Bahria University
Question
Asked 2 September 2021
How can I dissolve ciprofloxacin in water without decreasing the pH as it can affect my carrier when loading it? Will increasing the pH be efficient?
I need to prepare 20 mg/ml of ciprofloxacin solution
I tried using acetone and methanol but I got no fruitful results
All Answers (1)
Sonicate and heat, Ciprofloxacin HCl is soluble in water. if you talk about only base ciprofloxacin then you need to dissolve in anhydrous ethanol or methylene chloride . if still is issue the you need first dissolve in dilute acid solution then after that you adjust the required pH Through alkaline solution.
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