Abbas Ali Mahdi

• PhD,DScFAMSFIABS,FACBI
• Vice Chancellor at Era University

Background and objectives: Prostate cancer is the second most frequently diagnosed cancer in men aged 65 years and older globally. The association of prostate cancer with deranged lipid profile and insulin levels is inconsistent and not well understood. This study aimed to analyze the serum levels of lipids, insulin, insulin-like growth factor-1 (I...

Background: Curcumin (Cur) is a polyphenol phyto-compound found in turmeric (Curcuma longa) that inhibits tumorigenesis by introducing apoptosis and restricting cell survival and proliferation. This in vitro research article focuses on the pharmacodynamic interactions of Cur combined with the commercial drug doxorubicin (Doxo) to enhance the cytoto...

The circadian system plays a crucial role in regulating metabolic homeostasis at both systemic and tissue levels by synchronizing the central and peripheral clocks with exogenous time cues, known as zeitgebers (such as the light/dark cycle). Our body’s behavioral rhythms, including sleep-wake cycles and feeding-fasting patterns, align with these ex...

The process of tumorigenesis is highly associated with the disruption of cell-cycle regulators and derangement of various signaling pathways, which end up with the inhibition of apoptosis and hyper-activation of survival pathways. The PI3K medicated AKT/mTOR pathway is the widely explained mechanism for cancer cell survival which causes the overexp...

Background This study investigates the impact of blue light-emitting diode (LED) lighting on the physiological responses of Wistar rats. The circadian system plays a vital role in regulating physiological functions, allowing organisms to anticipate and adapt to environmental rhythms. The synchronization of endogenous circadian clocks with external...

Background: Early diagnosis remains a challenge for prostate cancer (PCa) due to molecular heterogeneity. The purpose of our study was to explore the diagnostic potential of microRNA (miRNA) in both tissue and serum that may aid in the precise and early clinical diagnosis of PCa. Materials and methods: The miRNA expression pattern analysis was carr...

Metabolic reprogramming occurs to meet cancer cells' high energy demand. Its function is essential to the survival of malignancies. Comparing cancer cells to non-malignant cells has revealed that cancer cells have altered metabolism. Several pathways, particularly mTOR, Akt, PI3K, and HIF-1 (hypoxia-inducible factor-1) modulate the metabolism of ca...

Background- Serious concerns about noncommunicable disease (NCD) healthcare services in a lower-middle-income nation like India arise from the prevalence of cardiovascular illnesses and lifestyle risk factors among middle-aged and elderly people. Women often have a lesser awareness of the risk associated with cardiovascular diseases (CVD), and thes...

Background: Lead is toxic to children and effects the cognitive development. The primary objective was to assess the association of blood lead level (BLL) with cognitive performance and general intelligence, of urban school going children aged 6–16 years from ten cities of India. Secondary objective was to assess the association of anaemia with cog...

Objective: Obesity and overweight are challenging health problems of the millennium that lead to diabetes, hypertension, dyslipidemia, nonalcoholic fatty liver disease (NAFLD), and atherosclerosis. Green coffee bean exhibited significant promise in healthy weight management, potentiating glucose-insulin sensitization and supporting liver health. T...

Background Lead, an environmental toxicant, accounts for 0.6% of the global burden of disease, with the highest burden in developing countries. Lead poisoning is very much preventable with adequate and timely action. Therefore, it is important to identify factors that contribute to maternal BLL and minimise them to reduce the transfer to the foetus...

Mercury poses serious health risks to people, and during the last century, its contamination of the ocean's surface has more than doubled. As a result, authorities and organizations have taken measures to shield people from exposure to this dangerous substance. Mercury pollution mainly comes from many anthropogenic activities, such as burning coal...

To assess the blood lead level (BLL) of school children in 10 cities of India. This multi-centric cross-sectional study enrolled participants from randomly selected schools. Data on demographic details, socioeconomic status (SES) and anthropometric indicators was collected. Samples were collected for assessment of lead level in blood. Inductively c...

Recent research has provided evidence that metal oxide nanoparticles (NPs) have the potential to traverse the placental barrier, potentially endangering the health of both pregnant individuals and the developing fetus. The function of oxidative stress is of utmost importance in the pathophysiology of poor pregnancy outcomes. The therapeutic potenti...

Background: Lead, a potential neurotoxin, is found in soil, water and air as a result of its non-biodegradable nature. Common sources of lead toxicity in children are household paints, leaded pipes for water supply, canned food, coloured toys, herbal/folk remedies and electronic wastes. Along with this, other child and parental attributes have been...

Adequate nutrition is necessary during childhood and early adolescence for adequate growth and development. Hence, the objective of the study was to assess the association between dietary intake and blood levels of minerals (calcium, iron, zinc, and selenium) and vitamins (folate, vitamin B12, vitamin A, and vitamin D) in urban school going childre...

Background Inflammation plays a very important role in the pathogenesis of a wide range of diseases, such as atherosclerosis myocardial infarction, sepsis, rheumatoid arthritis, and cancer. This study aimed to investigate the association of IL-8 in T-cell acute lymphoblastic leukemia (T-ALL) patients. Methodology IL-8 levels were estimated in 52 in...

Nymphaea is a genus of aquatic perennial plants having many medicinal properties; one of the species Nymphaea rubra (N. rubra) usually recognized as "Kumuda" and belongs to the family Nymphaeaceae. Here, the anti-inflammatory, hypoglycemic and antibacterial effect of ethyl acetate fraction of Nymphea rubra flowers was investigated. Ethyl acetate fr...

Berberine (BBR), a bioactive compound isolated from Coptidis Rhizoma, possesses diverse pharmacological activities including anti-bacterial, anti-inflammatory, antitumor, hypolipidemic, and anti-diabetic. However, its role as an anti-diabetic agent in animal models of dexamethasone (Dex)-induced diabetes remains unknown. Studies have shown that nat...

Background: Curcumin is a polyphenol phyto-compound found in turmeric (Curcuma longa), which inhibits tumorigenesis by introducing apoptosis as well as by restricting cell survival and proliferation. This in vitro research article focuses on the pharmacodynamics interactions of Curcumin (Cur.) combined with the commercial drug Doxorubicin (Doxo.) t...

Taurine chemically known as 2 aminoethanesulfonic acid; NH2CH2CH2SO3H it's a non essential amino acid, due to absence of car-boxyl group it does not participate in protein synthesis, it does not metabolized and thus not involved in gluconeogenesis, thereby not constituting a direct energy source, This wonderful molecule was discover in 1827 by two...

Taurine chemically known as 2 aminoethanesulfonic acid; NH2CH2CH2SO3H it's a non essential amino acid, due to absence of carboxyl group it does not participate in protein synthesis, it does not metabolized and thus not involved in gluconeogenesis, thereby not constituting a direct energy source, This wonderful molecule was discover in 1827 by two G...

Objective This study was aimed to investigate the effect of Light at night and Rotating night shift as risk factor for cardiovascular diseases. 24 hours chronomics of BP/HR in terms of Double amplitude, Acrophase and Hyperbaric index and its relation with circadian rhythm of salivary cortisol and 6 sulfatoxy melatonin levels in night shift nursing...

Background Owing to the heterogeneous nature of prostate cancer (PCa) and errors in the characterization of the disease, researchers have been trying to unveil molecular biomarkers like microRNA (miRNA) as diagnostic markers. The purpose of our study is to demonstrate the precision of a panel of miRNAs as biomarkers with diagnostic potential for ri...

Introduction: This study was designed to analyze in vitro antioxidant activity and estimate the metabolic profiling of non-polar and polar extracts of Tridax procumbens leaves stem and flowers. Materials and Methods: Antioxidant activity of hexane and methanol extract was determined through DPPH free-radical scavenging assay and nitric oxide assay...

Introduction: The aim of the present study was to explore the anti-breast cancer activity of crude hexane and ethanol extracts of flowers and leaves of Tridax procumbens. Materials and Methods: The cell cytotoxicity was determined using 3-(4, 5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay and colony formation assay. Apopto...

Introduction: This study aimed to find an association between psychological burden (in terms of depression, anxiety, and stress) and salivary cortisol among oral cancer (OC) and oral potentially malignant disorder (OPMD) patients at various time frames. Methods: In total, 50 patients with OC and OPMD were studied after their informed consent alo...

Purpose Gestational diabetes mellitus (GDM) is a state of leptin resistance which develops a vicious cycle of hyperinsu- linemia and hyperleptinemia leading to aggravation of an inflammatory situation. This study was done to find out the asso- ciation between IL-6, leptin and insulin in gestational diabetes among North Indian women. Method This cro...

Background Micronutrient deficiency (MD) is associated with deficits in cognitive functioning of children. However, no comprehensive multicentric study has been conducted in India to explore the role of multiple MD in cognition of children and adolescents. The present study aimed to explore association of MD with level of general intelligence and s...

Non-enzymatic glycosylation is glycation between protein and reducing sugar transforming into the formation of advanced glycation end products (AGEs). Many of the epidemiological studies have demonstrated a strong correlation between the formation of AGEs with the pathogenesis of several chronic complications like inflammation, diabetes, nephropath...

Prostate cancer and diabetes are the two highly prevalent health problems in men worldwide and have a high mortality rates but their association is quite complex and contradictory. This review reported several population based studies which tried to establish a possible association and explains the mechanism by which diabetes exhibits its effect on...

The present study was aimed to assess infant safety associated with the presence of persistent organochlorine pesticides (OCPs) in breast milk, a possible route of transfer of endocrine-disrupting chemicals to newborns in North India. Colostrum and breast milk samples (n = 130) were collected at different stages of lactation. Pesticides analysis wa...

Our bodies function optimally when we align our eating & sleeping patterns with our circadian rhythms, the innate 24-hour cycles that tell our bodies when to wake up, when to eat and when to fall asleep. Chronically disrupting this rhythm by eating late night meals & sleep could be a recipe for Hypertension, CVD, and metabolic trouble. The aim of t...

Time-restricted feeding (TRF) regulates the circadian rhythm of food intake that protects against metabolic disorders. The aim of our study are 12 hours time restricted feeding effects on diet induces obesity in rats model. Total 21 Wistar rats were included i.e. control, TRF and High Fat diet (HFD) group. HFD group was fed with fatty diet at ad li...

The present study was aimed to investigate effect of Light exposute at night on 24 hours chronomics of BP/HR in terms of Double amplitude, Acrophase and Hyperbaric index and its relation with circadian rhythm of salivary cortisol and 6 sulfatoxy melatonin in rotating night shift nursing professionals and actual day workers. 56 night shift nurses, a...

Owing to the heterogeneous nature of prostate cancer (PCa) and errors in the characterization of disease, researchers have been trying to unveil molecular biomarkers like microRNA (miRNA) as diagnostic markers. The purpose of our study is to demonstrate the precision of a panel of miRNAs as biomarkers with diagnostic potential for risk stratificati...

Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia. DM can lead to a number of secondary complications affecting multiple organs in the body including the eyes, kidney, heart, and brain. The most common effect of hyperglycemia on the brain is cognitive decline. It has been estimated that 20–70% of people with DM ha...

Chronic obstructive pulmonary disease (COPD) is characterized by inflammation. Tobacco smoking plays an important role in inflammation and subsequent disease progression. Therefore, inflammatory biomarkers (COX-2, TNF-α, IL-6 and IL-10 genes) expression levels were marked in patients with and without smoking habits and the severity of COPD. The se...

Background A frequent birth abnormality known as congenital talipes equinovarus (CTEV) results in severe abnormalities of one or both feet. The risk of CTEV has been shown to be significantly influenced by genetics. It is a typical congenital malformation. Diseases involving the articular cartilage and COL9A1 polymorphisms are linked. Materials an...

Taurine is a sulfur-containing amino acid that is converted to a neutral beta-amino acid, chemically known as (2-Amino-ethane sulfonic acid) having chemical formula C 2 H 7 NO 3 S. It was first isolated from Ox bile, and thus derives its name from the Latin word "Taurus", meaning 'ox' or 'bull'. This is the only amino acid that is extensively found...

Chronic administration of Bacopa monnieri extract exert neuroprotective potential in multiple animal models of neurodegenerative disorders such as Parkinson’s, Alzheimer’s, depression and cognitive impairments. However, its mechanism of action has remained unclear. Rotenone models of Parkinson’s disease (PD) have great potential for the investigati...

Visceral leishmaniasis (VL) is an infectious disease, and treatment to VL relies on few drugs which shows side effects as well as high cost make these drugs unavailable to poor in developing countries. Considering the current scenario of VL treatment, this study has been proposed to observe the effect of zinc sulfate on Leishmania. donovani parasit...

Genistein (GE) or 4′,5,7-trihydroxyflavone, a plant derived isoflavone, is a biologically active compound having several beneficial properties. Studies showed that GE possesses anti-neoplastic, anti-tumor, anti-helminthic, anti-oxidant, and anti-inflammatory activities. Herein, we investigated the neuroprotective effects of GE in a mouse model of h...

SARS‐CoV‐2 has been responsible for causing 6,218,308 deaths globally till date and has garnered worldwide attention. The lack of effective preventive and therapeutic drugs against SARS‐CoV‐2 has further worsened the scenario and has bolstered research in the area. The N‐terminal and C‐terminal RNA binding domains (NTD and CTD) of SARS‐CoV‐2 nucleo...

Chronic myeloid leukemia (CML) is potentially fatal blood cancer, but there is an unmet need to discover novel molecular biomarkers. The hypothesis of this study aimed to elucidate the relationship of HIF1α with the redox system, Krebs cycles, notch1, and other regulatory proteins to better understand the pathophysiology and clinical relevance in c...

Lead is a highly toxic element which can cross the placental barrier and enter the fetus during pregnancy. Parental lead exposure has adverse effect on infant as well as on maternal health. As part of our program to investigate the lead poisoning in human population we investigated the maternal blood lead levels (MBLL) and umbilical cord blood lead...

Introduction Childhood and adolescence require adequate amount of micronutrients for normal growth and development. The primary objective of study was to assess the prevalence of deficiencies of Vitamins (Vitamin A, 25 Hydroxy Vitamin D, Vitamin B12 and Folate) and minerals (Calcium, Zinc, Selenium and Iron), among urban school going children aged...

Blast crisis (BC) is an outcome that arises during the treatment process of chronic myeloid leukemia (CML), which is possibly attained by the dysregulation of the Notch and Ikaros signaling pathways, BCR-ABL translocation, redox, and inflammatory factors. This study demonstrated that biotherapeutic agents target aberrant molecular axis in CML-BC ce...

Background Lead (Pb) is ubiquitous, naturally occuring heavy metal that has a neurotoxic effect on the CNS and causes a range of health problems in humans, including cognitive impairment. Its toxicity remains a worldwide health issue, especially in developing countries. In this study, we tend to investigate the relationship between Pb poisoning and...

Encapsulation of apo human alpha-lactalbumin (α-LA) within oleic acid (OA) attains similar morphology as SNARE’s, which forms human α-lactalbumin-oleic acid (HALOA) complex by altering the methodology from previous studies. Firstly the native α-LA was treated with EDTA to remove Ca2+ ions (ICP-OES, and Arsenazo III) which leads to unfolding for mai...

In ammation plays a critical role in the pathogenesis of a large number of diseases, such as atherosclerosis myocardial infarction (MI), sepsis, rheumatoid arthritis, and cancer. The present study aimed to investigate the association of IL-8 in TALL patients. IL-8 levels have been estimated in 52 individuals, out of which 26 were healthy and diseas...

Inflammation plays a critical role in the pathogenesis of a large number of diseases, such as atherosclerosis myocardial infarction (MI), sepsis, rheumatoid arthritis, and cancer. The present study aimed to investigate the association of IL-8 in T-ALL patients. IL-8 levels have been estimated in 52 individuals, out of which 26 were healthy and dise...

Objective There are inconclusive data connecting single-nucleotide polymorphisms (SNPs) of TNF-α (rs361525) and TNF-β (rs909253) to potential malignant oral disorder (PMOD) such as lichen planus and oral fibrosis. Here, we have investigated the risk of oral squamous cell carcinoma as well as oral pre-cancerous lesions in North Indian population wit...

The nitrogen-fixing cyanobacterial strains Scytonema sp., Nostoc muscorum, Cylindrospermum sp., and Anabaena sp., were subjected to different concentrations of aluminum at different pH 4.0, 6.0, and 7.0 along with control. Al metal uptake was highest at pH 4. Enhanced peroxidase, superoxide dismutase activity and the accelerated lipid peroxidation...

Background and Objective: LEAD, an environmental toxicant, accounts for 0.6% of the global burden of disease, with the highest burden in developing countries. It can permeate through the foetus blood-brain barrier causing a negative impact on foetal growth and the developing brain. Literacy and awareness related to its impact are low and the clinic...

Introduction: Ischemia and oxidative stress leads to generation of hydroxyl free radicals and modification of 'N-terminus' of human serum albumin. This modified albumin molecule, known as Ischemia Modified Albumin (IMA), is elevated in early stages of ischemia. It has recently been approved by US Food and Drug Administration (US FDA) for its clini...

Aim The aim of the present study was to isolate and characterise chemical compounds from Anthocephalus cadamba Miq. bark and evaluate their anticancer activity by in silico, molecular docking and in vitro studies. Background Anthocephalus cadamba is a traditionally used Indian medicinal plant. The anticancer and phytochemical investigations of thi...

Prenatal lead exposure has known adverse effects on maternal health and infant outcomes across a wide range of maternal blood lead levels. In 2010, the Centers for Disease Control and Prevention issued the first guidelines regarding the screening and management of pregnant and lactating women who have been exposed to lead. In humans, the lead is ab...

Background: The aim was to study the association of serum total calcium, ionic calcium, and magnesium with increases in macular thickness parameters and photoreceptor ellipsoid zone (EZ) disruption in diabetic macular edema (DME). Methods: This study is a tertiary care center based observational cross-sectional study with sixty-six consecutive c...

Introduction Childhood and adolescence are the period of rapid physical and cognitive growth and development, requiring adequate nutrition. Malnutrition in the form of undernutrition or micronutrient deficiency or overweight/obesity affects the health, cognition and educational achievement of this age group. The objective of this study is to assess...

Background Chronic pulmonary obstructive disease (COPD) prevalence increases with tobacco smoking, suggesting a relationship between disease severity and an increased rate of systemic symptoms. Aim To evaluate IL-1β, IL-8 and NF-κB expression in COPD patients with smoking and non-smoking habits and determine their levels with disease severity comp...

Introduction: With expanding clinical spectrum of dengue fever, encephalitis has been documented with increasing frequency. The aim of this study was to investigate the incidence, predictors and prognostic factors of dengue encephalitis (DE) in the setting of dengue viruses (DENV) infection. Materials and methods: A hospital-based prospective co...

The dysregulation of glucose metabolism that includes the modification of biomolecules with the help of glycation reaction results in the formation of advanced glycation end products (AGEs). The formation of AGEs may activate receptors for advanced glycation end products which induce intracellular signaling, ultimately enhancing oxidative stress, a...

Lead (Pb) is found in almost all phases in environment and biological systems. Pb stimulated oxidative stress is a state that involves the generation of free radicals beyond the permissible limits, which can deplete the antioxidant reserves and can result in oxidative stress, thus hampering the ability of the biological system to reverse the result...

The present study was aimed to assess the correlation between transplacental transfer of xenobiotics and resulting biochemical alterations (including genotoxicity and oxidative stress) in non-occupational pregnant women of North India along with the effect on pregnancy outcomes. Maternal and cord blood samples were collected from 221 healthy mother...

Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of hematopoietic stem cells. Although there have been advancements in treatment, there is still a need to develop a biotherapeutic agent. A new variant of the human alpha-lactalbumin-oleic acid (HALOA) complex has been synthesized, which showed similarities with SNARE. The nativ...

Objective Locoregional recurrence in oral squamous cell carcinoma (OSCC) is a major concern that leads to metastasis. Its detection at earliest stage is very important to increase the overall survival of the patient. There is no any biomarker for locoregional recurrence in oral squamous cell carcinoma (OSCC). The aim of this study was to find a bio...

Camel milk is rich in nutritional factors, such as α- Lactalbumin, and important for brain development. It is known to act as a potential therapeutic candidate for brain disorder via regulation of inflammatory and apoptotic pathways. Mechanisms that are critically involved with Parkinson’s disease (PD) are apoptosis, inflammation, and oxidative str...

Purpose: This randomized clinical placebo-controlled trial was conducted to evaluate the effectiveness of Lactobacillus reuteri as a probiotic in guided pocket recolonization (GPR) for the treatment of chronic periodontitis (CP) adjunctive to scaling and root planing (SRP). Methods: Forty-eight CP patients were randomly assigned to 3 treatment g...

Chemoresistance is one of the biggest hurdles while treating cancer clinically. Due to its heterogeneous nature, complications of the chemoresistance mechanisms of breast cancer cannot be completely elucidated. Existing mechanisms of main-line drug treatment can slow down the process of malignancy with part and parcel called drug resistance. The co...

Alzheimer's disease is a common neurodegenerative disease in the elderly population and a leading cause of dementia. Genetics and environmental risk factors were considered to play a major role in the onset of the disease. This study aimed to examine the correlation between different metals levels and the gene expression in Alzheimer's patients wit...

A novel coronavirus (SARS-CoV-2) has rapidly spread from a regular seafood market in Wuhan, China to more than 200 countries, globally infecting millions of people with a dangerous pneumonia like fatal conditions. Depending upon the immunity of individual, the severity of infection and its viral load, symptoms varied from mild to severe leading to...

Purpose: To study the correlation of serum vitamin D levels with quantitative (central subfield thickness [CST], cube average thickness [CAT]), cross-sectional (disorganisation of retinal inner layer [DRIL] and ellipsoid zone [EZ]) and topographic parameters (retinal pigment epithelium [RPE]) on spectral domain optical coherence tomography (SD-OCT)...

Chronic obstructive pulmonary disease (COPD), a heterogeneous lung disorder that is characterized by airflow obstruction and the third leading cause of death, globally. COPD is influenced by environmental and genetic factors. Here, we measured the serum level of matrix metalloproteinase-9 (MMP-9), cyclooxygenase-2 (COX-2) and prostaglandin E-2 (PGE...

Genistein (GE), a plant-derived isoflavone, is a polyphenolic non-steroidal compound. Studies showed that GE possesses anti-cancer, anti-inflammatory, anti-microbial, anti-oxidant, and anti-apoptotic activities. However, the neuroprotective role of GE in amnesia has not been studied. This study aimed to evaluate the anti-amnesic potential of GE in...

Ethnopharmacological Relevance: Parkinson’s disease (PD) is characterized by progressive death of dopaminergic neurons. The presently used medicines only tackle the symptoms of PD, but none makes a dent on the processes that underpin the disease’s development. Herbal medicines have attracted considerable attention in recent years. Bacopa monnieri (...