Aafke van Montfoort

Aafke van Montfoort
Maastricht Universitair Medisch Centrum · Obstetrics and Gynaecology

PhD

About

86
Publications
10,989
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3,093
Citations
Additional affiliations
April 2013 - present
University of Groningen
Position
  • Senior Researcher
April 2002 - present
Maastricht University
Position
  • Senior Researcher

Publications

Publications (86)
Chapter
Since the birth of Louise Brown, the first “test tube baby,” in 1978, assisted reproductive technology (ART) has been widely implemented as a standard treatment for couples with subfertility problems. An estimated 8 million children have been born via ART worldwide and up to 6% of newborns in Europe and 1.5% in United States are conceived via this...
Article
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STUDY QUESTION Does lifestyle intervention consisting of an energy-restricted diet, enhancement of physical activity, and motivational counseling prior to IVF improve embryo utilization rate (EUR) and cumulative live birth rate (CLBR) in women with obesity? SUMMARY ANSWER A 6-month lifestyle intervention preceding IVF improved neither EUR nor CLBR...
Article
Study question Does human embryo culture in different IVF culture media lead to DNA methylation alterations in IVF offspring? Summary answer Genome-wide analyses identified no significant DNA methylation differences between culture medium groups in IVF children (neonates or 9-year olds) from two culture media studies. What is known already During...
Chapter
Whilst assisted reproduction techniques (ART) have become increasingly successful and largely standardized, there is still only a partial understanding of what constitutes a 'true' embryo environment. Replicating the varying physiological conditions of the in-vivo environment that the embryo travels through in the in-vitro culture is still a major...
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Study question: Is there a difference in DNA methylation status of imprinted genes in placentas derived from IVF conceptions where embryo culture was performed in human tubal fluid (HTF) versus G5 culture medium? Summary answer: We found no statistically significant differences in the mean DNA methylation status of differentially methylated regi...
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Study question: Do different oxygen levels during human IVF embryo culture affect embryo utilization, cumulative IVF success rates per cycle and neonatal birthweight? Summary answer: After 2 days of culture, a lower oxygen level (5%) leads to more good-quality embryos and more embryos that can be cryopreserved, and thereby to a higher cumulative...
Article
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Study question: What is the effect of growth velocity (height and weight) in early infancy on metabolic end-points and endothelial function in children born after ART? Summary answer: Neonatal, infant and childhood growth is positively related to blood pressure in 9-year-old IVF/ICSI offspring, while growth in childhood was negatively associated...
Article
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High density lipoproteins (HDL) are the main cholesterol carriers in follicular fluid (FF), the natural environment of oocyte development. Additionally, HDL have critical biological functions such as anti-oxidative capacity, which have not been studied in reproduction. Therefore, this study aimed to investigate whether the anti-oxidative function o...
Data
Supplementary material is available on the publisher’s website along with the published article.
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Objective: To evaluate the growth, health, and motor development of children born after preimplantation genetic diagnosis (PGD). Design: Observational cohort study and comparison of 5-year-old children born after PGD to similar aged children born after IVF/intracytoplasmic sperm injection (ICSI) and children from families with a genetic disorder...
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Preconceptional maternal bile acid species are significantly associated with birth weight of the offspring.
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PurposeWe aim to evaluate the safety of PGD. We focus on the congenital malformation rate and additionally report on adverse perinatal outcome. Methods We collated data from a large group of singletons and multiples born after PGD between 1995 and 2014. Data on congenital malformation rates in live born children and terminated pregnancies, misdiagn...
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STUDY QUESTION Do embryo culture media used during an IVF/ICSI treatment have an effect on cognitive development of singleton IVF children at 9 years of age? SUMMARY ANSWER Cognitive development of children born after culture in two different embryo culture media is comparable. WHAT IS KNOWN ALREADY Previously, we have shown that the culture medi...
Article
Objectives Although pregnancy rates of artificial reproductive techniques (ART) pregnancies have been optimized, these pregnancies have a higher risk of pregnancy complications due to impaired placentation during early pregnancy and thereby affecting placental vascularization, -structure and later on fetal growth. The aim of this study is to invest...
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The aim of this study was to test whether women who conceived after a period of subfertility are less likely to undergo invasive prenatal testing (IPT) and determine factors of influence in that decision. We conducted a retrospective study at the Maastricht University Medical Centre (MUMCþ) to compare the rates of IPT following abnormal results of...
Article
Background: mural granulosa cells (MGCs) and cumulus cells (CCs) are two specialized cell types that differentiate from a common progenitor during folliculogenesis. Although these two cell types have specialized functions and gene expression profiles, little is known about their microRNA (miRNA) expression patterns. Objective: to describe the mi...
Article
Study question: Is embryo culture media used during an IVF/ICSI treatment associated with differences in growth, body composition and cardiovascular development as determined in 9-year-old singleton IVF children? Summary answer: The choice of in vitro culture medium for human embryos is associated with differences in body weight, BMI, truncal ad...
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Two leading European professional societies, the European Society of Human Genetics and the European Society for Human Reproduction and Embryology, have worked together since 2004 to evaluate the impact of fast research advances at the interface of assisted reproduction and genetics, including their application into clinical practice. In September...
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Two leading European professional societies, the European Society of Human Genetics and the European Society for Human Reproduction and Embryology, have worked together since 2004 to evaluate the impact of fast research advances at the interface of assisted reproduction and genetics, including their application into clinical practice. In September...
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Purpose: The aim of this study was to determine whether BRCA1/2 mutation carriers produce fewer mature oocytes after ovarian stimulation for in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD), in comparison to a PGD control group. Methods: A retrospective, international, multicenter cohort study was performed on data of fi...
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Introduction and hypothesis: The treatment of post-hysterectomy vaginal vault prolapse (VVP) has been investigated in several randomized clinical trials (RCTs), but a systematic review of the topic is still lacking. The aim of this study is to compare the effectiveness of treatments for VVP. Methods: We performed a systematic review and meta-ana...
Article
Study question: Does embryo culture medium influence pregnancy and perinatal outcome in IVF? Summary answer: Embryo culture media used in IVF affect treatment efficacy and the birthweight of newborns. What is known already: A wide variety of culture media for human preimplantation embryos in IVF/ICSI treatments currently exists. It is unknown...
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We studied the mtDNA bottleneck in zebrafish to elucidate size, timing, and variation in germline and non-germline cells. Mature zebrafish oocytes contain, on average, 19.0 × 106 mtDNA molecules with high variation between oocytes. During embryogenesis, the mtDNA copy number decreases to ∼170 mtDNA molecules per primordial germ cell (PGC), a number...
Article
Study question: Does ammonium accumulate in commercially available culture media and protein supplements used for in vitro development of human pre-implantation embryos during storage and incubation? Summary answer: Ammonium accumulates in ready-to-use in vitro fertilization (IVF) culture media during storage at 2-8°C and in ready-to-use IVF cul...
Article
STUDY QUESTION What is the relative effect of common environmental and biological factors on transcriptome changes during human preimplantation development?
Article
Is gene expression in human preimplantation embryos affected by the medium used for embryo culture in vitro during an IVF treatment? Six days of in vitro culture of human preimplantation embryos resulted in medium-dependent differences in expression level of genes involved in apoptosis, protein degradation, metabolism and cell-cycle regulation. Sev...
Article
Does age of G-1 PLUS v5 embryo culture medium affect IVF outcome? Birthweight of singletons born after IVF showed an inverse association with age of the embryo culture medium, while no association was found between age of culture medium and fertilization rate, embryonic development or ongoing pregnancy. It has been reported that IVF culture media c...
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Are bile acids (BA) and their respective subspecies present in human follicular fluid (FF) and do they relate to embryo quality in modified natural cycle IVF (MNC-IVF)? BA concentrations are 2-fold higher in follicular fluid than in serum and ursodeoxycholic acid (UDCA) derivatives were associated with development of top quality embryos on Day 3 af...
Article
Do culture media influence birthweight of children born after IVF? Some studies have observed a significant effect of culture media on birthweight, while others have not, but since most studies compared different culture media, conventional meta-analysis was not possible. Animal studies suggest that in vitro culture of embryos can have a significan...
Article
STUDY QUESTION Is gene expression in placental tissue of IVF/ICSI patients altered when compared with a spontaneously conceived group, and are these alterations due to loss of imprinting (LOI) in the case of imprinted genes?
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The relationship among maternal lipid metabolism, fetal development, and adult disease of the offspring represents an emerging topic of high epidemiological relevance. The present review highlights the very early aspects of this process. Recent data suggest a link between lipid metabolism and reproduction/fertility, not only on the systemic level,...
Article
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Is post-natal growth during the first 2 years of life in IVF singletons affected by type of medium used for culturing human embryos during an IVF treatment? The in vitro culture of human embryos in medium from Cook resulted in singletons with a lower weight during the first 2 years of life compared with singletons born after embryo culture in mediu...
Chapter
Introduction Since the birth of the first in vitro fertilization (IVF) baby in 1978, there has been concern about the safety of IVF and other assisted reproduction technology (ART) procedures for the health of the ART-conceived children. Data show that ART singletons are at an increased risk for adverse perinatal outcomes like low birth weight and...
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Study question Is the metabolic profile of human embryos with chromosomal abnormalities different from the metabolic profile of normal embryos? Summary answer Differences are observed in the levels of metabolites, aminoacids, organic acids and sugars between embryos with and those without chromosomal abnormalies. What is known already Metabolic p...
Article
A good in vitro system is defined as one which mimics the in vivo system as closely as possible. In experimental developmental biology this allows observations to be made and manipulations to be carried out in vitro which are directly relevant to in vivo development, without fear of confounding artefacts. Within this paradigm clinical IVF can be co...
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Study question: What is the consequence of Tex19.1 gene deletion in mice? Summary answer: The Tex19.1 gene is important in spermatogenesis and placenta-supported development. What is known already: Tex19.1 is expressed in embryonic stem (ES) cells, primordial germ cells (PGCs), placenta and adult gonads. Its invalidation in mice leads to a var...
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Study question: When does a difference in human intrauterine growth of singletons conceived after IVF and embryo culture in two different culture media appear? Summary answer: Differences in fetal development after culture of embryos in one of two IVF media were apparent as early as the second trimester of pregnancy. What is known already: Abn...
Article
STUDY QUESTION: Does IVF/ICSI have an effect on the epigenetic regulation of the human placenta?SUMMARY ANSWERWe found a reduced DNA methylation level at the H19 and MEST differentially methylated regions (DMRs), and an increased RNA expression of H19 in placentas from pregnancies conceived by IVF/ICSI when compared with placentas from spontaneous...
Article
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BACKGROUND We have previously shown that the medium used for culturing IVF embryos affects the birthweight of the resulting newborns. This observation with potentially far-reaching clinical consequences during later life, was made in singletons conceived during the first IVF treatment cycle after the transfer of fresh embryos. In the present study,...
Article
We have previously suggested that TEX19, a mammalian-specific protein of which two paralogs exist in rodents, could be implicated in stem cell self-renewal and pluripotency. We have established here the expression profiles of Tex19.1 and Tex19.2 during mouse development and adulthood. We show that both genes are coexpressed in the ectoderm and then...
Article
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The subject of epigenetic risk of assisted reproduction treatment (ART), initiated by reports on an increase of children with the Beckwith-Wiedemann imprinting disorder, is very topical. Hence, there is a growing literature, including mouse studies. In order to gain information on transgenerational epigenetic inheritance and epigenetic effects indu...
Article
Knowledge of patients' preferences for elective single embryo transfer (eSET) or double embryo transfer (DET) and for singletons or twins is of great importance in counselling for embryo transfer (ET) strategies. In this study, the stability of IVF patients' preferences over time for either a healthy single child or healthy twins was measured and w...
Conference Paper
Full-text available
Introduction: Birthweight is an important predictor for perinatal and neonatal morbidity and mortality. In a previous study, we have shown that medium used for culturing embryos during the first few days after fertilization significantly affects the birthweight of resulting human singletons. Time of onset of this growth difference is still unknown....
Data
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Appendix 3: Characteristics of couples at randomisation by trial
Data
Appendix 2: Amount of missing data by randomised group
Data
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Appendix 1: Search strategy used for identification of studies
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To compare the effectiveness of elective single embryo transfer versus double embryo transfer on the outcomes of live birth, multiple live birth, miscarriage, preterm birth, term singleton birth, and low birth weight after fresh embryo transfer, and on the outcomes of cumulative live birth and multiple live birth after fresh and frozen embryo trans...
Article
The placenta is of utmost importance for intrauterine fetal development and growth. Deregulation of placentation can lead to adverse outcomes for both mother and fetus, e.g. gestational trophoblastic disease (GTD), pre-eclampsia and fetal growth retardation. A significant factor in placental development and function is epigenetic regulation. This r...
Article
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Introduction: Ovarian Hyperstimulation Syndrome (OHSS) is a severe health complication observed in some patients undergoing controlled ovarian stimulation (COS) during IVF. However prediction of OHSS prior to controlled ovarian stimulation in an individual IVF treatment cycle using only age and body mass index(BMI) remains a difficult task Monito...
Article
Introduction: Use of recombinant growth hormone (hGH) and successful development of oocyte donation (OD) have contributed to improve quality of life in young women with Turner syndrome (TS). However life expectancy in TS seems nevertheless reduced, mainly due to cardiovascular complications. Pregnancy itself should increase that risk and be associ...
Article
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In animal models, in vitro culture of preimplantation embryos has been shown to be a risk factor for abnormal fetal outcome, including high and low birthweight. In the human, mean birthweight of singletons after in vitro fertilization (IVF) is considerably lower than after natural conception, but it is not known whether culture conditions play a ro...
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A selective switch to elective single embryo transfer (eSET) in IVF has been suggested to prevent complications of fertility treatment for both mother and infants. We compared seven IVF strategies concerning their cost-effectiveness using a Markov model. The model was based on a three IVF-attempts time horizon and a societal perspective using real...
Article
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Besides the established selection criteria based on embryo morphology and blastomere number, new parameters for embryo viability are needed to improve the clinical outcome of IVF and more particular of elective single-embryo transfer. Genome-wide gene expression in cumulus cells was studied, since these cells surround the oocyte inside the follicle...
Chapter
Epidemiological background Following Belgium and Finland, also in the Netherlands concern was raised about the safety and risks of in vitro fertilization (IVF), and especially the risks involved in multiple pregnancies. To give an overall picture of IVF in the Netherlands, the Dutch Society of Obstetrics and Gynecology (NVOG) collects IVF outcome d...