AbdElkarim A. Abdrabo

Al-Neelain University, Sudan International University · Clinical Chemistry

Introduction: Vascular endothelial growth factor (VEGF), protein originally referred to as vascular permeability factor, maybe a signal protein produced by cells that stimulate the formation of blood vessels and a sub-family of growth factors. They are important signaling proteins engaged in both vasculogenesis and angiogenesis. It is a part of t...

Background: a strong relation was observed between body mass index and insulin resistance which were associated with type 2 DM. Objective: to correlate between bodies mass index and levels of insulin and lipids among type 2 diabetic patients with different body mass index. Methods: this study was conducted in Khartoum state, it included 80 with typ...

The objective of this study is to shed more light on the role of trace metals and their mode of action in hyperthyroidism and hypothyroidism. The content of the trace elements Zinc and Manganese (Zn and Mn) in the serum of patients was determined (Forty patients with hyperthyroidism (26 females and 14 males) and hypothyroidism (23 females and 17 ma...

ABSTRACT Background: Diabetes mellitus is a metabolic disease known as chronic hyperglycemia, resulting from defective insulin action and secretion. Various studies have documented liver disease as a major cause of mortality in patients with type 2 diabetes. Notably, the liver plays an important role in the maintenance of normal glucose levels duri...

Introduction: Breast cancer is the most frequent cancer in women globally as well asSudan, it has risen to become the second commonest cause of death in women.Vitamin D receptor (VDR) is a ligand-dependent transcription factor. Vitamin D-ligandedVDR, has anti-proliferative properties in a variety of tumor types by inducing cell cycle arrest, senesc...

Background: Generally, patients on hemodialysis for chronic renal failure also have endocrine defects and sexual function disorders. In this study, we aimed to assess the serum prolactin (PRL), luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in patients with chronic renal failure. Methods: This hospital-based case–control study was...

Background: Malaria is a major public health problem in tropical areas. It is responsible for infecting 300-500 million people and 1-3 million deaths annually. The liver takes part in malaria parasite live cycle, this leads to the destruction of liver cells and leads to liver function tests abnormalities. Objective: To assess liver function tests i...

Background: Delay in handling blood samples lead to inaccurate results because they may be exposed to light causing analyte degradation. The photodegradation of bilirubin will result in clinically significant changes in concentrations of bilirubin, this change might affect the clinical circumstances for which the test was requested. This study was...

Citation: Mohammed Rida., et al. "Role of Anti-Müllerian Hormone in Prediction of ICSI Outcome in Sudanese Women with Polycystic Ovaries Syndrome". EC Gynaecology 8.10 (2019): 978-983. Abstract Background: Polycystic ovary syndrome (PCOS) is the most common cause of infertility in women at reproductive age. The treatment of PCOS is expensive and ti...

Background: The leishmaniasis is a group of diseases with a broad range of clinical manifestations caused by several species of parasites belonging to the genus Leishmania. LL-37/hCAP18, the only cathelicidin in human, is expressed as an 18-kDa preproprotein. The most prominent function of cathelicidin is their ability to inhibit propagation of a d...

Background: Breast cancer has the highest cancer incidence in women and is one of the leading causes of mortality globally. Lactate dehydrogenase (LDH) and

Background Diabetes leads to metabolic abnormalities. These abnormalities produce problems in a variety of organ systems such as ophthalmopathies, neuropathies, nephropathies, and vasculopathies. Infertility is common in diabetic patients, caused by abnormal semen. Objectives This study was conducted to check semen quality in diabetic Sudanese pat...

Abstract: Background: Diabetic Retinopathy (DR) is one of the long-term complications of Diabetes Mellitus (DM) and constitutes the leading cause of blindness in working-age individuals. Prolactin (PRL) is a peptide hormone that is linked with lactation but many studies have demonstrated that PRL could have protective value against DR. Aim: To eval...

Atorvastatin is lipid lowering drug use in different cases to prevent complications of hyperlipidemia by lowering lipid mainly affect cholesterol, but it also affect in concentration of other serum parameters such as uric acid and creatinine. Case-control study was conducted during the period between Marchs to May 2017, included 100 participants 60...

Background: Diabetic nephropathy is principle cause of end stage kidney failure worldwide. Numerous research studies documented that 25(OH) vitamin D has numerous extra skeletal effects including glycemic control and diabetic nephropathy complication. Objectives: To compare the level of 25(OH) vitamin D between Type 2 diabetic patients with and wit...

Background: Accumulating evidence suggests that the typical and atypical antipsychotic drugs have serious metabolic disturbance. Objective: To compare the effects of atypical (Olanzapine) and typical (Haloperidol) antipsychotic medications on lipid profiles, plasma parathyroid hormone, bone minerals, glucose and insulin hormone levels in Sudanese s...

Anemia adds considerably to the morbidity in patients with rheumatoid arthritis (RA). Iron has many important functions in human body. This study aimed to evaluate the level of blood indices, serum Iron and Total Iron Binding Capacity (TIBC) and their correlation with durations and complications of disease. This is crosssectional study involved 48...

Background: Leukaemia is a malignant disorder of the bone marrow and it’s in a heterogeneous group of neoplasm arising from transformation of uncommitted or partial committed hematopoietic cells. This study was conducted at Khartoum state Sudan during October to December 2015. Aim: The aim of the study was to assess liver functions in leukemic pati...

The objective of this study is to shed more light on the role of trace metals and their mode of action in hyperthyroidism and hypothyroidism. The content of the trace elements Zinc and Manganese (Zn and Mn) in the serum of patients was determined (Forty patients with hyperthyroidism (26 females and 14 males) and hypothyroidism (23 females and 17 ma...

Citation: Lutfi MF, Elhakeem RF, Khogaly RS, Abdrabo AA, Ali AB, Gasim GI and Adam I (2015) Zinc and copper levels are not correlated with angiographically-defined coronary artery disease in sudanese patients. Front. Physiol. 6:191. We investigated zinc and copper levels in angiographically defined obstructive coronary artery disease (CAD) in patie...

Diabetes is a major and growing health problem worldwide and in the Sudan, zinc and vit D play a functional role on insulin function and glucose tolerance. Study aim to evaluate zinc level in type2 DM patients with vit D deficiency. Cross-sectional study was conducted on 120 type2 DM patients aged between 25-80 years old, classified based on vit D...

Chronic Renal Failure (CRF) patients are at risk of cardiovascular diseases due to the elevation of various forms of lipids. The present study was done to describe the impact of long term hemodialysis on the levels of lipids profile. A total of 70 patients with chronic renal failure under regular hemodialysis that does not share the same period of...

Objective: to evaluate and compare serum testosterone in patients with toxoplasmosis and normal healthy individuals. Materials and Methods: A case control study was conducted in 150 subjects in military hospital, during the period from February to June 2015. The studied population consisted: 100 patients already diagnosed as toxoplasmosis patients...

Objective: To estimate serum levels of zinc and magnesium among Sudanese children under 5 years with protein energy malnutrition (PEM), in comparison with apparently healthy volunteers. Materials and methods: A cross- sectional hospital based study conducted during the period from May to September 2013. Children with PEM were chosen from Omdurman T...

Background:Psoriasis is an inflammatory dermatosis thatis characterized with hyperproliferation of keratinocytes and inflammatory infiltration in the epidermis and dermis. The high prevalence of atherosclerosis has been reported in psoriatic patients. High serum lipid level has been suggested in the pathogenesis of this phenomenon. Aims:To compa...

Background: Delay in handling blood samples lead to inaccurate results because they may be exposed to light causing analyte degradation. The photodegradation of bilirubin will result in clinically significant changes in concentrations of bilirubin, this change might affect the clinical circumstances for which the test was requested. This study...

Objective: to estimate testosterone and prolactin levels in chronic Sudanese smokers regardless of their fertility functions. Materials and methods: the study was conducted at Omdurman area-Khatoum state-Sudan during the period from December 2012 to March 2013, it involved a control group of apparently healthy non smokers (N=50) matched for a...

Background: Thyroid dysfunction causes significant changes in kidney function. Both hypothyroidism and hyperthyroidism affect renal blood flow and glomerualr filteration rate (GFR). Aim: to evaluate serum creatinine, urea, and creatinine clearance concentrations in patients with thyroid dysfunctions. Materials and Methods: the study involved...

Context: Cigarette smoking is a risk factor for wide range of diseases; however, still there are no laboratory screening tests for early detection of the possible biochemical derangements induced by smoking. Aim: to evaluate serum cholesterol, liver enzymes, uric acid and hemoglobin concentrations in smokers regardless of their present complain. Ma...

Background: Previous data on the possible effects of age and gender on serum lipids profile of elderly people showed considerable debates. Aim: to evaluate the effects of age and gender on serum lipids profile measurements in over 55 years-old Sudanese individuals. Materials and methods: The study involved sixty-four males and forty age-matched fem...

2.5-10 ‫نانوغرام‬ / ‫مل‬. ‫البحث‬ ‫وطرق‬ ‫مواد‬ ‫مايو‬ ‫من‬ ‫الفتره‬ ‫في‬ 2009 ‫مارس‬ ‫حتى‬ 2012 ‫عدد‬ ‫تحويل‬ ‫تم‬ 540 ‫البولية‬ ‫المسالك‬ ‫جراحة‬ ‫بقسم‬ ‫الجامعى‬ ‫سوبا‬ ‫بمستشفى‬ ‫البروستات‬ ‫عن‬ ‫للكشف‬ ‫مريض‬. ‫من‬ ‫اختيار‬ ‫تم‬ ‫العدد‬ ‫ھذا‬ 236 ‫بين‬ ‫الكلي‬ ‫المتضد‬ ‫مستوى‬ ‫لديھم‬ ‫مريض‬ 2.5 ‫و‬ 10 ‫نانوغرام‬ / ‫مل‬. ‫ال‬ ‫بعدھا‬ ‫خضع‬ ‫كم...

To assess the significance of serum total prostate specific antigen (tPSA) and digital rectal examination (DRE) in the diagnosis of prostate cancer (PC). One hundred and eighteen patients with serum tPSA ranging between 2.5 and 10 ng/ml with lower urinary tract symptoms presented at the Urology Clinic of Soba University Hospital, Khartoum, Sudan fr...

To determine age-specific prostate-specific antigen (PSA) reference values in a community-based sample of Sudanese men, aged 40-90 years. This study was conducted in the Central Laboratory Services, Soba University Hospital, Khartoum, Sudan from January 2008 to May 2010. Total serum PSA in 3475 Sudanese men with no clinical evidence of lower urinar...