Question

Asked 7 March 2018

Tabriz University of Medical Sciences

What's the nitric oxide synthesis inhibitor's role in migrane headache?

I want to study the role of NO synthesis inhibitors in migraine headache via meta-analysis articles in this field.

Stellenbosch University

I do not know much about the Neuro field, but we use L-NAME and perhaps u can also try Melatonin

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Kenneth Lo

The Hong Kong Polytechnic University

This article may answer your question in certain extent:

Article Drugs targeting nitric oxide synthase for migraine treatment

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Stefan S Du Plessis

Stellenbosch University

Nitric oxide(NO) lead to vasodilation and is believed to be responsible in some instances for onset of certain types of migraines.(Drugs that dilate blood vessels can cause headaches, at least in some people.)

NO is a very important molecule in the regulation of cerebral and extra cerebral cranial blood flow and arterial diameters. It is also involved in nociceptive processing. Glyceryl trinitrate (GTN), a pro-drug for NO, causes headache in normal volunteers and a so called delayed headache that fulfills criteria for migraine without aura in migraine sufferers. Blockade of nitric oxide synthases (NOS) by L-NMMA effectively treats attacks of migraine without aura.

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Ramin Farajpour

Tabriz University of Medical Sciences

Dear Estefan, can you suggest me some of routine NOS inhibitors in neuroscience?

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Stefan S Du Plessis

Stellenbosch University

I do not know much about the Neuro field, but we use L-NAME and perhaps u can also try Melatonin

Cite

Does the Presence of a Network Meta-Analysis Nullify the Need for a Double-Armed Meta-Analysis?

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Asked 23 October 2024

Mohamed I. Mohamed

Greetings to the respected ResearchGate community:

I wanted to know if it would be invalid to conduct a double-armed meta-analysis (DAMA) if a network meta-analysis (NMA) already exists in the literature?

I'll provide you with two examples below:

1. I am willing to compare the efficacy of two different drug classes in the treatment of migraines through a double-armed, comparative meta-analytic review. A NMA already exists and ranks the different medication classes through its direct and indirect comparisons.

Would it be non-feasible to conduct a DAMA in this case?

What if the relationship/the ranking of medications - which has already happened in the NMA - was done through an indirect comparison... Would this necessitate the need for a direct comparison through a DAMA?

2. I am willing to compare the efficacy of two flaps used in plastic surgery through a DAMA. A planned NMA on PROSPERO is already present which aims to compare three different flap types (including the ones I've had in mind). Does this invalidate the need for such a DAMA?

As a clinician/headache specialist, would you be interested in such findings - given the pre-existence of a NMA?

As a plastic surgeon, would you be interested in such findings - given the pre-existence of a NMA?

Please advise me - if possible.

Thank you very much in advance.

What is the best way to comapre 3 different drugs against each other is a systematic review and meta-analysis?

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3 answers

Asked 26 March 2018

Assad Ahmed

Hi im currently doing a systematic review and meta-analysis for the first time, and i do not entirely understand how to effectively compare 3 PDE5 inhibitor drugs against each other for my data analysis ?

Would you construct a forest plot with all studies from all 3 drugs against placebo and see which had the greatest effect?

What are some natural options for a completey healthy patient with intertmittent cranial vascular headaches?

Question

3 answers

Asked 14 May 2018

Russ Brook

All tests and imaging show patient is healthy and has no visible abnormalities. Patient has headaches once a week that are triggered by vaso-dilation type stimuli (i.e hot weather, sugar, foods with nitric oxide). Patient's headaches are mitigated by vaso-constrictive stimuli (i.e. antihistamines, caffeine) but the headaches still contribute to lower quality of life when headache occurs.

Are there any in vivo inhibitors of peroxiredoxin 1?

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2 answers

Asked 22 July 2016

William L Stone

Specificity would be important as well as biochemical outcomes, e.g. measurement of increased oxidative stress.

What subject do you suggest for writing a systematic review in aromatherapy?

Discussion

4 replies

Asked 17 October 2018

Abohassan Farhang Sardrodi

I want a subject for writing a systematic review in aromatherapy.

My idea is on headache, but if you suggest a subject we can do this together.

sincerely yours

Abohassan Farhang S.

Does anyone know a specific membrane-permeable MnSOD inhibitor?

Question

4 answers

Asked 30 March 2016

Stefano Falone

Hi everyone,

I am looking for a specific chemical inhibitor of MnSOD (SOD2). It should be able to pass the plasma membrane freely.

Available literature is not helping.

Thank You very much in advance.

Regards

Stefano Falone

University of L'Aquila - Italy

Does anyone know a specific inhibitor for salicylic acid biosynthesis or signalling?

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Asked 1 June 2020

Islam M. Khattab

I'm mapping the stress signalling of a specific fungal toxin invitro using Vitis suspension cells. I already found many inhibitors manipulating the deathly pathway of the toxin, either by cell death assays or at transcriptomics levels. Some genes invloved in SA signalling were already regulated by different inhibitors. Working with a specific SA inhibitor will strengthen my hypothesis. Thanks in advance

To check for protein degradation pathways how to make a solution of chemical inhibitors?

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1 answer

Asked 28 October 2020

Deleted profile

I want to make a solution of 3-methyladenine and MG-132 that can be infiltrated into Nicotiana benthamiana. So, I tried dissolving in DMSO as per product guidelines and then diluted in PBS that resulted in inconsistent results. I would like to ask if anybody uses some other kind of solvents that resulted in reproducible results? P.S I am always making fresh solutions before using it.

Why such difference in Heterogeneity when comparing standard mean difference vs mean difference ?

Question

4 answers

Asked 17 April 2018

David Benavides-Zora

Hello,

I am doing a Sistematic review and meta-analysis of interventional techniques in headaches.

I am using revman and when calculating the effect size of the meta-analysis the MD vs SMD, the I2 drops from 95% to 50%. I wonder why? I am inclined to use MD despide its bigger heterogeneity because all studies use the same Pain scale (VAS), right ?

Thanks

Mediatorwirkungen im trigeminovaskulären System als Grundlage für die nozizeptiven Vorgänge bei der Kopfschmerzentstehung

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Nov 2007

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Zusammenfassung Es besteht eine hohe Komorbidität zwischen primären Kopfschmerzen und psychischen Erkrankungen. Eine gegenseitige Verstärkung und gemeinsame ätiologische Faktoren werden vermutet und wurden zum Teil nachgewiesen, so zum Beispiel bei Migräne und Depressionen. Eine nosologische Einteilung als sekundärer “Kopfschmerz zurückzuführen auf...

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