A. Alper Öztürk

Anadolu University · Department of Pharmaceutical Technology

Clarithromycin (CLR) is a macrolide derivative which is included in BCS class 2 with low oral bioavailability. Solid lipid nanoparticles (SLNs) have been studied by many researchers for drug application and are very popular systems that continue to be studied. However, the effects of lipids used in SLN production on the formulation properties are o...

Objective: In this study, we aimed to develop a candidate polymeric nanoparticle system that will kill cancer cells by taking them to apoptosis and also reduce pain. Significance: The primary goal of treatment, especially for metastatic cancers, is to control the growth of the cancer and to alleviate the symptoms. Pain is one of the commonest sympt...

Clarithromycin (CLR) is a member of the macrolide antibiotic group. CLR has low systemic oral bioavailability and is a drug of class II of the Biopharmaceutical Classification System. In many studies, using nanoparticles (NPs) as a drug delivery system has been shown to increase the e↵ectiveness and bioavailability of active drug substances. This s...

Angiogenesis is a fundamental process of wound healing, embryogenesis etc. but occurs in cancer and chronic inflammation pathologically. HET-CAM assay is a useful, well established and animal alternative test to screen anti-inflammatory potentials of pharmaceutical products as well as nano-formulations. Dexketoprofen trometamol (DT) belongs to the...

Spray drying is an important technology that is fast, simple, reproducible, and scalable. It has a wide application range, that is, in food, chemicals, and encapsulation of pharmaceuticals. The technology can be divided into conventional spray drying and nano spray drying. The key advantage of nano spray drying is the production of drug-loaded nano...

How to cite this article: Ekinci M, Öztürk AA, İlem-Özdemir D. Preparation, radiolabeling and cell culture studies of chitosan coated PLGA nanoparticles as a potential cancer diagnostic agent. J Res Pharm. 2022; 26(6): 1636-1645. ABSTRACT: Using the nanoprecipitation process, chitosan coated poly lactic-co-glycolic acid (PLGA) based polymeric nanop...

Background: Numerous pharmaceutical applications for chitosan, a polysaccharide made from the shells of crustaceans by deacetylating chitin that occurs naturally, are currently being researched. Chitosan, a natural polymer, is successfully used to prepare many drug-carrier systems, such as gel, film, nanoparticle, and wound dressing. Objective:...

Some of the most well-engineered and produced biomaterials are polyesters based on polyglycolic acid (PGA), polylactic acid (PLA), and their copolymers, polylactic acid co-glycolic acid (PLGA). In controlled release systems, PLGA is the most extensively used and popular polymer. Because of its biodegradability, biocompatibility, and favorable relea...

Background Angiogenesis is a natural and complex mechanism that is regulated by biomolecules formed by the body. Medicinal inorganic chemistry is increasing in popularity due to metal-based compounds, offering significant chances and possibilities for building novel anti-cancer medicines with promising anti-angiogenic effects. Objective This study...

Background Rapidly dissolving oral strips have many advantages, especially in pediatric and geriatric use. Benzydamine hydrochloride is an active substance with local analgesic, anesthetic, antimicrobial and non-steroidal anti-inflammatory properties. Objective The aim of the study was to formulate and characterize orally dispersible benzydamine h...

Background Ketorolac tromethamine (KT) is a non-steroidal anti-inflammatory drug from the heteroaryl acetic acid derivatives family. The most widely used new nanotechnological approaches for topical drug delivery are polymeric nanoparticles (NPs). Objective Successful results have been obtained with low doses in many treatments, such as cancer, an...

Introduction Angiogenesis is involved in many physiological and pathological conditions including cancer. A number of TRP channels induce angiogenesis, promote cell proliferation or induce apoptosis in several types of human cancers. Therefore, TRP channels may be considered potential pharmacological targets for therapeutic options of disorders cau...

In this study, vitamin A palmitate (VAP)-loaded poly(lactic-co-glycolic acid) (PLGA)/chitosan-coated PLGA nanoparticle (NP) systems were prepared by the nanoprecipitation technique. The prepared systems were characterized by parameters such as particle size, polydispersity index (PDI), ζ-potential, encapsulation efficiency, in vitro dissolution, an...

Nanopharmaceuticals developed to take advantage of theunique properties of different structures with nanotechnology approachesgive very useful results in diagnosis, treatment and therapeutic applica-tions. A review of the literature shows that nanopharmaceuticals arepromising for our future, especially in increasing the effectiveness of di-agnosis...

Lung cancer is the leading cause of death (male and female) globally, responsible for over 1.8 million deaths. Although there have been some advances in the treatment of lung cancer, the early detection remains an issue globally. The necessity of new drugs able to efficiently accumulate and image lung cancer is quite required. In this study was dev...

Quercetin (Q) and rutin (R) are well known and most studied flavonoids due to their activities in reduction of inflammation, oxidative damage, platelet aggregation and inhibition of cancer proliferation. Despite their remarkable potentials they have limited oral bioavailability due to the low water solubility. Therefore in this study inclusion comp...

ccording to the Cosmetic Law No. 5324 published in the OfficialGazette on March 30, 2005; preparations applied to external parts of the body(such as hair, epidermis, hairs, nails, lips, oral mucosa, teeth and external genitalorgans), whose main purpose is to clean these body parts, change or correct theirappearance, and remove body odors, are defin...

Corona virus disease-2019 (COVID-19) emerged in Wuhan, China in December 2019 and was declared as a pandemic by the World Health Organization in March 2020. Although there is no complete treatment protocol for COVID-19, studies on this topic are ongoing, and it is known that broad-spectrum antibiotics such as cephalosporins are used for coinfection...

The development of a new drug active substance is not only time-consuming and expensive, but also a chain of operations that often fails. However, increasing the bioavailability, effectiveness, safety, or targeting the drugs used in clinic by various methods, such as nanoparticles (NPs), may be a more effective way of using them in clinic. In addit...

Objective: The effect of polymers used in nanoparticle (NP) production on the formulation properties is one of the few studied issues. Therefore, this study aims to formulate flurbiprofen (FLB) loaded NPs with different molecular weight (Mw) PLGA and investigate the effect of Mw on NP character. One of the most important objectives is to provide a...

Aim To prepare lamivudine (LAM)-loaded-nanoparticles (NPs) that can be used in cancer treatment. To change the antiviral indication of LAM to anticancer. Background Development of anticancer drugs is a difficult process. One approach to accelerate the availability of drugs is to reclassify drugs approved for other conditions as anticancer. The mos...

Solid dispersions (SDs) prepared with water-soluble polymers have been successfully used to increase the solubility of many poorly water-soluble drugs. Although Cefdinir (CEF) is used in many microbial diseases, its bioavailability is quite low due to its low solubility in water. Therefore, CEF is a suitable candidate for the preparation of the SD....

INTRODUCTION: The aim of the present study was to formulate levocetirizine hydrochloride (LCD) loaded chitosan nanoparticles at submicron level with high entrapment efficiency and prolonged effect for optimizing plasma drug concentration that enhances bioavailability. METHODS: In this study, LCD was successfully incorporated into the chitosan nano...

How to cite this article: Öztürk AA, Aygül A. Design of cefaclor monohydrate containing nanoparticles with extended antibacterial effect by nano-spray dryer: A nanoenglobing study. J Res Pharm. 2020; 24(1): 100-111. ABSTRACT: Spray drying is an important method used in pharmaceutical product manufacturing for many years. The nano-spray dryer develo...

The objective of present study was to prepare positively charged carvedilol-loaded nanoparticles providing a controlled release formulation by spray dryer technique and was to examine the effect of different derivative of Eudragit ® polymers on entrapment efficiency (EE%), dissolution profile and release kinetics. Two non-biodegradable positively c...

Development, in vitro and in vivo evaluation of dexketoprofen trometamol (DT)-loaded nanosized drug delivery system was aimed in this study. DT-loaded solid lipid nanoparticles (SLNs) were prepared using probe sonication. DT release from SLNs prepared and their kinetics were investigated. Structures of SLNs were elucidated by particle size and zeta...

Spray drying is an important method used in pharmaceutical product manufacturing for many years. The nano-spray dryer developed in recent years provides ultrafine powders at nanoscale and high product yields. In this study, which was aimed at prolonged release in oral use, nanoparticles-(NPs) were obtained by nanoenglobation of cefaclor monohydrate...

There have been various efforts in designing different drug delivery systems (DDSs) for periodontal diseases based on the functionalized nanomedicines. The aim of this study is to review the recent treatment of periodontal diseases with nanomaterials. Moreover, this study also focuses on basic principles of utilizing the nanomaterials to create bet...

Nanotechnology is a frequently used approach to problem solving in disease treatment and it can be considered as a collection of tools and ideas that can be applied in the pharmaceutical technology. Chronic pain (CP) is generally known as any type of pain that lasts longer than 12 weeks. Drugs used to treat CP include analgesics such as opioids and...

Lamivudine (LAM), known as 3TC, is an antiviral drug in the class of nucleoside analogue reverse transcriptase inhibitors (NRTIs). LAM is widely used for treatment of human immunodeficiency virus (HIV) and proven effective against hepatitis B virus (HBV). It is commercially available in tablet and oral solution dosage forms and used both in childre...

Ketorolac Tromethamine (KT) is a non-steroidal anti-inflammatory drug (NSAID), acting as a non-selective COX inhibitor, from the class of heteroaryl acetic acid derivatives. KT has short plasma half-life (t1/2 » 5.5 h). Colloidal drug delivery systems, including nanoparti- cles (NPs), are good drug delivery candidates as they can enhance safety and...

Diclofenac sodium (DS) is a non-steroid anti-inflammatory drug (NSAID) and is the most prescribed for the treatment of pain and inflammatory diseases. Like all NSAIDs, DS exerts its effects by inhibiting prostaglandin synthesis by blocking COX-1 and COX-2 enzymes. Indications for use include rheumatic disease, migraine, musculoskeletal and postoper...

Cefdinir (CEF) is a semi synthetic third generation cephalosporin antibiotic used to treat bacterial infections. It has a short half-life of 1 to 2 hours with bioavailability of 20-25%. CEF is a Biopharmaceutics Classification System (BCS) Class IV drug which means it has low solubility and low permeability. Even though it has marketed dosage forms...

Ketoprofen lysine because of a short half-life (1-2 h) multiple dosing regimens are required for oral administration. For this reason, this study is concerned with the preparation of poly lactic-co-glycolic acid- based spray-dried nanoparticles to extend the activity of the ketoprofen lysine. Nanoparticles were produced with a spray dryer (B-90, Bü...

The aim of this study was to formulate Lamivudine (LAM) loaded poly lactic-co-glycolic acid (PLGA) nanoparticle (NP) formulations by 'double emulsion solvent evaporation' method for oral administration. PLGA with similar molecular weight but two different chemical end-groups (acid or ester terminated), were used in this study to to compare the effe...

Clarithromycin (CLR) is a macrolide derivative which is included in BCS class 2 with low oral bioavailability. Solid lipid nanoparticles (SLNs) have been studied by many researchers for drug application and are very popular systems that continue to be studied. However, the effects of lipids used in SLN production on the formulation properties are o...

The purpose of this study was to formulate Cefaclor monohydrate (CEF) loaded microemulsion formulations with the help of pseudo-ternary phase diagrams for topical application. Additionally, in this study also a new ultra-performance liquid chromatography (UPLC) method was developed for the determination of CEF, which was not previously entered into...

Development and in vitro evaluation of dexketoprofen trometamol (DT)-loaded nanosized and controlled release drug delivery system was aimed in this study. DT-loaded Eudragit® RL 100 polymeric nanoparticles were prepared using nano spray-dryer. Structures of DT-loaded polymeric nanoparticles were elucidated by particle size and zeta potential measur...

Purpose: To design, formulate and characterize sustained-release formulations of dexketoprofen trometamol (DT) nanoparticles (NPs) Methods: Dexketoprofen trometamol (DT)-loaded poly(lactic-co-glycolic acid) (PLGA) NPs were produced by double emulsion-solvent evaporation method. The NPs were variously characterized for drug loading and release, part...

Aims and objectives: Solid Lipid Nanoparticles (SLNs) are pharmaceutical delivery systems that have advantages such as controlled drug release, long-term stability etc. Particle Size (PS) is one of the important criteria of SLNs. These factors affect drug release rate, bio-distribution etc. In this study, the formulation of SLNs using high-speed h...

Context: Pain has a very important effect on the biological, psychological, sociological and economic situation of a patient. Nanoparticles (NPs) are being extensively investigated as drug delivery systems worldwide for pharmaceutical applications. Aims: To design and compare the release characteristics of sustained- release formulations of ketopro...

Development and in vitro evaluation of dexketoprofen trometamol (DT)-loaded nanosized and controlled release drug delivery system was aimed in this study. DT-loaded Eudragit® RL 100 polymeric nanoparticles were prepared using nano spray-dryer. Structures of DT-loaded polymeric nanoparticles were elucidated by particle size and zeta potential measur...

Context: Pain has a very important effect on the biological, psychological, sociological and economic situation of a patient. Nanoparticles (NPs) are being extensively investigated as drug delivery systems worldwide for pharmaceutical applications. Aims: To design and compare the release characteristics of sustained-release formulations of ketopro...

Seborrheic dermatitis (SD) is a skin disease with chronic recurrent erythematous plaques in areas where sebaceous glands are intense. The etiology of SD remains unknown, although many factors such as lipophilic yeasts of the Malassezia genus, hormones, genetic, environmental and general health factors have been shown to be causative. SD is affectin...

Objective: The purpose of this study was to formulate flurbiprofen (FLB) loaded methylcellulose (MC), hydroxypropyl methylcellulose (HPMC) and Carbopol®940 (C-940) based gel formulations with the help of dispersion method for topical application. Additionally, in this study also a new ultra performance liquid chromatography method was developed for...

The purpose of the present investigation was to design and compare the release characteristics of sustained-release formulations of Flurbiprofen (FLB) loaded nanoparticles (NPs) by using spray-dryer technique using Eudragit RLPO (RLPO), Eudragit RSPO (RSPO) and RLPO:RSPO 1:1 ratio. NPs Formulation were prepared by spray-dryer. Structures of nanopar...

Carvedilol (CVL) has advantages over the first generation of β-blockers in patients with heart failure due to its properties of reducing cardiovascular morbidity and mortality. On the other hand, CVL has a short half-life leading to administration of high dosage and frequent dosing range. The need of design and producing a new prolonged-release dos...

Carvedilol (CVL) has advantages over the first generation of β-blockers in patients with heart failure due to its properties of reducing cardiovascular morbidity and mortality. On the other hand, CVL has a short half-life leading to administration of high dosage and frequent dosing range. The need of design and producing a new prolonged-release dos...

Ketoprofen lysinate (KL), the water soluble lysine salt of ketoprofen, is one of the most commonly used non-steroidal anti-in ammatory drug (NSAIDs) in the symptomatic treatment of various chronic in ammatory diseases. However, due to its short half-life of 1–2 h, a multiple dose regimen is required. Therefore, KL is an ideal candidate for the deve...

Ketoprofen lysine (KL), the water soluble lysine salt of Ketoprofen, is one of the most widely used non-steroidal anti-inflammatory drugs (NSAIDs) in the symptomatic treatment of various chronic inflammatory diseases for its analgesic efficacy. However, due to its short half-life of 1–2 h, a multiple dose regimen is required therefore, KL is an ide...

Levocetirizine dihydrochloride (LCD) is a third generation non-sedative antihistamine. LCD works by blocking histamine receptors. It does not prevent the actual release of histamine from mast cells, but prevents it binding to receptors. In addition, it is an important drug in the treatment of allergies and idiopathic urticaria . Chitosan (CS) is a...

Nanoparticle systems are one of the multiparticulate delivery systems and are prepared to improve bioavailability or stability. Many advantages of nanoparticle-based drug delivery have been recognized. In vitro drug release studies are important and this studies help in evaluation of sustained and prolonged release dispersion systems. In this study...

Nanoparticles are one of the multiparticulate delivery systems and are prepared to improve bioavailability or stability. The object of the study was to formulate and characterize Eudragit® Nanoparticles containing carvedilol by determining their size and zeta potential, their external morphology for the treatment of hypertension.

The pain situation has a very important effect on the biological, psychological, sociological and economic situation of the patient. Dexketoprofen trometamol (DT) has been developed as a water-soluble trometamine salt. DT is a rapidly acting analgesic agent in the treatment of painful musculoskeletal disorders such as back pain and osteoarthritis....

Hypertension (HT), which de nes systolic blood pressure as >140 mmHg or diastolic blood pressure >90 mmHg. There are now several drugs that are available in the market, including carvedilol (CVL) which is used for the management of cardiovascular disease and HT. CVL-containing PLGA nanoparticles (NPs) were prepared by nanoprecipitation method.

The purpose of the present investigation was to design and compare the release characteristics of sustained-release formulations of Flurbiprofen (FLB) loaded nanoparticles (NPs) by using spray-dryer technique using Eudragit RLPO (RLPO), Eudragit RSPO (RSPO) and RLPO:RSPO 1:1 ratio. NPs Formulation were prepared by spray-dryer. Structures of nanopar...

Development and in vivo/in vitro evaluation of dexketoprofen trometamol (DT)-loaded nanosized, controlled release drug delivery system was aimed in this study. DT-loaded Kollidon® SR (KSR) and Eudragit® RS 100 (ERS) polymeric nanoparticles were prepared using Nano Spray-Dryer (B-90, Büchı Labortechnik AG, Flawil, Switzerland). Both delivery systems...

Quercetin is one of the most important flavonoid has been shown to exert anticancer and antiinflammatory effects. Rutin is also a flavonoid has demonstrated a number of pharmacological activities like antioxidant, cytoprotective, vasoprotective, anticarcinogenic effects. Different drug delivery materials are being constantly developed to overcome t...

Acute and chronic pain occur as a result of tissue damage either accidentally because of an injury or in consequence of surgery. The treat of acute/chronic pain and inflammation is a crucial component of patient care. Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most extensively used drugs worldwide owing to their efficacy in reducin...

Polymeric nanoparticles based on biocompatible and biodegradable polymers are preferred for drug delivery owing to their property of being adsorbed intact in the gastrointestinal tract after oral administration. Stability of polymeric nanoparticles are generally described as physical, chemical, long-term "pharmaceutical" and colloidal stabilities....

In this study, an economic, easy, basic, quick, sensitive and error-free reverse phase high performance liquid chromatography (RP-HPLC) modified method was developed for the determination of dexketoprofen trometamol. NUCLEODUR C18 (5.0 μ, 250 mm × 4.6 mm) was used as the stationary phase while acetonitrile-methanol (25:75 v/v) mixture was the mobil...