Question
Asked 22nd Feb, 2021

Sodium tert-butoxide: what are safety rules and precautions?

Does anyone has an experience with sodium tert-butoxide? How dangerous it actually is?
Do I need to use a glovebox while weighting and handling it?
Do I have to dissolve it in THF at -30C or room temperature will also do?
How do you store it after the can is opened?
We have 100g of sodium tert-butoxide in total, the planned amount for my synthesis is ca. 1.5 g.

Most recent answer

2nd Aug, 2022
Chuck A Arize
Texas A&M University-Commerce
Do not breathe dust/fume/gas/mist/vapours/spray. Avoid breathing dust/fume/gas/mist/vapours/spray. Use only outdoors or in a well- ventilated area.

All Answers (4)

3rd Mar, 2021
Paul Lane
University of Alabama at Birmingham
A safety data sheet (SDS) from one manufacturer attached. This material is very high risk and requires special handling and storage. It does not say on the SDS that it is incompatible with organic peroxides, but in contact, it will release hydrogen gas. I would recommend looking for a safer substitute if possible.
6th Mar, 2022
Chuck A Arize
Texas A&M University-Commerce
Precautions for safe handling
Do not breathe dust/fume/gas/mist/vapours/spray.
2nd Aug, 2022
Chuck A Arize
Texas A&M University-Commerce
Do not breathe dust/fume/gas/mist/vapours/spray. Avoid breathing dust/fume/gas/mist/vapours/spray. Use only outdoors or in a well- ventilated area.

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