Aaron Gazendam

Aaron Gazendam
McMaster University | McMaster · Division of Orthopedics

Doctor of Medicine

About

62
Publications
3,700
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
423
Citations
Citations since 2017
61 Research Items
422 Citations
2017201820192020202120222023050100150
2017201820192020202120222023050100150
2017201820192020202120222023050100150
2017201820192020202120222023050100150

Publications

Publications (62)
Article
PurposeThe risk of tumor recurrence after resection of soft tissue sarcoma (STS) necessitates surveillance in follow-up. The objective of this study was to determine the frequency/timing of metastasis and local recurrence following treatment for soft tissue sarcoma, and to use these data to justify an evidence-based follow-up schedule.Methods Utili...
Article
Background: Functional outcomes are commonly reported in studies of patients undergoing limb-salvage surgery for the treatment of musculoskeletal tumors; however, interpretation requires knowledge of the smallest amount of improvement that is important to patients: the minimally important difference (MID). We established the MIDs for the Musculosk...
Article
Introduction: Sarcoma patients undergoing surgical resection and endoprosthetic reconstruction often receive neoadjuvant chemotherapy (NACT). The objective of the current study was to determine if the timing of NACT impacts the rates of surgical site infections (SSI) and reoperations. Methods: This study was a secondary analysis of the recently...
Article
Aims: The aim of this study was to determine the prevalence and impact of tourniquet use in patients undergoing limb salvage surgery with endoprosthetic reconstruction for a tumour around the knee. Methods: We retrieved data from the Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) trial; specifically, differences in baseline character...
Article
Full-text available
Background and objectives: Functional outcomes are important for oncology patients undergoing lower extremity reconstruction. The objective of the current study was to describe patient reported function after surgery and identify predictors of postoperative function in musculoskeletal oncology patients undergoing lower extremity endoprosthetic rec...
Article
Full-text available
Importance In arthroscopic knee and shoulder surgery, there is growing evidence that opioid-sparing protocols may reduce postoperative opioid consumption while adequately addressing patients’ pain. However, there are a lack of prospective, comparative trials evaluating their effectiveness. Objective To evaluate the effect of a multimodal, opioid-s...
Article
Full-text available
Background Although periprosthetic joint infection (PJI) is a serious complication following a total joint arthroplasty procedure, there remains uncertainty regarding the diagnosis of PJI due to the lack of a globally accepted, standardized definition. The goal of this review is to critically analyze the quality of the evidence used for the novel 2...
Article
PurposePlatelet-rich plasma (PRP) represents a highly profitable biological therapy. Platelet-rich plasma is widely used to treat musculoskeletal disorders despite mixed evidence of its efficacy. As evidenced by literature from other domains, industry funding may influence the results of clinical trials. The objective of the current study was to de...
Article
Full-text available
Background The purpose of this systematic review was to analyze the available literature on fixation of distal radius fractures (DRFs) under wide-awake local anesthesia no-tourniquet (WALANT), and to examine postoperative pain scores and functional outcomes, operative data including operative time and blood loss, and the frequency of adverse events...
Article
Purpose Same-day home (SDH) discharge in total joint arthroplasty (TJA) has increased in popularity in recent years. The objective of this study was to evaluate the causes and predictors of failed discharges in planned SDH patients. Methods A consecutive cohort of patients who underwent total knee (TKA) or total hip arthroplasty (THA) that were sc...
Article
Background The use of quadratus lumborum nerve blocks (QLB) for pain control following elective total hip arthroplasty (THA) has increased substantially in recent years. The objective of this systematic review and meta-analysis was to compare outcomes from randomised controlled trials (RCTs) utilising QLBs following elective THA. Methods MEDLINE,...
Article
Full-text available
Purpose of Review The goal of this review is to provide an up to date understanding of the utility and limitations of the current tests utilized in the diagnosis of periprosthetic joint infection (PJI) in total knee and hip arthroplasty. Recent Findings Despite the growth in literature surrounding PJI diagnosis, there remains challenges in establi...
Article
Full-text available
Purpose The treatment of giant cell tumors (GCT) of the distal radius remains challenging, with no consensus on the optimal surgical management. Surgical management remains the mainstay of treatment with options including intralesional curettage and en-bloc resection with reconstruction. The objective of this systematic review and meta-analysis was...
Article
Full-text available
Background: There has been substantial interest from the pharmaceutical industry to study and develop new biologic agents. Previous studies outside of the biologics field have demonstrated that industry funding has the potential to impact the design and findings of clinical trials. The objective of this study was to evaluate the impact of industry...
Article
Background: The Accolade TMZF is a tapered-wedge cementless metaphyseal-coated femoral stem that was widely utilized from 2002 to 2012. In recent years, there have been reports of early catastrophic failure of this implant. The purposes of the present study were to establish the long-term survival of this stem and to analyze patients who underwent...
Article
Purpose: The use of virtual reality (VR) based rehabilitation has increased substantially within orthopedic surgery, particularly in the field of total knee arthroplasty (TKA). The objective of this systematic review and meta-analysis was to compare patient-reported outcomes and cost analyses from randomized controlled trials (RCT) utilizing VR-ba...
Article
Artificial intelligence (AI) is a broad term referring to the application of computational algorithms that can analyze large data sets to classify, predict, or gain useful conclusions. Under the umbrella of AI is machine learning (ML). ML is the process of building or learning statistical models using previously observed real world data to predict...
Chapter
Fracture dislocations about the knee joint are relatively rare injuries involving both bony and ligamentous disruptions resulting in instability. Fracture dislocations can occur about the tibiofemoral, patellofemoral, and tibiofibular joints; and in paediatric patients often through surrounding physes. There is a high risk of associated vascular an...
Article
Introduction : The adoption of evidence-based orthopaedics has shifted the focus from expert base opinions and anecdotal evidence to a focus on integrating the best available clinical research. This shift has led to an increased focus on randomized controlled trials (RCTs) within the field. Although RCTs are considered the highest level of evidence...
Article
Patient registries have grown in size and number along with general computing power and digitization of the healthcare world. In contrast to databases, registries are typically patient data systematically created and collected for the express purpose of answering health-related questions. Registries can be disease-, procedure-, pathology-, or produ...
Article
Background: Current literature suggests that 8-35% of patients undergoing total hip arthroplasty (THA) undergo a subsequent contralateral THA. This study aims to determine if functional outcomes following primary THA predict outcomes in the subsequent primary THA of the contralateral side. Methods: A retrospective cohort of patients undergoing s...
Chapter
Femoroacetabular impingement (FAI) is a biomechanically complex condition, and understanding the kinematics and pathomechanics of this condition is crucial to treating it appropriately. There are many etiologies for the development of cam type, pincer type, and mixed type FAI, including genetics, physical activity, and dysplasia. The presence of FA...
Article
Full-text available
The proximal femur is a common location for the development of bony metastatic disease. Metastatic bone disease in this location can cause debilitating pain, pathologic fractures, reduced quality of life, anemia or hypercalcemia. A thorough history, physical examination and preoperative investigations are required to ensure accurate diagnosis and p...
Article
Full-text available
Aim: The aim of this study was to systematically assess the risk of bias in osteosarcoma and Ewing’s sarcoma (ES) randomized controlled trials (RCT) and to examine the relationships between bias and conflict of interest/industry sponsorship. Methods: An OVID-MEDLINE search was performed (1976-2019). Using the Cochrane Collaboration guidelines, two...
Article
Background:. Inappropriate referencing of the existing literature has the potential to propagate false information. Quotation errors are defined as citations in which the referenced article fails to substantiate the authors’ claims. The aim of this study was to determine the rate of quotation errors in high-impact general orthopaedic and sports med...
Article
Full-text available
Background The direct anterior approach (DAA) has increased in popularity in recent years. Proponents cite its muscle-sparing approach and purported reduction in pain and improvement in function when compared to the traditional surgical approaches. There remains controversy surrounding the validity of these claims. The objective of this study was t...
Article
Full-text available
The pelvis is a common site of metastatic bone disease. Peri-acetabular lesions are particularly challenging and can cause severe pain, disability and pathologic fractures. Surgical management of these lesions has historically consisted of cementoplasty for contained lesions and Harrington reconstructions for larger, more destructive lesions. Due t...
Article
»: Telemedicine and remote care administered through technology are among the fastest growing sectors in health care. The utilization and implementation of virtual-care technologies have further been accelerated with the recent COVID-19 pandemic. »: Remote, technology-based patient care is not a "one-size-fits-all" solution for all medical and s...
Chapter
This chapter presents a case scenario of an 18‐year‐old varsity football player who presents to clinic complaining of right knee pain and instability after sustaining an injury in practice one month ago. The choice of graft can have important implications for outcome and function after anterior cruciate ligament (ACL) reconstruction. ACL ruptures a...
Chapter
This chapter presents a case scenario of a 50‐year‐old woman who presents with a growing mass in the medial thigh. Magnetic resonance imaging confirms a tumor with heterogeneous signal characteristics. Radiation therapy (XRT) is used in the management of soft tissue sarcomas (STS), with the goal of extending the virtual margin to the surrounding ti...
Article
Full-text available
Background Opioids continue to be the analgesic of choice for postoperative pain control following arthroscopic knee and shoulder surgery. Despite their widespread use, there are limited evidence-based clinical practice guidelines for postoperative opioid prescribing. The Non-Opioid Prescriptions after Arthroscopic Surgery in Canada (NO PAin) Trial...
Article
Full-text available
Synovial sarcomas (SS) represent a unique subset of soft tissue sarcomas (STS) and account for 5–10% of all STS. Synovial sarcoma differs from other STS by the relatively young age at diagnosis and clinical presentation. Synovial sarcomas have unique genomic characteristics and are driven by a pathognomonic t(X;18) chromosomal translocation and sub...
Article
Full-text available
Introduction The Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) randomized controlled trial (RCT) was the first study to prospectively enroll and randomize orthopedic oncology patients in multiple centers internationally. The objective of this study was to describe recruitment patterns, to examine the differences in enrollment across di...
Article
Objectives: To synthesize all-cause reoperations and complications data as well as secondary clinical and functional outcomes, after the management of very distal femur periprosthetic fractures (vDFPFs) in a geriatric patient population with either a distal femoral locking plate (DFLP) or distal femoral replacement (DFR). Data sources: MEDLINE,...
Article
Full-text available
Objective: An evolved understanding of the pathophysiology of greater trochanteric pain syndrome has led to a number of proposed nonoperative management strategies. The objective of this review was to compare the efficacy of the various nonoperative treatments for greater trochanteric pain syndrome (GTPS). Design: Systematic review and network m...
Chapter
This chapter presents the case scenarios of a 70‐year‐old woman who has an enlarging mass in the right axilla. A carefully placed biopsy with adequate tissue for diagnosis could have allowed this woman a limb‐sparing resection with an excellent chance of local control and probable cure. There are various methods of biopsy that are available to clin...
Article
Introduction The American Association of Hip and Knee Surgeons (AAHKS) Annual Scientific Meeting is a leading forum for the presentation and dissemination of research regarding the management of hip and knee pathology making research presented at these meetings a representation of the current literature in the field. The purpose of this study was t...
Article
Purpose The relationship between pain catastrophizing, emotional disorders and total joint arthroplasty (TJA) outcomes is an emerging area of study. The purpose of this study was to examine the association of these factors with one-year postoperative pain and functional outcomes. Methods A prospective cohort study of preoperative TJA patients usin...
Article
Introduction The fragility index (FI) is a method for evaluating the robustness of statistically significant findings from randomized controlled trials (RCTs) beyond the P value in trials with dichotomous outcomes. The FI is defined as the number of patients in one arm of a trial that would have to have a different outcome to change the results of...
Article
Full-text available
Background Endoprosthetic reconstructions have become increasingly common in the setting of significant bone loss. Indications include revision arthroplasty, trauma, and reconstruction in the setting of primary malignancies or bony metastases. Although the use of endoprostheses has several advantages, they carry a high risk of infection. The purpos...
Article
Purpose: The opioid epidemic has prompted an emphasis on investigating opioid-sparing alternatives for pain management following knee arthroscopy. This review evaluated the effects of perioperative nonopioid adjunct analgesia on postoperative opioid consumption and pain control in patients undergoing knee arthroscopy. Methods: A systematic revie...
Article
Objective Intra-articular (IA) injections represent a commonly used modality in the treatment of hip osteoarthritis (OA). Commonly used injections include corticosteroids (CCS), hyaluronic acid (HA) and platelet-rich plasma (PRP). A network meta-analysis allows for comparison among more than two treatment arms and uses both direct and indirect comp...
Article
Full-text available
PurposeIn the current COVID-19 pandemic, it is more important than ever to maximize communication in the scientific and medical community. In the context of academic meetings and conferences, there is the growing need for a set of guidelines secondary to the COVID-19 pandemic, and the growing environmental and economic challenges that large academi...
Article
PurposeThe purpose of this review is to quantify the landscape of current clinical trials ongoing for therapies in the treatment of COVID-19. A secondary purpose is to examine the relationship between public and scientific interests in potential therapies for COVID-19.MethodsA systematic search of clinicaltrials.gov was undertaken on April 22, 2020...
Article
Objective: To synthesize the best evidence surrounding the efficacy of cannabinoids for acute pain in the clinical setting based on subjective pain scores and observed adverse effects. Design: Systematic review with meta-analysis. Data Sources: PubMed, Embase, Cochrane Databases, and Google Scholar. Eligibility Criteria: English-language randomized...
Preprint
Full-text available
Introduction: The Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) randomized controlled trial (RCT) was the first study to prospectively enroll and randomize orthopaedic oncology patients in multiple centers internationally. The objective of this study was to describe recruitment patterns, examine the differences in enrollment across dif...
Preprint
Full-text available
Introduction: The Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) randomized controlled trial (RCT) was the first study to prospectively enroll and randomize orthopaedic oncology patients in multiple centers internationally. The objective of this study was to describe recruitment patterns, examine the differences in enrollment across dif...
Article
Background: Femoral shaft fractures are common and severe injuries that often occur alongside other complex, high-energy injuries. Definitive internal fixation using reamed, locked intramedullary nailing (IMN) has become the standard of care in adequately resuscitated patients, commonly performed in the supine position with utilization of a fractu...
Article
Full-text available
Study Design A retrospective case-control study. Objectives To determine factors influencing the ability to achieve coronal balance following spinal deformity surgery. Methods Following institutional ethics approval, the radiographs of 47 patients treated for spinal deformity surgery with long fusions to the pelvis, were retrospectively reviewed....
Article
Full-text available
Purpose: To determine the incidence of pseudarthrosis at the osteotomy site after three-column spinal osteotomies (3-COs) with posterior column reconstruction. Methods: 82 consecutive adult 3-COs (66 patients) with a minimum of 2-year follow-up were retrospectively reviewed. All cases underwent posterior 3-COs with two-rod constructs. The inferi...
Article
Study Design Retrospective case series. Objective To compare the early results of posterior column (PCO) and three-column (3CO) osteotomies performed in patients with previously fused idiopathic scoliosis and review their abilities to achieve coronal correction of residual deformities. Summary of Background Data Residual deformity of previously f...
Article
Background: Accurate diagnosis of Crohn's disease or ulcerative colitis is essential for surgical planning. This study compared the accuracy, safety, and utility of small bowel follow-through (SBFT) and magnetic resonance enterography (MRE) for detecting small bowel (SB) involvement preoperatively. Methods: A retrospective review of children who...
Article
Full-text available
Recent evidence shows that 85% of Canadian adults do not meet the recommended physical activity (PA) guidelines set forth by the Canadian Society for Exercise Physiology (Colley et al. 2011). In Kingston, Ontario, Canada 66% of males and 50% of females are overweight or obese, which may be associated with decreased PA levels among the Kingston comm...

Network

Cited By