ACS Nano

Publisher: American Chemical Society, American Chemical Society

Current impact factor: 12.88

Impact Factor Rankings

2016 Impact Factor Available summer 2017
2014 / 2015 Impact Factor 12.881
2013 Impact Factor 12.033
2012 Impact Factor 12.062
2011 Impact Factor 10.774
2010 Impact Factor 9.855
2009 Impact Factor 7.493
2008 Impact Factor 5.472

Impact factor over time

Impact factor
Year

Additional details

5-year impact 14.41
Cited half-life 3.40
Immediacy index 2.22
Eigenfactor 0.31
Article influence 3.98
Other titles ACS nano (Online), ACS nano, American Chemical Society nano
ISSN 1936-086X
OCLC 85374429
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

American Chemical Society

  • Pre-print
    • Author cannot archive a pre-print version
  • Restrictions
    • Must obtain written permission from Editor
    • Must not violate ACS ethical Guidelines
  • Post-print
    • Author cannot archive a post-print version
  • Restrictions
    • If mandated by funding agency or employer/ institution
    • If mandated to deposit before 12 months, must obtain waiver from Institution/Funding agency or use AuthorChoice
    • 12 months embargo
  • Conditions
    • On author's personal website, pre-print servers, institutional website, institutional repositories or subject repositories
    • Non-Commercial
    • Must be accompanied by set statement (see policy)
    • Must link to publisher version
    • Publisher's version/PDF cannot be used
    • If mandated sooner than 12 months, must obtain waiver from Editors or use AuthorChoice
    • Reviewed on 07/08/2014
  • Classification
    white

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Nanoparticles combining enhanced cellular drug delivery with efficient fluorescence detection are important tools for the development of theranostic agents. Here we demonstrate this concept by a simple, fast, and robust protocol of cationic polymer-mediated gold nanocluster (Au NCs) self-assembly into nanoparticles (NPs) of ca. 120 nm diameter. An extensive characterization of the monodisperse and positively charged NPs revealed pH-dependent swelling properties, strong fluorescence enhancement, and excellent colloidal and photostability in water, buffer, and culture medium. The versatility of the preparation is demonstrated by using different Au NC surface ligands and cationic polymers. Steady-state and time-resolved fluorescence measurements give insight to the aggregation-induced emission phenomenon (AIE) by tuning the Au NC interactions in the self-assembled nanoparticles using the pH-dependent swelling. In vitro studies in human monocytic cells indicate strongly enhanced uptake of the NPs compared to free Au NCs in endocytic compartments. The NPs keep their assembly structure with quite low cytotoxicity up to 500 μg Au/mL. Enhanced drug delivery is demonstrated by loading peptides or antibodies in the NPs using a one-pot synthesis. Fluorescence microscopy and flow cytometry confirmed intracellular co-localization of the biomolecules and the NP carriers with a respective 1.7-fold and 6.5-fold enhanced cellular uptake of peptides and antibodies compared to the free biomolecules.
    No preview · Article · Feb 2016 · ACS Nano
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    ABSTRACT: Mitochondrial oxidative stress is a key pathologic factor in neurodegenerative diseases, including Alzheimer's disease. Abnormal generation of reactive oxygen species, resulting from mitochondrial dysfunction, can lead to neuronal cell death. Ceria (CeO2) nanoparticles are known to function as strong and recyclable ROS scavengers by shuttling between Ce3+ and Ce4+ oxidation states. Consequently, targeting ceria nanoparticles selectively to mitochondria might be a promising therapeutic approach for neurodegenerative diseases. Here, we report the design and synthesis of triphenylphosphonium-conjugated ceria nanoparticles that localize to mitochondria and suppress neuronal death in 5XFAD transgenic Alzheimer's disease mouse model. The triphenylphosphonium-conjugated ceria nanoparticles mitigate reactive gliosis and morphological mitochondria damage observed in these mice. Altogether, our data indicate that the triphenylphosphonium-conjugated ceria nanoparticles are a potential therapeutic candidate for mitochondrial oxidative stress in Alzheimer's disease.
    No preview · Article · Feb 2016 · ACS Nano
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    ABSTRACT: One of the biggest obstacles for the development of HIV vaccines is how to sufficiently trigger crucial anti-HIV immunities via a safe manner. We herein integrated surface modification-dependent immunostimulation against HIV vaccine and shape-dependent biosafety, and designed a safe non-carrier adjuvant based on silver nanorods coated by both polyvinylpyrrolidone (PVP) and polyethyleneglycol (PEG). Such silver nanorods can significantly elevate crucial immunities of HIV vaccine, and overcome the toxicity which is a big problem for other existing adjuvants. This study thus provided a principle for designing a safe and high-efficacy material for an adjuvant, and allow researchers to really have a safe and effective prophylaxis against HIV. We expect this material approach to be applicable to other types of vaccines, being the preventative or therapeutic.
    No preview · Article · Feb 2016 · ACS Nano
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    ABSTRACT: The selectivity of Watson-Crick base pairing has allowed the design of DNA-based functional materials bearing an unprecedented level of accuracy. Examples include DNA origami, made of tiles assembling into arbitrarily complex shapes, and DNA coated particles featuring rich phase behaviors. Frequently the realization of conceptual DNA-nanotechnology designs has been hampered by the lack of strategies for effectively controlling relaxations. In this article we address the problem of kinetic control on DNA-mediated interactions between Brownian objects. We design a kinetic pathway based on toehold-exchange mechanisms that enables rearrangement of DNA bonds without the need for thermal denaturation, and test it on suspensions DNA-functionalized liposomes, demonstrating tuneability of aggregation rates over more than one order of magnitude. While the possibility to design complex phase behaviors using DNA as a glue is already well recognized, our results demonstrate control also over the kinetics of such systems.
    No preview · Article · Feb 2016 · ACS Nano

  • No preview · Article · Feb 2016 · ACS Nano

  • No preview · Article · Feb 2016 · ACS Nano
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    ABSTRACT: DNA nanostructures are versatile templates for low cost, high resolution nanofabrication. However, due to the limited chemical stability of pure DNA structures, their applications in nanofabrication have long been limited to low temperature processes or solution phase reactions. Here, we demonstrate the use of DNA nanostructure as a template for high temperature, solid-state chemistries. We show that programmably-shaped carbon nanostructures can be obtained by a shape-conserving carbonization of DNA nanostructures. The DNA nanostructures were first coated with a thin film of Al2O3 by atomic layer deposition (ALD), after which the DNA nanostructure was carbonized in low pressure H2 atmosphere at 800 - 1000°C. Raman spectroscopy and atomic force microscopy (AFM) data showed that carbon nanostructures were produced and the shape of the DNA nanostructure was preserved. Conductive AFM measurement shows that the carbon nanostructures are electrically conductive.
    No preview · Article · Feb 2016 · ACS Nano
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    ABSTRACT: Lithium-sulfur batteries are attractive electrochemical energy storage systems due to their high theoretical energy density, and very high natural abundance of sulfur. However, practically, Li-S batteries suffer from short cycling life and low sulfur utilization, particularly in the case of high sulfur loaded cathodes. Here, we report on a light-weight nanoporous graphitic carbon nitride (high-surface area g-C3N4) that enables a sulfur electrode with an ultralow long-term capacity fade rate of 0.04% per cycle over 1500 cycles at a practical C/2 rate. More importantly, it exhibits good high sulfur-loading areal capacity (up to 3.5 mAh cm-2) with stable cell performance. We demonstrate the strong chemical interaction of g-C3N4 with polysulfides with a combination of spectroscopic experimental studies and first-principles calculations. The 53.5% concentration of accessible pyridinic-nitrogen polysulfide adsorption sites is shown to be key for the greatly improved cycling performance compared to N-doped carbons.
    No preview · Article · Feb 2016 · ACS Nano
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    ABSTRACT: The tunable properties of molecular materials place them among the favorites for a variety of future generation devices. Besides, to maintain the current trend of miniaturization of those devices, a departure from the present top-down production methods may soon be required and self-assembly appears among the most promising alternatives. On-surface synthesis unites the promises of molecular materials and of self-assembly, with the sturdiness of covalently bonded structures: an ideal scenario for future applications. Following this idea, we report the synthesis of functional extended nanowires by self-assembly. In particular, the products correspond to one-dimensional organic semiconductors. The uniaxial alignment provided by our substrate templates allows us to access with exquisite detail their electronic properties, including the full valence band dispersion, by combining local probes with spatial averaging techniques. We show how, by selectively doping the molecular precursors, the product's energy level alignment can be tuned without compromising the charge carrier's mobility.
    No preview · Article · Feb 2016 · ACS Nano
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    ABSTRACT: Developing lithium ion batteries (LIBs) with fast charging/discharging capability and high capacity is a significant issue for future technical requirements. Transition metal oxides (TMOs) materials are widely studied as the next-generation LIB anode to satisfy this requirement, due to their specific capacity nearly three times than that of conventional graphite anode and low cost. Meanwhile, they also suffer from slow lithium diffusion and limited electrochemical and structural stability, especially at high charging/discharging rate. The structure design of TMO is an effective strategy to obtain desirable LIB performance. Herein, inspired by natural fibrous roots consisting of functional and supporting units that can enhance substances and energy exchange efficiently, fibrous-root-like ZnxCo3-xO4@Zn1-yCoyO binary TMO nanoarrays are designed and synthesized on Cu substrates through a facile one-pot, successive-deposition process, for use as an integrated LIB anode. In a multilevel array ordered by orientation, ultrafine ZnxCo3-xO4 nanowire functional units and stable Zn1-yCoyO nanorod supporting units synergize, resulting in superior rate performance. At a high current density of 500 mAg-1, they could maintain a discharge capacity as high as 804 mAhg-1 after 100 cycles, working much higher than unary cobalt-based and zinc-based nanoarrays. This binary synergistic nanoarray system identifies an optimized electrode design strategy for advanced battery materials.
    No preview · Article · Feb 2016 · ACS Nano
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    ABSTRACT: Molybdenum disulphide (MoS2) is one kind of the promising non-precious catalyst, but its performance is limited by the density of active sites and poor electrical transport. Its metallic 1T-phase possesses higher photoelectrocatalytic activity. Thus, how to efficiently increase the concentration of 1T-phase in the exfoliated two-dimensiaonal (2D) MoS2 nanosheets is an important premise. In this work, we propose a strategy to prepare 2D heterostructure of MoS2 nanosheets using supercritical CO2-induced phase engineering to form metallic 1T-MoS2. Theoretical calculations and experimental results demonstrate that the introduced CO2 in the 2H-MoS2 host can prompt the transformation of partial 2H-MoS2 lattices into 1T-MoS2. Moreover, the electrical coupling and synergistic effect between 2H and 1T phases can greatly facilitate the efficient electron transfer from the active sites of MoS2, which significantly improve the photocatalytic performance.
    No preview · Article · Feb 2016 · ACS Nano
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    ABSTRACT: Graphene electrodes are promising candidates to improve reproducibility and stability in molecular electronics through new electrode-molecule anchoring strategies. Here we report sequential electron transport in few-layer graphene transistors containing individual curcuminoid-based molecules anchored to the electrodes via pi-pi orbital bonding. We show the coexistence of inelastic co-tunneling excitations with single-electron transport physics owing to an intermediate molecule-electrode coupling; we argue that an intermediate electron-phonon coupling is the origin of these vibrational-assisted excitations. These experimental observations are complemented with density functional theory calculations to model electron transport and the interaction between electrons and vibrational modes of the curcuminoid molecule. We find that the calculated vibrational modes of the molecule are in agreement with the experimentally observed excitations.
    No preview · Article · Feb 2016 · ACS Nano
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    ABSTRACT: Studying the local solvent surrounding nanoparticles is important to understanding the energy exchange dynamics between the particles and their environment, and there is a need for spectroscopic methods that can dynamically probe the solvent region that is nearby contact with the nanoparticles. In this work, we demonstrate the use of time-resolved infrared spectroscopy to track changes in a vibrational mode of local water on the time scale of hundreds of picoseconds, revealing the dynamics of heat transfer from gold nanorods to the local water environment. We applied this probe to a prototypical plasmonic photo-thermal system consisting of organic CTAB bilayer capped gold nanorods, as well as gold nanorods coated with varying thicknesses of inorganic mesoporous-silica. The heat transfer time constant of CTAB capped gold nanorods is about 350 ps and becomes faster with higher laser excitation power, eventually generating bubbles due to superheating in the local solvent. Silica coating of the nanorods slows down the heat transfer and suppresses the formation of superheated bubbles.
    No preview · Article · Feb 2016 · ACS Nano
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    ABSTRACT: As more biological activities of ribonucleic acids continue to emerge, the development of efficient analytical tools for RNA identification and characterization is necessary to acquire an in-depth understanding of their functions and chemical properties. Herein, we demonstrate the capacity of label-free direct surface-enhanced Raman scattering (SERS) analysis to access highly specific structural information of RNAs at the ultrasensitive level. This includes the recognition of distinctive vibrational features of RNAs organized into a variety of conformations (micro-, duplex-, small interfering- and short hairpin-RNAs) or characterized by subtle chemical differences (single-base variances, nucleobase modifications and backbone composition). This method represents a key advance in the ribonucleic acid analysis and will have a direct impact in a wide range of different fields, including medical diagnosis, drug design, and biotechnology, by enabling the rapid, high-throughput, simple and low-cost identification and classification of structurally similar RNAs.
    No preview · Article · Feb 2016 · ACS Nano
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    ABSTRACT: This article reports a facile synthesis of radiolabeled PdCu@Au core-shell tripods for use in positron emission tomography (PET) and image-guided photothermal cancer treatment by directly incorporating radioactive 64Cu atoms into the crystal lattice. The tripods have a unique morphology determined by the PdCu tripods that served as templates for the coating of Au shells, together with well-controlled specific activity and physical dimensions. The Au shells provided the nanostructures with strong absorption in the near-infrared region and effectively prevented the Cu and 64Cu atoms in the cores from oxidization and dissolution. When conjugated with D-Ala1-peptide T-amide (DAPTA), the core-shell tripods showed great enhancement in targeting the C-C chemokine receptor 5 (CCR5), a newly identified theranostic target up-regulated in triple negative breast cancer (TNBC). Specifically, the CCR5-targeted tripods with an arm length of about 45 nm showed two- and six-fold increase in tumor-to-blood and tumor-to-muscle uptake ratio, respectively, relative to their non-targeted counterpart in an orthotopic mouse 4T1 TNBC model at 24 h post injection. The targeting specificity was further validated via a competitive receptor blocking study. We also demonstrated the use of these targeted, radioactive tripods for effective photothermal treatment in the 4T1 tumor model as guided by PET imaging. The efficacy of treatment was confirmed by the significant reduction in tumor metabolic activity revealed through the use of 18F-flourodeoxyglucose PET/CT imaging. Taken together, we believe that the 64Cu-doped PdCu@Au tripods could serve as a multifunctional platform for both PET imaging and image-guided photothermal cancer therapy.
    No preview · Article · Jan 2016 · ACS Nano
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    ABSTRACT: Scanning Kelvin Probe Microscopy (SKPM), a characterization method that could image surface potentials of materials at nanoscale, has extensive applications in characterizing the electric and electronic properties of metal, semiconductor and insulator materials. However, it requires deep understanding of the physics of the measuring process and being able to rule out factors that may cause artifacts to obtain accurate results.In the most commonly used dual-pass SKPM, the probe works in tapping mode to obtain surface topography information in first pass before lifting to a certain height to measure the surface potential. In this paper, we have demonstrated that the tapping-mode topography scan pass during the typical dual-pass SKPM measurement may trigger contact electrification between the probe and the sample, which leads to a charged sample surface and thus can introduce a significant error to the surface potential measurement.Contact electrification will happen when the probe enters into the repulsive force regime of tip-sample interaction and this can be detected by the phase shift of the probe vibration. In addition, the influences of scanning parameters, sample properties and probe's attributes have also been examined, in which lower free cantilever vibration amplitude, larger adhesion between the probe tip and the sample and lower cantilever spring constant of the probe are less likely to trigger contact electrification. Finally, we have put forward a guideline to rationally decouple contact electrification from surface potential measurement. They are decreasing the free amplitude, increasing the scanning amplitude, and using probes with lower spring constant.
    No preview · Article · Jan 2016 · ACS Nano
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    ABSTRACT: Copper nanowire (Cu NW) based transparent conductors are promising candidates to replace ITO (indium-tin-oxide) owing to the high electrical conductivity and low-cost of copper. However, the relatively low performance and poor stability of Cu NWs under ambient conditions limit the practical application of these devices. Here, we report a solution-based approach to wrap graphene oxide (GO) nanosheets on the surface of ultrathin copper nanowires. By mild thermal annealing, GO can be reduced and high quality Cu r-GO core-shell NWs can be obtained. High performance transparent conducting films were fabricated with these ultrathin core-shell nanowires and excellent optical and electric performance was achieved. The core-shell NW structure enables the production of highly stable conducting films (over 200 days stored in air), which have comparable performance to ITO and silver NW thin films (sheet resistance ∼28 Ω/sq, haze ∼2% at transmittance of ∼90%).
    No preview · Article · Jan 2016 · ACS Nano
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    ABSTRACT: We investigate the interlayer phonon modes in $N$-layer rhenium diselenide (ReSe$_2$) and rhenium disulfide (ReS$_2$) by means of ultralow-frequency micro-Raman spectroscopy. These transition metal dichalcogenides exhibit a stable distorted octahedral (1T') phase with significant in-plane anisotropy, leading to sizable splitting of the (in-plane) layer shear modes. The fan-diagrams associated with the measured frequencies of the interlayer shear modes and the (out-of-plane) interlayer breathing modes are perfectly described by a finite linear chain model and allow the determination of the interlayer force constants. Nearly identical values are found for ReSe$_2$ and ReS$_2$. The latter are appreciably smaller than but on the same order of magnitude as the interlayer force constants reported in graphite and in trigonal prismatic (2Hc) transition metal dichalcogenides (such as MoS$_2$, MoSe$_2$, MoTe$_2$, WS$_2$, WSe$_2$), demonstrating the importance of van der Waals interactions in $N$-layer ReSe$_2$ and ReS$_2$. In-plane anisotropy results in a complex angular dependence of the intensity of all Raman modes, which can be empirically utilized to determine the crystal orientation. However, we also demonstrate that the angular dependence of the Raman response drastically depends on the incoming photon energy, shedding light on the importance of resonant exciton-phonon coupling in ReSe$_2$ and ReS$_2$.
    No preview · Article · Jan 2016 · ACS Nano
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    ABSTRACT: HgSe/CdS core/shell CQD are synthesized, and the dynamic change of the optical properties under different treatment, including annealing and ligand exchange with ethanedithiol treatment are investigated. While HgSe quantum dots are naturally n-doped after synthesis, both as colloidal solutions and as films, they lose their n-doping after the CdS shell growth, as seen from the optical absorption in solution. However, n-doping is regained in films and the intraband luminescence of the films of HgSe/CdS is greater than that of the cores. The shell also vastly improves the stability of the quantum dots films at elevated temperatures. As a result, the HgSe/CdS films retain a narrow intraband emission after annealing at 200°C while they sustain a higher laser power leading to brighter emission at 5 microns.
    No preview · Article · Jan 2016 · ACS Nano
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    ABSTRACT: While the self-assembly of different types of DNA origami into well-defined complexes could produce nanostructures on which thousands of locations can be independently functionalized with nanometer-scale precision, current assembly processes have low yields. Biomolecular complex formation requires relatively strong interactions and reversible assembly pathways that prevent kinetic trapping. To characterize how these issues control origami complex yields, the equilibrium constants for each possible reaction for the assembly of a heterotetrameric ring, the unit cell of a rectangular lattice, were measured using fluorescence co-localization microscopy. We found that origami interface structure controlled reaction free energies. Cooperativity, measured for the first time for a DNA nanostructure assembly reaction, was weak. Simulations of assembly kinetics suggest assembly occurs via parallel pathways with the primary mechanism of assembly being hierarchical: two dimers form which then bind to one another to complete the ring.
    No preview · Article · Jan 2016 · ACS Nano