
Abdelouahed BelmalihCHU de Lyon - Hôpital Gériatrique Dr Frédéric Dugoujon
Abdelouahed Belmalih
About
28
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Publications (28)
Introduction
Wilson’s disease (WD) is a copper metabolism disorder characterised by a progressive accumulation of this metal mainly in the liver and the brain. Treatment is based on the removal of copper operated by the chelators, among which, D-penicillamine (DP) is prescribed as a first-line treatment in most situations. There is some evidence in...
OBJECTIVE: The aim of the study was to evaluate the performance of REC as a strong and reliable biochemical marker. It could be a useful tool for the efficiently diagnosis of WD for the pediatric patients with ALF. REC is defined as the percentage of exchangeable copper level and the total serum copper. It Is proven for REC to have a high specifici...
Objectives/introduction:
Determining 24-hour Urinary Copper Excretion (UCE) levels is useful for diagnosing Wilson's disease (WD) and for treatment monitoring. Exchangeable copper (ExC) is a novel potential marker, but its long-term changes have never been described in patients under chelation therapy. Our aim was to describe the long-term changes...
Background and study aims
Wilsonʼs disease is an autosomal recessive disorder, that affects copper metabolism, leading to copper accumulation in the liver, nervous system, and cornea. Data are lacking on the epidemiology, the clinical and laboratory characteristics, treatment, and survival of Wilsonʼs disease in Morocco. The aim of this study was t...
Background
Single daily dose (SDD) is a good way to improve adherence by simplifying treatment. Efficacy data concerning patients with Wilson disease (WD) taking an SDD are lacking.
Aim
To report the effectiveness of the use of SDD for the treatment of WD.
Methods
This retrospective study included WD patients followed in the French National Netwo...
Background/aim:
The spectrum of ATP7B variants varies significantly according to geographic distribution, and there is insufficient data on the variants observed in the French population.
Methods:
Clinical data of 113 children included in the French WD national registry were gathered from 01/03/1995 to 01/07/2020. Data included epidemiological,...
Objectives:
To describe a cohort of Wilson's disease (WD) paediatric cases, and to point out the diagnostic particularities of this age group and the long-term outcome.
Methods:
Clinical data of 182 paediatric patients included in the French WD national registry from 01/03/1995 to 01/06/2019 were gathered.
Results:
Diagnosis of WD was made at...
Long-term parenteral nutrition (PN) may induce bone complications. Tridimensional bone imaging techniques such as high-resolution peripheral quantitative computed tomography (HR-pQCT) allow the assessment of both compartmental volumetric densities and microarchitecture. Our aim was to evaluate these parameters in children and teenagers receiving lo...
The presence of modifier genes is now well recognized in severe liver disease outcome associated with Alpha-1-Antitrypsin Deficiency (A1ATD) but their identification remains to be fully elucidated. To address this goal, we performed a candidate gene study with the SORL1 gene, already identified as risk gene in early-onset Alzheimer Disease families...
The blood copper isotope composition recapitulates Wilson Disease progression and is therefore a potential prognostic biomarker.
Objectives
To identify prognostic factors for liver disease in children with alpha‐1 antitrypsin (AAT) deficiency, irrespective of phenotype, using the DEFI‐ALPHA cohort.
Methods
Retrospective, then prospective from 2010, multicentre study including children known to have AAT blood concentration below 0.8 g/L, born in France since 1989. Clinical a...
Introduction et but de l’étude
La nutrition parentérale (NP) au long cours pourrait induire des complications osseuses : ostéopénie, ostéoporose et risque accru de fracture. L’absorptiométrie par rayons X est l’examen usuel pour évaluer la densité osseuse chez l’adulte. Les nouvelles techniques d’imagerie osseuse 3D, comme la mesure par tomographie...
Background and aims:
Fifteen to twenty percent of alpha-1 anti-trypsin deficiency patients (A1ATD) have a severe liver outcome (portal hypertension - PHT) during childhood. Since they all share the same ZZ SERPINA1 genotype and that environmental factors such as alcohol cannot be advanced, the presence of modifier genes is now well-recognized. SNP...
Background
The most common and severe disease causing allele of Alpha 1-Antitrypsin Deficiency (1ATD) is Z-1AT. This protein aggregates in the endoplasmic reticulum, which is the main cause of liver disease in childhood. Based on recent evidences and on the frequency of liver disease occurrence in Z-1AT patients, it seems that liver disease progres...
We traced the cortical connections of the anterior sector (F5a) of the macaque ventral premotor (PMv) area F5 and compared them with those of the adjacent F5 sectors, F5c and F5p. F5a displays a very dense "intrinsic" connectivity with F5c and F5p, premotor connections limited to F4 and F6/pre-SMA, relatively robust prefrontal connections with area...
In the present study we first assessed that the hand motor field of the macaque ventral premotor area F5, involved in visuomotor control of hand actions, is connected to both the hand field of the primary motor cortex (M1) and the spinal cord. We then injected retroanterograde tracers in this field to completely illustrate its possible descending m...
We have found that the 2 architectonic subdivisions of the prefrontal area 45, 45A and 45B, display connectivity patterns that clearly distinguish them from one another and from their neighboring architectonic areas. Area 45A is primarily connected to the frontal areas 45B, 12l, caudal 12r, 12o, 10, rostrodorsal 46, 9/8B, 44, 8/FEF (frontal eye fie...
We used a cyto-, myelo-, and chemoarchitectonic (distribution of SMI-32 and calbindin immunoreactivity) approach to assess whether the rostral histochemical area F5 of the ventral premotor cortex (PMv) comprises architectonically distinct areas, possibly corresponding to functionally different fields. Three areas were identified, occupying differen...
We traced the cortical connections of the anterior intraparietal (AIP) area, which is known to play a crucial role in visuomotor transformations for grasping. AIP displayed major connections with 1) areas of the inferior parietal lobule convexity, the rostral part of the lateral intraparietal area and the SII region; 2) ventral visual stream areas...
The caudal part of the macaque ventrolateral prefrontal cortex (VLPF) is part of several functionally distinct domains. In the present study we combined a cyto- and a myeloarchitectonic approach with a chemoarchitectonic approach based on the distribution of SMI-32 and Calbindin immunoreactivity, to determine the number and extent of architectonica...
Over the last century, anatomical studies have shown that the cerebral cortex can be subdivided into structurally distinct regions, giving rise to a new branch of neuroanatomy: 'architectonics'. Since then, architectonics has been often accused of being overly subjective, and its validity for the definition of functionally different cortical fields...
We traced the cortical connections of the 4 cytoarchitectonic fields—Opt, PG, PFG, PF—forming the cortical convexity of the
macaque inferior parietal lobule (IPL). Each of these fields displayed markedly distinct sets of connections. Although Opt
and PG are both targets of dorsal visual stream and temporal visual areas, PG is also target of somatos...
The rostral part of the macaque ventral premotor cortex (PMv), corresponding to the histochemical area F5, is a functionally heterogeneous cortical sector. Two main populations of visuomotor neurons were electrophysiologically identified in this premotor sector : “Mirror neurons” and “Canonical neurons”. “Mirror neurons” were mostly found in the F5...