Abdelkader Hamdi Battah

• M.B,B.S; M.Sc; Ph.D
• Chairman at University of Jordan

Simple Summary When a couple faces infertility challenges like sperm motility issues, they often visit fertility clinics for assistance. Poor sperm motility can delay fertilization, making natural conception difficult. In an andrology laboratory, embryologists test the semen sample. Before assisted reproduction procedures, embryologists usually per...

Background: Poison centers (PCs) have been established in some of the Eastern Mediterranean region (EMR) countries; however, their history, scope of services, and data collection parameters have not been studied. Aims: To investigate whether PCs in the EMR offer standardized and harmonized services compared to PCs in developed countries.Methods: Re...

The use of chemotherapy has improved the overall treatment of breast cancer, which is frequently administered in the form of neoadjuvant chemotherapy (NAC). Apoptosis is an established cell stress response to NAC in preclinical models; however, there is limited understanding of its role in clinical cancer, specifically, its contribution to favorabl...

Introduction Acute accidental poisoning in children remains a significant public health issue and a predictable cause of morbidity around the world. To take preventive measures, it is necessary to identify the pattern of this problem. Objective To determine the extent and characteristics of paediatric poisoning, an epidemiological investigation sp...

Objectives The objectives of this study were to evaluate the relationships between serum sodium and glucose concentrations and outcomes among patients admitted to the surgical intensive care unit. Materials and Methods Patient records admitted to the surgical intensive care unit (SICU) between July 2020 and December 2020 were used in the study. Da...

Purpose Illicit drug use is a well-known global problem that has been noticed to be increased significantly among medical students. This study aims to assess the prevalence and consequences of illicit drug use among medical students in the country of Jordan using the validated Drug Abuse Screening Test-10 (DAST-10). Design/methodology/approach The...

Background: The utility of the Sequential Organ Failure Assessment (SOFA) score in predicting mortality in the intensive care unit (ICU) has been demonstrated before, but serial testing in various settings is required to validate and improve the score. This study examined the utility of the SOFA score in predicting mortality in Jordanian ICU patie...

Background: Anti-inflammatory corticosteroids are used in cancer treatment and COVID-19 infections. Data on the impact of non-dexamethasone corticosteroids on COVID-19 infection severity in cancer patients are minimal. This study investigates if corticosteroid treatment affects the disease severity in adult cancer patients. Methods: A total of 1...

Abstract Background: Anti-inflammatory corticosteroids are used in cancer treatment and COVID-19 infections. Data on the impact of non-dexamethasone corticosteroids on COVID-19 infection severity in cancer patients are minimal. This study investigates if corticosteroid treatment affects the disease severity in adult cancer patients. Methods: A tota...

Background: Dexamethasone is used to treat cancer, relieve chemotherapy-induced nausea and vomiting, enhance cancer patients’ appetites, and treat COVID-19 patients. There is little evidence of the impact of a dexamethasone treatment plan on the severity of COVID-19 infections in cancer patients. This study explores whether dexamethasone treatment...

Abstract: Background: Dexamethasone is used to treat cancer, relieve chemotherapy-induced nausea and vomiting, enhance cancer patients’ appetites, and treat COVID-19 patients. There is little evidence of the impact of a dexamethasone treatment plan on the severity of COVID-19 infections in cancer patients. This study explores whether dexamethasone...

Abstract Background: Dexamethasone is used to treat cancer, relieve chemotherapy-induced nausea and vomiting, enhance cancer patients’ appetites, and treat COVID-19 patients. There is little evidence of the impact of a dexamethasone treatment plan on the severity of COVID-19 infections in cancer patients. This study explores whether dexamethasone t...

Nanoparticles (NPs) that combine stimuli-triggered drug release and active targeting of tumors signify a dual smart strategy in chemotherapeutic inhibition of cancer growth. Recently, low molecular weight protamine (PrtLMW) has been utilized to replace its precursor protamine (Prt) in the clinic, as it exhibits less undesirable side effects. In thi...

Desmosomes are cellular structures that are critical in cell–cell adhesion and in maintaining tissue architecture. Changes in the expression of desmocollin-2 (DSC2) have been noted during tumor progression into an invasive phenotype and as cells undergo epithelial-mesenchymal transition. We have previously reported that breast MDA-MB-453 cancer cel...

Background COVID-19 pandemic is expected to affect the mental health, especially among medical students. Data from the literature in Jordan are scarce, especially during the second wave of the pandemic. We aimed to assess medical students’ level of fear, prevalence of depressive and anxiety symptoms—represented in psychological distress (PD)—and sl...

Twelve hair samples were collected from a selected representative worker group working in a battery plant. The hair samples were analyzed for lead (Pb) levels using Atomic Absorption Spectrophotometry (AAS). Blood lead (BPb) levels were predicted from the results of hair samples lead levels following application of Clayton and Wooler (1983) model....

REDICTING BLOOD LEAD LEVELS USING AIR LEAD LEVELS IN ACID BATTERY MANUFACTURING PLANT ALA’ ALI AHMAD AL-SUBEIHI1* AND ABDELKADER H. BATTAH2 1Department of Pharmacy, Faculty of Pharmacy, Amman Arab University, P.O. Box 2234, Amman 11953, Jordan. 2Department of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jord...

Gastric cancer (GC) is the fifth most common cancer and the third leading cause of cancer-related mortality worldwide. Although multidisciplinary therapeutic strategies have improved treatment outcomes, the overall prognosis for patients with GC remains poor. Recently, immunotherapeutic agents targeting immunosuppressive proteins such as anti-progr...

Synthetic cannabinoids (SCs) were developed to mimic the effects of ∆9-tetrahydrocannabinol (∆9-THC) on humans. Synthetic cannabinoids were distributed in the form of herbal blends, with smoking being the main method of consumption. These synthetic compounds have a wide range of physical, behavioral, and harmful effects on the body. However, this s...

Lead toxicity is a public health hazard particularly to the occupationally exposed workers. Evidence is mounting successively regarding the adverse health effects of lead at low levels. This study is conducted to assess lead cytotoxicity and the antioxidant status of selected groups of Jordanian workers occupationally exposed to lead poisoning or a...

Objectives: To study any possible correlation between blood lead levels and some oxidative stress parameters of selected groups of lead-exposed automobile occupational Jordanian workers. Material and methods: Blood lead levels were determined for a total of 90 male automobile workers aged within the range of 25-45 years old along with the group...

Background Dihydropyrimidine dehydrogenase (DPD) is a crucial enzyme in the catabolism of 5-fluorouracil (5-FU), a drug that is frequently used in cancer therapy. Patients with deficient DPD activity are at risk of developing severe 5-FU–associated toxicity. One possible cause of deficiency is genetic polymorphisms in the DPD gene, such as IVS14+1G...

OBJECTIVE: To investigate the histomorphometric alterations induced in testicular tissues by variable sizes of silver nanoparticles (SNPs). STUDY DESIGN: Male mice (BALB/C) were treated with SNPs (1 mg/kg) using 5 different sizes (10, 20, 40, 60, and 100 nm) for 35 days. Testicular biopsies from all mice under study were examined histomorphologica...

Nanosilver is widely used in medicine, industry, and other applications where it poses a high potential risk for human health, even though little information is available on its toxicity to vital organs. This study was conducted to determine the histopathological changes induced in renal tissues by various sizes of silver nanoparticles (SNPs). Male...

Nanosilver is widely used in medicine, industry, and other applications where it poses a high potential risk for human health, even though little information is available on its toxicity to vital organs. This study was conducted to determine the histopathological changes induced in renal tissues by various sizes of silver nanoparticles (SNPs). Male...

Background: An increased incidence of non-Hodgkin’s lymphoma (NHL) has been reported in farmers and other occupational groups working with pesticides. In these individuals, an increased prevalence of the chromosomal translocation t(14;18)(q32;q21), one of the most common chromosomal abnormalities in NHL, has been detected in peripheral blood lympho...

The chemical composition of volatile oil hydrodistilled from the aerial parts of Rosmarinus officinalis L. (Lamiaceae), collected from cultivated species in Jordan, has been analyzed by means of GC and GC-MS. The oil yield was 0.7 % (v/w of dried material). Fifty five compounds, counting for more than 99 % of the oil composition, were successfully...

Silver nanoprticles (SNPs) are invested in medical, industrial and environmental applications. Little if any, is known about the morphometric alterations induced by the toxicity of SNPs. The aim of the present work is to find out the effect of variable size of SNPs on different morphometric parameters. Adult healthy male mice (BAL/C) were subjected...

Abstract Background: Silver nanoparticles (SNPs) rapid involvement in industry and nanomedicine increased human exposure to variable forms of these particles, with possible potential risk on human health. Aims: The aim of this study is to investigate the biochemical changes induced by variable sizes of SNPs toxicity. Place and Duration of Study: F...

Alcohol and Psychoactive Drugs in Road Traffic Fatalities within Northern District of Amman Abdul Qader H. Battah, Momen S. Al-Hadidi, Emad M. Abdullat, Kamal A. Hadidi Abstract Objective: Several studies have demonstrated that alcohol and psychoactive drugs consumption are important risk factors underlying fatal accidents. This paper presents a...

Rapid intravenous administration of D-ribose may result in a significant reduction in cellular damage in patients with sudden ischemic insults. The development of an effective and clinically safe therapeutic regimen using the intravenous route in critically ill patients especially with cardiac diseases requires a comprehensive assessment of potenti...

To evaluate the potential toxic effects associated with the intravenous administration of an isotonic solution (4.2%) of d-ribose once per day for 14 days in Fischer rats (F-244), thirty rats were randomly divided into 3 groups (5 males and 5 females each). Rats in group 1 received 10 ml/kg of a 4.2% d-ribose solution intravenously once per day for...

Drug abusers are highly motivated to obtain negative results on urine drug abuse screens and may attempt to subvert the process by trying to adulterate their samples. One of the processes thought to make drug abusers escape a positive urine drug screen is the ingestion of different herbal and other foodstuff products along with drug intake. This pr...

A rapid auto-identification method was developed to reduce the time required for unknown detection in defined groups of compounds in postmortem biological materials. This was achieved by the creation of an excel sheet containing retention time and retention index of n-alkane mixture (C 15 – C 36). Then, a calculated retention index and the retentio...

This handbook provides a systematic description of the principles, procedures, and technology of the modern analytical techniques used in the detection, extraction, clean up, and determination of pesticide residues present in the environment. This book provides the historical background of pesticides and emerging trends in pesticide regulation....

In the present study, a rapid, simple and economical reversed phase-HPLC procedure has been developed for the determination of vitamin D 3 and vitamin D 2 in pharmaceutical preparations. The vitamins were separated isocratically on a Teknokroma C18 column (150×4.6mm, 3.5μm particle size) with a mobile phase consisting of isocratic acetonitrile and...

A practical and simple procedure was developed for the analysis of lysergic acid diethylamide (LSD) in blood samples utilizing solid phase extraction isolute HCX column. The analysis was performed on a reversed phase HPLC ODS-Hypersil column, eluted by a mobile phase of 0.3% triethylamine in 68:32 phosphate buffer (0. I M, pH 8.0):acetonitrile. LSD...

Five known compounds from the aerial parts of Gundelia tournifortii. L. (scopoletin, isoscopoletin, esculin, and a mixture of β.-sitosterol and stigmasterol) were isolated and identified on the basis of spectral evidence (1H NMR, 13C NMR, MS, and IR). The volatile oil from aerial parts of G. tournifortii. was obtained by hydrodistillation, for the...

A general multiresidue method cannot be applied unconditionally to all medicinal plants to extract the residues of interest. The main objective here was to evaluate the Association of Official Analytical Chemists (AOAC) official method 985.22 with Mentha piperita. L. samples. This AOAC method is one of the methods used in pesticide residue labs wor...

Origanum syriacum is a medicinal plant widely used in Jordan both as a folk remedy and in the food and beverage industry. As the plant can be treated with pesticides during commercial production, three different methods for pesticide multiresidue analysis of this plant have been evaluated. One method based on soxhlet extraction followed by acetonit...

To evaluate the benefits of using serial measurements of plasma cholinesterase (butyrylcholinesterase, BuChE) activity in the management of cholinesterase inhibitor insecticidal poisoning. After establishing and validating BuChE activity test, and making it available for clinical service in the toxicology laboratory at Jordan University Hospital. S...

Chlorinated hydrocarbons, pyrethroids, organophosphorus, and other miscellaneous pesticides in dried and powdered fruits of Pimpinella anisum were analyzed using two official Association of Official Analytical Chemists methods as a general guidance, and applying Florisil column cleanup. Both methods applied proved to show adequate recovery, repeata...

Abstract Stability of three commonly prescribed sulfonylureas (glipizide, chlopropamide and glibenclamide) in postmortem blood and water stored at –20, 4, and 25°C were evaluated over a 1-year period. The drugs were analyzed simultaneous by utilizing solid phase extraction techniques and were identified and quantified by high performance liquid chr...

The aim of this investigation is to study drug interaction between theophylline-famotidine and theophylline-diclofenac in New Zealand white male rabbits. The serum concentration-time profile and the pharmacokinetics parameters of theophylline given alone intravenously (10 mg/kg) and following pre-treatment with either oral famotidine (5 mg/kg) or i...

The effect of 600 mg/kg given by oral route to rats of Ferula hermonis roots extracts (petroleum ether, ethyl acetate, methanol and water) was evaluated on sexual behaviour of male rats. Petroleum ether and ethyl acetate extracts produced a significant decrease in both the mount rate (MR) and the intromission rate (IR), significant prolongation of...

Aluminum phosphide (AlP) pesticide is a highly toxic, low cost, and easily accessible rodenticidal agent. Its toxicity results from the liberation of phosphine gas upon exposure to moisture, which leads to multisystem involvement, resulting in serious consequences. The highly toxic parathion insecticide was a common cause of mortality in pesticide...

In Jordan, pursuing legal procedures related to alcohol intake usually depends on the physicians' clinical judgment. A study was carried out on 825 medico-legal cases over a 2 year period to evaluate the extent of physicians' clinical decisions on patients suspected to be under the influence of alcohol. A significant number of cases (12.6%, n = 104...

All post-mortem medicolegal reports issued by Jordan University Hospital (JUH) during the period 1978-96 were reviewed. Carbon monoxide (CO) as a silent killer was responsible for 31.5% (n = 110) of poisoning fatalities. These were due to unintentional exposure to CO sources in confined spaces (bedrooms (24.6%), worker lodgings (23.6%) and bathroom...

Trihexyphenidyl (THP) is an anticholinergic agent with forensic toxicological interest. The stability of THP was studied in postmortem blood and urine samples at a concentration of 0.25 microgram/ml under different storage temperatures. After solid phase extraction (SFE), THP was measured by gas chromatography. On day zero and at intervals over a 6...

The magnitude of alcohol-associated incidents in relation to medicolegal cases, including road traffic accidents and acts of violence, has not been evaluated in Jordan. Between 1993 and 1995, 825 such cases received at Jordan University Hospital were screened for the presence of alcohol. Blood alcohol was positive in 9.1% of vehicle passengers, 9.6...

Stability of Trihexyphenidyl in stored blood and urine specimens A. Battah, K. Hadidi. Abstract Trihexyphenidyl (THP) is an anticholinergic agent with forensic toxicological interest. The stability of THP was studied in postmortem blood and urine samples at a concentration of 0.25 μg/ml under different storage temperatures. After solid phas...

Stability of buprenorphine, carbamazepine, morphine, phenobarbitone, phenytoin, temazepam and trihexyphenidyl, prepared in aqueous solutions was examined over one year storage at -20,4 and 25°C. The aim of the project was to evaluate the use of pre-prepared solutions in the analytical procedure of these drugs to produce accurate and reliable result...

The pharmacokinetic parameters (AUC, Cmax, Tmax, and t1/2) of nifedipine following single oral administration of a 10 mg capsule of test product were compared to those of the same amount of a reference product. The two products in capsule form were administered according to a randomized two-way crossover design in 22 healthy male volunteers. Nifedi...

The pharmacokinetic parameters of digoxin given intravenously (0.075 mg/kg) alone and following treatment with oral cholestyramine (8 gm in 50 ml water) were studied in rabbits. Pretreatment with cholestyramine produced a significant decrease in the serum concentration of digoxin and significantly enhances its systemic clearance as indicated by a s...

The work described in this thesis was in the field of Forensic Toxicology, which is the study and practice of toxicology for legal purposes. Three different application areas were considered: (a) the analysis of drugs in blood by gas chromatography-mass spectrometry (GC-MS) following isolation from the biological matrix by solid phase extraction pr...