sodiumsulphite, TBAB and protic solvent also works very good.
Sodium hypo sulphite (Na2S2O4) (2.5 Mol eq ) in methanol:water (5:1) at 35-40°C. Yield is pretty high.
You can try Nickel boride (Ni2B) - not a common reagent but very easy to try: dissolve nitro compound in protic solvent (i.e. methanol, water or a mixture thereof). Add NiCl2-6H2O (1.0 eq) followed by NaBH4 (10.0 eq). A black precipitate (the active Ni2B species) will rapidly form along with H2 (g) evolution. After stirring 30 minutes at RT check by TLC - if the reaction is not complete additional equivalents of NiCl2-6H2O and NaBH4 can be added. After complete reduction the mixture is filtered through celite and the solvent evaporated. The residue is partitioned between water and a suitable organic solvent (i.e. CH2Cl2). The aqueous layer is further extracted with CH2Cl2 and the combined organic layers washed with brine, dried over Na2SO4 and filtered. Solvent removal under vacuum yields the crude amine which can be further purified if necessary (i.e. by column chromatography). Good luck!
Try to work out with Cu based materials...Try with CuO and CuNPs....Considering cost effective point of view it will work in great effect.
Nickel borohydride in methanol is the best reagent. You need to prepare nickel borohydride insitu using nickel chloride and sodium borohydride at around -10C. Reaction will be completed in 30 mins.
Activated zink in AcOH. Activation: Put Zn powder into water, add some drops of HCl, when ceasing of H2 started, remove water phase and wash with MeOH. You can store Zn in MeOH.
Best cheaper reagents to reduce aromatic nitro to amine Fe/HCl.
To reduce nitro aromatics in amines you can use LiAlH4 in THF. The solvent THF must be well dried. Dissolve the nitro aromatic compound in THF. Add LiAlH4 and boil the solvent with mixing for 2 to 4hours. After hydrolysis (water and NH4Cl), Add NaOH until pH reaching 9-10. Extract the aromatic amine from water with Ether or CH2Cl2 if necessary.
use activated Zn
R L Fine Chem, Bangalore, India
Mehul M Patel
Charotar University of Science and Technology
University of the Republic, Uruguay
Université Sultan Moulay Slimane
Guillermo Martinez Ariza
The University of Arizona
Amrita Vishwa Vidyapeetham
@Appleton Scientific Ltd
Dr Lakkireddy Srinivasula Reddy
Dr. Reddy's Laboratories
Nanda M Verhoeven
University Medical Center Utrecht