Abdelkareem Abdallah Ahmed

Botswana University of Agriculture and Natural Reseources/Darfur University College · Veterinary Sciences

This study presents a comprehensive transcriptome analysis of canine intestinal epithelial cells following treatment with sulforaphane (SFN), a naturally occurring compound found in cruciferous vegetables with established anti-inflammatory and antioxidant properties. Through high-throughput sequencing, we identified 29,993 genes, among which 1,612...

Food-borne diseases have been rising daily, significantly affecting the health and economy of developing countries. Proper preparation and handling can decrease the incidence of foodborne diseases. This study aimed to assess the knowledge, attitude, and practices regarding food safety among students of English institutes in Central Darfur, Sudan. A...

Heat stress (HS) is a significant concern in broiler chickens, which is vital for global meat supply in the dynamic field of poultry farming. The impact of heat stress on the ileum and its influence on the redox homeostatic genes in chickens remains unclear. We hypothesized that adding zinc to the feed of heat-stressed broilers would improve their...

Introduction: The gastrointestinal tract is integral to defending against external contaminants, featuring a complex array of immunological, physical, chemical, and microbial barriers. Mycotoxins, which are toxic metabolites from fungi, are pervasive in both animal feed and human food, presenting substantial health risks. Methods: This review exami...

Scientific evidence for intelligence in donkeys could expose their historical unmerited cognitive derogatory status. Psychometric testing enables quantifying animal cognitive capabilities and their genetic background. They have an excellent memory, and a great ability to learn a lot from the surrounding environment. Despite their enormous contribut...

This study aimed to assess the knowledge, attitudes, and practices related to meat hygiene among butchers and meat workers in abattoirs and markets in Garsila. A total of one hundred structured questionnaires were used to collect data on participants' knowledge and practices regarding meat hygiene, and data analysis was performed using SPSS version...

The livestock sector plays a critical role in the Sudanese economy and the welfare of the whole population. Despite the sector’s significant contribution to peoples’ livelihoods, the veterinary services and education environment has always faced daunting challenges in Sudan. However, there is no literature on the challenges faced by the veterinary...

As a member of alpha-coronaviruses, PEDV could lead to severe diarrhea and dehydration in newborn piglets. Given that lipid peroxides in the liver are key mediators of cell proliferation and death, the role and regulation of endogenous lipid peroxide metabolism in response to coronavirus infection need to be illuminated. The enzymatic activities of...

The study attempted to use systematic and thematic analysis of reported top 100 cited articles on Gum research. We adopted systematic and thematic analysis using bibliometric analysis tools, such as Scopus database to search relevant documents in Gum. Data were analyzed by RStudio and VOSviewer, and the top 100 cited articles were systematically cl...

Deoxynivalenol (DON), one of the most common mycotoxins contaminating food and feed, has been shown to induce hepatotoxicity. Lactoferrin (LF) enriched in human milk is a critical functional food component and performs the hepatoprotection function. Here, we aimed to explore whether dietary LF supplementation can protect from DON-induced hepatotoxi...

Most people around the world eat meat and billions of animals are slaughtered each year to meet that demand. For many, eating meat is a biocultural activity steeped in tradition and formative in cuisines and identity. Eating meat, however, comes with a myriad of ethical and practical considerations. In tandem with animal rights and environmental su...

Climate change is considered a main factor that negatively impacts agriculture and animal production. In addition, it also influences the animal's immune functions and diet intake, making it susceptible to infectious diseases. Recent nutritional research involving genomics proposes a rational ability to prevent disease occurrences. Scientific evi...

Cattle in Sudan serves multiple purposes in agricultural systems, and producing milk is crucial for raising income and providing for domestic needs. However, there is no historical data on the assessment of cattle welfare in Sudan, especially in Nyala. The current study was carried out on 11 dairy farms with Frisian cows from January to March 202...

Abstract Genetic polymorphism studies in domestic animals aim at assessing genetic variations within and across breeds mainly for preservation purposes. The bone morphogenetic protein 15 (BMP 15) gene is a growth factor and a member of the transforming growth factor (TGFβ) superfamily specifically expressed in oocytes. One of the very exciting an...

Introduction: Liver damage due N-diethylnitrosamine (DEN) is a global health challenge. The aim of this study was to assess the efficacy of roselle (Hibiscus sabdariffa L.) calyces’ water-extract as a Hepatoprotective material against liver damage induced by DEN in rats. Material and methods: Twenty-five (25) adult female albino Wistar rats were gr...

Working horses in Low and Middle income countries have a significant impact on people’s lives. In spite of their best, the well-being of Sudanese working horses are neglected. There is no information on Sudanese working horse’s welfare. The purpose of this study was to investigate working horse welfare and owners’ perceptions in two states. A metho...

Background The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index...

Background The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index...

Background The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index...

Background The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index...

Background The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index...

The donkey (ass) Equus asinus is an important domestic animal in all African countries. They play a crucial role in the economies of undeveloped countries; Sudan is no exception. Sudan has approximately 7.5 million heads of donkeys. They contribute to goods transport, riding, and holding people by cart and agriculture activities. However, the welfa...

General public attitudes to key animal welfare issues

Background Deoxynivalenol (DON) is a major mycotoxin present in staple foods (particularly in cereal products), which induces intestinal inflammation and disrupts intestinal integrity. Lactoferrin (LF) is a multifunctional protein that contributes to maintaining intestinal homeostasis and improving host health. However, the protective effects of LF...

Our perceptions shape our intentions, our motivations, our behavior, and in doing so, our reality. In this age of the Anthropocene, our perceptions also impact the lives and welfare of other animals. One of the key principles associated with the success of international animal welfare initiatives is an understanding of local audiences and contexts....

In impoverished nations, donkeys help people make a living. The welfare of donkeys in Sudan is neglected compared with developed countries. However, there is no information available about donkey welfare in Nyala. This study aimed to assess the welfare of donkeys in Nyala. Donkeys were divided into two groups (n=50), working and nonworking. The don...

Rheumatoid arthritis (RA) is an autoimmune multi-systemic inflammatory disease affecting joints result in dysfunction and ultimately damage, sero-negative RA has the clinical manifestations but negative diagnostic markers of RA. The aims from this study are to highlight and report an unusual presentation of sero-negative RA in young Sudanese patien...

Under the influences of modern lifestyle, metabolic syndromes (MetS), including insulin resistance, obesity, and fatty liver, featuring a worldwide chronic disease, greatly raise the risk of type 2 diabetes, heart disease, and stroke. However, its pathogenesis is still unclear, and there are limited drugs with strong clinical efficacy and specifici...

Obesity is a metabolic disease associated with high morbidity and mortality worldwide. Previously we showed that Gum Arabic (GA) inhibited obesity in fed with diet-induced obesity. However, the mechanism underlying the mode of action is not fully elucidated. Here we aimed to identify the effects of GA on CCAAT-enhancer-binding protein- α (C/EBP- α)...

Introduction Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation of the synovial membrane. RA is classified as seropositive or seronegative, according to the absence or presence of primarily IgM RF, RF, and/or ACPA. The aim of this study is to identify the relationship between the serotype of rheumatoid arthritis...

SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients.Since surgical patients are already at higher risk of venous thromboembolism than general populations, thisstudy aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk ofvenous thromboembolism. We...

Abdominal pain does have a wide differential diagnosis, however, gastrointestinal involvement is not unusual in SLE, and this report is to describe an unusual case of intussusception due to SLE in a Sudanese woman. image

Background Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery during the COVID-19 pandemic in periods of lockdown versus light restriction.

Background: Surgery is the main modality of cure for solid cancers and was prioritised to continue during COVID-19 outbreaks. This study aimed to identify immediate areas for system strengthening by comparing the delivery of elective cancer surgery during the COVID-19 pandemic in periods of lockdown versus light restriction. Methods: This internati...

A middle-aged Sudanese woman has been presented complained about multiple joint pain, skin rash, chest pain, hair loss, severe abdominal pain associated with abdominal distension, bloody diarrhoea and vomiting. Lab investigation and computed tomography (CT) abdomen revealed the patient have an intussusception on top of SLE. The patient was treated

Objectives: Diabetes mellitus (DM), an endocrine disorder, epidemic all over the world which causes dysfunction of reproductive capacity. Gum Arabic (GA), a dietary fibre has potential health effects on reproductive system. Visfatin is one of the adipokines which has a crucial role in reproductive function. Aims: We hypothesized that the testicular...

Systemic Lupus Erythromatous (SLE) is an auto immune disease characterized by multi-organ affection, Guillain–Barré syndrome (GBS) is considered as an unusual and one of the least neuropsychiatric syndromes in SLE, this case report aiming to report a rare association of GBS as an initial presentation for an SLE in a female patient. A middle age fem...

Peri-operative SARS-CoV-2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS-CoV-2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Su...

Jaccoud's Arthropathy (JA) is a condition characterized clinically by reversible joint deformities such as ulnar deviation, swan neck, thumb subluxation and hallux valgus, along with an absence of articular erosions on a plain radiograph. This report aims to highlight the clinical presentation and medical management of JA as well as to draw attenti...

Rheumatoid Arthritis (RA) is a common autoimmune multi-systemic inflammatory disease affecting joints result in dysfunction and ultimately damage. Bronchiectasis (BR) is a long term pulmonary condition that is characterized by permanent dilation of the bronchial, the association of RA and BR has been recognized since the past five decades. This is...

Obesity is a global health problem associated with high morbidity and mortality. However, the effect of GA on anti-inflammatory cytokines is not reported. We intended to investigate the effects of GA on anti-inflammatory cytokines in mouse fed with high fat diet. Forty five female CD-1 mice of 90 days old were randomly divided into three groups (n=...

Systemic lupus erythematosus (SLE) is a systemic disease which affects mainly young females and can cause life-threatening conditions. Pleural effusion can occur in SLE patients and usually tends to be mild and bilateral. This report aims to highlight the clinical presentation and medical management of massive unilateral pleural effusions in SLE pa...

Exposure to excess Glucocorticoids (GCs) during embryonic development influences offspring physiology and behaviors and induces change in Hypothalamic-Pituitary-Adrenal (HPA) axis genes expression and serotonergic system in mammals. Whether prenatal corticosterone (CORT) exposure induces similar effects in avian species remains unclear. In the pres...

Glucocorticoids (GCs) are a class of stress hormones that play a large number of biological actions in the body. The levels of GCs regulated by the intracellular enzyme 11β-hydroxysteroid dehydrogenases (11β-HSD 1 & 2) and are associated with the pathogenesis of metabolic syndrome. Here we aimed to investigate effect of Gum Arabic (GA) on GCs plasm...

Corona viruses are the most important single-stranded RNA viruses, which infects both animal and human, causing respiratory diseases. In late December 2019, in Wuhan, China; there were a group of patients admitted to the hospitals with a principal diagnosis of pneumonia of an unknown etiology. The history of the patients was related to seafood and...

Amyloidosis is a group of rare, serious disorders caused by deposition of amyloid protein in tissues, such as the kidney, heart and brain. However, there is no case reported from Sudan. Here, we report one male case of renal amyloidosis, possibly secondary to abdominal tuberculosis (Tb). A male, 30 years of age, complained of systemic body swelling...

Abnormal epigenetic modifications are a trademark of cancer, and endocrine system related organs cancers are without exception. Lately, studies have acknowledged an ever-growing number of epigenetic modifications in both DNA methylation and histone modifications in the endocrine system organs cancers. Novel ultra-deep sequencing and microarray tech...

Systemic lupus erythematosus (SLE) is a systemic disease that affects many organs. A few patients with SLE develop Stevens–Johnson syndrome (SJS), a life-threatening disease characterized by the appearance of a partial-thickness burn in the skin and mucous membranes. This report aims to increase awareness among clinicians about the relationship bet...

The Corona virus disease 2019, caused by severe acute respiratory syndrome coronavirus 2, and has become the furthermost popular clinical entity since the beginning of the year 2020, as a viral infection spread rapidly and has significant mortality rate. The aim of this study is to report the first case of COVID 19 in Sudan. Here we are report a...

A serious of unexplained cases with pneumonia have been reported in Wuhan, china. The disease has a very similar clinical manifestation of viral pneumonia. After multiple sequences analysis of respiratory tract samples, a novel strain of coronavirus was isolated, and has been named Coronavirus Disease 2019 (COVID19). Common symptoms include cou...

Systemic Lupus Erythematosus (SLE) is a systemic, autoimmune inflammatory disease with an unknown aetiology and various presentations. Many infections, certain drugs and dermatological diseases may mimic SLE. this report describes two case of SLE mimicked by secondary syphilis. A 24 years old lady complained of maculopapular skin rash, fever, loss...

Antiphospholipid syndrome (APS) is an autoimmune disease with autoantibodies and hypercoagulability. Although APS has a variable clinical presentation, APS commonly presents vascular thrombosis and obstetrical complications, such as repeated miscarriages in women. Here, we report an elderly male with the clinical manifestations of APS and recurrent...

Antiphospholipid syndrome (APS) is an autoimmune disease with autoantibodies and hypercoagulability. Although APS has a variable clinical presentation, APS commonly presents vascular thrombosis and obstetrical complications, such as repeated miscarriages in women. Here, we report an elderly male with the clinical manifestations of APS and recurrent...

The phenotype of organisms is not only influenced by genetic factors, but also by environmental factors that play a critical role in shaping their morphology, physiology, behavior and reproductive capacity. In avian species, maternal influences have aroused much attention after the discovery that avian eggs contain a variety of maternal derived ste...

The phenotype of organisms is not only influenced by genetic factors, but also by environmental factors that play a critical role in shaping their morphology, physiology, behavior and reproductive capacity. In avian species, maternal influences have aroused much attention after the discovery that avian eggs contain a variety of maternal derived ste...

Background Acute rheumatic fever (ARF) is an inflammatory disease caused by autoimmune responses to bacterial infection. Rheumatic heart disease (RHD) damages one or more heart valves through recurrent episodes of ARF. We aimed to determine the changes in sensitivity, specificity and predictive values in RHD Jones diagnostic guidelines following th...

Down’s syndrome is a chromosomal disorder caused by trisomy of chromosome 21. It presents with different phenotypes including autoimmune diseases and arthritis. The aim of this case report is to describe and document rheumatoid arthritis and gouty arthritis in patient with Down's syndrome. Here we are reporting a case of 44 year-old female with Dow...

Background: Ovarian carcinoma is the fifth leading cause of cancer death worldwide. The tumour mostly associated with various factors such as advanced age, early menstruation and gene association. We aimed to highlight the effectiveness of second-line chemotherapy in the management of ovarian cancer patients in Sudan. Methods: The data collected fr...

Systemic Lupus Erythematosus (SLE) is a disease with various manifestations. Its treatment aims to reduce the symptoms and to prevent the flairs. In this report, we are discussing three cases of SLE who required treatment with Rituximab. The first case was an 18-year-old female who presented with urinary symptoms and subsequently she developed lupu...

Hypothyroidism is a major disorder of the endocrine system in which the thyroid gland has not ability to produce enough thyroid hormones. Diabetes Mellitus is one metabolic disease associated with hyperglycemia resulting from defect in insulin secretion or insulin action or both of them. Hypothyroidism associated with T2DM is not reported In southe...

Cancer is a sickness, initiated and driven via accumulation and interaction of genetic and epigenetic modification of genes involved in regulation of cell communication, signaling and growth division. Epigenetics is known as heritable changes in the expression of genes which are different from mutations that are not attributable to modification of...

Breast cancer id one of the common types of tumours, and the main leading cause of death due to cancer in women in all the globe [1], in 2018 approximately more than million and a half new cases of this cancer were diagnosed, fifty per cent of all breast cancer cases and sixty per cent of the deaths in developing countries [2]. Breast cancer treatm...