Question
Asked 5 January 2019

How is the methodology quality assessed in vitro studies?

I am doing a systematic review with in vitro and in vivo (animals and human models) studies about different treatments to improve bone remodelling.
I used to use, to describe the methodological quality of the selected articles, the PEDro scale and the guidelines of the Dutch Institute for Healthcare Improvement (CBO). PEDro scale assesses the risk of bias of RCTs to provide a global overview of internal validity of the studies. But this does not rate the external validity. For this reason it is necessary to determining the level of Evidence using the Dutch CBO Guidelines.
But, my questions is...these scales and guidelines, could be used in vitro studies too?or what other scales or guidelines should I use?
Thank you so much,

All Answers (2)

Sebastian Hoffmann
seh consulting + services
Quality assessment for in vitro (or also mechanistic) evidence is a field that is currently investigated in detail. There are some tool out there already, which address reporting, risk-of-bias and methodological issues (or a mixture of these). Have a look at Samuel et al. ( ), who recently scoped the field. Maybe this will guide you to something useful?!
2 Recommendations
Alba Camacho-Cardenosa
University of Extremadura
Thank you so much

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