Asked 30th Jul, 2022
  • Northern Trans-Ural State Agricultural University, Russia, Tyumen

How to explain the acceleration of the progression of desminopathy (myofibrillar myopathy) after suffering Covid-19?

A patient with desminopathy survived Covid-19 six months ago without pneumonia, but with a temporary loss of smell and taste. After Covid-19, we note an accelerated progression of desminopathy, penetration accelerates, new muscles are quickly involved in the pathological process, muscle mass decreases, and heart function worsens. Perhaps the infection or its consequences are somehow connected with the mechanism of progression of desminopathy?

Most recent answer

Margo Benge
You are most welcome! I only wish I could work more closely with researchers like you!

Popular answers (1)

All Answers (7)

Nice question and follow
Dear Professor Viacheslav Pauls ,
There are still many doubts about COVID-19 and chronic manifestations are prevalent and bring a great decrease in the quality of life of many patients.
I have studied the pathophysiology of COVID-19 and I have a hypothesis for the wasting syndrome, with significant loss of skeletal muscle and systemic inflammation.
Intracellular organisms, in general, divert the host cell's metabolism - from aerobic respiration to aerobic glycolysis - something similar to the metabolism of neoplastic cells (Warburg effect).
This deviation happens so that the host cell metabolism prioritizes substrate formation for the formation of new bacteria or viruses. Thus, activation of the pentose pathway is observed, with the formation of purines. At the same time, the need for BCAAs and glutamate, which are present in large amounts in muscle - hence the consumption. The lipid pathway is also hyperstimulated, its molecules being a substrate for viral lipid membrane formation, for example.
The truncation of the citric acid cycle promotes elevation of Pyruvate, stimulating the expression of LDH, converting Pyruvate to Lactate, which will be metabolized into glucose by the CORI cycle.
But what would be the reason that in the infection by SARS-CoV-2 we find such a high muscle consumption?
I think the answer is hypoxia that enhances the Warburg effect - thinking that a neoplastic cell is surrounded by a hypoxemic microenvironment.
The hypoxemia and the alteration in the tryptophan pathways promoted by SARS-COV-2 seem to act in a way to increase the magnitude of the metabolic deviation that the virus causes and that in other diseases are of lesser intensity, however they are not associated with lesions that cause such great hypoxemia and in such a short time.
It is something that is coherent, but we still need many studies to prove this hypothesis.
My best regards
3 Recommendations
Viacheslav Pauls
Northern Trans-Ural State Agricultural University, Russia, Tyumen
Dear Wesam Salah Mohamed Ibrahim, Mohmmed Faris, Luiz Gonzaga Francisco de Assis Barros D'Elia Zanella, thank you very much for your answers and links to articles!
Margo Benge
I have theorized that COVID-19 attacks the body through concentrations in the area where lymph does not flow; hence the wide range of alternative symptoms. A generally poor understanding of lymph blockages and the side effects thereof impact many conditions. Desminopathy shares the same type of damages I've seen lessened through release of those blockages. The two compounded would further aggravate the overall system; acceleration does not surprise me.
1 Recommendation
Viacheslav Pauls
Northern Trans-Ural State Agricultural University, Russia, Tyumen
Dear Margo Benge, thank you very much for your reply!
Margo Benge
You are most welcome! I only wish I could work more closely with researchers like you!

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SCHRÖDINGER'S MEETING: How would a conference call with 50 similar voices work? How does perceived communication break-down?
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  • Patrick Henry WhitePatrick Henry White
Imagine you're going into a voice meeting with 50 different people, except every one of their voices sounds similar, how hard would it be to have a productive meeting? Now imagine learning 50 different subjects from 50 different PDFs that all look similar. This last example, however, is our reality.
(Will a single sentence form from two people talking in succession?)
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  • Person 2: "Okay sir, thanks how are you?"
  • Persons 1 + 2 becomes: "Are you okay, sir."
How hard would it be to memorize, comprehend and respond?
What would be the implications in terms of neurology, personal distress, memory formation, etc?
It is named after Schrödinger's Cat, a quantum mechanics thought experiment - where the cat is considered to be in an unknown state, described in physics as superposition. Just as the cat's state is unknown, so may be the context of a 'seemingly' coherent communication within a Schrödinger's Meeting. The example above shows, if you cannot distinguish between the two speakers' voices then the fundamental mechanics required for coherent communication have the opportunity to break down or be absent entirely. "Person 1 + 2" does not exist, and did not say "Are you okay, sir." as discussed in the example above, however, it is possible for a listener to hear that artificial sentence and label it as intentional and coherent.
The Schrödinger's Meeting example highlights the importance of stimuli distinguishability in our everyday lives. Investigations into stimuli distinguishability and homogeneity, particularly regarding digital text comprehension, is the groundbreaking work of my team. Further materials and research papers related to the topic can be found on my profile.
Environmental stimuli distinguishability as it pertains to the general public is a massively underexplored area of neurology and information theory. My team and I look forward to hearing others' reasoning regarding the possible effects of a Schrödinger's Meeting and/or the effects of sensory distinguishability on the modern human.
Aside from the significant implications on neurology and human health, Schrödinger's Meeting may further prove useful in information science, by helping to answer the question of: What is the exact definition of a "communication"? Has the hybrid "Person 1+2" and their artificial sentence communicated? Many people would be hesitant to define this hybrid-sentence as a communication, however, the hybrid-sentence is certainly intelligible to the listener and therefore communicable. To paraphrase, the current definition of "communication" as described by Oxford is a process involving the transmission of information. By this definition, the hybrid sentence is certainly a communication.
At a glance, this thought experiment may seem pointless. However, it highlights the importance of defining exactly what "communications" are.
In addition to digital text-technology advancement, answer(s) to this question may provide mechanical insight into important properties of large data sets, such as metadata, quantum computation datasets, and image-capture rendering. Additionally, Schrodinger's Meeting may provide insight into composite waveform systems, providing context for deciphering probabilistic rates at which coincidentally-coherent noise may form in a given wave-mixing data set.
If possible, as mentioned above, defining a firm definition for what makes a "communication" separable from coherent noise would be very important.
Are there opportunities for good grades but poor income for biotechnologists?
3 answers
  • Zahraa OzeerZahraa Ozeer
Hello to all my fellow Biologists.
I have resorted to posting this question as my last desperate attempt to find a place for myself in the world of biotechnology.
I am a first class student with relatively good grades (GPA 3.77/4.00) in BSc. of Biotechnology (Hons), excellent extra-curriculars and competitions under my belt, 6 months of work as a Field/Research Assistant and 4 years of previous work experience in events management. I have experience in the microbiology, molecular biology, antivirals, nutraceuticals and cell culture disciplines. I have also taken a great liking to scientific communication and create visual content to make biology simpler for the Layman, both bother and in my own time.
Despite all this, I haven't had a single postgraduate application succeed for the last 2 years. And though I do understand there is high competition for available spots, I also wonder what I may be lacking despite some telling me I have an "impressive CV" and can do a direct PhD.
It is unfortunate however that my family is not doing financially well, therefore I can only afford opportunities with a scholarship or that are work/salary-based. Perhaps this narrows available opportunities but regardless, studentship scholarships have very evidently not opted for me, simply because "there were too many applicants this time around". Perhaps lacking funds is not enough of a criteria? (Hint of sarcasm).
Additionally, I was born and raised in the UAE (I do not get citizenship), therefore I am also looking for a potential country to eventually settle down in while doing the work I love.
I would greatly appreciate if anyone would know of opportunities I may be able to apply for like fully funded PhDs, or skilled/summer programs and workshops/internships, or even Research or Lab assistant positions you or someone you know may be looking for, because unfortunately, I'm 2 rejections away from being completely out of options.
I would greatly appreciate any input you may have or can share with me! I have also added my CV for your reference.
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I look forward to hearing from you all.
Zahraa Ozeer

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