Abbas Pardakhty

• PharmD, PhD, Professor of Pharmaceutics
• Vice Chancellor for Research and Technology at Kerman University of Medical Sciences

Background: Acne vulgaris, a chronic inflammatory condition of sebaceous glands, is often linked to microbial colonization (e.g., Cutibacterium acnes , Staphylococcus epidermidis, Staphylococcus aureus ) and inflammatory factors. This study explores the potential of Eucalyptus galbie and green tea ( Camellia sinensis ) extracts, delivered via nioso...

Nanophytosomes (NPS) loaded with whole pomegranate fruit extract with peel and arils (PFE) at different levels of phosphatidylcholine (PC) were produced using a thin‐film hydration method and reinforced with calcium ions. PFE was obtained by pressing whole pomegranates, followed by mixing with PC at ratios of 1:1, 1:2, and 1:3, which then strengthe...

Background Non-ionic surfactant-based vesicles (niosomes) as coherent and selforganization capability structures form organized core/shell nanostructures. Objective In this academic research, Ni/NiAl2O4 core/shell nanostructures were successfully synthesized with the ultrasound-assisted direct micelle (UADM) method and these structures were used a...

Purpose Currently, there is a crucial need for alternative strategies to control leishmaniasis, which threatens more than 1 billion people worldwide. The simultaneous use of combination therapy and nanostructured lipid carriers aimed to assess the leishmanicidal activity of silver and dapsone niosomes co-administration in vitro and in silico. Meth...

Exposure to cadmium chloride (Cd) is linked to reproductive disorders. Curcumin (CUR), a traditional medicinal compound, has been considered for its therapeutic properties. The present study evaluated the antioxidant effects of CUR and liposomal CUR on Cd-induced testicular toxicity. Mice were exposed to Cd (2.5 mg/kg as a single intraperitoneal do...

Purpose Sorafenib is known as one of the oral anti-cancer drugs used in liver cancer. However, its lipophilic nature can lead to side effects, variable pharmacokinetics, and poor absorption. The use of novel drug delivery systems, such as niosomes, may help address these issues and improve the effectiveness of sorafenib. Methods Different niosomal...

Background: Candida albicans is the yeast that causes the fungal infection known as candidiasis. One of the standard methods for treating candida is the application of fluconazole. The low solubility of fluconazole in aqueous media is a big problem in the use of this agent. Novel drug delivery systems, such as microemulsions, could be applied to so...

Background Treatment of vitiligo is still a big challenge for dermatologists. The efficacy of statins in the treatment of vitiligo is controversial. Aim and Objective We studied possible therapeutic effect of topical 1% niosomal atorvastatin ointment combined with topical 0.1% tacrolimus in treatment of non‐segmental vitiligo. Methods This is a t...

This study aimed to prepare and characterize a topical niosomal formulation of benzoyl peroxide (BP) and clindamycin phosphate (CMP) for the treatment of acne vulgaris. Different combinations of Polyoxyethylene Alkyl Ethers (Brij), sorbitan esters (Span), and their ethoxylated derivatives (Tween), and cholesterol were used to produce the niosomes....

Background: Several coronavirus disease 2019 (COVID-19) vaccines, utilizing different platforms, have successfully obtained emergency clinical use authorization to prevent severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections. Most published data from COVID-19 vaccine trials have frequently observed mild-to-moderate side effects,...

Background: Adalimumab is an anti-inflammatory medicine used to treat a variety of disorders, although its effectiveness in improving the clinical status of COVID-19 patients is debatable. The goal was to evaluate the efficacy of adalimumab as an alternate treatment in COVID-19 patients. Methods: This non-randomized pilot clinical trial study in...

Temozolomide is used commonly in the treatment of some types of cancers, but it may also result in cognitive impairments such as memory deficits. l -Dopa, a well known medicine for the central nervous system, has been shown to have positive effects on some cognitive disorders. Here we sought to investigate the effect of l -Dopa on temozolomide-indu...

Nanoliposomes with a great surface area within nano scales of about 20–100 nm have acceptable stability profiles for direct drug carriers. The present study focuses on the nanoliposomes loaded with α-Al2O3 quantum dots nanoparticles (QDNPs) for the in vivo imaging study. The final nanoliposomes loaded with α-Al2O3 QDNPs were synthesized with the mi...

Leishmaniasis as a widespread neglected vector-borne protozoan disease is a major public health concern in endemic areas due to 12 million people affected worldwide and 60,000 deaths annually. Several problems and side effects in using current chemotherapies leads to progression of new drug delivery systems against leishmaniasis. For instance, laye...

Background The concurrent usage of herbal medicines with conventional therapies is an important concern in cancer treatment which can lead to unexpected consequences like herb-drug interactions. This study aimed to determine the prevalence of potential herb-drug interactions and to predict factors associated with herb-drug interactions for cancer p...

Introduction Targeted delivery of drugs to the brain is a complicated activity. This complication is caused by the blood–brain barrier (BBB). Interestingly, there are various transporters on the surface of the BBB that are naturally used for the transportation of specific compounds. A practical approach for brain drug delivery is targeting these tr...

The present investigation was conducted to evaluate the vascular-toxicity of empagliflozin (EMP) in embryonic vasculature. Firstly, the vascular-toxicity of the drug as well as its interaction with apoptotic regulator proteins was predicted via in silico approach. In the next step, the apoptotic-signaling pathway in embryonic vasculature was evalua...

The present attempt developed a simple sensing system based on the modification of screen-printed carbon electrode (SPCE) with MoSe2/reduced graphene oxide (rGO) nanocomposite (MoSe2-rGO/SPCE) to voltammetrically co-detect amitriptyline and carbamazepine. Different techniques such as field emission scanning electron microscopy (FE-SEM), energy disp...

Background Miltefosine (MIL), hexadecyl phosphocholine, is the only oral medicine used to treat leishmaniasis. This drug has a major limitation and is expensive and potentially teratogenic. Objective: This study aimed to evaluate the toxic effect of MIL and its niosomal form on human umbilical vein endothelial cells (HUVECs), the expression genes,...

Introduction: Cerebral ischemia reperfusion (I/R) injury is one of the major causes of permanent physical and other irreversible disabilities. Alpha-lipoic acid (ALA) is one of the lipophilic vitamin-like potent antioxidants [1]. Niosomes are considered as carriers that allow the intravenous administration of lipophilic molecules and their crossing...

D614G is one of the most reported mutations in the spike protein of SARS-COV-2 that has altered some crucial characteristics of coronaviruses, such as rate of infection and binding affinities. The binding affinity of different antiviral drugs was evaluated using rigid molecular docking. The reliability of the docking results was evaluated with the...

Background: One of the dermatologic problems in elderly people is skin aging, which is a natural and complex biological process. Morin is a flavonoid with high radical scavenging activity as well as antityrosinase effects but its low water solubility has restricted its application. Aims: This research aimed to develop, characterize, and optimize...

Due to the limitations of current chemotherapy for the treatment of leishmaniasis, there is an urgent requirement to search for new anti-leishmanial compounds and nano-drug delivery systems including niosomes. Therefore, the aim of this study was to prepare zirconium/tioxolone niosomes using the film hydration method and evaluate the physicochemica...

Background: The concurrent usage of herbal medicines with conventional therapies is an important concern in cancer treatment which can lead to unexpected consequences like herb-drug interactions. The aim of this study was to determine the prevalence of potential herb-drug interactions and to predict factors associated with herb-drug interactions fo...

Drug development for cancer treatment is a complex process that requires special efforts. Targeting crucial proteins is the most essential purpose of drug design in cancers. Bcl-xl is an anti-apoptotic protein that binds to pro-apoptotic proteins and interrupts their signals. Pro-apoptotic Bcl-xl effectors are short BH3 sequences that form an alpha...

Dexamethasone (DEX) has been widely used to treat a variety of diseases, including autoimmune diseases, allergies, ocular disorders, cancer, and, more recently, COVID-19. However, DEX usage is often restricted in the clinic due to its poor water solubility. When administered through a systemic route, it can elicit severe side effects, such as hyper...

Tetrabutyl phosphonium sulfate ([TBP]2SO4), as novel room-temperature ionic liquid (RTIL), was synthesized by a simple cost-effective method, characterized by ¹H, ¹³C, ³¹P NMR and FT-IR spectrophotometry. The newly prepared catalyst was used as an efficient catalyst in some four multicomponent reactions (4MCRs) e. g., to synthesis pyridazino[1,2-a]...

The brain is one of the most challenging organs for drug delivery. It is preserved by the blood-brain barrier (BBB), which controls the transport of components into and out of the brain. Although various approaches have been utilized to cross the BBB, the drug delivery into the brain is still less successful than the other human body parts. Compreh...

Introduction: Drug-Drug interactions (DDIs) are one of the considerable consequences of polypharmacy. Due to the influence of polypharmacy and drug interactions on cancer treatment and patients` health outcomes, the present study aimed to determine the prevalence of polypharmacy and potential DDIs among adult cancer patients in Kerman province, so...

Brain-derived exosomes (BDEs) are extracellular nanovesicles released by all central nervous system cell lineages and contain cargo from the cells that produced them. In physiological and pathological conditions, they are becoming more well-known as critical mediators of communication and waste management between neurons, glial cells, and connectiv...

Meloxicam (MLX) is a generic drug with a wide range of pharmaceutical applications in the world. In this study, the nanostructural form of MLX was prepared using the microemulsion (ME) method. The size distribution of droplets was measured by dynamic light scattering (DLS). Among several substances, oleic acid was chosen as the oily phase, and Twee...

As a powerful antioxidant compound, crocin can partially protect against renal ischemia/reperfusion (I/R) injuries. The encapsulation of components in niosomes (non-ionic surfactant-based vesicle) as nano-sized carrier systems has been proposed as they improve the solubility, stability, and bioavailability of drugs. Herein, the encapsulation of cro...

Breast cancer is considered one of the utmost neoplastic diseases globally, with a high death rate of patients. Over the last decades, many approaches have been studied to early diagnose and treat it, such as chemotherapy, hormone therapy, immunotherapy, and MRI and biomarker tests; do not show the optimal efficacy. These existing approaches are ac...

PurposeThis study aimed to develop a niosome-encapsulated clindamycin phosphate (CMP) formulation for topical delivery.Methods The possibility of encapsulation of this antibiotic in niosomes, its stability, cytotoxicity, and antibacterial capability were evaluated. Diverse combinations of sorbitan esters and their ethoxylated derivatives with chole...

Glioblastoma is the most common and destructive brain tumor with increasing complexity. Flavonoids are versatile natural compounds with the approved anticancer activity, which could be considered as a potential treatment for glioblastoma. A quantitative structure-activity relationship (QSAR) can provide adequate data for understanding the role of f...

Coagulase-Negative Staphylococci (CoNS) are an important reservoir of resistance genes. Due to the important role of CoNS in the transmission of antibiotic resistance genes, increasing knowledge about the mechanisms of antibiotic resistance in this bacterium in hospital settings has an important role in controlling infection and preventing the spre...

Nowadays, medicinal herbs and their phytochemicals have emerged as a great therapeutic option for many disorders. However, poor bioavailability and selectivity might limit their clinical application. Therefore, bioavailability is considered a notable challenge to improve bio-efficacy in transporting dietary phytochemicals. Different methods have be...

Leishmaniasis is one of the biggest concerns of the World Health Organization (WHO) due to its severe side effects, the emergence of resistance, and secondary bacterial infections; therefore, it was reported as an epidemic, especially in immunocompromised individuals. The main purpose of this study was to synthesize and characterize the polylactic...

pH-sensitive nanocarriers can effectively deliver anticancer drugs to tumors and reduce the adverse effects of conventional chemotherapy. In this light, we prepared a novel pH-responsive deferasirox (DFX)-loaded vesicle and comprehensively performed in silico, in vitro, and in vivo studies to examine the properties of the newly synthesized formulat...

Purpose: Free radicals such as hydroxyl and peroxide are contributing factors to neuronal destruction in cerebral ischemia. Alpha-lipoic acid (ALA) is one of the potent known antioxidants. Preparation of ALA niosomes allows IV injection and can increase bioavailability and penetration into the central nervous system (CNS). Methods: Film hydration m...

Leishmaniasis as a third most important vector-borne disease caused by different species of a Leishmania flagellum protozoan. Leishmaniasis as a one of the biggest concerns of the World Health Organization due to the severe side effects, the emergence of resistance, secondary bacterial infections, reports as epidemics especially in immunocompromise...

Objective: Application of vesicular drug delivery systems has made major progress in pharmaceutical science and technology. Niosomal drug delivery is potentially efficient to improve the pharmacokinetic and pharmacological properties of many compounds. Curcumin (CUR) has several documented anticancer activities; however, it has a low bioavailabili...

The aim of the present work is the preparation of a LiAl nanoparticles (NPs) functionalized with graphene oxide quantum dots (GOQDs) for the controlled release of chlorpheniramine maleate (CPAM). Also, the role of lemon and egg withe extracts as oxidation agent were investigated on the morphology and particle size of the products. Graphene quantum...

In this paper, a new magnetically separable catalytic system based on Palladum (Pd) encapsulated with tartaric acid (TA) as a linker (Fe3O4@TA-Pd) is introduced in which TA as a hydroxy organic acid grafted onto the Fe3O4 nanoparticles (Fe3O4 NPs) readily forms complexes with Pd²⁺. To assess the catalytic capability of the prepared catalyst bearing...

The United States Environmental Protection Agency (USEPA) has reported 4-chlorophenol (4-CP) as a priority pollutant. In this study, nanoparticles decorated on Fe3 O4 @SiO2-Schiff base (Fe3 O4 @ SiO2-APTMS-SALAL) were synthesized to remove 4-CP from aqueous solutions. The Fe3 O4 @SiO2-APTMS-SALAL nanocomposite (NC) was characterized using field emi...

Introduction Despite all the efforts to treat COVID-19, no particular cure has been found for this virus. Since developing antiviral drugs is a time-consuming process, the most effective approach is to evaluate the approved and under investigation drugs using in silico methods. Among the different targets within the virus structure, as a vital comp...

Leishmaniasis is a parasitic disease that can be transmitted to individuals by a species of the Leishmania flagellated protozoan. Due to problems such as toxicity, high cost, long duration of treatment, increased drug resistance, painful injections, and side effects, leishmaniasis is considered as an important epidemic in people with systemic defic...

Background: Oral mucositis is a common debilitating complication of cancer chemotherapy and radiotherapy that can reduce the quality of patient’s lives. Hence, treating this condition plays an important role in increasing the patient’s tolerance. Objectives: Doxepin mucoadhesive gel is useful for treating oral mucosa inflammation caused by long-ter...

In this work, Pd nanoparticles (Pd-NPs) were decorated on modified magnetic nanoparticles (MNPs) and used as an efficient and recyclable catalyst for the Suzuki cross-coupling reaction of aryl halides with phenylboronic acid (PhB(OH)2) in a green solvent. The prepared nanocomposite was characterized by field emission scanning electron microscopy, e...

Virosomes as membranous vesicles with viral fusion protein in their membrane are versatile vehicles for cargo delivery. The vesicular stomatitis virus glycoprotein (VSV-G) is a common fusogenic protein used in virosome preparation. This glycoprotein has been used in liposomal systems so far, but in this study, we have tried to use the niosomal form...

The aim of this study is synthesize of Fe3O4@SiO2-Schiff base nanocomposite (Fe3O4@SiO2-APTMS-HBA) as a new and effective adsorbent in the removal of CIP antibiotic from aqueous medium. Field emission scanning electron microscope (FESEM) with energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR), X-ray powder diffract...

BACKGROUND: Nowadays, great attention has been directed to novel gene editing platforms including CRISPR/Cas9 systems. It appears that carbon dots (CDs) might be considered as potential candidates for gene delivery. METHODS: hi the present study we sought to find an efficient non-viral nanocarrier system to transfer CRISPR/Cas9 plasmid into A549 ce...

Liposomes with innovative chemical and physical properties revealed huge potential as drug delivery systems for cancer treatment. Major cause of death is cancer and a main issue in cancer therapy is less ability of target trapy. The current research, objects to advance a unique electromagnetic drug delivery system to carry an anticancer drug (Imati...

Epithelial to mesenchymal transition (EMT) is a complex plastic and reversible cellular process that has critical roles in diverse physiological and pathological phenomena. EMT is involved in embryonic development, organogenesis and tissue repair, as well as in fibrosis, cancer metastasis and drug resistance. In recent years, the ability to edit th...

Gene therapy by expression constructs or down-regulation of certain genes has shown great potential for the treatment of various diseases. The wide clinical application of nucleic acid materials dependents on the development of biocompatible gene carriers. There are enormous various compounds widely investigated to be used as non-viral gene carrier...

An economical and sensitive nanostructured sensor based on carbon paste electrode (CPE) for the determination of kojic acid (KA) was developed in the current work. The applied CPE was modified with 1-butyl-3-methylimidazolium tetrafluoroborate (1B3MITFB) as a conductive binder and NiO nanoparticles (NiO/NPs). The proposed modified ionic liquid-base...

Glioblastoma multiform (GBM) is one of the most incurable invasive and malignant cancers of the central nervous system. The lifespan of the patients from the diagnosis is less than 15 months due to the lack of an effective treatment strategy to eliminate it. The potential of nanotechnology to revolutionize the strategies to fight against cancer has...

Purpose of ReviewIn this review article, we discuss the potential for employing nanotechnological strategies for the diagnosis, monitoring, and clinical management of osteoarthritis (OA) and explore how nanotechnology is being integrated rapidly into regenerative medicine for OA and related osteoarticular disorders.Recent FindingsWe review recent a...

The overall aim of this work was developing and optimized NaF nanoparticles in micelles structures loaded on polylactic acid nanoscaffolds as biocompatible and biodegradable polymers for use in dental delivery. In this research, NaF nanoparticles were successfully synthesized in micelles structures and loaded on the biopolymers on as dental resins...

ARTICLE INFO Original Article Propolis Breast cancer Cytotoxicity Apoptosis Cell cycle Cancer is one of the major health problems worldwide and natural resources are being explored to develop anticancer drugs with fewer side effects. Iranian propolis contains components including flavonoids and polyphenols and has various medicinal properties. The...

The development of novel methods plays a fundamental role in early diagnosis and controlling of neurological disorders (NDs). Blood-brain barrier (BBB) is the most challenging barrier for the development of neuro drug delivery systems due to its inhibiting ability to enter drugs and agents into central nervous system (CNS). Carbon dots (CDs) have s...

In this study, a new and effective catalyst for the synthesis of pyridazino[1,2-a]indazole, indazolo[2,1-b]phthalazine and pyrazolo[1,2-b]phthalazine derivatives was introduced. Triethanolammonium acetate ([TEAH][OAc]) accelerates the reaction in a one-pot and four-component condensation of aldehydes, hydrazine hydrate, succinic/phthalic anhydride,...

The blood–brain barrier (BBB) acts as a barrier to prevent the central nervous system (CNS) from damage by substances that originate from the blood circulation. The BBB limits drug penetration into the brain and is one of the major clinical obstacles to the treatment of CNS diseases. Nanotechnology-based delivery systems have been tested for overco...

Objectives: One of the best approaches for recognition of protein function is the induction of mutations for a gene knockout. In line with this strategy, gene editing tools allow researchers to induce these mutations. Lung cancer is one of the leading causes of death worldwide. ZEB1 and ZEB2 genes are the candidates for this disease. Methods: Th...

Topoisomerase enzymes have shown unique roles in replication and transcription. These enzymes which were initially found in Escherichia coli have attracted considerable attention as target molecules for cancer therapy. Nowadays, there are several topoisomerase inhibitors in the market to treat or at least control the progression of cancer. However,...

Purpose: Combination of benzoyl peroxide (BPO) with topical antibiotics can lead to higher efficacy and less bacterial resistance, but it in turn increases adverse effects such as skin irritability and dryness. In this study, the efficacy of combination therapy of niosomal BPO 1% and clindamycin (CL) 1% is compared with niosomal CL in acne vulgaris...

Over the past decades, an increase in the incidence rate of cancer has been witnessed. Although many efforts have been made to manage and treat this life threatening condition, it is still one of the leading causes of death worldwide. Therefore, scientists have attempted to target molecular signaling pathways involved in cancer initiation and metas...

Over the past decades, an increase in the incidence rate of cancer has been witnessed. Although many efforts have been made to manage and treat this life threatening condition, it is still one of the leading causes of death worldwide. Therefore, scientists have attempted to target molecular signaling pathways involved in cancer initiation and metas...

Over the past decades, an increase in the incidence rate of cancer has been witnessed. Although many efforts have been made to manage and treat this life threatening condition, it is still one of the leading causes of death worldwide. Therefore, scientists have attempted to target molecular signaling pathways involved in cancer initiation and metas...

Autophagy modulation is considered to be a promising programmed cell death mechanism to prevent and cure a great number of disorders and diseases. The crucial step in designing an effective therapeutic approach is to understand the correct and accurate causes of diseases and to understand whether autophagy plays a cytoprotective or cytotoxic/cytost...

In this study, we carried out extensive in vitro studies on various concentrations of tioxolone along with benzoxonium chloride and their niosomal forms against Leishmania tropica. Niosomes were prepared by the hydration method and were evaluated for morphology, size, release study, and encapsulation efficiency. This study measured leishmanicidal a...

Background: Exosomes are natural nanoparticles that are involved in intercellular communication via transferring molecular information between cells. Recently, exosomes have been considered for exploitation as novel drug delivery systems due to their specific properties for carrying specific molecules and surface proteins. Methods: In this study...

A simple and green method for the synthesis of 1,5-dihydropyrano[2,3-c]chromene derivatives has been reported by three component reaction of aromatic aldehydes, malononitrile, and 3-hydroxycoumarin in the presence of a series of novel crown ether-based ionic liquids (CE-based ILs) in H2O/EtOH (1:1), at the reflux conditions. The novel CE-based ILs...

Aims: In many references of Traditional Iranian Medicine (TIM), there are methods to produce medicinal products from plant fruit based on extraction of active substances into oils. One of these recommendations is to import cucurbit or pumpkin seed oil into an entirely ripe fruit of Solanum melongena plant. In this study for the first time, the extr...

Purpose: This research aims to analyze and visualize the structure of Iranian scholarly networks in the field of “pharmacology and pharmacy”. This study includes an overview of co-authorship, efficiency and ranking of the researches, visualizing the co-authorship network, changes in the main core of the publications and macro and micro-level metric...

In this study, for the first time nanoparticles were synthesized and encapsulated in non-ionic surfactant-based vesicle (biology and chemistry). The non-ionic surfactant-based vesicle is formed mostly by non-ionic surfactant and cholesterol incorporation as an excipient by green capping agent. We researched a novel processing route for produce Cu n...

Benzoxonium chloride is an anti-infective agent that is used as anti-septic drugs for disinfection of the mucus membrane, skin surface and anti-bacterial, and it is also found to be effective against cutaneous leishmaniasis. The present study aims to evaluate the leishmanicidal activity of benzoxonium chloride and niosomal forms against Leishmania...

The main aim of this study is to synthesize and prepare polyacrylamide (PAM)/polylactic acid (PLA) co-assembled core/shell nanofibers in order to investigate an effective dapsone-loaded capability and dapsone-release in the aqueous medium. Dapsone (4,4-diamino-diphenyl sulfone) has high permeability and low solubility in water. In vitro release tes...

Background and Purpose: Using of herbal medicines is common for cancer treatment. The aim of this study was to determine the prevalence, reasons, and predicting factors for the use of herbal medicines by Iranian cancer patients. Materials and methods We conducted this cross-sectional study on 315 cancer patients through face-to-face interview in K...

In this study, for the first time, calcium oxide (CaO)/polylactic acid nanoscaffolds were synthesized by co‐precipitation assistant reverse micelles method. The physical and chemical (physicochemical) properties of the structures as dental resin composites were also studied. Nanocomposite materials as primary and basic dental compounds can be conve...

Recently, carbon dots (CDs) have attracted great attention due to their superior properties, such as biocompatibility, fluorescence, high quantum yield, and uniform distribution. These characteristics make CDs interesting for bioimaging, therapeutic delivery, optogenetics, and theranostics. Photoluminescence (PL) properties enable CDs to act as ima...

Objective: To explore the antileishmanial effect of tioxolone and its niosomal form against Leishmania tropica. Methods: Tioxolone niosomes were prepared by the hydration method and were evaluated for morphology, size, release study, and encapsulation efficiency. The cytotoxicity of tioxolone and its niosomal form was measured by MTT assay, leishma...

In this work we synthesized ZnO/CuO nanostructures pegylated by simple and fast microwave method assistant reverse micelles, Reverse micelles protocol creates many advantages in stability, particle size control, morphology, density, loading level, distribution, uniformity, charge and purification. Based on the statistical results ZnO/CuO nanostruct...

This work reported a novel processing route for producing Ag nanoparticles in non-ionic surfactant structures through microwave assisted reverse micelle method and investigation its application for degradation of methylene blue. In addition, Taguchi statistical design method was applied in order to optimize parameters affecting nanoparticle synthes...

Current treatment modalities in cutaneous leishmaniasis have low efficacy and high toxicity as well as high rate of resistance to treatment. In this study, for the first time we decided to evaluate efficacy of intralesional Glucantime plus niosomal zinc sulphate in comparison with intralesional Glucantime plus cryotherapy in the treatment of acute...

Purpose: In Traditional Persian Medicine (TPM), different natural treatments have been suggested for skin damages such as Narcissus tazetta L. bulb application. New drug delivery systems such as niosomes have shown considerable increase transdermal drug delivery through stratum corneum, the main barrier against substances transport into skin. The...

Thrombosis is a shared perpetrating event in the pathophysiology of several cardiovascular disorders such as ischemic stroke, venous thromboembolism, atherosclerosis, and myocardial infarction. Despite holding a wide range of ammunition in our arsenal to ameliorate such conditions, we are still facing with many stumbling blocks in the satisfactory...