Abdelrahim Osman Mohamed

Abdelrahim Osman Mohamed
University of Khartoum · Department of Biochemistry

Dr. Med Sci.

About

57
Publications
10,602
Reads
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489
Citations
Citations since 2016
26 Research Items
251 Citations
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
20162017201820192020202120220102030405060
Additional affiliations
September 1985 - present
University of Khartoum
Position
  • Professor (Full)

Publications

Publications (57)
Article
Full-text available
There is a large gap between diagnostic needs and diagnostic access across much of sub-Saharan Africa (SSA), particularly for infectious diseases that inflict a substantial burden of morbidity and mortality. Accurate diagnostics are essential for the correct treatment of individuals and provide vital information underpinning disease surveillance, p...
Article
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Background: The CYP1A1 catalyses polycyclic aromatic hydrocarbons activation to reactive metabolites, causing deoxyribonucleic acid (DNA) damage and cancer. It is highly polymorphic and displays ethnic differences in various populations. Aim: To evaluate the association of three polymorphic variants in the CYP1A1 gene with breast cancer in Sudanes...
Article
Full-text available
Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is the most common enzymopathy globally, and deficient individuals may experience severe hemolysis following treatment with 8-aminoquinolines. With increasing evidence of Plasmodium vivax infections throughout sub-Saharan Africa, there is a pressing need for population-level data at on the preval...
Article
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Background Bone morphogenetic proteins (BMP) are multifunctional proteins. They work as cytokines regulating osteogenesis during fracture healing process. The objectives of this study were to assess changes in BMPs during fracture and their correlations to Fracture’s healing. Methods Case-Control hospital–based study conducted from January 2018 to...
Article
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Background The Novel Corona virus SARS-CoV-2 emerged to affect the human population in 2019 causing COVID-19 pandemic. The only preventive measures available are social distancing, hand washing and face masks. This study aims to assess the knowledge, attitude and practice of the Sudanese people towards COVID-19. Methods An online cross-sectional s...
Article
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Background: Current malaria control and elimination strategies rely mainly on efficacious antimalarial drugs. However, drug resistance is a major threat facing malaria control programs. Determination of drug resistance molecular markers is useful in the monitoring and surveillance of malaria drug efficacy. This study aimed to determine the mutatio...
Article
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Introduction: Essential hypertension (EH) is a disease caused by various environmental and genetic factors. Nitric oxide (NO) is important for the functional integrity of the endothelium. It is produced in endothelial cells by endothelial NO synthase (eNOS) that mediates the conversion of the amino acid arginine into NO and citrulline. Asymmetric...
Preprint
Full-text available
Background: The pathogenesis of type 2 diabetes mellitus is due to two major abnormalities including insulin resistance and dysfunction, which lead to the inability to regulate blood glucose level. Adiponectin is a hormone secreted by the adipose tissue and it takes part in glucose metabolism with insulin-sensitising properties. Low levels of adipo...
Preprint
Full-text available
Background: The pathogenesis of type 2 diabetes mellitus is due to two major abnormalities including insulin resistance and dysfunction, which lead to the inability to regulate blood glucose level. Adiponectin is a hormone secreted by the adipose tissue and it takes part in glucose metabolism with insulin-sensitising properties. Low levels of adipo...
Preprint
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Background: The Novel Corona Virus (SARS-CoV-2) had emerged to affect the human population in 2019 causing COVID-19 pandemic. The disease has no vaccine and no definitive treatment; the only preventive measures available are social distancing, hand washing and masks. This study aims to assess the knowledge, attitude and practice of the Sudanese peo...
Preprint
Full-text available
Background: The Novel Corona Virus (SARS-CoV-2) had emerged to affect the human population in 2019 causing COVID-19 pandemic. The only preventive measures available are social distancing, hand washing and face masks. This study aims to assess the knowledge, attitude and practice of the Sudanese people towards COVID-19. Methods: An online cross-sect...
Article
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Background: Plasmodium falciparum malaria is a public health problem worldwide. Malaria treatment policy has faced periodic changes due to emergence of drug resistant parasites. In Sudan chloroquine has been replaced by artesunate and sulfadoxine/pyrimethamine (AS/SP) in 2005 and to artemether-lumefantrine (AL) in 2017, due to the development of d...
Article
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Background: The emergence of resistant parasites to artemisinin poses a threat to malaria treatment. The study aimed to investigate K13 gene mutations in Plasmodium falciparum artesunate (AS)/sulfadoxine-pyrimethamine (SP) efficacy study in Sudan. Methods: A total of 31 (14 failures and 17 adequate clinical and parasitological response [ACPR]) p...
Article
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Background Essential hypertension (EH) is influenced by various environmental and genetic factors. Nitric oxide is important for the functional integrity of the vascular endothelium and is produced in endothelial cells by the enzyme endothelial nitric oxide synthase (eNOS). EH has a strong genetic component, and the NOS3 gene, which encodes eNOS, r...
Article
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Background: Management of type 2 diabetes mellitus aims to maintain a normal glycemic status, which if not, it may lead to acute and/or chronic diabetic complications. Earlier studies found Lipocalin-2 elevated in complications associated with type 2 diabetes mellitus such as ischemic heart disease. These lipocalin-2 changes had been linked to obe...
Article
Background: Vitamin D Receptor (VDR) gene polymorphisms has been reported to be associated with different cancers, including breast cancer. geographical and environmental factors have an impact on vitamin D (VD) metabolism. This study aims to evaluate VDR-gene polymorphisms (Fok1, Bsm1, Taq1, Apa1) and its association with breast cancer risk among...
Article
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Background Artemisinin-based combination therapy (ACT), together with other control measures, have reduced the burden of falciparum malaria in sub-Saharan countries, including Sudan. Sudan adopted ACT in 2004 with a remarkable reduction in mortality due to falciparum malaria. However, emergence of resistance to the first-line treatment artesunate a...
Article
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Objectives: To study the association of mannose-binding lectin gene (MBL2) polymorphisms, and serum MBL levels in Sudanese patients with rheumatoid arthritis. Methods: We studied 88 patients and 53 healthy controls for the variants of the MBL2 gene at codons 52 (D), 54 (B), and 57 (C) by using PCR-RFLP. MBL levels were quantitatively measured by EL...
Article
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ABSTRACT: The Sudanese diabetic patients may have high frequency of dyslipidaemia, which contribute to accelerated coronary atherosclerosis. This study aims to assess Lp (a) and HbA1C in blood samples of Sudanese diabetic patients. In this cross-sectional prospective study, blood samples of 150 Sudanese diabetic patients were collected. Diabetic pa...
Article
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Original Article Background: Diabetes mellitus (DM) is the most common endocrine-metabolic disorder in children and adults. Cardio Vascular Disease (CVD) is a common complication of diabetes mellitus. The cause of the increased risk of CVD in diabetes is multi-factorial, including poor glycaemic control and dyslipidaemia. Aim of Study: This study w...
Article
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SCA causes chronic haemolysis which is a risk factor for cholelithiasis. To determine the prevalence and outcome of children with SCA complicated with gallstones treated at the sickle cell clinic at the children emergency hospital Khartoum state. 261 patients age 4 months to 16 years were studied. AUS examination was carried out. The 30 patients in...
Article
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Abstract Introduction: Anti Nuclear Antibodies are one of the auto antibodies which are involved in screening, diagnosis and pathology of some auto and non autoimmune and drug induced diseases including Lupus Erythrymatosus. Objectives: The aim of this study is to investigate, if there is any correlation between tamoxifen side effects and the blood...
Article
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The pre-dietary rehabilitation levels of acute phase proteins (APP) namely, alpha-1-antitrypsin (AAT), orosomucoid (ORO), haptoglobin (HAP), fibrinogen (FIB) and C-reactive protein (CRP) in the plasma of Sudanese children with severe protein energy malnutrition (PEM) were compared with those of normal controls, and with the levels after dietary reh...
Article
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A hospital-based case control study was carried out to determine the pattern of infections and immunoblobulin levels in Sudanese children with severe protein energy malnutrition (PEM). The pre-dietary rehabilitation levels of the three major immunoglobulins (IgG, IgA and IgM) were compared with those of normal controls, and with the levels after di...
Article
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The aim of this study was to investigate the efficacy of artemether-lumefantrine in treating uncomplicated Plasmodium falciparum malaria in four sentinel areas in Sudan with different malaria transmission (Damazin, Sinnar, and Kosti in the north, and Juba in the south). World Health Organization protocol for assessing antimalarial drug efficacy in...
Article
Background: Malaria has remained the major killer in Africa as a million children die of the disease every year. This problem is compounded by the emergence of resistance to the commonly used anti-malarial treatments. However, the collective action of the international community led to the establishment of the global fund which made more resources...
Article
Background: Sickle cell anaemia is a congenital hemolytic disorder caused by mutation in the â-globin gene at position 6 with replacement of glutamic acid by valine. Patients who arehomozygous for this mutation suffer from hemolytic anaemia and other serious complications. Theunderlying pathology of much of these complications is the occurrence of...
Article
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This study was designed to compare antigen content of normal with cancerous breast tissues from Sudanese patients. Fifty tissue samples (normal and cancerous) from 25 Sudanese patients with primary breast cancer were analyzed for their protein content using 2D PAGE, and for protein identification using LC/MS and nr.fasta data base search. Four prot...
Article
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Sudan experienced a long standing armed conflict in the south between the rebels and the central government. This 22 years old armed conflict resulted in mass displacement of people of southern Sudan to the north making Sudan to have the largest numbers of internally displaced people (IDPs) mounting to 4 million and half a million refugees in the n...
Article
Schistosomiasis is a chronic parasitic infection with over 200 million people infected worldwide. In Schistosoma mansoni infections, parasite-derived eggs get trapped in the liver, causing the formation of granulomas, which may develop into periportal fibrosis and portal hypertension, and thus severe morbidity. Eosinophil cationic protein (ECP) is...
Article
The presence of a geographical pattern in the distribution of the sickle cell gene (S gene) and its association with malaria is well documented. To study the distribution of the S gene among various ethnic and linguistic groups in the Sudan we analyzed a hospital-based sample of 189 sickle cell anemia (SCA) patients who reported to the Khartoum Tea...
Article
Full-text available
In an efficacy trial of artemisinin-based combination treatments (ACT) in central Sudan, cases of uncomplicated, Plasmodium falciparum malaria were given artesunate-sulfadoxine-pyrimethamine (ASP) or artemether-lumefantrine (AL) as first-line treatment. On enrolment, the 71 patients given ASP were similar to the 72 given AL, apart from having gener...
Article
Objectives: Sudanese health authority adopted a new antimalarial drug policy in response to the reported high level of chloroquine resistance. "Artesunate+ sulfadoxine/pyrimethamine" (ASP) and "artemether/lumefantrine" (A/L) are recommended as first and second lines for the treatment of uncomplicated falciparum malaria respectively. This study aims...
Article
We have earlier indicated neutrophil activation in severe malaria by measuring myeloperoxidase (MPO) and lysozyme, leukocyte granule proteins secreted by neutrophils as well as by other blood cells (monocytes/macrophages). In this study we evaluated the plasma levels of human neutrophil lipocalin (HNL), a specific neutrophil granule protein, in rel...
Article
Full-text available
338 women with age ranging from 15 to 69 years in a suburban Sudanese community were randomly selected and studied. Urine sample, high vaginal swabs and blood samples were investigated for bacterial vaginosis, candidiasis, trichomoniasis, gonorrhoea, HIV and syphilis. The sensitivity and specificity of some laboratory tests were evaluated. Bacteria...
Article
Eight patients with homozygous sickle cell anemia, 15 heterozygotes, and eight control individuals were investigated with respect to plasma concentrations of the inflammatory markers lysozyme and myeloperoxidase and the complement activation marker C3d. The patients showed significantly increased levels of myeloperoxidase and C3d, but not lysozyme,...
Article
Fifty-nine patients with homozygous sickle cell anaemia, 17 heterozygous individuals and 22 controls were investigated in respect to serum (S) 5'nucleotidase (5'NT, EC 3.1.3.5). The patients showed a significantly higher mean value of S-5'NT compared to the controls. However, this rise was heterogeneous as it occurred only among a subgroup of patie...
Article
Membrane-bound glyceraldehyde 3-phosphate dehydrogenase activity was measured in erythrocytes from 43 patients with sickle cell anaemia, 24 heterozygous and 27 controls. A significant increase of the activity was found among the patients but no such difference was observed between the heterozygous and the control individuals. The patients showed ne...
Article
Forty-three patients with homozygous sickle cell disease (haemoglobin SS), 24 heterozygous (AS) subjects and 24 controls (AA) from Sudan were investigated by haemolytic activation for complement function via the classical and the alternative pathways, respectively, and by determination of the plasma levels of C3, C4 and factor B as well as of immun...
Article
Ninety homozygous patients with Hb S haemoglobinopathy from Sudan were reported with respect to clinical findings, haematological and serum parameters. For comparison, 27 Hb AS heterozygous subjects and 28 Hb AA controls were investigated also. The patients showed an extreme type of illness presenting with severe clinical signs such as dactylitis,...
Article
Full-text available
Twelve patients suffering from sickle cell anaemia (Hb less than 75 g/l) with SS-haemoglobin were studied with special regard to Band 3-protein content in their erythrocyte membranes on SDS-PAGE. They were compared in this respect with 7 asymptomatic individuals with AS-haemoglobin and 10 healthy controls with the ordinary adult haemoglobin. A hete...

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