Aaftaab Sethi

Aaftaab Sethi
Aurigene Discovery Technologies · Medicinal Chemistry

PhD

About

23
Publications
6,839
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
189
Citations
Citations since 2016
23 Research Items
186 Citations
2016201720182019202020212022020406080
2016201720182019202020212022020406080
2016201720182019202020212022020406080
2016201720182019202020212022020406080
Introduction
Aaftaab Sethi is currently working on developing small molecule inhibitors to selectively inhibit different isoforms of galectin family of proteins. In addition, he focuses on introducing greener techniques for widely used synthetic transformations.
Additional affiliations
May 2021 - present
Aurigene Discovery Technologies
Position
  • Researcher
Education
August 2017 - April 2021
June 2015 - July 2017
Panjab University
Field of study
  • Organic Chemistry
July 2012 - May 2015
University of Delhi
Field of study
  • Chemistry

Publications

Publications (23)
Article
Full-text available
A novel series of imidazo[2,1-b]thiazole-sulfonyl piperazine conjugates (9aa-ee) has been synthesized and evaluated for carbonic anhydrase (CA, EC 4.2.1.1) inhibitory potency against four isoforms: The cytosolic isozyme hCA I, II and trans-membrane tumor-associated isoform hCA IX and hCA XII, taking acetazolamide (AAZ) as standard drug, using a sto...
Article
For the first time, inclusion has been crafted between a carbohydrate based molecule and β-CD hydrophobic cavity for the asymmetric catalytic applications. This novel D-glucosamine based inclusion compound has been synthesized in high yields using innovative and proficient acoustic cavitation technology and well characterized by using various techn...
Article
Full-text available
The Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) has been rapidly transmitting and leaving its footprints across the globe. Stringent measures like complete lockdown and extensive testing have been employed by many countries to slow it down in its tracks until a viable treatment is found. Therefore, in the current scenario, prompt...
Article
In continuation of our quest to develop non-carbohydrate galectin-1 inhibitors, we have designed and synthesized 20 indole-coumarin hybrids linked via chalcone. Compounds 6i and 7e were found to decrease galectin-1 levels significantly in galectin-1 enzyme assay at 20 µM concentration. Binding affinity studies carried out by fluorescence spectrosco...
Article
Introduction – Galectins are ubiquitous in nature. They have established themselves as a protein family of high therapeutic potential. They have been found to play a role in a wide variety of diseases like cancer, fibrosis, and Alzheimer’s. Within the galectin family, galectin- 1 and galectin- 3 have been widely studied and their roles and function...
Preprint
Full-text available
With the economic and societal progress, a great escalation in energy demands has been witnessed over the years. A major proportion of total energy consumed globally is accounted by the transportation sector where fossil fuels or derivatives such as petrol, diesel and jet fuel are predominantly utilized. This has led to a very high contribution to...
Preprint
Full-text available
Herein, we report a metal-free protocol for the activation of nitrile towards the nucleophilic addition and subsequent annulation under an aqueous medium for the first time. The protocol divulges an efficient route for the construction of diversified aminated isoquinolines. Differently substituted primary as well as secondary amines underwent the r...
Article
In the recent past, chitosan demonstrated intriguing applications in the different domains of biomedical science, probably due to its biodegradability, biocompatibility, minimal toxicity, cost-effectiveness, and easy-going synthetic procedures. Chitosan is the second most prevalent amino polysaccharide after cellulose, generated from a deacetylated...
Article
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has generated a critical need for treatments to reduce morbidity and mortality associated with this disease. However, traditional drug development takes many years, which is not practical solution given the current pandemic. Therefore, a viable option is to repurpose existing...
Article
Full-text available
In the dire need of novel inhibitors of enzymes, computational approaches have significantly expedited the drug discovery process. Aspartic protease enzymes of Plasmodium falciparum such as plasmepsin II (PfPlm II) and plasmepsin IV (PfPlm IV) have been recognized as an attractive drug target for antimalarial drug discovery. In line with this, we p...
Article
Full-text available
Novel coronavirus disease 2019 (COVID-19) has significantly altered the socio-economic status of countries. Although vaccines are now available against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a causative agent for COVID-19, it continues to transmit and newer variants of concern have been consistently emerging world-wide. C...
Article
Full-text available
In drug discovery applications, high throughput virtual screening exercises are routinely performed to determine an initial set of candidate molecules referred to as “hits”. In such an experiment, each molecule from a large small-molecule drug library is evaluated in terms of physical properties such as the docking score against a target receptor....
Article
Lectins are a family of glycan-binding proteins, many of which have been established as key targets for therapeutic intervention. They play a central role in many physiological and cellular processes. With the advances in protein crystallography, NMR spectroscopy and computational power over the past couple of decades, the carbohydrate-receptor int...
Preprint
Full-text available
In drug discovery applications, high throughput virtual screening exercises are routinely performed to determine an initial set of candidate molecules referred to as "hits". In such an experiment, each molecule from large small-molecule drug library is evaluated for physical property such as the binding affinity (docking score) against a target rec...
Presentation
In continuation of our quest to develop synthetically viable galectin-1 inhibitors, we constituted an extensively curated 3D-QSAR model involving galectin-1 inhibitors. Training and validation of QSAR predictive model was performed on a master dataset consisting of 52 compounds. The molecular structures and binding affinities of the compounds were...
Article
Full-text available
Galectin-3 is a carbohydrate-binding protein that plays a crucial role in cancer and fibrosis. Its inhibitors have largely evolved from naturally occurring saccharides to many synthetic forms with significantly improved affinity. However, there haven't been any substantial and sizeable structure-activity relationship studies in order to develop pot...
Poster
The Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) spread like wildfire throughout the globe and continues to do so. Stringent measures like complete lockdown and extensive testing have been employed by many countries to slow it down in its tracks as no viable treatment is available till date. Therefore, in the current scenario, prom...
Article
With an aim to develop potent lead molecules as a novel class of reverse transcriptase (RT) inhibitors, we have synthesized amide and ether conjugates of 2,3‐diaryl‐1,3‐thiazolidin‐4‐one derivatives. The compounds 9a and 9f exhibited IC50 values of 0.21113 ± 0.013μM and 12.6804 ± 0.062μM respectively from the in vitro human immunodeficiency virus t...
Article
Global HIV statistics by World Health Organization (WHO) for the year 2017 was estimated to be 36.9 (31.1–43.9) million. Antiviral drug resistance poses a serious threat to the public health and requires immediate action. Retroviral integrase (IN) a component enzyme in the retroviral pre-integration complex (PIC) enables a retrovirus to incorporate...
Poster
β-Cyclodextrin immobilized amino sugar was prepared by sonicating the mixture of β-CD and amino sugar for 15 min in Ethanol- Water (1/1,v/v). This reaction mixture was further lyophilized to obtain the solid inclusion complex. The formation of the Inclusion Complex (IC) was supported by using standard techniques such as FT-IR, UV-visible absorption...

Network

Cited By

Projects

Projects (2)
Project
To design carbohydrate and non-carbohydrate Galectin 1 and 3 inhibitors using computational tools like similarity coefficients, fingerprint mapping, molecular docking, molecular dynamics, machine learning and QSAR. In addition, explore their potential implication in diseases threatening public health.
Project
The purpose of the OpenTox Association is to promote the community-based exchange and use of open knowledge, methods, tools, data, reference resources, and standards including open software, ontology and application programming interfaces in the scientific activities of predictive toxicology, safety assessment and risk management, including the “3Rs” goal of the Reduction, Refinement and Replacement of Animal Testing.