Abdellah El Maghraoui

Mohammed V University of Rabat | um5a · Private office of Rheumatology

Despite of the availability of several effective bDMARDs, a significant proportion of rheumatoid arthritis (RA) and ankylosing spondylitis (AS) patients discontinued bDMARDs. The aims of this study were to analyze causes of bDMARDs discontinuation in RA and AS included in the Moroccan registry RBSMR. A historical prospective multicenter cohort stud...

Background Glucocorticoid (GC) use is well established in the treatment of rheumatics diseases, particularly rheumatoid arthritis (RA). The use of low dose GC has been endorsed by EULAR recommendations for the management of rheumatic and musculoskeletal diseases even if in the context of SARS-CoV-2, but long-term use is generally discouraged. Obje...

Background Acute anterior uveitis is the most frequent extra-articular manifestation in spondyloarthritis (SpA). [1] Objectives The purpose of this study is to assess the prevalence of uveitis during SpA and to identify associated factors with its presence. Methods A cross-sectional multicentric observational study was conducted; the main data so...

Background Limited data have been published on tolerance and efficacy of biotherapy in elderly patients with rheumatoid arthritis (RA) [1] Objectives To assess in real life the efficacy and safety of biological treatments in elderly patients with rheumatoid arthritis (RA) and to identify predictive factors for a good therapeutic response. Methods...

Introduction: rheumatoid arthritis (RA) is a systemic autoimmune disease primarily affecting the joints. Arthritic disorders are associated with mutations of the Mediterranean fever (MEFV) gene. The aim of this study is to show whether MEFV mutations will be involved in the pathogenesis of RA, to explore the frequency of these mutations and to stu...

Dual-energy X-ray absorptiometry (DXA) is recognized as the reference method to measure bone mineral density (BMD) with good precision and reproducibility and acceptable accuracy errors. The World Health Organization (WHO) has established DXA as the best densitometric technique for assessing BMD in postmenopausal women and based the definition of o...

Introduction Dans les pays Nord-Africains, ayant un contexte infectieux différent des pays occidentaux, peu de données sont disponibles sur le risque infectieux sous anti-TNFα. À travers les données du registre de biothérapie de la Société marocaine de rhumatologie (RBSMR), on va évaluer le risque infectieux (hors tuberculose) sous anti-TNFα dans l...

Introduction Le Rituximab RTX est utilisé habituellement en deuxième intention selon les recommandations européennes et internationales. Au Maroc il est utilisé en première intention pour sa meilleure tolérance pour la tuberculose, son prix accessible et son utilisation séquentielle facile. L’objectif de ce travail est l’étude de l’efficacité et de...

Introduction Les calcifications aortiques abdominales (CAA) détectées lors de l’évaluation morphologique vertébrale a été validée comme indicateur de risque accru de fractures vertébrales (FV) dans d’autres populations, mais cette relation n’a jamais été évaluée chez les patientes atteintes de polyarthrite rhumatoïde (PR). L’objectif de cette étude...

Introduction Les spondyloarthrites (SPA) correspondent à un groupe de rhumatismes inflammatoires chroniques caractérisés par une atteinte axiale, une atteinte articulaire périphérique, une atteinte enthésique, des atteintes extra-articulaires spécifiques, un terrain génétique particulier et une tendance à l’ankylose. Les critères ASAS des spondyloa...

Résumé Objectifs : Les études sur l’efficacité des bDMARD (biological Disease-Modifying Anti-Rheumatic Drugs) en fonction du statut des anticorps anti-peptides cycliques citrullinés (ACPA) dans la polyarthrite rhumatoïde (PR) trouvent de nombreuses discordances. Dans le but de contribuer à lever l’équivoque, notre étude visait à évaluer l’associati...

Before the initiation of biotherapy in the treatment of rheumatic diseases, it is highly recommended for the patients to be screened for latent tuberculosis infection (LTBI). The objective of this study is to identify the prevalence of LTBI among patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA) before the initiation of biologic t...

Background Objectives The aim of this study was to estimate the annual direct cost of biologics in rheumatoid arthritis and to evaluate the impact of social factors on biological use and costs. Methods Patients in the Moroccan register of biologicals (RBSMR) with available 1-year data were included. Variables related to socio-economic status, dis...

Background NA Objectives To estimate the annual direct costs of biological therapies in Spondyloarthropathies (SpA) and to establish possible factors associated with those costs. Methods The main data source was the Moroccan registry of biological therapies in rheumatic diseases (RBSMR). We included SpA patients with available 1-year data. Variab...

Objectives The aim of this study was to calculate direct costs amount in rheumatoid arthritis (R.A) patients in the Moroccan register of biologicals RBSMR registry. Methods Patients in the Moroccan register of biologicals RBSMR registry with available 1-year data were included. Variables related to socio-economic status, disease and biological the...

Objectives The aims of our study are to determine the new comorbidities appearing under biologic therapy, their prevalence, and the factors implicated in their appearance. Methods It’s a multicentric historical-prospective cohort including 10 rheumatology departments of Moroccan University Hospitals. The data were collected from the national regis...

Introduction:This study aims at reporting the RA male frequency while undergoing biotherapy and describing the epidemiological characteristics (clinical, biological and radiological) in relation to female RA. It also evaluates its impact on the response to biological treatments. Materials and methods: There are 224 patients followed for rheumatoid...

Background: Treatment advances have reduced the adverse events associated with hematopoietic stem cell transplant (HSCT) and led to an increased number of transplants performed. HSCT patients are living longer with concerns on long-term outcomes. Bone fragility and fracture are at the forefront for long-term morbidities post-HSCT. Results: In HS...

The aim of the study was to estimate the annual direct costs of biological therapies in rheumatoid arthritis (RA), and to establish possible factors associated with those costs. The main data source was the Moroccan registry of biological therapies in rheumatic diseases (RBSMR Registry). We included patients with available 1-year data. Variables re...

Introduction: the aim of our study is to determine, from data of the Moroccan register of biotherapies, the factors influencing the choice of the first prescribed biological treatment. Methods: cross-sectional multicenter study including rheumatoid arthritis patients who were initiated the first biological treatment either: Rituximab, an anti-TN...

Several studies have reported changes in body composition in rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Our study showed that body composition measurements obtained by absorptiometry were highly reproducible in patients suffering from these diseases. This study justifies the use of absorptiometry measurements in longitudinal studies...

Introduction Le diabète et la polyarthrite rhumatoïde (PR) sont deux maladies chroniques et fréquentes. La glycémie à jeun élevée est associée à une inflammation et une synthèse des produits terminaux de glycation avancée et un stress oxydatif qui pourraient être responsables de dégradations articulaires. Le but de cette étude est d’évaluer l’impac...

Introduction Les recommandations actuelles conseillent une stratégie additive en commençant par un traitement de fond synthétique conventionnel puis en cas d’efficacité insuffisante, l’ajout d’une thérapeutique ciblée. L’objectif de ce travail est d’évaluer l’efficacité et la tolérance du traitement biologique seul et en association avec un traitem...

Introduction Le CT-P13 (Remsima®) est un biosimilaire du produit de référence de l’infliximab INX (Remicade®) et est prescrit, la plupart du temps pour les mêmes indications que l’infliximab. Notre objectif était de comparer l’efficacité et la tolérance du CT-P13 versus INX chez les patients atteints de spondyloarthrite (SpA) inclus dans le registr...

Introduction Le switch d’un anti-TNF au rituximab a prouvé son efficacité et sa bonne tolérance chez les malades ayant une polyarthrite rhumatoïde. Or, dans un pays comme le nôtre où le rituximab est fréquemment prescrit autant que premier biologique, on est amené à switcher vers une autre biothérapie (souvent un anti-TNF) sans avoir assez de recul...

Introduction La sarcoïdose musculaire est rarement symptomatique et affecte principalement les muscles proximaux des membres inférieurs. Cependant, la localisation distale dans les membres supérieurs est rare. Nous avons utilisé une approche systématique pour analyser la littérature et nous n’avons identifié que trois cas de sarcoïdose musculaire d...

Introduction La polyarthrite rhumatoïde (PR) est le plus fréquent des rhumatismes inflammatoires chroniques. Il s’agit d’une maladie auto-immune systémique avec un état inflammatoire chronique et un traitement a base de corticothérapie,qui peuvent induire une perte osseuse, ce qui rend le dépistage de l’ostéoporose indispensable [1], [2]. Plusieurs...

Introduction La prise en charge de la spondylarthrite doit avoir pour objectif la rémission clinique ou à défaut une activité minimale, en tenant compte des différents aspects de la maladie. La CRP élevée représente un critère de mauvais pronostic dans la spondylarthrite. Notre étude a pour but de trouver une relation entre le taux initiale de CRP...

Introduction La dépression représente une comorbidité fréquente au cours des rhumatismes inflammatoires chroniques. Elle s’accompagne souvent d’un niveau élevé d’activité de la maladie chez les patients rhumatisants, et peut donc fausser ou interférer dans l’évaluation de la réponse au biologique. Matériels et méthodes Au total, 418 patients ont é...

Introduction Les nouveaux bio-médicaments ont considérablement amélioré le pronostic des patients souffrant de rhumatisme inflammatoire chroniques. Toutefois, ils arrivent que certains malades soient réfractaires à plusieurs biologiques. À partir de 3 biologiques, on définit le caractère réfractaire. L’objectif de cette étude est de déterminer les...

Introduction Le tocilizumab, anticorps monoclonal humanisé spécifique de la sous-unité alpha du récepteur de l’interleukine 6 (IL-6), occupe une place importante dans l’arsenal thérapeutique de la polyarthrite rhumatoïde active, modérée à sévère, en cas de réponse inadéquate ou intolérance à un ou plusieurs traitements de fond. L’objectif de notre...

Introduction Le traitement de la polyarthrite rhumatoïde (PR) chez le sujet âgé notamment par biothérapie est rendu plus difficile par la présence de pathologies associées et par l’augmentation des effets secondaires. Le but de notre travail est d’évaluer l’efficacité et la tolérance des biothérapies à 12 mois chez les sujets âgés. Matériels et mé...

Introduction D’après une méta-analyse publiée en 2014, il existe une discordance entre les études au sujet de l’association entre le statut ACPA et la réponse clinique chez les patients PR sous anti-TNF alpha [1]. Ceci mérite que d’autres études soient entreprises dans ce sens. Nous avons donc souhaité évaluer l’association entre le statut ACPA et...

Introduction Le statut socioéconomique constitue un élément déterminant l’activité de la polyarthrite rhumatoïde (PR) à plusieurs égards. Le niveau éducationnel des patients atteints de PR, un des paramètres les plus important du statut socioéconomique, pourrait avoir une influence sur l’évolution et le pronostic de la maladie. L’objectif de notre...

Objectives Vertebral fracture assessment (VFA)-detected abdominal aortic calcification (AAC) has been validated as an indicator of increased risk of vertebral fractures (VFs) in other populations but this relationship in rheumatoid arthritis (RA) is unclear. We assess the prevalence of AAC on VFA scans and its potential relationship with prevalent...

Background: The aim of our study is to determine, from data of the Moroccan register of biotherapies, the factors influencing the choice of the first prescribed biological treatment. Methods: Cross-sectional multicenter study including rheumatoid arthritis patients who were initiated the first biological treatment either: Rituximab, an anti-TNF, or...

Résumé Introduction: La biothérapie permet un contrôle sur l’activité des spondyloarthrites et une réduction ou un arrêt des traitements symptomatiques est espéré. Il y a peu d’études qui se sont intéressées à l'utilisation concomitante des AINS et des antalgiques avec les biologiques. À partir des données du registre de biothérapie de la Société M...

Muscular sarcoidosis is rarely symptomatic and mainly affects proximal muscles of the lower extremities. However, the distal localization in the upper extremities is rare. We used systematic approach to analyze all relevant literature review and we identified only three cases of muscular sarcoidosis of the upper extremities. We report the case of a...

Background Diabetes mellitus (DM), a worldwide high prevalence disease, is associated with a large variety of musculoskeletal (MS) disorders. They are poorly treated, as compared to microvascular complications. However, they are a common source of disability. Objectives We designed this study to assess the prevalence of MS disorders among diabetic...

Background Adherence to conventional DMARDs (disease-modifying anti-rheumatic drugs) is highly variable in rheumatoid arthritis (RA), ranging from 22 to 107%. Many studies have evaluated these drugs adherence, but only one single systematic review evaluated specifically methotrexate adhesion in patients with RA. Objectives The aim of this study is...

INTRODUCTION: A potential role of Homocysteine (HCY) in bone metabolism has been considered from the observation of high prevalence of osteoporosis in subjects with Homocystinuria about 50 years ago. But the mechanism linking the increased level of HCY to increased fracture risk is not clear. The objective of this study was to investigate this poss...

Autologous and allogeneic hematopoietic stem cell transplantation (HSCT) is the treatment of choice for patients with some malignant and non-malignant hematological diseases. Advances in transplantation techniques and supportive care measures have substantially increased the number of long-term HSCT survivors. This has led to an increasing patient...

Introduction La dysplasie spondylo-épiphysaire tardive (DSET) est une chondrodysplasie génotypique rare qui altère spécifiquement les épiphyses et les vertèbres, caractérisée par une petite taille disproportionnée à l’adolescence ou à l’âge adulte [1]. Observation Patiente âgée de 18 ans ayant un frère aîné présentant la même symptomatologie clini...

Introduction. A variety of musculoskeletal disorders (MS) have been associated with diabetes mellitus (DM). This study aimed at assessing the prevalence and associated factors of MS disorders in Moroccan diabetic patients. Methods. A cross-sectional study enrolled consecutive patients with DM.We recorded demographic features of patients and charact...

La polyarthrite rhumatoïde (PR) est le rhumatisme inflammatoire chronique le plus fréquent, elle touche 0,5% à 1% de la population mondiale. La pneumopathie interstitielle diffuse (PID) constitue la manifestation respiratoire la plus fréquente de la PR. Elle affecte significativement le pronostic vital et limite les possibilités thérapeutiques de l...

Abstract: Interstitial lung disease is the most common respiratory manifestation of rheumatoid arthritis. It significantly affects the prognosis and limited treatment options for rheumatoid arthritis. A link between the use of methotrexate, which is the ordinary treatment of rheumatoid arthritis and the appearance of interstitial lung disease, has...

Antitumor necrosis factor therapies have revolutionized the treatment of some inflammatory diseases. However, the use of these agents is associated with the development of many paradoxical autoimmune diseases. Less well-recognized is the association with sarcoidosis. We report a 55-year-old female with long-standing ankylosing spondylitis who devel...

Introduction: osteoporosis and cardiovascular diseases are two major public health problems. Their relationship towards each other was often controversial. In this context, the objective of this study was to examine the influence of homocysteine (Hcy) and asymptomatic osteoporotic vertebral fractures (VFs) using vertebral fracture assessment (VFA)...

BACKGROUND-AIM The concentration of 25-hydroxyvitamin D in serum, is considered to be the most reliable determination of the overal vitamin D status. The importance of vitamin D in the blood circulation is increasing worldwide and correlates with the recent studies showing positive correlation between vitamin D insufficiency and metabolic diseases,...

The main of this study was to examine the relationship between plasma homocysteine (Hcy), asymptomatic osteoporotic vertebral fractures (VFs) using vertebral fracture assessment (VFA) and prevalent abdominal aortic calcification (AAC) in Moroccan postmenopausal women. The study cohort consisted of 188 consecutive postmenopausal women with no prior...

Aim of the work: The aim of this study was to assess the influence of anti-cyclic citrullinated peptide (anti-CCP) on disease activity, radiological severity, functional disability and bone loss in Moroccan women with rheumatoid arthritis (RA). Patients and methods: One hundred and thirty-six women with RA were recruited. Age, weight, height, disea...

Vitamin D has an important role in bone metabolism and may be involved in the process of vascular calcification. The objective of this study was to evaluate the effect of vitamin D status on the presence of abdominal aortic calcification (AAC). We enrolled, in a cross-sectional study, 429 postmenopausal women [mean age, weight, and BMI of 59.5???8....

Objective: to evaluate the impact of changing from male to female database for T-score derivation on mean T-score, and bone mineral density diagnostic classification when applying the WHO criteria, in men. Material and methods: 1200 men were enrolled. Lumbar spine and femur scans were obtained using a bone densitometer. Initially, the male normativ...

Osteoporosis is the most common bone disease in humans. With its related fragility fracture, it represents a major public health problem in our region, with a significant medical and socio-economic burden. The high prevalence rate of vitamin D deficiency, the increase in life expectancy, the low socioeconomic level and the significant restriction t...

Impact of the change in the bone densitometer reference database on the prevalence of osteoporosis and vertebral fractures.

Background: A number of questionnaire-based systems and the use of portable quantitative ultrasound scanners (QUS) have been devised in an attempt to produce a cost-effective method of screening for osteoporosis. Objective: to assess the sensitivity and specificity of different techniques and their ability to act as screening tools in relation to d...

Purpose: The main purpose of this study was to describe and compare the vitamin D status, parathormone, calcium, and phosphate of healthy Moroccan men and women aged 50 years and older. Methods: We conducted two cross-sectional studies, in postmenopausal women from October 2008 to November 2009 and in men over 50 years old, from December 2009 to...

Background Osteoporosis is a well-known complication of ankylosing spondylitis (AS). However, data about body composition modifications and muscle performance showed conflicting results. The aim of the study was to determine the prevalence and risk factors of pre-sarcopenia, sarcopenia and cachexia in patients with AS and analyze its relationship w...

Background: A number of questionnaire-based systems and the use of portable quantitative ultrasound scanners (QUS) have been devised in an attempt to produce a cost-effective method of screening for osteoporosis. Objective: to assess the sensitivity and specificity of different techniques and their ability to act as screening tools in relation to d...

Background It is well established that weight is an important determinant of bone health. Whereas obesity is associated with increased mortality and morbidity from diabetes and cardiovascular diseases, high body weight is widely believed to be associated to hypovitaminosis D and protective against the development of osteoporosis and fracture risk....

La lombalgie aiguë est la pathologie rhumatismale la plus fréquente en Afrique. L’épidémiologie et la présentation clinique ne diffèrent pas de celles observées sur les autres continents. En revanche, les aspects psycho-sociaux, la disponibilité des traitements, l'accès aux soins et le poids culturel des médecines traditionnelles sont autant de spé...

Introduction Gonadal steroid hormones play a crucial role during skeletal growth and maturation in both men and women. The aim of this study is to evaluate the relationship of sex hormone levels, bone mineral density and biochemical markers of bone turnover in healthy Moroccan men. Methods 142 Moroccan men who had no previous diagnosis of osteopor...

A 20-year-old girl is consulting for perineal pain associated with mictional urgency evolving for 3 months. Clinical examination and laboratory tests are without defects. The renal bladder ultrasound examination is unremarkable. Cystometry shows an overactive bladder. An MRI of the lumbar spine reveals a terminal cone at a lower position below L5 w...

Rheumatoid arthritis (RA) is a cardiovascular risk factor (CV) as important as diabetes. Indeed, the cardiovascular disease increases mortality in patients with RA. Traditional risk factors do not explain alone the occurrence of fatal CV complications. However, it is important to look for other parameters responsible in the occurrence of a CV event...

Introduction Le présent travail se propose d’étudier la relation entre les hormones sexuelles, notamment l’œstradiol et l'indice de l’œstradiol libre, le sulfate de déhydroépiandrosterone et la sex hormone binding globulin, les marqueurs de remodelage osseux et la densité minérale osseuse chez une population de femmes marocaine ménopausées. Méthod...

To assess the prevalence and risk factors of rheumatoid cachexia (RC) and evaluate its relationship with osteoporosis and vertebral fractures (VF) in patients with rheumatoid arthritis (RA). We enrolled into a cross-sectional study 178 consecutive patients with RA (82.6% women) with a mean age of 54.1 ± 11.5 years (25-82) and who fulfilled the Amer...

This article reports a taxonomic classification of rare skeletal diseases based on metabolic phenotypes. It was prepared by The Skeletal Rare Diseases Working Group of the International Osteoporosis Foundation (IOF) and includes 116 OMIM phenotypes with 86 affected genes. Rare skeletal metabolic diseases comprise a group of diseases commonly associ...