Lab

Physiology Physiopathology and Biochemistry of Nutrition PPaBioNut

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Featured research (10)

Highlights  Protective effect of linseed oil on lipid peroxidation and antioxidant activity was evaluated in pregnant and lacing overfed obese rats and their offspring  Linseed oil supplementation contribute to reduce body weight and lipid peroxidation in obese rats  Linseed oil supplementation significantly improves antioxidant status in diet-induced obese rats and their offspring.  It is suggested that Linseed oil could present a new strategy to treat obesity during pregnancy. Graphical Abstract J Nat Prod Res App 2021, 1 (2) : 1-16 2 Abstract The aim of the present study was to evaluate the protective effects of linseed oil on lipid peroxidation, antioxidative capacity, as well as serum glucose, total cholesterol (TC), LDL-C and TG levels, in cafeteria-diet-fed dams during gestation and lactation, and in their offspring throughout adulthood. Food and energy intakes were also evaluated. The cafeteria diet led to higher energy intake, body weight, hyperglycemia and hyperlipidemia (higher TC, LDL-C and TG) in dams' rats and their pups. Plasma vitamin C, Erythrocyte GSH levels and catalase activity were lower, whereas plasma diene conjugates (DC), Malondialdehyde and protein carbonyl levels (PC) in plasma and erythrocytes were higher in cafeteria-diet-fed mothers and their pups compared to controls. Supplement of linseed oil significantly enhanced plasma antioxidant defense capacities, as evaluated by the marked increase in the levels of plasma vitamin C and erythrocyte GSH as well as the activities of CAT and the significant reduction in lipid peroxidation (lower DC and MDA) and PC in CAFL-diet-fed mothers and their offspring. Simultaneous intake of linseed oil also reduced body weight, plasma TG, TC and LDL-C contents in obese pregnant and lactating dams and their pups at day 30 and day 90. The flaxseed oil supplementation may prevent lipid peroxidation and metabolic disorders which might be helpful in preventing obesity complications in mothers during pregnancy and lactation and in their offspring.
Evaluation de l’activité antioxydante des pépins de raisin de l’Ouest Algérien DIDI A., MALTI N., MEJDOUB A., BOUDGHENE-GERRICHE A., BENAMAR A., DIDI M.A., MERZOUK H. Laboratoire des technologies de séparation et de purification, Département de chimie, Faculté des Sciences, Université AbouBekr Belkaid-Tlemcen-Algérie. ² Laboratoire de physiologie, physiopathologie et biochimie de la nutrition, Département de biologie, Faculté SNVSTU, Université AbouBekr Belkaid-Tlemcen-Algérie. 3 Laboratoire de matériaux et catalyse, Faculté des sciences, Université Djillali Liabes-Sidi Belabbes. * didiamel13@gmail.com Résumé : La production viticole, notamment en Algérie, génère différents types de résidu tel que les pépins de raisin qui ont fait l’objet de cette étude. L’huile de pépins de raisin est riche en composés bioactives qui lui confère de nombreuses vertus thérapeutiques. Dans ce contexte, notre étude a pour objectif la valorisation écologique et économique de ce résidu industriel en évaluant son activité antioxydante. Ces derniers ont été apportés de la wilaya d’Ain Témouchent. Notre travail consiste en premier lieu à l’extraction solide-liquide discontinue sur pilote MP1035 des extraits de pépins de raisin par différents solvants, l’étude de différentes propriétés physicochimiques de l’huile, ainsi que le dosage des polyphénols totaux et des flavonoïdes. Le pouvoir antioxydant de ces extraits a aussi été évalué par trois méthodes. Nos résultats révèlent que cette huile est riche en antioxydants. De plus notre étude démontre l’efficacité des extraits sur le piégeage des radicaux libres. Il serait intéressant donc d’approfondir cette étude pour mieux cerner les bienfaits de cette matière résiduelle et envisager de les utiliser comme une source facilement accessible d’antioxydants naturels et moins coûteuse pour remplacer les antioxydants synthétiques dans les domaines pharmaceutiques et argo-alimentaires. Mots clés : Pépins de raisin (Vitis vinifera L), antioxydants, polyphénols, flavonoïdes, DPPH, FRAP, β-carotène.
INTRODUTION The present study was designed to confirm the idea that Bunium incrassatum tubers can be used as a source of nutraceuticals or as a functional food to reduce the risk of chronic diseases and as a diet by providing basic nutrition. The present study aimed at determining the effectiveness of Bunium incrassatum tubers' powder as dietary supplement on body weight and histological (liver, thyroid, testes, and kidney) and biochemical parameters (glycaemia, cholesterol, triglycerides, urea, creatinine, HDL, LDL, AST and ALT). Twelve male Wistar rats (08 weeks-old), weighing between 90 and 100 g were used. Animals used in this study were divided into two cages of 6 rats each. The first cage received a standard diet (ONAB) and the second cages male received a standard diet enriched with 15% of B.incrassatum tubers. After 15 days rats were sacrificed, Blood biochemistry and organs (liver, kidney, thyroid, and testes) histology were analyzed.

Lab head

Hafida Merzouk
Department
  • Département de Biologie

Members (25)

Mokhtari-Soulimane Nassima
  • Abou Bakr Belkaid University of Tlemcen
Sid Ahmed Merzouk
  • Abou Bakr Belkaid University of Tlemcen
S. Bouanane
  • Abou Bakr Belkaid University of Tlemcen
Fatima-Zohra Baba Ahmed
  • Laboratory of Physiology and Biochemistry of Nutrition
Nassima Malti
  • Abou Bakr Belkaid University of Tlemcen
Bouchra Loukidi
  • Abou Bakr Belkaid University of Tlemcen
Sabri Cherrak
  • Abou Bakr Belkaid University of Tlemcen
Sidi Mohammed Bachir Bensenane
  • Abou Bakr Belkaid University of Tlemcen
Hafida Merzouk
Hafida Merzouk
  • Not confirmed yet
Hafida Merzouk
Hafida Merzouk
  • Not confirmed yet
Nassima Malti
Nassima Malti
  • Not confirmed yet
M. Belarbi
M. Belarbi
  • Not confirmed yet
A. Malti
A. Malti
  • Not confirmed yet
M. Saker
M. Saker
  • Not confirmed yet
Amel Medjdoub
Amel Medjdoub
  • Not confirmed yet
Amel Saidi
Amel Saidi
  • Not confirmed yet