Asked 11th Feb, 2018
  • Dupont, Retired

BCM7 from AI protein in milk?

When digested, AI milk releases beta-casomorphin7 (BCM7), an opioid with a structure similar to that of morphine that some studies have linked with autism. Does anyone have information on the mechanism of BCM7 formation?

All Answers (3)

13th Feb, 2018
Laxmana Naik
ICAR-National Dairy Research Institute. Southern Regional Station, Bengaluru
Hello... Anthony Foris
In vitro studies have shown that, the bioactive peptide β-casomorphin-7 (BCM‐7) is produced by the successive gastrointestinal proteolytic digestion of β-casein A1, but such cases were not seen in β-casein A2 type milk.
Kindly see these two articles:
Pictorial representation made by me is also in attachment.
2 Recommendations
18th Feb, 2018
Anthony Foris
Dupont, Retired
Dear Laxmana Naik,
Thank you for the information on the mechanism of release of BCM-7, and the very nice pictorial representation. Best of luck in your research. AF

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