Usmanu Danfodiyo University Sokoto
Discussion
Started 16 July 2024
Which molecules link skin whitening with anti-aging?
Apparently the lack of tyrosinase:
"Inhibition of tyrosinase can reduce the production of melanin and achieve skin whitening, effectively solving pigmentation (Lall and Kishore, 2014). Therefore, the development of antioxidants, tyrosinase inhibitors, and elastase inhibitors play important roles in solving skin aging and pigmentation" ( https://www.google.com/url?q=https://www.sciencedirect.com/science/article/abs/pii/S0926669020309766&sa=U&ved=2ahUKEwjE4pTd0KyHAxUzHEQIHTzCCpIQFnoECAEQAw&usg=AOvVaw0gD_VQbHW1t1Go0zkPQyIW ).
Ming-Xiang Li, Jing Xie, Xue Bai, Zhi-Zhi Du,
Anti-aging potential, anti-tyrosinase and antibacterial activities of extracts and compounds isolated from Rosa chinensis cv. ‘JinBian’,
Industrial Crops and Products,
Volume 159,
2021,
113059,
ISSN 0926-6690,
Abstract: Rosa chinensis cv. ‘JinBian’, a cultivar of Rosa chinensis Jacq., is one of major raw material of rose tea and possesses sufficient plant resources in China. However, the studies on the chemical constituents and cosmetic activities of R. chinensis cv. ‘JinBian’ are almost blank. The main purpose of this study was to evaluate the anti-aging, skin-whitening, and antibacterial potentials of extracts and chemical constituents of the flower by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, elastase inhibition, anti-tyrosinase, and antibacterial assays. Bioassay results suggested both 95 % and 65 % ethanol extracts possessed significant antioxidant, elastase inhibition, and anti-tyrosinase activities. The combined active extract was studied with bioassay-guided fractionation to give a new compound, kaempferol 3-O-α-l-rhamnopyranosyl (1→6)-(2”,3”-O-digalloyl)-β-d-glucopyranoside (1) and fourteen known compounds (2–15). All compounds were firstly isolated from this species and subjected to the above mentioned bioassays. Ten compounds exhibited antioxidant activities with DPPH radical scavenging rate from 63.40 %–94.04 % under the concentration of 100 μg/mL. The antioxidant activities of 1, 2-phenylethyl 1-O-β-d-(6'-O-galloyl)-glucopyranoside (12), vomifoliol (14), and 4, 4'-dimethoxy-3'-hydroxy-7, 9': 7', 9-diepoxylignan-3-O-β-d-glucopyranoside (15) were firstly found with DPPH radical scavenging rate of 83.24 %, 91.10 %, 63.40 %, and 77.75 %, respectively. The moderate elastase inhibitory activities of 12, ethyl gallate (13), and 15 were firstly found with the inhibitory rate of 43.69 %, 43.25 %, and 35.34 % at the concentration of 100 μg/mL. Multiflorin B (3), 12, and 13 showed strong tyrosinase inhibitory activities with the inhibition rate at 43.83 %–55.80 %, comparing with the positive control, α-arbutin (22.15 %). In addition, 1 showed significant antibacterial activity against Staphylococcus aureus with the MIC50 of 8.51 ± 0.26 μg/mL. Compounds 2–4 and 12–14 showed moderate antibacterial activities against S. aureus. Compounds 6 and 13 also exhibited moderate inhibitory effects against Klebsiella pneumoniae. Above results manifested that R. chinensis cv. ‘JinBian’ possessed potential application values in the development of natural anti-aging, skin-whitening and antibacterial products.
Keywords: Rosa chinensis cv. ‘JinBian’; Antioxidant; Elastase inhibitory activity; Tyrosinase inhibitory activity; Antibacterial activity; Cosmetic potential
All replies (1)
Similar questions and discussions
Is there a cell culture flask available that provides the same surface area as a T25 flask but has less volume capacity?
- Domiziano Tosi
I need to culture cell in a completely filled flask because it will be put in a shaker and to avoid mechanical stress due to bubbles or convective flow I was searching for a flask that will use less media volume.
Normally a t25 has a capacity of 84cm3, I have found one that has 30cm3 (https://www.diagnocine.com/Product/iPTEC-Flask25/54583) but costs 4 time more than the common one.
There is also a similar concept used in another type of flask (Nunc OptiCell) that has a capacity of 10cm3, but it got discontinued.
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