Center of Rehabilitation Engineering and Neuromuscular and Sensory Research

About the lab

The mission of CIRINS is "To carry out research and development of techniques, devices and novel systems used in diagnosis, treatment and rehabilitation of the nervous and muscular systems dysfunctions"


Featured projects (1)

To develop computational intelligence techniques for pattern recognition of graphic elements (e.g. event-related potential, auditory evoked potential, k-complex, spindle) included in electro-encephalographic signals.

Featured research (3)

Brain computer interfaces (BCI) represent an alternative for patients whose cognitive functions are preserved, but are unable to communicate via conventional means. A commonly used BCI paradigm is based on the detection of event-related potentials, particularly the P300, immersed in the electroencephalogram (EEG). In order to transfer laboratory-tested BCIs into systems that can be used by at homes, it is relevant to investigate if it is possible to select a limited set of EEG channels that work for most subjects and across different sessions without a significant decrease in performance. In this work, two strategies for channel selection for a single-trial P300 brain computer interface were evaluated and compared. The first strategy was tailored specifically for each subject, whereas the second strategy aimed at finding a subject-independent set of channels. In both strategies, genetic algorithms (GAs) and recursive feature elimination algorithms were used. The classification stage was performed using a linear discriminant. A dataset of EEG recordings from 18 healthy subjects was used test the proposed configurations. Performance indexes were calculated to evaluate the system. Results showed that a fixed subset of four subject-independent EEG channels selected using GA provided the best compromise between BCI setup and single-trial system performance.
The P300 component of event-related potentials (ERPs) is widely used in the implementation of brain computer interfaces (BCI). In this context, one of the main issues to solve is the binary classification problem that entails differentiating between electroencephalographic (EEG) signals with and without P300. Given the particularly unfavorable signal-to-noise ratio (SNR) in the single-trial detection scenario, this is a challenging problem in the pattern recognition field. To the best of our knowledge, there are no previous experimental studies comparing feature extraction and selection methods for single trial P300-based BCIs using unified criteria and data. In order to improve the performance and robustness of single-trial classifiers, we analyzed and compared different alternatives for the feature generation and feature selection blocks. We evaluated different orthogonal decompositions based on the wavelet transform for feature extraction, as well as different filter, wrapper, and embedded alternatives for feature selection. Accuracies over 75% were obtained for most of the analyzed strategies with a relatively low computational cost, making them attractive for a practical BCI implementation using inexpensive hardware.
Introduction: Brain computer interface is an emerging technology to treat the sequelae of stroke. The purpose of this study was to explore the motor imagery related desynchronization of sensorimotor rhythms of stroke patients and to assess the efficacy of an upper limb neurorehabilitation therapy based on functional electrical stimulation controlled by a brain computer interface. Methods: Eight severe chronic stroke patients were recruited. The study consisted of two stages: screening and therapy. During screening, the ability of patients to desynchronize the contralateral oscillatory sensorimotor rhythms by motor imagery of the most affected hand was assessed. In the second stage, a therapeutic intervention was performed. It involved 20 sessions where an electrical stimulator was activated when the patient's cerebral activity related to motor imagery was detected. The upper limb was assessed, before and after the intervention, by the Fugl-Meyer score (primary outcome). Spasticity, motor activity, range of movement and quality of life were also evaluated (secondary outcomes). Results: Desynchronization was identified in all screened patients. Significant post-treatment improvement (p < 0.05) was detected in the primary outcome measure and in the majority of secondary outcome scores. Conclusions: The results suggest that the proposed therapy could be beneficial in the neurorehabilitation of stroke individuals.

Lab head

Rubén Carlos Acevedo
About Rubén Carlos Acevedo
  • My areas of interest are digital processing of biomedical signals (wavelet transforms, time frequency distributions, others) and machine learning (feature extraction and selection) applied in brain computers interfaces.

Members (12)

José A. Biurrun Manresa
  • National Scientific and Technical Research Council
Gerardo Gentiletti
  • National University of Entre Rios
Carolina B Tabernig
  • National University of Entre Rios
Lucia Carolina Carrere
  • National University of Entre Rios
Yanina Atum
  • National University of Entre Rios
Christian A Mista
  • National University of Entre Rios
Luciano Schiaffino
  • National University of Entre Rios
Esteban Osella
  • National University of Entre Rios