About the lab
The Cardiac Translational Research Laboratory is located at the University of Ottawa Heart Institute, and is directed by Dr. Darryl Davis. Our lab is working on to translating fundamental biological principles to the clinical setting. We are positioned within the Cardiology research program with projects addressing cardiac arrhythmias and regenerative medicine. Currently we are looking into more biological therapies for heart arrhythmias such as atrial fibrillation. These include the therapeutic effects and abilities of extracellular vesicles, and heart explant-derived cells, and more.
Featured research (1)
While encapsulation of cells within protective nanoporous gel cocoons increases cell retention and pro-survival integrin signaling, the influence of cocoon size and intra-capsular cell-cell interactions on therapeutic repair are unknown. Here, we employ a microfluidic platform to dissect the impact of cocoon size and intracapsular cell number on the regenerative potential of transplanted heart explant-derived cells. Deterministic increases in cocoon size boosted the proportion of multicellular aggregates within cocoons, reduced vascular clearance of transplanted cells and enhanced stimulation of endogenous repair. The latter being attributable to cell-cell stimulation of cytokine and extracellular vesicle production while also broadening of the miRNA cargo within extracellular vesicles. Thus, by tuning cocoon size and cell occupancy, the paracrine signature and retention of transplanted cells can be enhanced to promote paracrine stimulation of endogenous tissue repair.
- Department of Cellular and Molecular Medicine
About Darryl R Davis
- Darryl Davis is a clinician scientist and a cardiac electrophysiologist with a longstanding interest in the fundamental mechanisms underlying cardiac disease. He leads a biotechnology lab located at the uOttawa Heart Institute focused on the discovery & development of biological therapies for heart disease. Areas of interest include: atrial fibrillation, cell modelling, extracellular vesicles, induced pluripotent stem cells and cardiac sarcoidosis.