Abd. Kakhar Umar

Abd. Kakhar Umar
Universitas Padjadjaran | UNPAD · Pharmaceutics and Pharmaceutical Technology

Ph.D. Research Scholar in Pharmaceutical Sciences and Technology
Looking for collaboration on drug design and development

About

21
Publications
11,929
Reads
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102
Citations
Citations since 2016
21 Research Items
101 Citations
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Introduction
I work on delivery systems for biomolecules (growth factors, secretome of mesenchymal stem cell, genes, etc.) and other natural drugs (curcumin, alpha mangosteen, brazillin, quercetin, concentrated deepsea minerals) for diabetic wound healing and cancer therapy. The drug delivery systems are usually prepared from liposome or polymer, or their complexed form. I also love coding. I have been developing several software and systems to support pharmaceutical research and service.
Education
January 2022 - December 2024
Chulalongkorn University
Field of study
  • Pharmaceutical Sciences and Technology
August 2019 - July 2020
Universitas Padjadjaran
Field of study
  • Pharmaceutical science
February 2018 - February 2019
Universitas Padjadjaran
Field of study
  • Apothecary

Publications

Publications (21)
Article
Full-text available
Background: Hypertonic and hypotonic conditions in pharmaceutical preparations decrease the drug's absorption and bioavailability. In addition, it can cause tissue damage. There are several calculation methods to regulate hypotonic preparations. However, there are no methods that can be used to regulate hypertonic preparations without causing dose...
Article
Full-text available
Film-forming sprays offer many advantages compared to conventional topical preparations because they can provide uniform drug distribution and dose, increased bioavailability, lower incidence of irritation, continuous drug release, and accelerated wound healing through moisture control. Film-forming sprays consist of polymers and excipients that im...
Article
Full-text available
Human epidermal growth factor (hEGF) has been known to have excellent wound-healing activity. However, direct application to the wound area can lead to low hEGF bioavailability due to protease enzymes or endocytosis. The use of liposomes as coatings and carriers can protect hEGF from degradation by enzymes, chemical reactions, and immune reactions....
Article
Full-text available
Stem cells’ secretome contains biomolecules that are ready to give therapeutic activities. However, the biomolecules should not be administered directly because of their in vivo instability. They can be degraded by enzymes or seep into other tissues. There have been some advancements in localized and stabilized secretome delivery systems, which hav...
Article
Full-text available
Diabetes-related wounds have physiological factors that make healing more complicated. High sugar levels can increase microbial infection risk while limiting nutrition and oxygen transfer to the wound area. The secretome of mesenchymal stem cells has been widely known for its efficacy in regenerative therapy. However, applying the secretome directl...
Chapter
Full-text available
Phytoantioxidants refer to chemicals of plant origin such as flavonoids (flavones, flavonones, flavonols, flavononol, isoflavones, and flavan‐3‐ols) and other polyphenols (phenolic acids, stilbenes, lignans, and tannins). Phytoantioxidants have been reported to act against parasitic diseases (malaria, dengue, chikungunya, leishmaniasis, Zika virus,...
Article
Full-text available
Mangosteen fruit has been widely consumed and used as a source of antioxidants, either in the form of fresh fruit or processed products. However, mangosteen peel only becomes industrial waste due to its bitter taste, low content solubility, and poor stability. Therefore, this study aimed to design mangosteen peel extract microcapsules (MPEMs) and t...
Article
Full-text available
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected billions and has killed millions to date. Studies are being carried out to find therapeutic molecules that can potentially inhibit the replication of SARS-CoV-2. 3-chymotrypsin-like protease (3CL pro) involved in the polyprotein cleavage process is believed to be the key targ...
Article
Full-text available
The present study was aimed to develop silybin phytosome (SIBP) and evaluate its effectiveness against cerebral ischemia-reperfusion (CIR) injury in rats. Initially, SIBP was prepared and characterized with Fourier transform-infrared spectroscopy, differential scanning calorimetry, and scanning electron microscopy. Drug loading and entrapment effic...
Article
Full-text available
Liposomes have been used extensively as micro- and nanocarriers for hydrophobic or hydrophilic molecules. However, conventional liposomes are biodegradable and quickly eliminated, making it difficult to be used for delivery in specific routes, such as the oral and systemic routes. One way to overcome this problem is through complexation with polyme...
Article
Full-text available
Buah Merah, a typical fruit from Papua, Indonesia which is used empirically in cancer therapy is rich in carotenoids and flavonoids. However, the mechanisms by which Buah Merah ameliorates cancer remained unknown. Natural antioxidant enzymes and pro-oxidant enzymes modulation significantly suppressed ROS production and cancer growth. Therefore,...
Article
Full-text available
Quercetin derivatives are known to have significant anticancer activity. The activity is strongly influenced by the type and position of the substituent group. By studying the structural pattern of quercetin and its impact on their binding affinity, the development of quercetin-based drugs can be optimized. The study aimed to determine the impact o...
Article
Full-text available
Background COVID19 is a global pandemic that threatens all nations. As there is no effective antiviral drug for COVID19, we examined the potency of natural ingredients against the SARS-CoV-2 main protease (PDB ID 6YNQ). Buah merah is a typical fruit from Papua, Indonesia, which is known to contain high levels of carotenoids and flavonoids. The cont...
Article
Full-text available
Indonesia is a maritime country with abundant seawater mineral content. One of the regions with the highest salt production is Pamekasan Madura. Minerals are known to have many roles and benefits for our bodies, such as regulating fluid balance and metabolism. Therefore, this study aimed to characterize the physicochemical and microbial properties...
Article
Full-text available
A Seawater contains many types of minerals that can be used in the medical sector as raw materials for medicines and supplements. In Indonesia, one of the biggest mineral salt-producing areas is Pamekasan Madura with a recent record income of 2,768,809.95 tons. With the many mineral resources available and the potential development of medicinal raw...
Article
Full-text available
Colorectal cancer is one of the most common cancer diseases with the increase of cases prevalence >5% every year. Multidrug resistance mechanisms and non-localized therapy become primary problems of chemotherapy drugs for curing colorectal cancer disease. Therefore, the enteric-coated nanoparticle system has been studied and proved to be able to re...
Article
Full-text available
Human epidermal growth factor (hEGF) and autologous serum are considered safer and more effective in treating dry eye syndrome. However, suitable formulas and preparation methods are needed to obtain eye drop containing autologous serum and hEGF, which are stable during storage and use. Therefore, this study aimed to develop a stable and effective...
Article
Full-text available
Context: Human epidermal growth factor (hEGF) has biological activities and can be used in medicines and cosmetics. A high level of effectiveness of hEGF can be obtained when three disulfide bonds fold perfectly. Extracellular secretion from E. coli BL21 using the PelB signal peptide is a new way to obtain hEGF with a structure that folds appropri...
Article
Full-text available
Kata kunci: anti-asma; in silico; kipas laut (G. marie); sterol. ABSTRAK. Kipas laut (Gorgonia mariae) telah digunakan masyarakat Maluku secara turun-temurun sebagai obat asma. Kandungan metabolit sekunder yang paling dominan dalam kipas laut adalah sterol, dimana memiliki aktivitas terapi melalui efek sinergisme antara senyawa metabolit dengan pol...
Article
Full-text available
The administration of human Epidermal Growth Factor (hEGF) for diabetic ulcer treatment has been known to have high effectiveness because hEGF has mitogenic properties and has been proved to increase epithelial cell proliferation both in vitro and in vivo. However, hEGF in environmental conditions of diabetic ulcers is known to have low stability,...
Article
Full-text available
In designing the preparation of the drug, appropriate excipients are required in the formulation. A mixture of incompatible additives will result in poor quality of preparations. The purpose of this research is to design software algorithms capable of analyzing excipient incompatibility based on incompatibility data in Handbook of Pharmaceutical Ex...

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Projects

Projects (6)
Project
To be a leading example for adapting an advanced & a sustainable approach for investigating the biological activity, bioavailability, and toxicity of phytochemicals.