Arabian Journal of Chemistry
Current impact factor: 3.73
Impact Factor Rankings
|2016 Impact Factor ||Available summer 2017 |
|2014 / 2015 Impact Factor ||3.725 |
|2013 Impact Factor ||2.684 |
|2012 Impact Factor ||2.266 |
|2011 Impact Factor ||1.367 |
Impact factor over time
|5-year impact ||3.39 |
|Cited half-life ||2.80 |
|Immediacy index ||0.42 |
|Eigenfactor ||0.00 |
|Article influence ||0.59 |
|ISSN ||1878-5352 |
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- Publisher last reviewed on 03/06/2015
Publications in this journal
[Show abstract] [Hide abstract] ABSTRACT: Ferric activation was novelly used to prepare sludge-based adsorbent (SBA) through pyrolysis treatment of biological sludge, and the adsorbents were applied to adsorb Pb2+ ions from aqueous solution. The ferric-activated SBA showed a favorable porous structure development and enhanced Pb2+ ions removal, with the maximum sorption capacity of 42.96 mg/g. The optimum adsorption was observed in a wide pH range of 4-6. The adsorption data fitted the Freundlich model well, indicating heterogeneous lead coverage on the adsorbents. Pseudo-second order model validated the kinetic data, suggesting that the rate-limiting step of the adsorption process was chemical sorption. The mechanism of Pb2+ ions removal involved ion exchange, precipitation, and surface complexation. The higher adsorption of ferric-activated SBA was due to the enhancive surface area that provided a larger number of active sites for adsorbate, the precipitation, and the formation of the surface complex Fe-OPb2+. The results demonstrate that ferric-activated SBA can be used as an effective adsorbent for Pb2+ ions removal from aqueous solution, which will also provide an option for sludge valorization.
[Show abstract] [Hide abstract] ABSTRACT: The virtual screening of a library of chalcone derivatives led us to the identification of potential new MDM2 ligands. The chalcones with the best docking scores obeying the Lipinski rule of five were subsequently prepared by base-catalyzed aldol reactions. The activity of these compounds as inhibitors of p53–MDM2 interaction was investigated using a yeast-based screening assay. Using this approach two chalcones (3 and 4) were identified as putative small molecule inhibitors of p53–MDM2 interaction. The activity of both chalcones was further investigated in a panel of human tumor cells. Chalcones 3 and 4 revealed a pronounced tumor cell growth inhibitory effect on tumor cell lines. Additionally, chalcone 4 caused alterations in the cell cycle profile, induced apoptosis and increased the levels of p53, p21 and PUMA proteins in NCI-H460 cells. Computational docking studies allowed to predict that, like nutlin-3A (a well-known small-molecule inhibitor of p53–MDM2 interaction), chalcones 3 and 4 bind to the p53-binding site of MDM2. The results here presented will be valuable for the structure-based design of novel and potent p53-MDM2 inhibitors.
[Show abstract] [Hide abstract] ABSTRACT: Phase-pure cubic SmLuO3 and EuLuO3 interlanthanides were synthesized for the first time from nanostructured hydrothermally-derived precursors. LuO(OH), Sm(OH)3 and Eu(OH)3 materials were firstly obtained by hydrothermal synthesis at 250°C for 24h. X-ray diffraction, micro-Raman spectroscopy, scanning and transmission electron microscopies were employed to investigate the thermal behavior of the mixed systems Sm(OH)3–LuO(OH) and Eu(OH)3–LuO(OH), up to 1600°C. It was observed that the precursors were converted to lanthanide oxides in the temperature range 800–1200°C, followed by chemical reactions that allowed the production of a mixture of monoclinic and cubic SmLuO3 or EuLuO3 materials at 1400°C. Phase-pure cubic (Ia3¯ space group, #206) interlanthanides were produced at 1600°C, as corroborated by micro-Raman scattering probing the phonon modes, which were determined and assigned. The results showed that both systems could be promising materials for optical applications.
[Show abstract] [Hide abstract] ABSTRACT: Four complexes of different Cd(II) salts with 6,6’’-dimethyl-2,2’:6’,2’’-terpyridine L have been synthesized of the following structural formulae: Their properties have been established through analytical and spectroscopic (ESI-MS, IR, 1HNMR and UV-Visible absorption and emission) methods as well as by X-ray structure determinations. Quite high quantum yield values were obtained for the solution luminescence, despite the fact that presented compounds are ‘open species’ i.e. are susceptible to the effect of external environment. Titration experiments proved speciation i.e. formation of both 2:1 and 1:1 (L:Cd2+) species in MeCN, yet only the latter ones can be isolated in their crystalline form. In the solid state, there appears to be a correlation between the emission intensity and the stacking arrays in the lattice. There is no evidence that the methyl substituents exert a major influence upon the properties of the complexes, it is implied however that they might also be responsible for preferential formation of 1:1 complexes in the solid state due to observed intermolecular packing lattices.
[Show abstract] [Hide abstract] ABSTRACT: This manuscript presents results of a study on sorption effectiveness of orthophosphate and nitrate III and V in an equimolar mixture of P–PO4, N–NO2 and N–NO3 using chitosan in the form of hydrogel beads. Analyses were carried out for: the effect of pH on sorption intensity of orthophosphate and of nitrate III and V onto chitosan, sorption kinetics onto chitosan, and the maximum sorption capacity of P–PO4, N–NO2 and N–NO3 by chitosan in a mixture.
[Show abstract] [Hide abstract] ABSTRACT: The aims of the present study were the synthesis, an original spectroscopic characterization, an evaluation of antiproliferative activities and lipophilicity indices along with pharmacokinetic properties of a novel class of fused azaisocytosine-containing congeners. An optimized, well-established and scalable general method for the synthesis of the target molecules (10–18) via the [4+2] annulation strategy was worked out successfully, which enables reacting the molar equivalents of 1-aryl-2-hydrazinylideneimidazolidine hydroiodides (1–9) and ethyl 4-nitrophenylglyoxylate upon gently heating in n-butanol containing triethylamine and further refluxing in a solvent mixture n-butanol/DMF. The synthesis was hypothesized to proceed via ketimine intermediates that undergo intramolecular cyclization. All the synthesized compounds (10–18) revealed antiproliferative effects in four tumour cell lines of the epithelial origin, exerting superior cytotoxic activities in A549, HeLa and T47D cells to that of a reference drug – pemetrexed. Especially the 12, 13, 14, 15 and 18 seem to be the most promising lead structures for designing more selective cytotoxic agents as they have a lower toxicity for normal epithelial cells after 24-h incubation period. In addition, a number of the innovative antimetabolite-type molecules have been preselected that possess the optimum lipophilicity range significantly correlated with some in silico bioactivity descriptors relevant to the satisfactory pharmacokinetic profile in vivo. Thus, these original molecules might be useful as drug discovery leads to an early phase of drug design.
[Show abstract] [Hide abstract] ABSTRACT: The high electric field on the surface of tourmaline particles has a potential of enhancing electrostatic reactions during adsorption. However, information concerning the adsorption characteristics of dyes onto tourmaline is currently unavailable. In the present study, the behavior and efficiency of powdered tourmaline (PT) in removing the diazo Direct Red 23 (DR23) dye from aqueous solution was investigated. The observations from batch adsorption experiments indicated that the adsorption were more favorable under low adsorbate surface loading, low pH, high temperature, and low ionic strength conditions. A homogeneous particle diffusion model (HPDM) was used to characterize the process, and the rate of adsorption was found to be controlled by intra-particle diffusion. An activation energy of 4.54 kcal/mol was calculated, suggesting that the adsorption proceeded with a low energy barrier and that a physisorption was involved. The functional groups binding anionic DR23 on the PT particles were also identified. A maximum adsorption capacity of 153 mg/g was determined according to the Langmuir isotherm. The PT was subjected to a total of 5 regeneration runs without losing much of its dye-adsorption capacities. Due to its low price, abundant availability, and superb adsorption capacity, PT has a great potential for use as an effective adsorbent in removing DR23 from aqueous solutions.
[Show abstract] [Hide abstract] ABSTRACT: In the present study green chemistry was employed for synthesizing ZnO nanoparticles using the extract of black tea solid waste and Zn acetate dihydrate. The characterization of the green synthesized ZnO was conducted by XRD, SEM, HR-TEM, DLS and EDAX. Urine samples from donors under medication with Ibuprofen, Ephedrine and Propranolol were separated and collected through a diversion toilet. A batch experiment was conducted in order to determine the optimum dose of green synthesized ZnO nanoparticles for the removal of the pharmaceutical compounds from human urine. The determined optimum dose of the ZnO nanoparticles was 1.5 g/l. ZnO nano-particle posses the ability to adsorb the Pharmaceutical active compounds (PAC’s) on the surface. In addition, it binds such adsorbed particles and facilitates their precipitation. Coagulant reagents react with some of the suspended and colloidal particles in water/wastewater to enhance their binding together. Thus, allow their removal in the subsequent treatment processes. The mechanism of aggregation consists of the combination of charge neutralization, entrapment, adsorption and /or complexion with the coagulant ions to form insoluble precipitate. Thus, the particles and colloids can be removed. A semi-pilot plant consisted of mixing tank for chemical coagulation using the predetermined ZnO nanoparticles followed by microfiltration unit, was designed and operated continuously for the treatment of the separated urine. The overall results of the semi-pilot study showed that the concentration of Ibuprofen, Ephedrine and Propranolol decreased from 5.0, 10.15 and 15.2 mg/l to 0.01, 0.10 and 0.03 mg/l respectively. The overall removal rate exceeded 99%. Meanwhile, the treatment system succeeded to improve the physical and chemical characteristics of the contaminated human urine. The treated urine could be safely used for agriculture purposes without any environmental threat.
[Show abstract] [Hide abstract] ABSTRACT: Fourteen phthalazine-triones bearing different substituents at C-4 position were synthesized through multicomponent reactions (MCR) by using phthalhydrazide, dimedone and various aldehydes as starting materials, p-sulfonic acid calixarene as catalyst and ethyl lactate as solvent under microwave irradiation. Compounds 7-16 were obtained in excellent to moderate yields (94-51%) in only 10 minutes of reaction using this methodology. The antiproliferative activity against cancer cells was disclosed, for the first time, for synthesized compounds. The capacity of all compounds to inhibit cancer cells growth was dependent on the histological origin of cells. Compound 20 was active against more than one strain.
[Show abstract] [Hide abstract] ABSTRACT: In this paper, a novel approach for water-based strippable coatings for surface decontamination is reported. The novelty of this work consists in the development of a new method of removing heavy metals from contaminated surfaces by using polyvinyl alcohol strippable coatings containing bentonite clay.Viscosity measurements, evaporation rate tests, thermal analyses, FT-IR and tensile tests were performed for the optimization of the decontamination solution composition. For the decontamination experiments, copper surfaces were contaminated with mercury and, further, the decontamination water solutions containing polyvinyl alcohol, glycerol, EDTA and bentonite were applied onto these surfaces. After the removal of the polymer films, the copper coupons were subjected to SEM-EDX analysis, which revealed that introduction of bentonite in the polymer solution leads to a significant increase of the decontamination factor.
[Show abstract] [Hide abstract] ABSTRACT: Marine invertebrates are widely used as food and feed supplements throughout the world. Among these organisms, crustaceans are highlighted, which have high potential to provide valuable nutritive products. Montagu’s crab (Lophozozymus incisus (H. Milne Edwards) is abundant in the north-eastern Atlantic Ocean and in the Mediterranean Sea. Nevertheless, this is a poorly studied crab and information about its compositional profile is needed to facilitate processing, utilization and marketing of value-added products. The main purpose of our work was to improve the knowledge on its chemical composition, in order to obtain more information on potential healthy constituents, as well as on its biological properties. A chemical characterization of the ethanol extract was performed by GC-MS and HPLC-DAD. Twenty-eight metabolites were identified and quantified for the first time in this crab. Astaxanthin and alanine were the main carotenoid (ca. 57.0% of total carotenoids) and amino acid (ca. 33% of total amino acids content), respectively. Concerning to fatty acids, those unsaturated were predominated (ca. 86.0% of total fatty acids) and cholesterol was the only identified sterol. A dose-dependent response was revealed against cholinesterases, monoamino oxidase A (MAO-A) and α-glucosidase. Therefore, taking into account the biological properties of the identified metabolites, the consumption of this crab could have a positive impact in the human health.
[Show abstract] [Hide abstract] ABSTRACT: Photodegradation of 1,2-dichlorobenzene over illuminated trimetallic oxide consist of rutile TiO2 in major portion together with WO3 and SnO2 was studied with respect to the effect of physicochemical properties of the catalyst. The photocatalytic activity enhancement by the presence of surface defects due to calcination temperature was investigated with the information obtained from XRD, DRUV, PL, FESEM and XPS. Calcination of TiO2 at 950°C resulted in highest activity. Decrease in percent degradation of 1,2-dichlorobenzene was noted when it was immobilized on PVC film and chitosan beads. The effect of calcination temperature, catalyst loading and pH was investigated for slurry and after immobilization. Further optimization study was carried out with the aid of response surface methodology utilizing Box-Behnken design. High correlation was obtained for the experimental and the predicted value (R2 = 0.9992, Adj. R2 = 0.9982 and Pred. R2 = 0.9971). Optimization result showed that the maximum percent degradation was achieved at calcination temperature of 961.2°C, with catalyst loading of 0.22 g and pH 7.2. The presence of two intermediates was identified during the reaction using GCMS. On top of that the photocatalyst could also be reused for several times.
[Show abstract] [Hide abstract] ABSTRACT: The aim of this study was to evaluate the antioxidant and lipid-lowering effects ofPterodon emarginatusVog. oil obtained from the dried fruits by usingCaenorhabditis elegansas an experimental model. Worms were exposed to different concentrations of P. emarginatus oil for 30 minutes. Following treatments, survival, lifespan, reproduction, lipid accumulation and oxidative stress endpoints were assessed. The oil composition was analyzed by GC-MS. The oil extract (0.2, 0.5, 1.0 mg/mL) increased worms longevity without affecting their reproduction. Under oxidative stress conditions, the oil provided protection against pro-oxidants, decreased reactive oxygen species production and increased antioxidant enzymes levels, thus indicating that increased survival against the pro-oxidants might be associated to the increase in antioxidant response, possibly by modulation of gene expression. Furthermore, we observed that the oil extract reduced lipid accumulation and triglycerides. We determined flavonoids and total phenolic content, which revealed a small amount of these phytochemicals. The GC-MS analysis demonstrated the presence of different components such as sesquiterpenes, which in association to flavonoids may be contributing to the antioxidant activity and to the reduction in lipid accumulation observed in C. elegans, thus indicating that this oil should be further studied as a functional food.
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