European journal of radiology

Publisher: Elsevier

Current impact factor: 2.37

Impact Factor Rankings

2016 Impact Factor Available summer 2017
2014 / 2015 Impact Factor 2.369
2013 Impact Factor 2.16
2012 Impact Factor 2.512
2011 Impact Factor 2.606
2010 Impact Factor 2.941
2009 Impact Factor 2.645
2008 Impact Factor 2.339
2007 Impact Factor 1.915
2006 Impact Factor 1.332
2005 Impact Factor 1.888
2004 Impact Factor 1.745
2003 Impact Factor 1.06
2002 Impact Factor 1.118
2001 Impact Factor 1.084
2000 Impact Factor 0.822
1999 Impact Factor 0.574
1998 Impact Factor 0.537
1997 Impact Factor 0.537
1996 Impact Factor 0.358
1995 Impact Factor 0.449
1994 Impact Factor 0.418
1993 Impact Factor 0.41
1992 Impact Factor 0.308

Impact factor over time

Impact factor
Year

Additional details

5-year impact 2.41
Cited half-life 4.40
Immediacy index 0.40
Eigenfactor 0.03
Article influence 0.76
ISSN 1872-7727

Publisher details

Elsevier

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    • Publisher last reviewed on 03/06/2015
  • Classification
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Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Purpose: To evaluate the correlation between grade of pancreatic neuroendocrine tumours (pNETs) based on the 2010 World Health Organization (WHO) classification and the apparent diffusion coefficient (ADC), and to assess whether the ADC value and WHO classification can predict recurrence-free survival (RFS) after surgery for pNETs. Methods: This retrospective study was approved by the Institutional Review Board. The requirement for informed consent was waived. Between March 2009 and November 2014, forty-nine patients who underwent magnetic resonance (MR) imaging with diffusion-weighted image and subsequent surgery for single pNETs were included. Correlations among qualitative MR imaging findings, quantitative ADC values, and WHO classifications were assessed. An ordered logistic regression test was used to control for tumour size as a confounding factor. The association between ADC value (or WHO classification) and RFS was analysed. Results: All tumors (n=49) were classified as low- (n=29, grade 1), intermediate- (n=17, grade 2), and high-grade (n=3, grade 3), respectively. The mean ADC of pNETs was moderately negatively correlated with WHO classification before and after adjustment for tumour size (ρ=-0.64, p<0.001 and ρ=-0.55, p=0.001 respectively). RFS was significantly associated with WHO classification (p=0.007), but not with the ADC value (p=0.569). Conclusion: The ADC value of pNETs is moderately correlated with WHO tumour grade, regardless of tumour size. However, the WHO tumour classification of pNET may be more suitable for predicting RFS than the ADC value.
    No preview · Article · Jan 2016 · European journal of radiology
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    ABSTRACT: Purpose: It is very important to identify whether there is extramedullary involvement in acute leukemia (AL), especially in those with recurrent disease. This retrospective study aimed to assess the role of (18)F-FDG PET/CT for diagnosing extramedullary AL. Materials and methods: PET/CT examinations were performed in 9 patients with newly diagnosed AL, and 70 patients suspected to have recurrent AL. All the patients were diagnosed with AL by bone marrow biopsy. The diagnosis of extramedullary lesions was established according to the combination of pathology, physical examination, and imaging techniques including magnetic resonance imaging (MRI) and PET/CT, and/or cerebrospinal fluid (CSF) cytologic testing, and clinical follow-up. Results: Of the 79 patients, including 34 acute lymphocytic leukemia (ALL) and 45 acute myeloid leukemia (AML) cases, 30 patients were diagnosed with extramedullary AL. (18)F-FDG PET/CT demonstrated (18)F-FDG positive lesions in the extramedullary regions in 42 patients. Among them, 28 patients were diagnosed to have extramedullary AL and the other 14 were diagnosed with non-hematological malignancies (false positive disease). The sensitivity, specificity, and accuracy of (18)F-FDG PET/CT in diagnosing extramedullary involvement of AL were 93.3% (28/30), 71.4% (35/49), and 79.7%, respectively. The (18)F-FDG uptake of lesions was not significantly different between extramedullary AL and false positive cases (SUVmax: 6.66±2.65 vs. 5.85±1.88, t=1.275, P=0.206). The FDG uptake of extramedullary AL between ALL and AML were also not significantly different (SUVmax: 7.01±2.82 vs. 6.10±2.29, t=1.332, P=0.188). The predominant locations of extramedullary AL were the spleen, soft tissue, lymph nodes, central nerve system, liver, testis, and kidney. A total of 48.2% (27/56) of extramedullary AL lesions presented as diffuse FDG uptake compared with 6.25% (1/16) in the false positive lesions (χ(2)=9.221, P=0.002). Conclusion: (18)F-FDG PET/CT is a sensitive, but not specific imaging modality for diagnosing extramedullary AL. Diffuse (18)F-FDG uptake in extramedullary lesions may indicate leukemia involvement.
    No preview · Article · Jan 2016 · European journal of radiology
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    ABSTRACT: Purpose: To assess T2 HASTE MR in acute abdominal imaging and ascertain if it is a reliable alternative to CT in patients under 60. Method and materials: In a prospective diagnostic performance study from January 2009 to December 2013, patients under 60 presenting with acute abdominal pain, that required imaging following surgical review, were imaged with T2 HASTE MR. Rapid acquisition HASTE (Half Fourier Acquisition Single Shot Turbo Spin Echo) coronal and axial sequences were obtained, without intravenous contrast. Patients were followed up clinically for a minimum of 3 months. Results: 468 cases included in the study. 349 were negative for acute abdominal pathology, 116 positive for acute abdominal pathology and 3 were indeterminate. In the MR positive group (n=116), 64 had surgery confirming findings (34 appendicitis, 14 SBO, 3 ovarian torsion, 3 LBO, intussusception, ovarian carcinoma, ovarian dermoid, 2 pelvic inflammatory disease, diverticular abscess, crohns, 4 endoscopy for acute bowel pathology) while 51 were managed conservatively with concordant follow up (4 SBO, 11 diverticulitis, 6 pelvic inflammatory disease, 7 inflammatory bowel disease, 7 colitis, 6 pyelonephritis, 2 cholecystitis, renal abscess, pseudomembranous colitis, splenic haematoma, mesenteric adenitis, 2 pancreatitis, lymphoma, epiploic appendagitis). 1 patient had an MR diagnosis of appendicitis but at laparoscopy a sigmoid diverticular perforation was diagnosed and the appendix was normal. In the MR negative group (n=349), 324 had uneventful follow-up, 22 had negative laparoscopies, while 3 had subsequent appendectomies, with appendicitis on histology (3 days, 10 days and 2 months post scan). In the MR indeterminate group (n=3), one was treated conservatively with uneventful follow up, one had laparoscopic appendectomy with normal appendix on histology, one had laparoscopic appendectomy with acute appendicitis on histology. When MR correlated with clinical follow up (n=468), overall diagnostic accuracy is 99% (463/468). When MR findings correlated with direct visualisation at surgery/endoscopy (n=90), sensitivity is 98% (95% CI) and specificity is 92% (95% CI). Conclusion: This study demonstrates that rapid acquisition axial and coronal T2 HASTE MR is a practical, safe and effective method in the diagnosis of acute abdominal pain. MR is the preferred option to CT in patients of an age prone to radiation with a potential surgical diagnosis. Clinical relevance/application: MRI in acute abdominal imaging is both effective and practical and is the preferred imaging option in patients of an age prone to radiation with a potential surgical diagnosis.
    No preview · Article · Nov 2015 · European journal of radiology
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    ABSTRACT: Purpose: To compare radiation dose, image quality and diagnostic performance of low dose CT enterography (CTE) protocol combined with iterative reconstruction algorithm (iDose(4)) with standard dose CTE in follow-up of patients with known Crohn's disease (CD). Materials and method: Thirty-six patients (12 females), with CD underwent a low-dose CTE scan during single venous phase on 256 MDCT scanner, with the following parameters: 120kV, automated mAs dose-modulation, slice thickness 2mm and iDose(4) iterative reconstruction algorithm. A control group of thirty-seven patients underwent standard dose CTE examination on the same CT scanner. Two radiologists, blinded to clinical and pathological findings, independently evaluated in each scan, HU values in bowel wall and any presence of CD activity features and disease complications. Image noise and diagnostic quality were evaluated using a 4-point scale. Dose-length product (DLP) and CT-dose-index (CTDI) were recorded and data from both examinations were compared and statistically analyzed. Results: Low-dose CTE protocol showed high diagnostic quality in assessment of Crohn's disease obtaining significantly (p≤0.001) lower values of DLP and CTDI (604.98mGy*cm and 12.29mGy) as compared to standard dose examinations (974.85mGy*cm and 19.71mGy), with an overall dose reduction of 37.6%. Noise resulted slightly higher in iDose(4) images (SD=15.97) than in standard dose ones (SD=13.61) but this difference was not statistically significant (p=0.064). Conclusion: Low-dose CTE combined with iDose(4) reconstruction algorithm offers high quality images with significant reduction of radiation dose, and therefore can be considered a useful tool in the management of CD patients, considering their young age and the frequent imaging follow-up required.
    No preview · Article · Nov 2015 · European journal of radiology
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    ABSTRACT: Purpose: The lower limb misalignment as calculated by radiography has an evident effect on the development and progression of knee osteoarthritis (OA). However, whether the knee malalignment has an influence on ankle alignment is unknown. The purpose of this study was to discuss the correlation between knee and ankle alignment in varus and valgus gonarthrosis. Methods: This is a retrospective study of 149 patients with symptomatic varus and valgus knee OA who intend to take total knee arthroplasty (TKA) between January and October 2013. A protocol for the measurement of knee-ankle alignment and angles on full-length standing anteroposterior radiographs of the lower extremity was outlined in detail with step-by-step instructions. Two observers measured the angles chosen. The Pearson's correlation tests were used for the statistical analysis. Results: Pearson's correlation test results for unilateral varus or valgus gonarthrosis showed that the varus or valgus deformity of the knee can influence the tilt angle and tibiotalar angle of the ankle in operative side signficantly(p<0.05), and the tilt angle of the ankle can also be affected in nonoperative side (p<0.05). Moreover, the tilt angle of the bilateral ankle can be simultaneously affected in bilateral varus gonarthrosis (p<0.05). Conclusion: These findings suggest that the varus and valgus deformity of the knee can induce the tilt of the ankle and influence the ankle alignment, which may further accelerate the degeneration of the ankle. Moreover, the knee alignment in the nonoperative side can also result in the change of ankle alignment at the same time.
    No preview · Article · Nov 2015 · European journal of radiology
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    ABSTRACT: Objective: To retrospectively determine the effect of an arm traction device on image quality and radiation exposure during a neck computed tomography (CT) scan. Materials and methods: Standard neck CT examinations with an automatic tube current modulation technique were compared for two groups (intervention group: patients with an arm traction device, n=45; control group: no particular positioning optimization, n=45). Image quality was the primary outcome and was assessed using image noise and the streak artifact. The secondary outcome was radiation exposure, which was measured by the volume CT dose index (CTDIvol) and dose-length product. Potential confounders, including the effective diameter of the neck and scan length, were also assessed. Results: Image noise and the streak artifact at the lower neck and the supraclavicular fossa were significantly improved in the intervention group compared with the control group (p<0.001). There was a significant decrease in the CTDIvol in the intervention group versus the control group (p=0.042). DLP showed a tendency toward a decrease in the intervention group that was non-significant (p=0.106). The effective diameter and scan length showed no statistical difference between the two groups. Conclusion: An arm traction device improves the image quality in the lower neck and the supraclavicular fossa during a neck CT. Application of this device also reduces the tendency for radiation exposure.
    No preview · Article · Nov 2015 · European journal of radiology
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    ABSTRACT: Purpose: The first aim was to compare Response Evaluation Criteria in Solid Tumor (RECIST) 1.1, modified Response Evaluation Criteria in Solid Tumor (mRECIST), Choi and European Association for the Study of the Liver (EASL) evaluations to assess the response to sorafenib for hepatocellular carcinoma (HCC). The second aim was to describe the evolution of HCC and to identify whether some imaging features are predictive of the absence of response. Materials and methods: This retrospective study included 60 patients with advanced HCC treated with sorafenib. Patients must have undergone a scan prior to treatment to identify the number of lesions, size, enhancement and endoportal invasions, and repeat scans thereafter. Computed tomography (CT) scans were analyzed using RECIST 1.1, mRECIST, Choi and EASL criteria. Overall survival was analyzed. Results: The median overall survival was 10.5 months. On the first CT reevaluation, the sorafenib response rates were 20%, 5%, 7% and 3% according to Choi, EASL, mRECIST and RECIST 1.1. The responders based on Choi exhibited significantly better overall survival compared with non-responders (20.4 months; hazard ratio (HR) 0.042, 95% confidence interval (CI): 0.186-0.94, p=0.035). A modification of imaging findings was observed in 48.3% of patients, and necrosis was present in 44.1% of patients. Conclusion: This study found a significant difference between Choi versus RECIST 1.1, mRECIST and EASL when evaluating the response to sorafenib in HCC patients.
    No preview · Article · Nov 2015 · European journal of radiology
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    ABSTRACT: Purpose: To assess differences in fat signal fraction (FSF) in skeletal muscle as determined by two-point Dixon technique at 3T before and after application of intravenous gadoterate meglumide (Gd-DOTA). Materials and methods: Eight patients (mean age, 50.8 years; range, 41-72 years) underwent clinical whole-body MRI at 3T for myopathic symptoms. Two-point Dixon technique based T1-weighted turbo spin-echo images were acquired before and after the administration of intravenous Gd-DOTA. On both image sets, the FSF was calculated in the gluteus medius, gluteus maximus, and quadriceps muscles bilaterally. Pre- and post-contrast FSF values were compared by linear regression, Bland-Altman plot as well as paired Student t-tests with Bonferroni correction. Results: The mean pre- and post-contrast FSF of included muscles were 28.7%±14.9% and 27.8%±15.1%, respectively. Linear regression indicated almost equivalent FSF estimation between pre- and post-contrast measurements (sum of squared residuals R(2), 0.92±0.04; slope, 0.97; X-intercept, -0.05; Y-intercept, +0.05). The Bland-Altman plot revealed a minimal systematical bias of the post-contrast FSF measurements of -0.87%. Paired Student t-tests did not reveal significant differences (overall p-value, 0.168). Conclusion: Gd-DOTA does not significantly influence FSF quantification in skeletal muscle based on the two-point Dixon technique at 3T.
    No preview · Article · Nov 2015 · European journal of radiology
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    ABSTRACT: Purpose: To evaluate the quantitative accuracy of dual-source computed tomography (DSCT) on measurements of pulmonary artery in pediatric patients with cyanotic congenital heart diseases (CCHDs) when compared with transthoracic echocardiography (TTE). Methods: Thirty-five patients (mean age: 27.88±28.27 months) with CCHDs underwent DSCT and TTE for evaluating the diameter of the main pulmonary artery (MPA), right pulmonary artery (RPA), and left pulmonary artery (LPA). Surgical measurements were obtained and served as the reference standard. The agreement was tested by linear regression analysis, Pearson's correlation coefficient, and Bland-Altman analysis. The intra- and extracardiac malformations were also observed. Results: There was a markedly positive correlation between DSCT and surgical measurements of the MPA, RPA, and LPA (r=0.95-0.97; all p<0.001), although the overestimation of the measurements of MPA, RPA, and LPA (bias 0.15±0.95, 0.31±0.63 and 0.35±0.68mm, respectively) was observed. However, there was a moderate correlation between TTE and surgical measurements of MPA, RPA, and LPA (r=0.61-0.84; all p<0.001), and the underestimation of the measurements of MPA, RPA, and LPA (bias-1.20±1.69, -1.80±1.77, and -1.50±2.30mm, respectively) was observed. In addition, DSCT was more efficient in finding associated malformations than TTE (40/40 vs. 33/40). Conclusions: As a reliable, noninvasive and radiation-save imaging modality, DSCT can provide more accurate pulmonary artery measurements than TTE in cardiac surgical procedures.
    No preview · Article · Nov 2015 · European journal of radiology
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    ABSTRACT: Purpose: To evaluate the diagnostic accuracy, subjective image quality, and interobserver agreement of non-contrast Controlled Aliasing In Parallel Imaging Results In Higher Acceleration (CAIPIRINHA) volumetric interpolated breath-hold examination (VIBE) 3T magnetic resonance imaging (MRI) for the detection of pulmonary nodules with intra-individual comparison to computed tomography (CT). Materials and methods: We evaluated 54 patients (27 male, 27 female; mean age, 60.8±11.5 years) who prospectively underwent thoracic 3T-MRI using CAIPIRINHA-VIBE sequences and chest CT. Diagnostic accuracy for the detection of lung nodules on CAIPIRINHA-VIBE MRI by three independent observers were compared to the reference standard CT. Subjective image quality was rated using a 5-point grading scale. Diagnostic accuracy was calculated and interobserver agreement was assessed using intraclass correlation coefficient (ICC). Results: Sensitivity of 3T-MRI for the detection of pulmonary lesions compared to CT was 88.1% (95% confidence interval [CI]: 0.81-0.93) and specifity was 79.1% (95% CI: 0.50-0.95). Sensitivity for lesions <5mm was 77.2% (95% CI: 0.59-0.90) and for lesions from 5 to 10mm was 87.2% (95% CI: 0.76-0.94). Sensitivity for lesions >10mm was 100%. Observer ratings regarding subjective image quality were good to excellent for 3T-MRI (1.54) and CT (1.14) with almost perfect interobserver agreement for 3T-MRI and CT (ICC=0.83, 95% CI: 0.78-0.89; ICC=0.89, 95% CI: 0.85-0.94). Conclusions: Non-contrast CAIPIRINHA-VIBE 3T-MRI allows for the reliable detection of pulmonary lesions with a diameter >5mm in comparison with chest CT with high diagnostic accuracy, subjective image quality, and interobserver agreement.
    No preview · Article · Nov 2015 · European journal of radiology
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    ABSTRACT: Purpose: Posteromedial olecranon impingement (PMOI) is the most common diagnosis in baseball players with throwing-induced elbow injuries. CT imaging manifestations of PMOI have seldom been previously reported. Our purpose is to investigate the additional value of CT imaging in the evaluation of PMOI. Materials and methods: From July 2010 to December 2013, 47 baseball players with throwing-induced elbow pain received imaging studies (CT and/or MRI) of the elbow at our institution. After retrospectively reviewing the clinical records and imaging studies, 31 of the 47 players were diagnosed with PMOI by the criteria of posteromedial elbow pain with clinical consistency for PMOI and characteristic osteoarthrosis at the posteromedial ulnotrochlear articulation (posteromedial olecranon space, PMOS) detected by CT and/or MRI. The imaging modalities of these 31 players including radiography, CT, and MRI were reviewed by 2 experienced musculoskeletal radiologists. Results: The most common imaging manifestations of PMOI by CT or MRI include joint space narrowing, subchondral sclerosis, and osteophytes at the PMOS. CT was superior to MRI with a statistically significant (P<0.05) difference in detecting joint space narrowing, medial olecranon subluxation, as well as the number of loose bodies. In contrast, bone marrow edema and associated soft tissue injuries in PMOI are more readily observed on MRI. Conclusions: CT is superior in identifying some imaging features of PMOI. Whenever PMOI is diagnosed in the pitching elbow of a baseball player, CT should be considered prior to surgical intervention as it will often provide additional information to the surgeon that may alter surgical management.
    No preview · Article · Nov 2015 · European journal of radiology
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    ABSTRACT: Purpose: To determine the capability and influence of the mathematical method on dynamic contrast-enhanced (CE-) perfusion area detector CT (ADCT) for early prediction of treatment response as well as progression free and overall survival (PFS and OS) of non-small cell lung cancer (NSCLC) patients treated with chemoradiotherapy. Materials and methods: Sixty-six consecutive stage III NSCLC patients underwent dynamic CE-perfusion ADCT examinations, chemoradiotherapy and follow-up examinations. Response Evaluation Criteria in Solid Tumors (RECIST) criteria were used to divide all patients into responders and non-responders. Differences in each of the indices for all targeted lesions between measurements obtained 2 weeks prior to the first and the third course of chemotherapy were determined for all patients. ROC analyses were employed to determine the capability of perfusion indices as markers for distinguishing RECIST responders from non-responders. To evaluate their capability for early prediction of therapeutic effect, OS of perfusion index-based responders and non-responders were compared by using the Kaplan-Meier method followed by log-rank test. Results: Area under the curve (Az) for total perfusion by means of the dual-input maximum slope method was significantly larger than that of pulmonary arterial perfusion using the same method (p=0.007) and of perfusion with the single-input maximum slope method (p=0.007). Mean OS demonstrated significantly difference between responder- and non-responder groups for total perfusion (p=0.02). Conclusion: Mathematical models have significant influence on assessment for early prediction of treatment response, disease progression and overall survival using dynamic CE-perfusion ADCT for NSCLC patients treated with chemoradiotherapy.
    No preview · Article · Nov 2015 · European journal of radiology
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    ABSTRACT: Purpose: To directly compare the capability of hybrid-type iterative reconstruction (i.e., adaptive iterative dose reduction using 3D processing: AIDR 3D) and filter back projection (FBP) for radiation dose reduction during dynamic contrast-enhanced (CE-) perfusion area-detector CT (ADCT) for lung and nodule perfusion assessment. Materials and methods: Thirty-six patients with lung cancers who underwent perfusion ADCT (SD-ADCT) at 120mA and were enrolled in this study. ADCT data at 80mA (reduced-dose ADCT: RD-ADCT), 60mA (low-dose ADCT: LD-ADCT) and 40mA (very low-dose ADCT: VLD-ADCT) were computationally simulated using SD-ADCT data, and reconstructed with and without AIDR 3D. Image noise and lung and nodule perfusion parameters were evaluated using ROI measurements. To determine the utility of AIDR 3D for dose reduction, image noise was compared between each protocol with and without AIDR 3D by means of the t-test. Correlations and limits of agreement for parameters obtained with SD-ADCT and other protocols were also evaluated. Results: Image noise of all protocols with AIDR 3D was significantly lower than that of LD-ADCT and VLD-ADCT without AIDR 3D (p<0.05). Significant correlations for image noise between SD-ADCT and all protocols with AIDR 3D (0.45≤r≤0.99, p<0.0001) were equal to or better than that without AIDR 3D (0.28≤r≤0.99, p<0.0001). The limits of agreement for perfusion parameters with AIDR 3D were smaller than those without AIDR 3D for each tube current. Conclusion: AIDR 3D is more effective than FBP for dose reduction of perfusion ADCT while maintaining image quality and reducing measurement errors.
    No preview · Article · Nov 2015 · European journal of radiology
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    ABSTRACT: Background: Two-dimensional (2DUS) contrast enhanced voiding urosonography has been used in the diagnosis and treatment monitoring of the vesicoureteral reflux in children for over 15 years. The opportunity of performing this examination with the use of three-dimensional static (3DUS) and real-time (4DUS) techniques opens up new diagnostic horizons. Objective: To analyze if 3DUS/4DUS bring additional information leading to an increased detection rate or change in the grading of reflux compared to 2DUS and voiding cystouretrography. Material and methods: We evaluated 69 patients (mean 4.1 years) who underwent 2DUS/3DUS/4DUS contrast enhanced voiding urosonography (ceVUS) and voiding cystourethrography (VCUG) for the diagnosis and grading of vesicoureteral reflux. Results: 2DUS and 3DUS/4DUS urosonography diagnosed 10 more refluxes (7.25%) than cystourethrography and in 3 refluxes (2.17%) detected a higher grade. In 9 refluxes (6.52%) 3DUS/4DUS urosonography and cystourethrography diagnosed a higher grade than 2DUS. There was a statistically significant difference between cystourethrography and 3DUS/4DUS urosonography when the number of detected refluxes and differences in grading were compared. 4DUS enabled a better visualization of reflux than 3DUS. Conclusions: 3DUS/4DUS techniques bring additional information leading to a change in reflux grading compared to 2DUS and a detect higher number of refluxes compared to cystourethrography.
    No preview · Article · Nov 2015 · European journal of radiology
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    ABSTRACT: Background and purpose: Crossed cerebellar diaschisis (CCD) is most commonly investigated using hemodynamic PET and SPECT imaging. However, noninvasive MRI offers advantages of improved spatial resolution, allowing hemodynamic changes to be compared directly with structural findings and without concerns related to ionizing radiation exposure. The aim of this study was to evaluate relationships between CCD identified from cerebral blood flow (CBF)-weighted arterial spin labeling (ASL) MRI with cerebrovascular reactivity (CVR)-weighted blood oxygenation level dependent (BOLD) MRI, Wallerian degeneration, clinical motor impairment, and corticospinal tract involvement. Methods: Subjects (n=74) enrolled in an ongoing observational stroke trial underwent CBF-weighted ASL and hypercapnic CVR-weighted BOLD MRI. Hemispheric asymmetry indices for basal cerebellar CBF, cerebellar CVR, and cerebral peduncular area were compared between subjects with unilateral supratentorial infarcts (n=18) and control subjects without infarcts (n=16). CCD required (1) supratentorial infarct and (2) asymmetric cerebellar CBF (>95% confidence interval relative to controls). Results: In CCD subjects (n=9), CVR (p=0.04) and cerebral peduncular area (p<0.01) were significantly asymmetric compared to controls. Compared to infarct subjects not meeting CCD criteria (n=9), CCD subjects had no difference in corticospinal tract location for infarct (p=1.0) or motor impairment (p=0.08). Conclusions: CCD correlated with cerebellar CVR asymmetry and Wallerian degeneration. These findings suggest that noninvasive MRI may be a useful alternative to PET or SPECT to study structural correlates and clinical consequences of CCD following supratentorial stroke.
    No preview · Article · Nov 2015 · European journal of radiology