-year survival rate, survivors of childhood ALL often suffer from late effects, including cardiometabolic disorders. Contributing factors such as inflammation and oxidative stress, combined with drug treatments, can induce premature a...
Background: Extracellular RNAs (exRNAs) are found in numerous extracellular fluids, including milk. Until recently, microRNAs were the focus of research in this area, leaving aside other exRNAs. Recently, a modified small RNA-sequencing (sRNA-seq) approach led to the discovery of very short, 12 and 13 nucleotides (nt) ribosomal RNA (rRNA) fragments...
Chondrosarcomas and osteosarcomas are malignant bone tumors with a poor prognosis when unresectable or metastasized. Moreover, radiotherapy and chemotherapy could be ineffective. MiRNAs represent an alternative therapeutic approach. Based on high-throughput functional screening, we identified four miRNAs with a potential antiproliferative effect on...
The hallmark of HIV-1 infection is the rapid dysregulation of immune functions. Recent investigations for biomarkers of such dysregulation in people living with HIV (PLWH) reveal a strong correlation between viral rebound and immune activation with an increased abundance of extracellular vesicles (EVs) enriched with microRNA-155. We propose that th...
RNA-sequencing has led to a spectacular increase in the repertoire of bacterial sRNAs and improved our understanding of their biological functions. Bacterial sRNAs have also been found in outer membrane vesicles (OMVs), raising questions about their potential involvement in bacteria-host relationship, but few studies have documented this issue. Rec...
Small RNA sequencing (sRNA-Seq) approaches unveiled sequences derived from longer non-coding RNAs, such as transfer RNA (tRNA) and ribosomal RNA (rRNA) fragments, known as tRFs and rRFs, respectively. However, rRNAs and RNAs shorter than 16 nt are often depleted from library preparations/sequencing analyses, although they may be functional. Here, w...
Recently, we discovered a new family of unusually short RNAs mapping to 5.8S ribosomal RNA (rRNA) and which we named dodecaRNAs (doRNAs), according to the number of core nucleotides (12 nt) their members contain. To confirm these small RNA-sequencing (RNA-Seq) data, validate the existence of the two overly abundant doRNAs-the minimal core 12-nt doR...
Using a modified RNA-sequencing (RNA-seq) approach, we discovered a new family of unusually short RNAs mapping to ribosomal RNA 5.8S, which we named dodecaRNAs (doRNAs), according to the number of core nucleotides (12 nt) their members contain. Using a new quantitative detection method that we developed, we confirmed our RNA-seq data and determined...
Children treated for acute lymphoblastic leukemia (ALL) often suffer serious side-effects, including vomiting, diarrhea, severe infections, and cardiometabolic disorders. We hypothesized that deregulation of the intestinal microbiota, and its metabolites, is related to these side effects, and promotes inflammation and cardiometabolic disorders in t...
Extracellular vesicles (EVs) and their contents (proteins, lipids, messenger RNA, microRNA, and DNA) are viewed as intercellular signals, cell-transforming agents, and shelters for viruses that allow both diagnostic and therapeutic interventions. EVs circulating in the blood of individuals infected with human immunodeficiency virus (HIV-1) may prov...
Malnutrition impacts approximately 50 million children worldwide and is linked to 45% of global mortality in children below the age of five. Severe acute malnutrition (SAM) is associated with intestinal barrier breakdown and epithelial atrophy. Extracellular vesicles including exosomes (EVs; 30–150 nm) can travel to distant target cells through bio...
Ebola virus (EBOV) is a virulent pathogen, notorious for inducing life-threatening hemorrhagic fever, that has been responsible for several outbreaks in Africa and remains a public health threat. Yet, its pathogenesis is still not completely understood. Although there have been numerous studies on host transcriptional response to EBOV, with an emph...
To gain an in-depth understanding of human diseases , biologists typically mine patient data for relevant patterns. Clinical datasets are often unlabeled and involve features, a.k.a. markers, split into classes w.r.t. biological functions, whereby target patterns might well mix both levels. As such heterogeneous patterns are beyond the reach of cur...
Chemotherapy used to treat pediatric cancers often causes significant side effects including vomiting, diarrhea, and severe infections. Bacteria composing the intestinal microbiota play a major role in the health of individuals. The modification of the gut microbiota profile (by nutrition, antibiotics, or other chemical agents) can lead to benefici...
Milk is a complex fluid that contains various types of proteins and extracellular vesicles (EVs). Some proteins can mingle with EVs, and interfere with their isolation. Among these proteins, caseins form micelles of a size comparable to milk EVs, and can thus be co-isolated with EVs. Preliminary steps that affect milk are crucial for EV isolation a...
Despite improvements in donor screening and increasing efforts to avoid contamination and the spread of pathogens in clinical platelet concentrates (PCs), the risks of transfusion-transmitted infections remain important. Relying on an ultraviolet photo activation system, pathogen reduction technologies (PRTs), such as Intercept and Mirasol, utilize...
Objective:
The lymphatic system is a circulatory system that unidirectionally drains the interstitial tissue fluid back to blood circulation. Although lymph is utilized by leukocytes for immune surveillance, it remains inaccessible to platelets and erythrocytes. Activated cells release submicron extracellular vesicles (EV) that transport molecules...
Extracellular vesicles (EVs) are involved in cell-to-cell communication and modulation of numerous physiological and pathological processes. EVs are found in large quantities in milk and contain several inflammation- and immunity-modulating proteins and microRNAs, through which they exert beneficial effects in several inflammatory disease models. H...
MicroRNA (miRNA) are small gene-regulatory noncoding RNA that are highly enriched in cow milk. They are encapsulated in different extracellular vesicle (EV) subsets that protect them from the extracellular milieu and the harsh conditions of the gastrointestinal tract during digestion. Here, we isolated pellets enriched in 4 different EV subsets, vi...
Extracellular vesicles (EVs) are cellular “fragments” actively released in all biological fluids.
They are transported through body circulation and transmit their bioactive content to remote recipient cells. Milk is the biological fluid most enriched in EVs and these encapsulate several bioactive elements with anti-cancer and anti-inflammatory effe...
Chemotherapy used to treat pediatric cancers often causes significant side effects including vomiting, diarrhea and severe infections. Bacteria composing the intestinal microbiota play a major role in the health of individuals. The modification of the gut microbiota profile (by nutrition, antibiotics or other chemical agents) can lead to beneficial...
Extracellular Vesicles (EVs) are small vesicular bodies surrounded by a phospholipidic membrane. Multiple EVs subsets are found in all biological fluids, conjointly with other particles that can be confounders in EVs studies. Microvesicles are derived from the plasma membrane. Exosomes are secreted when multivesicular bodies (MVB) fuse with the cel...
MicroRNAs are small noncoding RNAs responsible for regulating 40% to 60% of gene expression at the posttranscriptional level. The discovery of circulating microRNAs in several biological fluids opened the path for their study as biomarkers and long‐range cell‐to‐cell communication mediators. Their transfer between individuals in the case of blood t...
The advent of RNA-sequencing (RNA-Seq) technologies has markedly improved our knowledge and expanded the compendium of small non-coding RNAs, most of which derive from the processing of longer RNA precursors. In this review article, we will present a nonexhaustive list of referenced small non-coding RNAs (ncRNAs) derived from eukaryotic ribosomal R...
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many...
The advent of RNA-sequencing (RNA-Seq) technologies has markedly improved our knowledge and expanded the compendium of small non-coding RNAs, most of which derive from the processing of longer RNA precursors. In this review article, we will discuss about the biogenesis and function of small non-coding RNAs derived from eukaryotic ribosomal RNA (rRN...
Extracellular vesicles (EVs), like exosomes, are small membrane vesicles involved in cell-to-cell communications that modulate numerous biological processes. We previously discovered a new EV subset in milk (sedimenting at 35,000 g; 35 K) that protected its cargo (RNAs and proteins) during simulated digestion and was more enriched in microRNAs than...
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many...
MicroRNAs are small gene-regulatory RNAs that are found in various biological fluids, including milk, where they are often contained inside extracellular vesicles (EVs), like exosomes. In a previous study, we reported that commercial dairy cow’s milk microRNAs resisted simulated digestion and were not exclusively associated with canonical exosomes....
Introduction: MicroRNAs are short (~22 nucleotides), non-coding RNAs that play an essential role in post-transcriptional gene regulation. Found in several biological fluids, including milk, they are often associated with extracellular vesicles (EVs), like exosomes. In a previous study, we found that commercial dairy cow milk microRNAs resist digest...
Background:
MicroRNAs are small, gene-regulatory noncoding RNA species present in large amounts in milk, where they seem to be protected against degradative conditions, presumably because of their association with exosomes.
Objective:
We monitored the relative stability of commercial dairy cow milk microRNAs during digestion and examined their a...
MicroRNAs are small, gene regulatory non-coding RNA species that are present in large amounts in milk where they seem to be protected against degradative conditions, presumably because of their association with exosomes. We monitored the relative stability of commercial dairy milk microRNAs, under the gastrointestinal (GI) tract conditions that pre...
MicroRNAs are small, gene regulatory non‐coding RNA species that are present in large amounts in milk where they seem to be protected against degradative conditions, presumably because of their association with exosomes. We monitored the relative stability of commercial dairy milk microRNAs, under the gastrointestinal (GI) tract conditions that pre...
Questions
Questions (2)
Hello,
I wanted to share with you the tool we developed called BiblioVid, accessible at Bibliovid.org. It is a post-publication review platform that provides a quality assessment of the literature on COVID-19 as well as a review and summary of its content. The literature is classified by field, thematics and quality of evidence. We are 30+ scientists and doctors working on it, in French and English. We are set in 15+ countries and working with international teams for development on different research projects. Primarily aimed at healthcare workers, it is embedded within a research project centered on the psychological distress of health workers during COVID-19. If you are interested in joining in the effort for evidence-supported medicine, you can engage in the adventure. We will soon have a collaborative platform that will allow everyone to analyze articles and submit them. Until then, we have a dynamic team of translators and analysts that needs all the help possible as the number of literature on COVID-19 is skyrocketing while the overall quality of the productions remains very low and tangible evidence fairly hard to entangle from the mass of low trustworthiness evidence.
Have a good day,
Abderrahim
Vice-president international development of the Bibliovid.org scientific non-profit organization.
Mistake of the author or of researchgate ?
