You would have to enclose the protein in something to protect it, such as a capsule with an enteric coating, but the protein would still be digested in the small intestine. That is why protein drugs are always delivered by subcutaneous injection or intravenous injection.
You may introduce protective groups that will help prevent enzymatic degradation of the foreign protein.
Cyclization of foreign protein can increase its half-life by protecting it from the digestion of exo- and endopeptidases. Cyclization of peptides and proteins generate more rigid conformations, and it exhibits decreased susceptibility to enzymatic degradation.
You can also protect the foreign protein from proteases by covalently attaching it to a biocompatible polymer, leading to reduced immunogenicity, enhanced bioavailability, and enriched pharmacokinetic profile.
For more information, you may refer to the attached paper.
An affinity resin containing Argininal (aldehyde) ligands is synthesized for the purification of proteases with trypsin-like specificity. The synthesis of arginine semicarbazone (Argal-SC) from Cbz-(ω-NO2)-L-Arg, the joining of Argal-SC to an agarose matrix, and the removal of the semicarbazone function to form argininal is described. Argininal bin...
In this paper, the DNA fragment of trypsin genes from eight crustaceans were cloned and sequenced. The amino acid composition
of the 24 deduced and 42 selected trypsin sequences were compared. Low arginine, methionine, and proline content and high
aspartic acid, glutamic acid, and isoleucine content attributed to the distinct catalytic efficiency o...