Patas monkeys (Erythrocebus patas) receiving a low protein diet were infected with a mildly enteropathogenicEscherichia coli 055 strain. The subsequent immunologic response including agglutinin, opsonin and immunocyte formation was reduced relative to controls which received full protein rations. The infective organisms were excreted for a longer time by patas given a low protein diet. Total serum protein and albumin declined in patas with a low protein intake. Immunoglobulin G, A and M measurements in the spleen, mesenteric lymph nodes and intestines after infection were less than those in the controls. Total RNA values and amino acid uptake decreased. A shift of the ribosomal fractions was observed. It was concluded that lack of dietary protein impaired protein synthesis, including that of cell-bound antibodies, and that it is feasible to use patas monkeys to study the relationship between enteric infections and protein malnutrition.
The absorption of whole horse serum (WHS), horse IgG (IgG), and horse albumin (Alb) was studied in newborn unfed pigs, after suckling, after starving, and after starving and monocontamination withEscherichia coli. All horse serum proteins were readily absorbed by all groups of piglets. The amount of absorption of a single test dose of protein was shown to precipitously decrease during the first 2 days of life, whether or not the intestine was exposed to protein.E coli (055B5) also decreased the amount of absorption; however, through what means is not clear from this study.
The clinical experiences in 125 patients, both as to immediate and late effect, with a new antacid “Mucotin” (aluminum hydroxide,
magnesium trisilicate and gastric mucin mixture) are discussed in the light of recent ideas as to ulcer prevention and ulcer
This substance led to rapid clinical improvement during the stage of exacerbation and also apparently prolonged the pain-free
intervals, having a recurrence rate of 15 to 18% in 12 to 24 months respectively.
Two case histories are presented as demonstrating the rapid healing in gastric ulcer.
The possible basis for the beneficial effect of this substance is discussed.
Salivary, gastric, and pancreatic secretory responses to intravenous 13-norleucine-motilin (13-nle-motilin), a synthetic analog of motilin and biologically equivalent to the natural polypeptide, were studied in healthy volunteers. 13-nle-Motilin in doses of 100 ng/kg body wt/hr significantly stimulated gastric pepsin output, while H + secretion and serum gastrin levels remained unchanged. Enhanced pepsin secretion was not accompanied by an increase in gastric secretion of cyclic 3', 5'-adenosine monophosphate, nor did gastric mucosal levels of the cyclic nucleotide rise. A dose of 13-nle-motilin, which stimulated gastric pepsin output, did not exert any significant effect on salivary and pancreatic secretions.
A case of Budd-Chiari syndrome in a young woman taking oral contraceptives is described. Her main complaints were abdominal pain and ascites without hepatosplenomegaly and the subsequent development of shock. Diagnosis was established by selective hepatic arteriogram and vena cavagram. She was treated with supportive measures, anticoagulants and neomycin. At the time of this report, the patient is slowly convalescing, taking coumadin, diuretics and Aldactone, as well as supplementary vitamins. Reviewed are 14 cases of Budd-Chiari syndrome occurring while patients were taking oral contraceptives.
Summary The history of obesity since the end of the 18th century is reviewed, with particular attention to events connected with the
Banting dietary. This treatment appears to have been, originally, one in which carbohydrates were restricted but the total
food intake was not restricted. Lacking a rationale, it became modified to. fit current concepts; it underwent transformation
into a low calorie diet in which fat was greatly restricted.
Another, more recent, diet in which carbohydrate is restricted while the total caloric intake is not restricted is presented.
The rationale for this treatment is indicated.
The clinical, radiologic, and histologic features of 16 patients hospitalized with clindamycin-associated colitis are presented. The findings are tabulated and compared to 33 cases reported in the literature. The majority of patients were caucasian females over 40 years of age. The clinical presentation varied from mild persistent diarrhea to acute surgical abdomen. Proctoscopic examination revealed nonspecific colitis in 9 and pseudomembranous colitis in 7 cases. No specific radiologic or histologic fingings for postanitbiotic colitis were found. Therapy was nonspecific and varied according to the severity of the clinical course. Clinically, there appeared to be some benefit from systemic steroid therapy. 4 of the 16 patients died. None of the recovered patients have had spontaneous relapses off medication during follow-up evaluation. The pathogenic mechanism for postantibiotic colitis secondary to clindamycin remains unknown and does not appear dose related. Clindamycin therapy should be limited to disorders with specific indications.
A patient is reported who survived 17 years after portacaval shunt for esophageal hemorrhage from varices. The liver at autopsy contained a diffuse primary carcinoma. If medical and surgical treatments prolong life in persons with cirrhosis, then primary liver carcinoma may be encountered more frequently since it usually is found in livers with cirrhosis of long duration.
10 patients with Crohn's disease in various states of activity have been injected with 3.3 times 10-9 plaque-forming units of the bacteriophage phi chi 174, as a test for their capacity to produce antibodies. 9 patients had a completely normal primary and secondary antibody response. One patient had higher levels of preimmunization antibodies than have been encountered in normal subjects and developed a secondary (IgG) response to the first dose of antigen. We conclude that there is no evidence of a general disturbance of antibody-producing capacity in subjects with Crohn's disease.
As presented here, this case demonstrates that diabetes can be of long duration, can at times be unusually severe, can be
complicated by severe coma, (with the highest recorded blood sugar with survival in the world’s medical literature), and by
various infections (pneumonia, abscesses, pyelonephritis, pelvic inflammatory disease), and can be subjected to the strain
of many surgical procedures and of multiple pregnancies, yet can escape the vascular degenerative changes usually associated
in the minds of many with diabetes that has been under other than constant normoglycemic control.
It is noted that for more than 15 years of the 20 years that this patient was known to have diabetes, she was being treated
according to the method of compatible hyperglycemia as described by Sindoni, Ger-ber, Bove and Zibold (5), using post-prandial
blood sugars as the guide to therapy.
A 10-year retrospective analysis of 15 patients with amebic liver abscess is reviewed and represents a continuation of the previous 2-decade experience at our institution (37 patients). Records were studied to determine the population affected, presenting symptoms, physical and laboratory findings, type and response to therapy. Most patients were rural males of lower socioeconomic status in the third to fifth decade of life. They presened as a febrile illness with abdominal pain for an average of 2 1/2 months duration. Significanct physical abnormalities were tender hepatomegaly (93%), right-sided pulmonary changes (40%), and fever (66%). All patients had abnormal liver scan, positive amebic serology, and hypoalbuminemia. All patients promptly responded to amebicidal therapy except one whose therapy was delayed. Clinical suspicion, liver scanning, serologic testing, and response to therapy are the keys to diagnosis.