A. Inkeri Lokki

A. Inkeri Lokki
University of Helsinki | HY · Department of Bacteriology and Immunology

PhD

About

67
Publications
5,890
Reads
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513
Citations
Citations since 2017
52 Research Items
415 Citations
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Introduction
A. Inkeri Lokki currently works at the Department of Bacteriology and Immunology and Immunobiology Research Program, University of Helsinki. Inkeri does research in Molecular Biology, Immunology, Placentology, and Genetics. One of their current projects is 'Complement system and candidate genes in pre-eclampsia'.
Additional affiliations
March 2019 - present
University of Helsinki
Position
  • Group teacher
Description
  • Instructor for small group learning. Immunology course for second year medical students.
November 2017 - present
University of Helsinki
Position
  • Researcher
Description
  • Immunogenetics of HELLP. Recurrent miscarriages.
August 2016 - present
University of Helsinki
Position
  • Group teacher
Description
  • Instructor for small group learning. Immunology course for third year denistry students.
Education
February 2010 - November 2017
University of Helsinki
Field of study
  • Immunogenetics, placentology
September 2005 - June 2011
University of Helsinki
Field of study
  • Ecology and Evolutionary Biology, Genetics
July 2003 - June 2004
Murdoch University
Field of study
  • Biology

Publications

Publications (67)
Article
Full-text available
Preeclampsia (PE) is a common disorder of pregnancy originating in the placenta. We examined whether excessive activation or poor regulation of the complement system at the maternal-fetal interface could contribute to the development of PE. Location and occurrence of complement components and regulators in placentae were analyzed. Cryostat sections...
Article
Preeclampsia is a common pregnancy-specific vascular disorder characterized by new-onset hypertension and proteinuria during the second half of pregnancy. Predisposition to preeclampsia is in part heritable. It is associated with an increased risk of cardiovascular disease later in life. We have sequenced 124 candidate genes implicated in preeclamp...
Article
Full-text available
Preeclampsia is a serious vascular complication of the human pregnancy, whose etiology is still poorly understood. In preeclampsia, exacerbated apoptosis and fragmentation of the placental tissue occurs due to developmental qualities of the placental trophoblast cells and/or mechanical and oxidative distress to the syncytiotrophoblast, which lines...
Article
Full-text available
Objective: To study genetic variants and their function within genes coding for complement receptors in preeclampsia. Design: A case-control study. Setting: Preeclampsia is a common vascular disease of pregnancy. The clearance of placenta-derived material is one of the functions of the complement system in pregnancy. Population: We genotyped 500...
Article
Full-text available
Lamellar metaplastic bone, osteoid metaplasia (OM), is found in atherosclerotic plaques, especially in femoral arteries. In carotid arteries OM has been documented to be associated with plaque stability. This study investigated the clinical impact of OM load in femoral artery plaques of patients with lower extremity artery disease (LEAD) using a de...
Article
Full-text available
Background Clinical implications of different types of vascular calcification are poorly understood. The two most abundant forms of calcification, nodular and sheet calcification, have not been quantitatively analyzed in relation to the clinical presentation of lower extremity arterial disease (LEAD). Methods The study analyzed 51 femoral artery p...
Article
The Early-Career Complementologists (ECCO) is a task force that was established, in close collaboration with the European Complement Network (ECN) and the International Complement Society (ICS), with the specific mission to support and connect early-career researchers (ECRs) in the complement field. ECRs are junior scientists at the early stages of...
Article
Full-text available
Background Vaginal microbiome and the local innate immune defense, including the complement system, contribute to anti- and proinflammatory homeostasis during pregnancy and parturition. The relationship between commensal vaginal bacteria and complement activation during pregnancy and delivery is not known. Objective To study the association of the...
Preprint
Full-text available
Preeclampsia is a vascular pregnancy disorder that affects 3-5% of all pregnancies. Genetic contribution to preeclampsia susceptibility is well established, but the actual risk loci have remained largely unknown. To make further discoveries of the underlying genetic architecture, we performed a new genome-wide association study (GWAS) for maternal...
Article
Full-text available
Preeclampsia (PE) generally manifests in the second half of pregnancy with hypertension and proteinuria. The understanding of the origin and mechanism behind PE is incomplete, although there is clearly an immune component to this disorder. The placenta constitutes a complicated immune interface between fetal and maternal cells, where regulation and...
Preprint
Full-text available
Vascular calcification exists in different forms that reflect variable clinical and histological implications. Categories of calcification have not been quantified in relation to the clinical presentation of lower extremity arterial disease. The study analyzed 51 femoral plaques collected during femoral endarterectomy, characterized by > 90% stenos...
Article
Research on the complement system, like most areas of immunology, has seen tremendous progress over the last decades. Further advances in the complement field will rely on the next generation of scientific leaders, which are today's early-career researchers (ECRs). ECRs are emerging scientists who obtained their PhD degree within the past five year...
Article
Full-text available
Preeclampsia is a multifactorial vascular disease unique to human pregnancy. While genetic and antiangiogenic factors are important contributors to preeclampsia susceptibility, recent studies have shown that dysregulation and/or over-activation of the complement system has an integral role in disease etiology. Furthermore, the role of the coagulati...
Article
Full-text available
Editorial on the Research Topic Editorial: Innate Immunity in Normal Pregnancy
Article
Full-text available
BACKGROUND: Human pregnancy alters profoundly the immune system. The local involvement and mechanisms of activation of the complement system in the cervicovaginal milieu during pregnancy and delivery remain unexplored. OBJECTIVES: To determine whether normal pregnancy and delivery are associated with local activation of complement or changes in the...
Article
Full-text available
Preeclampsia is a pregnancy-specific disorder affecting ca 3% of all pregnant women. Preeclampsia is the source of severe pregnancy complications. Later life consequences for mother and infant include increased risk of cardiovascular disease. Preeclampsia is caused by the dysfunction of the endothelium with subsequent activation of complement and c...
Data
The healthy co-existence of two genetically different organisms during pregnancy is a great immunological challenge. Complement has previously been described to play a role in pre-eclampsia, a pathology, where this immunological balance is disturbed. When the feto-maternal barrier in the human placenta, the syncytiotrophoblast layer, is damaged, th...
Article
Full-text available
It is essential for early human life that mucosal immunological responses to developing embryos are tightly regulated. An imbalance of the complement system is a common feature of pregnancy complications. We hereby present the first full analysis of the expression and deposition of complement molecules in human pre-implantation embryos. Thus, far,...
Preprint
Full-text available
It is essential for early human life that immunological responses to developing embryos are tightly regulated. An imbalance in the activation and regulation of the human complement system occurs in pregnancy complications, such as pre-eclampsia and recurrent miscarriage. We hereby present the first full analysis of the expression and deposition of...
Article
Objective Maternal vitamin D level in pregnancy may have implications for both the mother and fetus. Deficiency of vitamin D has been linked to several pregnancy complications and fetal skeletal health. Smoking has been associated with reduced serum level of the vitamin D metabolite, 25-hydroxyvitamin D (25(OH)D). Design A nested case–control stud...
Article
Full-text available
Pregnancy is an immunological challenge to the mother. The fetal tissues including the placenta must be protected from activation of the maternal immune system. On the other hand, the placental tissue sheds into the maternal circulation and must be adequately identified and phagocytized by the maternal immune system. During a healthy pregnancy, num...
Thesis
Full-text available
The human pregnancy is a unique immunological process. The foetus is tolerated and nourished through the complex yet transient organ, placenta, which bears the genetic fingerprint of the developing baby. Human placentation involves several waves of invasion, whereby the placenta is deeply attached to layers of the uterine wall, through the mucosal...
Article
Complement C4 genes are linked to pediatric inflammatory bowel disease (PIBD), but the mechanisms have remained unclear. We examined the influence of C4B gene number on intestinal microbiota and in vitro serum complement activation by intestinal microbes in PIBD patients. Complement C4A and C4B gene numbers were determined by genomic RT-PCR from 64...
Article
Full-text available
Inflammation is an important mediator of obesity-related complications such as the metabolic syndrome but its causes and mechanisms are unknown. As the complement system is a key mediator of inflammation, we studied whether it is activated in acquired obesity in subcutaneous adipose tissue and isolated adipocytes. We used a special study design of...
Article
Full-text available
Preeclampsia is a common vascular disease of pregnancy with genetic predisposition. Dysregulation of the complement system has been implicated, but molecular mechanisms are incompletely understood. In this study, we determined the potential linkage of severe preeclampsia to the most central complement gene, C3. Three cohorts of Finnish patients and...
Article
Full-text available
Objectives: Preeclampsia is divided into early-onset (delivery before 34 weeks of gestation) and late-onset (delivery at or after 34 weeks) subtypes, which may rise from different etiopathogenic backgrounds. Early-onset disease is associated with placental dysfunction. Late-onset disease develops predominantly due to metabolic disturbances, obesit...
Data
The risk ratios and 95%CI of the least frequent clusters. The marking C20 etc. is referring to certain row in the heatmap. If the risk factor is inside brackets, only a portion of women in the cluster had that risk factor. (PDF)
Data
The heatmap with Bonferroni corrections. Results of the cluster analysis. The heatmap presents the risk factors (columns) in the different clusters on the left side with black boxes. The rows correspond to the 25 clusters (C1-C25) identified on the basis of the risk factor profiles, and the sizes of the clusters are shown on the left side of the he...
Article
Full-text available
Introduction: Preeclampsia is a common and partially genetic pregnancy complication characterized by hypertension and proteinuria. Association with cardiovascular disease and type 2 diabetes has been reported in 9p21 by several genome-wide association studies. It has been hypothesized that cardiometabolic diseases may share common etiology with pr...
Article
Full-text available
Pre-eclampsia is a leading cause of maternal and perinatal morbidity and mortality worldwide. The etiology is not clear, but an immune attack towards components of placenta or fetus has been indicated. This involves activation of the complement system in the placenta. We have previously described the presence of the complement-regulating protein sa...
Article
Full-text available
Preeclampsia is a common disorder of pregnancy characterized by endothelial dysfunction. It may be life-threatening for the mother and fetus in severe cases. Dysregulation of the complement system has been suggested to predispose women to preeclampsia. Complement is part of the innate and adaptive immune systems and potentially capable of causing i...
Article
Full-text available
Pre-eclampsia is an idiopathic pregnancy disorder promoting morbidity and mortality to both mother and child. Delivery of the fetus is the only means to resolve severe symptoms. Women with pre-eclamptic pregnancies demonstrate increased risk for later life cardiovascular disease (CVD) and good evidence suggests these two syndromes share several ris...
Article
Background: Preeclampsia is a multisystem disorder of pregnancy, originating in the placenta. Cytochrome P450 (CYP)-dependent eicosanoids regulate vascular function, inflammation, and angiogenesis, which are mechanistically important in preeclampsia. Methods and results: We performed microarray screening of placenta and decidua (maternal placent...
Article
Full-text available
Pre-eclampsia/eclampsia is a common vascular pregnancy disorder associated with high maternal and infant mortality and morbidity worldwide. The role of Activin A and more recently type 2 Activin A receptor (ACVR2A) in the pathogenesis of pre-eclampsia has been the subject of genetic and biochemical research with controversial results. We genotyped...
Article
Full-text available
Fulani are a widely spread African ethnic group characterized by lower susceptibility to Plasmodium falciparum, clinical malaria morbidity and higher rate of lactase persistence compared to sympatric tribes. Lactase non-persistence, often called lactose intolerance, is the normal condition where lactase activity in the intestinal wall declines afte...

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Projects

Projects (4)
Project
Early-Career Complementologists (ECCO) is a new initiative from the European Complement Network (ECN) and the International Complement Society (ICS), two professional societies managed by researchers and clinicians investigating the complement system in health and disease. ECCO aims to support, engage and connect early-career scientists in the complement field worldwide. We share information about great science (paper of the week, clinical highlight of the month, scientist of the month), job opportunities, fellowship-calls, as well as social activities. Follow our weekly updates on social media and participate in shaping your complement society. Follow us, and message us directly on: - Email: ECCO@complement.org - Twitter: @EccoComplement - LinkedIn: Early-Career Complementologists - Facebook: https://www.facebook.com/EarlyComplement/ We encourage all early-career researchers in the Complement field to become a member of ECCO! Sign-up for membership at the link below to receive access to our newsletter and information about upcoming events/awards. Membership is FREE and OPEN internationally to all early-career scientists: - https://t.co/rRP6BQIpNb
Project
Immunology, genetics and histology in atherosclerosis.
Project
Studying the rare HELLP syndrome in human pregnancy using clinical and genetic tools.