The long-term neurologic sequelae, neurodevelopment, and cognitive function of 142 children with a history of enterovirus (EV) 17 infection with CNS involvement were determined in a study at the National Taiwan University Hospital, Taipei; and Chang Gung Children's Hospital, Taoyuan, Taiwan.
The usage and usage trends for methylphenidate (MPH) treatment of ADHD from
1990 through 1995 were estimated by the Departments of Psychiatry and Pediatrics, Johs Hopkins
University School of Medicine, Baltimore County Health Department, and the Schools of Pharmacy and
Medicine, University of Maryland, Baltimore, MD.
Hand strength, function and disease-related symptoms were determined in 84 children, aged 2-16 years, with Charcot-Marie-Tooth disease type 1A (CMT1A) at University of Sydney, Children’s Hospital at Westmead, and Royal Children’s Hospital, Parkville, Australia.
The International League Against Epilepsy (ILAE) Commission on
Classification and Terminology has revised concepts, terminology, and approaches for classifying
seizures and forms of epilepsy, last updated in 1981 for seizures and in 1989 for
Measurements of routine head sonographic scans of 57 term infants with trisomy 21 born between 2000 and 2005 were performed within 7 days after birth and were compared with scans of 21 randomly selected, healthy, term infants without trisomy 21 at Shaare Zedek Medical Center, Jerusalem; Ben Gurion University of the Negev, Beer Sheva; and Hadassah University Hospital, Jerusalem, Israel.
A 12-year-old mentally retarded girl with a large deletion of the long arm
of chromosome 21 and congenital hypothyroidism is reported from the Department of Clinical Genetics
and Pediatrics, University Hospital, Uppsala, Sweden.
Investigators at Universite de Lille Nord de France, and other centers in
France, report the identification of a novel causative gene for spinocerebellar ataxia 21, an
autosomal dominant disorder, initially mapped to chromosome 7 and designated as SCA21.
A 24 year-old severely retarded, hyperactive woman with a long history of
foul smelling discharge from the nasal fossae, requiring removal under general anesthesia of foreign
material (rocks, crayon, cotton, paper) on 9 separate occasions by an ENT surgeon, is reported from
my own practice records in Chicago.
Investigators at Bambino Genu Children's Hospital, Rome, and multiple
additional centers in Italy conducted a retrospective and prospective study of clinical
manifestations at diagnosis and during follow-up of 228 patients with 22q11.2 deletion
Neuromotor, sensory, language, communication and social development, and cerebral MRI and PET studies were performed in 8 children with 22ql3.3 deletion syndrome, at the National Institutes of Health, Necker-Enfants Malades Hospital, and other centers in Paris, France.
The brain anatomy of 39 children and adolescents with 22qDS (mean age 11 years; IQ 67) and 26 sibling controls (mean age 11 years; IQ 102) was compared using MRI and automated voxel-based morphometry, and behavioral differences were correlated with affected brain regions in a study at King’s College, Institute of Psychiatry, London, UK; Royal College of Surgeons, Dublin, Ireland; and Academic Medical Center, Amsterdam, Holland.
The incidence and risk factors of acute recurrence of unprovoked seizures within 24 hours of admission to an Emergency Department (ED) were analyzed by a retrospective chart review at Schneider Children’s Hospital, New York.
Investigators at Washington University School of Medicine, St Louis, MO, evaluated retrospectively clinical, laboratory, and muscle histochemistry and oxidative enzyme characteristics in 49 children with suspected mitochondrial disorders.
The relation of cytochrome P450 2D6 (CYP2D6) activity to metabolism,
response and adverse effects of atomoxetine was determined by CYP2D6 genotyping in 10 out of 100
children treated for attention deficit hyperactivity disorder at Amphia Hospital, Breda, The
A newly recognized autosomal dominant epilepsy syndrome with linkage to chromosome 2p11.1-q12.2 is described in an Italian pedigree of 8 patients reported from the Neurosciences Unit, Institute of Child Health and Great Ormond Street Hospital for Children, London, UK.
The prevalence and common clinical manifestations of the mitochondrial DNA 3243A > G mutation in children in a defined population in Finland were studied at the Universities of Oulu and Turku and other centers.
Investigators from the Children's Hospital of Philadelphia, PA, and McGill
University, Montreal, Quebec, CA, report an adolescent learning-disabled girl who presented at age
14 years with an epilepsy syndrome initially diagnosed as juvenile myoclonic epilepsy.
Investigators from Fujita Health University, Toyoake, and National
Epilepsy Center, Shizuoka, Japan, studied the pathogenic role of HHV-6B in patients with
mesial temporal lobe epilepsy (MTLE). Of 75 intractable MTLE patients, 52 had mesial
temporal sclerosis (MTS) and 23 were non-MTS patients.
Follow-up studies were conducted in 63 previously healthy children with enterovirus 71 brainstem encephalitis (49 stage II, 7 stage Ilia, and 7 stage Illb) at National Cheng Kung University Hospital, Tainan, Taiwan.
The neurologic complications associated with the 1998 Taiwan enterovirus 71
epidemic are reported from National Cheng Kung University, Tainan; Chang Gung Children’s Hospital,
Kaohsiung; and National Defense Medical Center, Taipei, Taiwan.
ADHD symptoms as long-term sequelae of virus-confirmed enterovirus 71 infection were evaluated in 86 children, aged 4 to 16 years, followed at National Taiwan University Hospital, Taipei, and Chang Gung Children’s Hospital, Taoyuan, Taiwan.