Journal of Crohn s and Colitis (J CROHNS COLITIS)

Publisher: Oxford University Press (OUP)

Current impact factor: 6.23

Impact Factor Rankings

2016 Impact Factor Available summer 2017
2014 / 2015 Impact Factor 6.234
2013 Impact Factor 3.562
2012 Impact Factor 3.385
2011 Impact Factor 2.566
2010 Impact Factor 2.628
2009 Impact Factor 1.729
2008 Impact Factor 0.812

Impact factor over time

Impact factor

Additional details

5-year impact 5.43
Cited half-life 2.60
Immediacy index 1.42
Eigenfactor 0.01
Article influence 1.27
ISSN 1876-4479
OCLC 196647401
Material type Series, Periodical
Document type Journal / Magazine / Newspaper

Publisher details

Oxford University Press (OUP)

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Publications in this journal

  • No preview · Article · Apr 2016 · Journal of Crohn s and Colitis
  • No preview · Article · Apr 2016 · Journal of Crohn s and Colitis
  • [Show abstract] [Hide abstract] ABSTRACT: Backgroud and aims: Amyloidosis is a rare complication of inflammatory bowel disease; its low prevalence has hindered both descriptive and therapeutic studies. The aim of this study was to estimate the prevalence of amyloidosis in IBD and the risk factors associated with this complication. Methods: This paper presents an observational study, followed by a systematic review of the epidemiological and clinical characteristics of the disease and a review of the diagnostic and therapeutic options. Results: The prevalence of amyloidosis among IBD patients is 0.53% (95%CI: 0.32-0.75), although epidemiological data suggest that it may be underdiagnosed. The phenotype most frequently associated to amyloidosis is in males, with aggressive and extensive Crohn's disease, fistulizing behavior, perianal disease and extraintestinal complications, with the development of proteinuria and renal failure. Conclusions: Identifying risk factors of amyloidosis in IBD patients and screening for proteinuric renal dysfunction are useful to improve diagnostic accuracy. Referral of biopsies to a tertiary centre should also be considered to improve diagnostic accuracy. Although there is no reliable evidence on the effectiveness of treatment, it seems reasonable to treat the underlying disease with potent immunosuppression to minimize inflammatory activity and thereby switching off amyloidogenesis.
    No preview · Article · Apr 2016 · Journal of Crohn s and Colitis
  • No preview · Article · Apr 2016 · Journal of Crohn s and Colitis
  • [Show abstract] [Hide abstract] ABSTRACT: Background and aims: Psoriasis and Hidradenitis Suppurativa (HS) co-occur more often with Inflammatory Bowel Disease (IBD) than expected due to shared pathogenic and genetic features. It is known that IBD patients harbour an altered intestinal microbiome characterized by a depletion of Faecalibacterium prausnitzii and increase of Escherichia coli. At present, it is unclear whether a similar intestinal microbiome trend can be identified in IBD-associated skin disorders. We therefore investigated the F. prausnitzii and E. coli abundance in psoriasis and HS, with and without concomitant IBD. Methods: Using quantitative PCR, we compared the F. prausnitzii and E. coli abundance in the faecal samples from healthy controls (n=33) with samples from patients with psoriasis (n=29), IBD (n=31), concomitant IBD and psoriasis (n=13). Likewise, we analysed samples from patients with HS (n=17), and concomitant IBD and HS (n=17). Results: Psoriasis patients harboured a significantly lower abundance of F. prausnitzii in their stool than healthy controls (p<0.001), which was similar to IBD patients. Together with the reduced F. prausnitzii levels, the psoriasis patients had a significantly higher abundance of E. coli (p<0.001). No significant difference in F. prausnitzii or E. coli abundance was found in HS. It was apparent that patients with concomitant IBD and associated skin disorder had the greatest decrease of F. prausnitzii and increase of E. coli. Conclusions: The study demonstrates, for the first time, an IBD-like decrease of F. prausnitzii together with an increase of E.coli in psoriasis, supporting the presence of a gut-microbiome-skin axis in psoriasis and IBD.
    No preview · Article · Mar 2016 · Journal of Crohn s and Colitis
  • [Show abstract] [Hide abstract] ABSTRACT: Background and aims: Cytomegalovirus (CMV) often reactivates in the course of inflammatory bowel disease, but the significance of this remains disputable.Our aim was to evaluate whether severity of CMV colitis is associated with a colectomy risk in ulcerative colitis (UC) patients.The secondary aim was to evaluate agreement between immunohistochemistry (IHC) and blood CMV polymerase chain reaction (PCR). Methods: UC patients with IHC CMV assessment in the colon hospitalized in a referral unit between 2005-2012 were retrospectively identified. The course and severity of the disease were analyzed, with inflammation graded histologically across the range 0-3. The numbers of IHC-positive cells per biopsy section were counted, while results for blood CMV PCR were also retrieved. Data on colectomies were also collected. Results: Of 141 patients, 95 were analyzed, with 33 found to be IHC-positive, and 62 negative. The colectomy risk was significantly higher in patients with ≥5 IHC-positive cells, as opposed to those with none or less than 5 (p=0.014) with median follow-up of 1.9 and 3.2 years, respectively. The IHC-positive had lower hemoglobin (median 11.0 g/dl vs 12.0; p=0.028) and albumin (median 29.5 g/l vs 33.1; p=0.038) levels and more intense histologic inflammation (p=0.020) compared with the negative. There was substantial agreement between IHC and blood PCR (Cohen's kappa coefficient 0.72). Conclusions: Five or more CMV IHC-positive cells per biopsy section was indicative of a greater colectomy risk. CMV infection was related to more severe inflammation. Blood CMV PCR is a useful tool in UC.
    No preview · Article · Mar 2016 · Journal of Crohn s and Colitis
  • No preview · Article · Mar 2016 · Journal of Crohn s and Colitis
  • [Show abstract] [Hide abstract] ABSTRACT: Background: Enteral nutrition (EN) was reported to be as effective as steroids in achieving short-term remission in patients with CD, and exclusive EN (EEN) is widely used as primary therapy in children with CD. The aim of this study was to investigate the effect of a specific multi-fibre mix (MF) designed to match the fibre content of a healthy diet on intestinal epithelial barrier function in IL-10 knockout (IL-10(-/-)) mice with spontaneous chronic colitis. Methods: IL-10(-/-) mice of 16 weeks with established colitis were used for the experiments with multi-fibre mix diet (MF) for 4 weeks. Severity of colitis, levels of SCFA in caecum contents, expression of STAT 3 and STAT 4 proteins, CD4(+) CD45(+) lymphocytes, CD4(+)Foxp3(+) regulatory T cells (Tregs) and cytokines in the lamina propria (LP), epithelial expression of tight junction proteins, TNF-α/TNFR2 mRNA expression, as well as epithelial apoptosis in proximal colon were measured at the end of the experiment. Results: MF feeding effectively attenuated disease activity index and colitis associated with decreased lamina propria CD4(+) CD45(+) lymphocytes, IFN-γ/IL-17 mRNA expression, p-STAT 3 and p-STAT 4 expression in colonic mucosa of IL-10(-/-) mice (P<0.05). Furthermore, CD4(+)Foxp3(+) Tregs in the LP and Concentrations of total SCFA, acetate, propionate and butyrate in the caecum were markedly increased after MF feeding in IL-10(-/-) mice. After MF feeding, increased epithelial expression and correct localization of tight junction proteins (occludin and ZO-1), as well as reduced TNF-α/TNFR2 mRNA expression and epithelial apoptosis were also observed in IL-10(-/-) mice. Conclusions: These results indicated that EEN supplemented with the tested fibre mix, known to modulate the intestinal microbiota composition and SCFA production, could possibly further improve efficacy in inducing remission in patients with active CD.
    No preview · Article · Mar 2016 · Journal of Crohn s and Colitis
  • [Show abstract] [Hide abstract] ABSTRACT: Objectives: We evaluated the performance of blood and fecal biomarkers for differentiating between endoscopic inflammation and mucosal healing, clinically active disease and sustained clinical remission and determined the predictive value for a flare in patients with ulcerative colitis (UC). Methods: Clinical activity Index (CAI), fecal lactoferrin (FLA), calprotectin (CAL), PMN-elastase (PMN-e), CRP, WBC, endoscopic index (EI) and UC-Disease activity Index (DAI) were determined repeatedly during 12-months and at acute flares. Results: Of 91 patients (45 female; mean age 48.1±13.4 years) entering in remission, 42 (46%) patients developed a clinical flare. A total of 529 CAI and 179 EI assessments were performed. Median levels for active disease confirmed by EI (n=35) vs clinical remission with endoscopic inflammation (n=37) vs mucosal healing (n=107) for FLA were 44/37/4µg/g, CAL 25/20/10µg/g (both p<0.0001), PMN-e 0.06/0.03/0.02µg/g, CRP 0.7/0.2/0.2mg/dl (both p<0.001) and WBC 7.0/6.5/6.4/nl (p=0.1). There was no difference for any of the markers for defining mucosal healing by EI=0 vs. EI=1 with the exception of PMN-e (p=0.03), where the difference was very small and with questionable clinical relevance. Using manufacturers' cut-offs, only FLA at baseline was associated with a significant higher Relative Risk (RR) of flaring (RR1.69; p=0.018). Using optimized cut-offs Cal, PMN-e and CRP were also predictive of a flare. Conclusions: Fecal biomarkers FLA, CAL and PMN-e were able to distinguish between UC patients with mucosal healing from clinical remission and mild disease, showed significant correlations with endoscopy and were predictive of a flare.
    No preview · Article · Feb 2016 · Journal of Crohn s and Colitis
  • [Show abstract] [Hide abstract] ABSTRACT: Background: There is no consensus and very few studies concerning the choice between 2 and 3-stage for ileal pouch-anal anastomosis (IPAA) in inflammatory bowel diseases (IBD). This study aimed to compare operative results between both surgical procedures. Methods: Only patients who underwent a laparoscopic IPAA for IBD were included. They were divided into 2 groups: 2-stage (IPAA and stoma closure) (Group A) and 3-stage IPAA (subtotal colectomy, IPAA, stoma closure) (Group B). Results: From 2000 to 2015, 185 patients (107 men, median age of 42 [range, 15-78] years) were divided into Groups A (n=82) and B (n=103). Patients in Gr. B were younger than in Gr. A (39 [15-78] vs 43 [16-74] years (p=0.019), presented more frequently Crohn's disease (16% vs 5%, p<0.04), and were more frequently operated in emergency for acute colitis (37% vs 1%, p<0.0001). Cumulative operative time and length of stay were significantly longer in Gr. B (580 [300-900] min., and 19 [13-60] days) than in Gr. A (290 [145-490] min. and 10 [7-47] days; p<0.0001). Cumulative postoperative morbidity, delay for stoma closure, and function were similar between the 2 groups. Long-term morbidity was similar between Gr. A (13%) and Gr B (21%; p=0.18). Conclusion: Our study suggested that postoperative morbidity was similar between 2- and 3-stage laparoscopic IPAA. It suggested that 3-stage procedure is probably safer for high-risk patients (i.e. acute colitis).
    No preview · Article · Feb 2016 · Journal of Crohn s and Colitis
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    Preview · Article · Feb 2016 · Journal of Crohn s and Colitis
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    Preview · Article · Feb 2016 · Journal of Crohn s and Colitis
  • [Show abstract] [Hide abstract] ABSTRACT: Background and aims: Inflammatory bowel disease (IBD) has a major impact on psychological well-being. How an individual copes with IBD determines quality of life. We aimed to develop a brief, IBD-specific questionnaire to assess coping strategies (IBD-Cope) and to determine its test-retest reliability and validity. Methods: Twenty IBD coping strategies were initially deemed to have face validity. Participants were recruited from an existing study, specialist outpatient clinics, and via email. Distribution analyses were performed before test-retest reliability was determined. Exploratory factor analyses (EFA) were then performed before cross-sectional validity was tested. Results: The majority of participants in the study samples were female and most had Crohn's disease. All participants were aged between 18 and 65 years. EFA on the initial validation sample produced two components explaining 42% of the variance, and broadly reflected "good" and "bad" coping. EFA on the repeat validation sample showed three questions consistently clustering into either "good" or "bad" coping strategies. "Good" and "bad" coping strategies defined using the IBD-Cope were positively associated with adaptive (r = 0.57, p<0.01) and maladaptive (r = 0.55, p<0.01) coping on the Brief Coping Operations Preference Enquiry (Brief COPE), respectively. Conclusions: The IBD-Cope is a concise IBD specific coping strategy questionnaire with demonstrated reliability and validity. The IBD-Cope subscales are moderately correlated with adaptive and maladaptive subscales of the Brief COPE. Prospective studies are required to determine whether the six questions represented in the IBD-Cope accurately identify IBD patients who may benefit from interventions to improve coping strategies.
    No preview · Article · Feb 2016 · Journal of Crohn s and Colitis
  • No preview · Article · Jan 2016 · Journal of Crohn s and Colitis
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    [Show abstract] [Hide abstract] ABSTRACT: Case 1 Following two years of rectal blood loss, a 31-year old male was diagnosed with ulcerative pan-colitis in 1978. Initial treatment consisted of both topical and systemic 5-aminosalicylic acids (5-ASA) and remission was achieved. In both 1984 and 1986 he was hospitalized due to exacerbations necessitating treatment with intravenous corticosteroids. The following years went well without disease activity under treatment of 5-ASA. In 1997, at the age of 50 years, a surveillance colonoscopy showed a stenotic process with a macroscopic irregularity in the sigmoid region. Histology revealed at least high-grade dysplasia (HGD) and signs of an invasive growth pattern which could indicate colorectal cancer (CRC). The patient underwent restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA). Histology of the resection specimen confirmed active inflammation in the colon and rectum and a carcinoma in situ was identified in the sigmoid colon without invasive growth. This patient did not have significant co-morbidities like primary sclerosing cholangitis (PSC) and the CRC family history was negative. What pouch surveillance strategy should be recommended?
    Preview · Article · Jan 2016 · Journal of Crohn s and Colitis