How can I calculate the relative retention of impurity in HPLC ?

In high pressure liquid chromatography (HPLC), the compound is injected through a column of different sized beads.The amount of time it takes for the compound to pass through the column is the retention time (RT).

While people focused on mdpi but surprisingly the de-indexing is from other reputable publishers.

Clarivate announced the exclusion of 82 journals from the Web of Science core collection. This also means that these de-listed journals lost their Impact Factor.

The announcement was made in the midst of a series of complaints that have been made against major scientific publishers suspected of not carrying out the due process of peer review, publishing articles without scientific rigor in exchange for high publication fees, mostly paid with public money.

The released note says:

Among the publishers most affected by the measure, we have:

It is important to analyze the number of de-listed journals and the total number of journals that each publisher has in the core collection. Wiley-Hindawi (15,4% of journals de-listed), AME Publishing Company (11,1% of journals de-listed) and Hindawi LTD (9,2% of journals de-listed) were the hardest hit. The Wiley and Hindawi partnership has been the target of criticism by researchers around the world, mainly due to the dubious reputation of the publisher Hindawi

In the coming months, further removals may occur, as stated in the note released by Clarivate.

The full list of all de-listed journals (March, 2023):

I want to use size exclusion chromatography for drug-encapsulated PLGA nanoparticles. I am going to use Sephadex. but I couldn't find any suitable procedure for nanoparticle separation using SEC. did anyone use SEC for nanoparticles?

In the ScholareOne system, after the peer-review is completed, the status changes to "Evaluating Recommendation". How long does this status typically takes before hearing back from the journal editor?

Over the last couple days, my colleagues recently noticed a significant amount of baseline drift in their chromatograms from one HPLC (see attached). Across columns, methods and samples it seems to have a consistent type of baseline shift. I've monitored the pressure and it is what I expect it to be/stable. Additionally, the washes (see attached) have a sharp increase, plateau and then drop in all of them. Just a day or two prior, the baselines were perfectly fine. I am not sure what is causing this sudden issue nor how to resolve it. Please advise. Thank you.

I would like calculate the dissolution efficiency (DE) and mean dissolution time (MDT) based on data obtained from in-vitro, comparative dissolution and calculations of f1 (difference) and f2 (similarity) factors. Actually, I know the equation of DE, but don't know how to apply for. Any help, please?

Thanks in advance!

Dear Expert/Expertise,

I need to analyze minor alkaloid in LC MS/MS. I try to use buffer carbonate instead of common buffer such as acetate/formate. Does anyone could share the use of ammonium carbonate (carbonate buffer) in LC MS/MS exp do's and dont's using carbonate?

THanks a lot for your kind sharing

Manuscript, Journal, Tracking report

Because someone told me that its reputation is not good.