Neuroscience & Biobehavioral Reviews (NEUROSCI BIOBEHAV R)

Publisher: Elsevier

Journal description

The journal will publish original and significant review articles dealing with all aspects of neuroscience, where the relationship to the study of psychological processes and behavior is clearly established. Conversely, the journal will also publish articles whose primary focus deals with psychological processes and behavior, and which have relevance to one or more aspects of neuroscience. Submissions to the journal are actively encouraged which deal with topics not only in the more traditional areas, but also in the following areas, whenever the reviews bring new insights into brain-behavior relations: neuropsychology cognitive neuroscience brain imaging in vivo monitoring of the brain's electrical and biochemical activities molecular biology genetics neurocomputation Theoretical articles and mini-reviews, for which the scope and literature coverage are more restricted, will also be published. The table of contents for this journal is now available pre-publication, via e-mail, as part of the free ContentsDirect service from Elsevier Science. Please send an e-mail message to for further information about this service.

Current impact factor: 8.80

Impact Factor Rankings

2016 Impact Factor Available summer 2017
2014 / 2015 Impact Factor 8.802
2013 Impact Factor 10.284
2012 Impact Factor 9.44
2011 Impact Factor 8.65
2010 Impact Factor 9.015
2009 Impact Factor 7.791
2008 Impact Factor 7.804
2007 Impact Factor 8.147
2006 Impact Factor 8.293
2005 Impact Factor 7.443
2004 Impact Factor 6.346
2003 Impact Factor 5.482
2002 Impact Factor 5.504
2001 Impact Factor 5.212
2000 Impact Factor 3.382
1999 Impact Factor 3.595
1998 Impact Factor 3.316
1997 Impact Factor 2.786

Impact factor over time

Impact factor

Additional details

5-year impact 10.53
Cited half-life 6.40
Immediacy index 1.66
Eigenfactor 0.04
Article influence 3.59
Website Neuroscience & Biobehavioral Reviews website
Other titles Neuroscience and biobehavioral reviews, Neuroscience & biobehavioral reviews
ISSN 1873-7528
OCLC 3552135
Material type Periodical, Internet resource
Document type Journal / Magazine / Newspaper, Internet Resource

Publisher details


  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • Authors pre-print on any website, including arXiv and RePEC
    • Author's post-print on author's personal website immediately
    • Author's post-print on open access repository after an embargo period of between 12 months and 48 months
    • Permitted deposit due to Funding Body, Institutional and Governmental policy or mandate, may be required to comply with embargo periods of 12 months to 48 months
    • Author's post-print may be used to update arXiv and RepEC
    • Publisher's version/PDF cannot be used
    • Must link to publisher version with DOI
    • Author's post-print must be released with a Creative Commons Attribution Non-Commercial No Derivatives License
    • Publisher last reviewed on 03/06/2015
  • Classification

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: The sensation of gentle touch of the mammalian hairy skin is mediated by morphologically and physiologically distinct classes of low-threshold mechanoreceptors (LTMs) which are classified, according to their axonal conduction velocities, into A�-, A�- and C-LTMs. Although A�-LTMs (D-hair cells) were first described about five decades ago, and have been found in hairy skin of every species examined including humans, it is commonly assumed that all A�-fiber neurons are nociceptors. This view is endorsed by many textbooks. This article reviews the evidence that A�-LTMs exist in substantial proportions in different species, and that their peripheral and central axonal endings, molecular markers, receptive, electrophysiological and cytochemical properties are distinct from those of A�-high-threshold mechanoreceptors (A�-HTMs). A brief overview of some of the ion channels and markers that are expressed by the two populations of primary afferent neurons is also provided. Failure to recognize the existence and properties of A�-LTMs might lead/have led to misinterpretations of data. A�-LTMs and C-LTMs have been reviewed elsewhere and are not subject of this review.
    No preview · Article · Dec 2016 · Neuroscience & Biobehavioral Reviews
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    ABSTRACT: Animal research has shown it possible to want a reward that is not liked once obtained. Although these findings have elicited interest, human experiments have produced contradictory results, raising doubt about the existence of separate wanting and liking influences in human reward processing. This discrepancy could be due to inconsistences in the operationalization of these concepts. We systematically reviewed the methodologies used to assess human wanting and/or liking and found that most studies operationalized these concepts in congruency with the animal literature. Nonetheless, numerous studies operationalized wanting in similar ways to those that operationalized liking. These contradictions might be driven by a major source of confound: expected pleasantness. Expected pleasantness underlies cognitive desires and does not correspond to animal liking, a hedonic experience, or to animal wanting, which relies on affective relevance, consisting of the perception of a cue associated with a relevant reward for the organism’s current physiological state. Extending the concept of affective relevance and differentiating it from expected pleasantness might improve measures of human wanting and liking.
    No preview · Article · Feb 2016 · Neuroscience & Biobehavioral Reviews
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    ABSTRACT: Relatively little is known about the neuropathophysiology of binge-eating disorder (BED). Here, the evidence from neuroimaging, neurocognitive, genetics, and animal studies are reviewed to synthesize our current understanding of the pathophysiology of BED. Binge-eating disorder may be conceptualized as an impulsive/compulsive disorder, with altered reward sensitivity and food-related attentional biases. Neuroimaging studies suggest there are corticostriatal circuitry alterations in BED similar to those observed in substance abuse, including altered function of prefrontal, insular, and orbitofrontal cortices and the striatum. Human genetics and animal studies suggest that there are changes in neurotransmitter networks, including dopaminergic and opioidergic systems, associated with binge-eating behaviors. Overall, the current evidence suggests that BED may be related to maladaptation of the corticostriatal circuitry regulating motivation and impulse control similar to that found in other impulsive/compulsive disorders. Further studies are needed to understand the genetics of BED and how neurotransmitter activity and neurocircuitry function are altered in BED and how pharmacotherapies may influence these systems to reduce BED symptoms.
    No preview · Article · Feb 2016 · Neuroscience & Biobehavioral Reviews
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    ABSTRACT: We conducted a meta-analysis on the available data from studies investigating SERTs in ecstasy users and polydrug using controls. From 7 studies we compared data from 157 ecstasy users and 148 controls across 14 brain regions. The main effect suggested ecstasy/MDMA related SERT reductions (SMD=0.52, 95% CIs [0.40, 0.65]; Z=8.36, p<.01, I2=89%). A significant effect of subgroups (X2=37.41, df=13, p<.01, I2=65.3%) suggested differential effects across brain ROIs. Ecstasy users showed significant SERT reductions in 11 out of the 14 regions, including every neocortical and limbic region analysed. Greatest effects were observed in the occipital cortex (SMD=1.09, 95% CIs [0.70, 1.48]). No group effects were observed in subcortical areas of the caudate, putamen and midbrain. Literature on Postsynaptic 5HT2A receptor imaging was synthesised with these results. We conclude that, in line with preclinical data, serotonin axons with the longest projections from the raphe nuclei appear to be most affected by ecstasy/MDMA use.
    No preview · Article · Feb 2016 · Neuroscience & Biobehavioral Reviews
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    ABSTRACT: This meta-analysis summarises research examining whether transcranial electrical stimulation (transcranial direct current stimulation with oscillating and constant currents; transcranial alternating current stimulation), administered during sleep, can modulate declarative and procedural memory consolidation. Included in the meta-analysis were 13 experiments that represented data from 179 participants. Study findings were summarised using standardised mean difference (SMD) which is an effect size that summarises differences in standard deviation units. Results showed electrical stimulation during sleep could enhance (SMD = 0.447; p = .003) or disrupt (SMD = −0.476, p = .030) declarative memory consolidation. However, transcranial electric stimulation does not appear to be able to enhance (SMD = 0.154, p = .279) or disrupt (SMD = 0.076, p = .675) procedural memory consolidation. This meta-analysis provides strong evidence that TES is able to modulate some consolidation processes. Additional research is required to determine the mechanisms by which transcranial electrical stimulation is able to influence declarative memory consolidation. Finally, it is yet to be determined whether transcranial electrical stimulation can modulate procedural memory consolidation.
    No preview · Article · Jan 2016 · Neuroscience & Biobehavioral Reviews
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    ABSTRACT: Oxytocin is widely used by obstetricians to induce or facilitate labor. The long lasting consequences of oxytocin administration remain however unknown. Here, we discuss recent evidence suggesting a link between oxytocin labor induction and developmental social impairments such as autism spectrum disorders (ASD). Because these associations are methodologically questionable, we provide a review of animal studies investigating the long term effects of neonatal injection of oxytocin to shed light on the biological mechanisms that mediate the contribution of early oxytocin supplementation on the development of social impairments. In contrast to this potential negative impact on development, oxytocin has been shown to ameliorate social skills of ASD patients. However, results of chronic oxytocin administration from animal experiments are contradictory. We also review recent studies looking at chronic oxytocin effects in animal and in humans. Obstetric and psychiatric uses of exogenous oxytocin both impact on oxytocinergic neurotransmission but the effects may be sharply dissimilar.
    No preview · Article · Jan 2016 · Neuroscience & Biobehavioral Reviews
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    ABSTRACT: Clinical observations in human autoimmune diseases such as multiple sclerosis (MS) suggest a pivotal role of sex-related factors in the etiopathogenesis. These include a female preponderance in MS incidence and an increasing sex bias over time, a parent-of-origin effect in MS inheritance, and the protective effect of pregnancy on disease activity. The complex interplay of factors contributing to these clinical phenomena, however, is incompletely understood and may include sex hormones as well as genetic or epigenetic sex differences. While genetic and hormonal effects are impossible to study independently in humans, novel mouse models have started to unravel the cause-effect relationship between individual sex-related factors and autoimmunity. Here, we present the evidence for mechanisms underlying sex differences in the immune system and the central nervous system (CNS) and how these might help to explain some of clinically observed sex differences in MS. A better understanding of the molecular underpinnings may ultimately help to devise sex-specific treatment strategies as well as highlight novel avenues for therapy in both sexes.
    No preview · Article · Jan 2016 · Neuroscience & Biobehavioral Reviews
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    ABSTRACT: Central nervous system (CNS) development is a finely tuned process that relies on multiple factors and intricate pathways to ensure proper neuronal differentiation, maturation, and connectivity. Disruption of this process can cause significant impairments in CNS functioning and lead to debilitating disorders that impact motor and language skills, behavior, and cognitive functioning. Recent studies focused on understanding the underlying cellular mechanisms of neurodevelopmental disorders have identified a crucial role for insulin-like growth factor-1 (IGF-1) in normal CNS development. Work in model systems has demonstrated rescue of pathophysiological and behavioral abnormalities when IGF-1 is administered, and several clinical studies have shown promise of efficacy in disorders of the CNS, including autism spectrum disorder (ASD). In this review, we explore the molecular pathways and downstream effects of IGF-1 and summarize the results of completed and ongoing pre-clinical and clinical trials using IGF–1 as a pharmacologic intervention in various CNS disorders. This aim of this review is to provide evidence for the potential of IGF–1 as a treatment for neurodevelopmental disorders and ASD.
    No preview · Article · Jan 2016 · Neuroscience & Biobehavioral Reviews
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    ABSTRACT: We conducted a comprehensive search and the overview included 22 systematic reviews (SRs) for treating tic disorders (TDs). Three SRs indicated typical antipsychotics (i.e., haloperidol, pimozide) were efficacious in the reduction of tic severity compared with placebo but with poor tolerability. Six SRs assessed the efficacy of atypical antipsychotics and indicated that atypical antipsychotics (i.e., risperidone, aripiprazole) could significantly improved tic symptoms compared with placebo or typical antipsychotics with less AEs. Four SRs indicated alpha adrenergic agonists (i.e., clonidine, guanfacine) could improve tic symptoms. Two SRs assessed the efficacy of antiepileptic drugs and indicated topiramate was a promising therapy. Six SRs evaluated the efficacy of behavior therapy and showed habit reversal therapy (HRT) and exposure and response prevention (ERP) were effective. One SR evaluated the efficacy deep brain stimulation (DBS) and indicated DBS is a promising treatment option for severe cases of TS. In conclusion, RCTs directly comparing different pharmacological treatment options are scarce. In practice, typical and atypical antipsychotics are often considered firstly while other pharmacological medications are suggested as alternatives in the case of treatment failure or contradictory outcomes. Behavioral therapies can be used either alone or in combination with medication.
    No preview · Article · Jan 2016 · Neuroscience & Biobehavioral Reviews
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    ABSTRACT: The existence of sex differences in Parkinson's disease (PD) incidence is well documented with greater prevalence and earlier age at onset in men than in women. These reported sex differences could be related to estrogen exposure. In PD animal models, estrogen is well documented to be neuroprotective against dopaminergic neuron loss induced by neurotoxins. Using the 1-methyl 4-phenyl-1,2,3,6 tetrahydropyridine (MPTP) mouse model, we showed that several compounds are neuroprotective on dopaminergic neurons including estrogen, the selective estrogen receptor modulator raloxifene, progesterone, dehydroepiandrosterone, the estrogen receptor alpha (ERα) agonist PPT as well as the G protein-coupled membrane estrogen receptor (GPER1) specific agonist G1. Accumulating evidence suggests that GPER1 could be implicated in the neuroprotective effects of estrogen, raloxifene and G1 in collaboration with ERα. We recently reported that the 5α-reductase inhibitor Dutasteride is also neuroprotective and could bring an alternative to estrogens for therapy in male. Additional studies are needed to optimize therapies with these gonadal drugs into safe personalized treatments according to sex for treatment of PD.
    No preview · Article · Dec 2015 · Neuroscience & Biobehavioral Reviews