Asked 27th Feb, 2016

Do dietary components have any effects on FTO gene expression in blood cells?

I am interested in the relationship between diet and FTO gene expression. Most studies have been performed on FTO expression changes in hypothalamus. But as we know, FTO is expressed ubiquitous. We are going to do a research on this subject in adolescents in Iran and I look forward to hearing from everybody that can help us.
Thank you

All Answers (2)

13th Aug, 2016
Dr Pratibha Arya
Bundelkhand University Jhansi
i  can give you genral idea  ,
 diet is sourse of  micronutrient and marconutrient    .   indivual nutrient   such as  mineral , phytochemical   a  peak  level  is nesseary  for  any gene expresson require  ,  phytochemical  may  increase or decrease  maybe  involve  repair system .   you  shoud be  first reconize  nutrient   need in  FTO exoression  then their  source  food with proper bioavilbilty.  i think its effect  lipid metabolism,  so  if you give high lipotropic factar rich diet  like Zn,Mn,Se, mufa,  vitamin E , B12, etc
then see effect.
20th Aug, 2016
Saeid Doaei
Shahid Beheshti University of Medical Sciences
Thank you for you response
Studies in recent years has been shown the FTO role in cell metabolism through mTOR pathway. so we expect the FTO gene expression can influenced by many dietary factors such as calorie intake, dietary protein, dietary fat and so on.
But about The gene expression changes in blood cell, we don't know anything...

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Is there a reference discussing glycated haemoglobin and fasting blood glucose as predictors of two different subtypes of type 2 diabetes?
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  • Dmitry M. DavydovDmitry M. Davydov
Dear colleagues, during a recent hypothesis-driven study of type 2 diabetes my research group confirmed our prediction that HbA1c and FBG levels are related to two different early pathophysiological subtypes of type 2 diabetes that may be partly overlapping in later stages. In this case HbA1c and FBG should be considered as independent predictors of different pathologies, but not as interchangeable alternatives as suggested by expert committees in diabetes. Outcome may be different protection management and protecting treatment against the disease development.
Editors of Diabetes and Diabetes Care considered that our finding "does not contain sufficient new or novel information" for sending our submission to external peer review. On behalf of my co-authors I myself would like to reach external peers and appeal for your opinion on this forum. I would appreciate very much if anybody on this forum could help us with a reference to similar finding (i.e., with respect to different pathophysiological subtypes associated with HbA1c and FBG), because I could not find such during my literature search.
FYI: Our pathophysiological subtypes are not among rare subtypes like MODY, LADA and hemochromatosis-related diabetes, as well as are not related to pathophysiological (insulinopenic, hyperinsulinemic, or classic) forms developing later in type 2 diabetes.
Unfortunately, I cannot say more about our findings, because do not lose hope to publish them. Your suggestions in a journal that does not use a modern editorial politics for restricting peer reviewing of submissions like in Diabetes and Diabetes Care are very appreciated.
Thank you.

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