Online ISSN: 2278-4357
Several 1,8-naphthyridine derivative were prepared using Vilsmeier-Haack synthization. 2-chloro-3-formyl-1,8-naphthyridine was synthesized by reacting N-(pyridin-2-yl) acetamide with POCl3 in dimethylformamide. 1,8-naphthyridine group was oxidized with NIS-K2CO3 in methanol at room temperature to yield 2-chloro-3-methoxy carbonyl -1,8-naphthyridine (2), acid hydrazide was then prepared by treating the methyl ester with hydrazine hydrate in ethanol (3), the synthesis of 2-chloro-3[2(1,3,4-oxadiazol-5-thiol-1,8-naphthyridine (4) was obtained from compound(3) reaction with CS2 in basic medium, acid hydrazide was then converted to the corresponding carbothioamide (5) by treating with benzyl isothiocyanate respectively. Thiosemicarbazide (5) was reacted with mercuric oxide in methanol to produce 1,3,4-oxadiazole (6). 2-chloro-3-[2(1,3,4-oxadiazole)]-1,8-naphthyridine (8)was yielded from acid hydrazide reaction with formic acid followed by PbO2. Acid hydrazide (3) was treated with benzaldehyde to formhydrazone (9) which then reacted with PbO2 to give 1,3,4-oxadiazole (10). Finally. The structures of synthesized compounds were confirmed spectroscopically using IR and1HNMR in addition to another physical data. The newly synthesized compounds (4,6,8,10) show a significant antibacterial activity.
Medicinal plants against urinary stones
Urolithiasis is a common worldwide problem with high recurrence. This review covers Euphorbiaceae twenty (20), Cucurbitaceae eighteen (18), Acanthaceae and Amaranthaceae fifteen (15), Cupressaceae twelve (12), Caryophyllaceae eleven (11), Anacardiaceae ten (10), Amaryllidaceae, Apocynaceae and Asparagaceae nine (09), Ericaceae and Equisetaceae eight (08), Arecaceae and Caesalpiniaceae seven (07), Chenopodiaceae six (06), Aspleniaceae, Capparidaceae and Crassulaceae five (05) plants used globally in different countries. Hopefully, this review will not only be useful for the general public but also attract the scientific world for antiurolithiatic drug discovery.
Top-cited authors
Mohammad Gayoor Khan
Umama Yezdani
  • MRM college of Pharmacy, india
Mohammed Rahmatullah
  • University of Development Alternative
Md Shahadat Hossan
  • University of Wisconsin–Madison
Shiblur Rahman
  • Centre for Injury Prevention and Research, Bangladesh