Cape Verde, a West Africa Island country, is exposed to climate change effect. An effective way of reducing its poverty and achieving food security is to provide its agricultural sector with water. The purpose of this study is to monitor treated water quality to ensure that any pollutants are below the limits set to ensure the safety and sustainability of reuse because only 10% of its treated wastewater is reused. For the first time on Cape Verde islands, besides chemical quality, the occurrence of 11 pharmaceutical compounds (PhC) in the influent and effluent of two natural wastewater treatment plants (WWTPs) was monitored to assess the effectiveness of the treatment technologies and removal efficiencies of these pollutants. Of the 11 target PhC, 9 were detected in influent samples within the ng·L−1 to μg·L−1 range. Lower concentrations were detected in one WWTP vs. the other. Nevertheless, the removal efficiencies for most compounds were similar in both WWTPs: within the ranges of 82–92% for beta-blockers, 48–99% for stimulants and 44–95% for nonsteroidal anti-inflammatories, while carbamazepine (anticonvulsant) concentrations increased in effluents. WWTPs produce water that meets water quality standards for irrigation if a properly designed and managed reusing system is adopted.

Treated water use for agriculture will promote sustainable irrigation development and food sovereignty. The aim of this study is to assess the feasibility of subsurface drip irrigation (SDI) compared to drip irrigation (DI) and of reclaimed water (RW) versus conventional groundwater (CW), to produce forage sustainably in a warm arid region. A sorghum experiment was conducted in a field on Santiago Island (Cape Verde). A forage yield of 200 t fresh matter·ha⁻¹·year⁻¹, irrigated by RW, was obtained. Considering Cape Verde regulations, it is possible to irrigate sorghum using a drip system and RW without adding fertilizers. Soil fertility (OM and Ntot) increased, while risk parameters (EC, nitrate, and Na) returned to their initial values after the rainy season. The best irrigation water use efficiency was obtained by RWSDI (200 L·kg⁻¹ DM) compared to RWDI, which needed 34% more water. According to the results, a high nitrate elimination rate in treatment plants might not be desirable if agricultural reuse is planned to irrigate high-N-demanding species. Establishing new salinity tolerance levels under reuse conditions with SDI, and irrigating in rainy months to promote the lixiviation of salts in arid regions are also necessary.