Journal Impact: 3.34*
*This value is calculated using ResearchGate data and is based on average citation counts from work published in this journal. The data used in the calculation may not be exhaustive.
Journal impact history
|2016 Journal impact ||Available summer 2017 |
|2015 Journal impact ||3.34 |
|2014 Journal impact ||3.65 |
|2013 Journal impact ||3.90 |
|2012 Journal impact ||3.27 |
|2011 Journal impact ||2.98 |
|2010 Journal impact ||2.50 |
|2009 Journal impact ||1.88 |
|2003 Journal impact ||1.73 |
|2002 Journal impact ||0.73 |
Journal impact over time
|Cited half-life ||6.90 |
|Immediacy index ||0.24 |
|Eigenfactor ||0.01 |
|Article influence ||0.65 |
|ISSN ||1879-0739 |
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Publications in this journal
[Show abstract] [Hide abstract] ABSTRACT: Phytosterols (PSs) are reported to lower the serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDLC) concentrations enriched in some fatty foods, such as margarine. However, these high-fat foods are not very suitable for older people. Soy milk is the favorite food for elderly people in China; therefore, we hypothesized that the consumption of soy milk powder supplemented with PSs would decrease the serum cholesterol levels in older Chinese people independent of the genotypes of lipoprotein E (ApoE). Mild to moderate hyperlipidemic patients (n = 170) were recruited from different communities and treated with placebo soy milk powder or 3.4 g PS esters-enriched soy milk powder (2.0 g/d free PS in 30 g soy milk powder). The fasting serum lipid profiles at the baseline and after 3 months and 6 months of intervention were measured. The ApoE genotype was also determined. After 3 months of PS intervention, the serum lipid profile was not changed significantly in either group. The serum TC, LDLC, and non- high-density lipoprotein cholesterol (HDLC) levels decreased 9.3%, 11.4%, and 12.6%, respectively, in the PS group at the end of the intervention (6 months) compared to the control group, while the serum HDLC and triglyceride (TG) levels were not affected significantly. In the PS group, both the ApoE3 and ApoE4 carriers had a similar response to PS consumption. These findings suggested that PS-fortified soy milk powder was effective in lowering the serum cholesterol levels in older Chinese volunteers with mild to moderate hypercholesterolemia in both the ApoE3 and ApoE4 carriers.
[Show abstract] [Hide abstract] ABSTRACT: Poor dietary exposure disproportionately affects African-Americans and contributes to the persistence of disparities in health outcomes. In this study, we hypothesized that fortified dietary intervention (FDI) will improve measured dietary and related health outcomes and will be acceptable among low-income African-American women living in Tampa, FL. These objectives were tested using a prospective experimental study using pretest and posttest design with a control group, using a community-based participatory research approach. The intervention (FDI) was designed by the community through structural modification of a preexisting, diet-based program by the addition of a physical and mental health component. Paired sample t tests were used to examine preintervention and postintervention changes in study outcomes. A total of 49 women participated in the study, 26 in the FDI group and 23 controls. Two weeks postintervention, there were significant improvements in waist circumference and health-related quality of life related to physical health (P< .0001), physical fitness subscores (P= .002), and nutritional subscores (P= .001) in the FDI group. Among overweight/obese women, improvement in health-related quality of life related to physical health, a significant decrease in depressive score, and a reduction in waist circumference were noted. In the control group, a decrease in waist circumference was observed. Implementation of the FDI through a community-based participatory research approach is feasible and effective among low-income African-American women in general and overweight/obese women in particular. Social reengineering of a nutritional intervention coupled with community-based approach will enhance health outcomes of low-income women.
[Show abstract] [Hide abstract] ABSTRACT: Bioactive polyphenols in grapes are influenced by grape variety and cultivation conditions. The V. labrusca L. varieties are cultivated in tropical regions and used for grape juice production. We hypothesized that polyphenols from tropical grape juices would beneficially affect redox homeostasis in humans. Therefore, the effects of acute consumption of organic and conventional grape juices from V. labrusca L. on antioxidants biomarkers were investigated in healthy individuals. In a controlled, randomized, crossover, intervention trial, 24 individuals were assigned to drink either 400 mL of conventional juice, organic juice or water. Each intervention was followed by a 14-day washout period. Blood samples were obtained before and 1-hour after acute intake and analyzed for erythrocyte reduced glutathione (GSH), serum total antioxidant capacity (TAC), antioxidant enzymes in erythrocytes, and glucose and uric acid in serum. The ingestion of both grape juices resulted in elevated levels of GSH (P < .001), serum TAC (P < .05) and increased activity of catalase (P < .001), superoxide dismutase (P < .001) and glutathione peroxidase (P < .05) compared with the control intervention, with no significant differences between grape juices (P < .05). The intake of juices did not affect significantly the concentrations of glucose or uric acid. Grape juice polyphenols were associated with increased antioxidants and the chemical differences between organic and conventional juices were not predictive of the observed responses. The results suggest a bioactive potential of V. labrusca L. juices to improve redox homeostasis, which is involved in defense against oxidative stress in humans.
[Show abstract] [Hide abstract] ABSTRACT: To investigate the hypothesis that misreporting observed in dietary assessments would be associated with nutrition knowledge and health consciousness, we compared the degree of misreporting between 99 female dietitians and 117 non-dietitians who worked at welfare facilities in Japan. Sodium, potassium, and protein intake were assessed by two 24-h urine collections, four-day semi-weighed dietary records, and two validated diet history questionnaires. Intake of these three nutrients measured by each method was compared. The ratio of self-reported intake to biomarker-based intake was used as an index of reporting accuracy, and compared between dietitians and non-dietitians. Pearson correlation coefficients between biomarker-based and self-reported intakes were also compared between dietary assessment methods within the same group, as well as between the two groups. The dietitians tended to under-report sodium and protein intake more severely than the non-dietitians, and over-reported potassium intake more obviously. However, the degree of misreporting did not significantly differ between the two groups. The correlation coefficients between biomarker-based and self-reported intakes were significantly lower with the two diet history questionnaires than with the diet record, particularly in the dietitians. In conclusion, misreporting was strongly suspected to be more severe among the dietitians, and the validity of the diet history questionnaires differed between the two groups and this result suggests that misreporting might be associated with higher nutrition knowledge and health consciousness.
[Show abstract] [Hide abstract] ABSTRACT: The association between the age at introduction of complementary feeding and the risk of overweight or obesity during childhood has been hotly debated, but the result remains uncertain. This meta-analysis of prospective cohort studies attempted to evaluate this association, as well as provide evidence for infant feeding recommendations. The PubMed, Embase, and Cochrane databases were systematically searched for relevant original articles published prior to March 1, 2015 that met predefined inclusion criteria. The pooled relative risks (RRs) and corresponding 95% confidence intervals (CIs) were calculated using fix-effect or random-effect models, which were chosen based on heterogeneity among studies. Ten articles consisting of thirteen studies, where eight measured being overweight as an outcome and five measured being obese, were included in this meta-analysis. There were a total of 63,605 participants and 11,900 incident cases in the overweight studies, and 56,136 individuals and 3,246 incident cases in the obese studies. The pooled results revealed that introducing complementary foods before 4 months of age compared to at 4-6 months was associated with an increased risk of being overweight (RR, 1.18; 95%CI, 1.06-1.31) or obese (RR,1.33; 95%CI, 1.07-1.64) during childhood. No significant relationship was observed between delaying introduction of complementary foods after 6 months of age, and being overweight (RR, 1.01; 95%CI, 0.90-1.13) or obese (RR, 1.02; 95%CI, 0.91-1.14) during childhood. The results of this study suggest that the introduction of complementary foods to infants before 4 months of age should be avoided to protect against childhood obesity.
[Show abstract] [Hide abstract] ABSTRACT: A maternal low-protein (LP) diet programs fetal pancreatic islet beta cell development and function and predisposes offspring to metabolic dysfunction later in life. We hypothesized that maternal protein restriction during pregnancy differentially alters beta and alpha cell populations in offspring by modifying islet ontogeny and function throughout life. We aimed to investigate the effect of an LP maternal diet on pancreatic islet morphology and cellular composition in female offspring on postnatal day (PND) 7, 14, 21, 36 and 110. Mothers were divided into two groups: during pregnancy, the control group (C) was fed a diet containing 20% casein, and the LP group was fed an isocaloric diet with 10% casein. Offspring pancreases were obtained at each PND and then processed. Beta and alpha cells were detected by immunohistochemistry, and cellular area and islet size were quantified. Islet cytoarchitecture and total area were similar in C and LP offspring at all ages studied. At the early ages (PND 7–21), the proportion of beta cells was lower in LP than C offspring. The proportion of alpha cells was lower in LP than C offspring on PND 14 and higher on PND 21. The beta/alpha cell ratio was lower in LP compared to C offspring on PND 7 and 21 and higher on PND 36 (being similar on PNDs 14 and 110). We concluded that maternal protein restriction during pregnancy modifies offspring islet cell ontogeny by altering the proportions of islet sizes and by reducing the number of beta cells postnatally, which may impact pancreatic function in adult life.
[Show abstract] [Hide abstract] ABSTRACT: Diet induced obesity has been shown to reduce bone mineral density (BMD) and Ca absorption. However, previous experiments have not examined the effect of high fat diet (HFD) in the absence of obesity or addressed the type of dietary fatty acids. The primary objective of this study was to determine the effects of different types of high fat feeding, without obesity, on fractional calcium absorption (FCA) and bone health. It was hypothesized that dietary fat would increase FCA and reduce BMD. Mature 8-month-old female C57BL/6J mice were fed one of three diets: a HFD (45% fat) enriched either with monounsaturated fatty acids (MUFAs) or with saturated fatty acids (SFAs), and a normal fat diet (NFD; 10% fat). Food consumption was controlled to achieve a similar body weight gain in all groups. After 8wk, total body bone mineral content and BMD as well as femur total and cortical volumetric BMD were lower in SFA compared with NFD groups (P < 0.05). In contrast, femoral trabecular bone was not affected by the SFAs, whereas MUFAs increased trabecular volume fraction and thickness. The rise over time in FCA was greater in mice fed HFD than NFD and final FCA was higher with HFD (P < 0.05). Intestinal calbindin-D9k gene and hepatic cytochrome P450 2r1 protein levels were higher with the MUFA than the NFD diet (P < 0.05). In conclusion, HFDs elevated FCA overtime; however, an adverse effect of HFD on bone was only observed in the SFA group, while MUFAs show neutral or beneficial effects.
[Show abstract] [Hide abstract] ABSTRACT: Nonalcoholic fatty liver disease (NAFLD) is one of the most common complications of obesity. Mulberry is an important source of phytochemicals, such as anthocyanins, polyphenols and flavonoids, which are related to its antioxidant activity. In this study, we developed a hypothesis that mulberry exerted beneficial effects on metabolic disorders and evaluated the influence of the mulberry ethanol extract (MEE) on high-fat diet-induced hepatic steatosis and insulin resistance in mice. Thirty-six male C57BL/6 J mice were assigned into three groups and fed either a low-fat diet or a high-fat diet with or without supplementation with MEE. Our results showed that administration of MEE reduced diet-induced body weight gain, improved high-fat diet-induced hepatic steatosis and adipose hypertrophy, alleviated insulin resistance and improved glucose homeostasis. Analysis of hepatic gene expression indicated that MEE treatment changed the expression profile of genes involved in lipid and cholesterol metabolism. In conclusion, the present study demonstrated that MEE supplementation protected mice from high-fat diet-induced obesity, hepatic steatosis and insulin resistance. Moreover, the protective effects of MEE were associated with the induction of fatty acid oxidation and decreased fatty acid and cholesterol biosynthesis.
[Show abstract] [Hide abstract] ABSTRACT: In this study, we examined the cell differentiation effect of an ethanol extract of Cyclolepis genistoides D. Don, an herbaceous perennial belonging to the family Asteraceae (vernacular name: palo azul). Palo azul has numerous physiological effects that contribute to the prevention of metabolic syndromes, although the mechanism remains unclear. We previously suggested that palo azul has anti-diabetic activity via an adipose differentiation effect. Here, we focused on whether palo azul promoted the differentiation of myoblasts. The mouse muscle myoblast cell line C2C12 was cultured and differentiated using horse serum with or without an ethanol extract of palo azul (12.5–200 μg/mL). Quantitative real-time PCR was performed to evaluate differentiation markers, including insulin-like growth factor-1 and myogenin. To evaluate myotube formation, myosin heavy chain (MHC) expression and localization were detected by immunohistochemistry. Palo azul increased the expression of the differentiation markers. Further, immunohistochemistry analysis revealed increased formation of MHC myotubes after palo azul treatment along with increased diameter and fusion indices of the myotubes. The expression level of MHC was also increased. In conclusion, palo azul may increase muscle mass in the body and improve insulin resistance conditions by facilitating the formation of myotubes by promoting myocyte differentiation.
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