Journal of Digestive Diseases

Publisher: Chinese Society of Gastroenterology, Wiley

Current impact factor: 1.96

Impact Factor Rankings

2016 Impact Factor Available summer 2017
2014 / 2015 Impact Factor 1.959
2013 Impact Factor 1.924
2012 Impact Factor 1.853
2011 Impact Factor 1.589
2010 Impact Factor 1.87
2009 Impact Factor 1.791

Impact factor over time

Impact factor
Year

Additional details

5-year impact 2.07
Cited half-life 3.40
Immediacy index 0.22
Eigenfactor 0.00
Article influence 0.51
Other titles Journal of digestive diseases (Online)
ISSN 1751-2980
OCLC 123124871
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

Wiley

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    • If OnlineOpen is available, AHRC and ESRC authors, may self-archive after 24 months
    • Publisher last contacted on 07/08/2014
    • This policy is an exception to the default policies of 'Wiley'
  • Classification
    yellow

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: The ingestion of foreign bodies is a common emergency in clinical practice, representing about 4% of all emergency endoscopies. If not treated promptly, ingested foreign bodies may cause serious complications, even result in death. Currently, the international guidelines and consensuses on the management of foreign bodies in the upper gastrointestinal tract mainly include Management of ingested foreign bodies and food impactions by the American Society for Gastrointestinal Endoscopy (ASGE), Management of ingested foreign bodies in children: a clinical report of the NASPGHAN Endoscopy Committee by the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN), Pediatric button battery injuries: 2013 task force update by the American Broncho-Esophagological Association (ABEA); Management of ingested magnets in children by the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and NASPGHAN; and Clinical guidelines for imaging and reporting ingested foreign bodies by the American Roentgen Ray Society (ARRS). But no guideline or consensus on the endoscopic management of foreign bodies in the upper gastrointestinal tract is available in China. Thus, the Chinese Society of Digestive Endoscopy has led and organized experts from various disciplines, including gastroenterology, digestive endoscopy, thoracic surgery, gastrointestinal surgery, otorhinolaryngology, emergency medicine, pediatrics, and radiology, to co-develop this consensus based on the current status of management for upper gastrointestinal foreign bodies in China, with reference to the latest international guidelines and consensuses. This article is protected by copyright. All rights reserved.
    No preview · Article · Jan 2016 · Journal of Digestive Diseases
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    ABSTRACT: Objectives: To determine the impact of the Asia-Pacific guidelines on gastric cancer prevention and Helicobacter pylori infection on clinical practice. Methods: An electronic survey was carried out among Asian Pacific Digestive Week (APDW) medical delegates in 2012. The survey questionnaire captured details such as demographic data, awareness of the guidelines, knowledge of the key guideline recommendations, impact of the guidelines on individual practice and on national policies, and sources of medical information which the individual used to make clinical decisions. A total of 1372 APDW medical delegates were invited via e-mail to participate in the electronic survey and 432 (31.5%) responded. Results: Among the respondents, 57.6% were familiar with at least one of the guidelines. Among those familiar with the guidelines, 85.9% felt that there was an influence on their clinical practice. More than half (64.9%) reported that the guidelines clarified treatment indications for them. In terms of knowledge content, 85% of the participants provided correct responses to at least 4 of the 6 questions on understanding. More than half of the participants (52.7%) felt that the guidelines had an impact on national policies. Conclusion: The Asia-Pacific guidelines on gastric cancer and H pylori had a positive impact on individual clinical practice and national policies.
    No preview · Article · Jan 2016 · Journal of Digestive Diseases
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    ABSTRACT: Aim: Robot-assisted surgery has been reported to be a safe and effective alternative to conventional laparoscopy to treat patients with rectal cancer in a minimally invasive manner. Never the less, substantial data concerning functional outcomes and long term oncological adequacy are still lacking. We aimed to assess the current role of robotics in rectal surgery focusing on functional and oncological outcomes. Methods: A comprehensive review of the English-language literature was conducted for articles dealing with robotic-assisted rectal resections. All relevant papers were evaluated on functional implications such as postoperative sexual and urinary dysfunction and oncological outcomes. Results: Robotics showed a general trend toward lower rates of sexual and urinary postoperative dysfunction and earlier recovery compared to laparoscopy. The rates of 3-year local recurrence, disease free survival and overall survival compare favourably with those of laparoscopy. Conclusions: At present, the literature fails to provide solid evidence to draw definitive conclusions on whether robotic systems could be useful in ameliorating the outcomes of minimally invasive surgery for rectal cancer. However, the available data suggest potential advantages over conventional laparoscopy with reference to functional outcomes.
    No preview · Article · Jan 2016 · Journal of Digestive Diseases
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    ABSTRACT: Aim: Due to high sustained virologic response rates(SVR), sofosbuvir based regimens are currently a mainstay for hepatitis C virus(HCV) therapies. Addition of pegylated-interferon(peginterferon) and ribavirin impact patients' quality of life during treatment. This study compared severe adverse events(SAE) amongst therapeutic combinations for HCV in a community clinic setting. Methods: Beginning in December 2013 to July 2014, 128 chronic HCV patients were treated with sofosbuvir based therapies, which included sofosbuvir, ribavirin and weekly peginterferon for 12 weeks(cohort 1), 12 or 24 weeks of sofosbuvir and ribavirin(cohorts 2 and 3), or sofosbuvir plus simeprevir for 12 weeks(cohort 4). Clinical and laboratory adverse events were recorded from baseline through 12 or 24 weeks of treatment. Results: Severe adverse events appeared in 16-54% of ribavirin-inclusive treated patients compared to 5% in the ribavirin-free regimen. Peginterferon, sofosbuvir plus ribavirin had the highest frequencies of fatigue, headache and rash compared to either 12 or 24 weeks of ribavirin and sofosbuvir(p=0.011-0.018). However, sofosbuvir and ribavirin regimens led to a significant increase in dyspnea, need for ribavirin dose reductions and withdrawal from treatments due to SAEs. Anemia also was more frequent in ribavirin-inclusive combinations(p<0.001). Conversely, sofosbuvir plus simeprevir reached similar SVR rates at week 12 post-treatment compared to all ribavirin containing regimens, but with significantly fewer adverse events(p=0.006). At post treatment week 12, 13 of 34(38.2%) of cirrhosis patients experienced virologic relapse compared to 13 of 83(15.7%) of non-cirrhosis patients(p=0.019). Conclusions: Ribavirin-inclusive HCV therapies increased the frequencies of SAEs resulting in higher dropout rates and increased patient morbidity.
    No preview · Article · Jan 2016 · Journal of Digestive Diseases
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    ABSTRACT: A 21 year old female with a past medical history significant for borderline personality disorder and multiple foreign body ingestions, presented to the emergency department from a psychiatric unit after she intentionally ingested a ball point pen. She was found to be hemodynamically stable with a benign abdominal exam. An abdominal x-ray showed a pen lodged in the stomach. Using a novel dual snare technique, the foreign body was removed rapidly and safely in its entirety using a regular single-channel esophagogastroduodenoscope. Due to associated complications, long and sharp foreign objects require removal, often involving specialized equipment and/or excessive time and effort. This case demonstrates a dual snare technique using a single channel endoscope that enables easy and safe removal of long sharp foreign objects, does not require any special equipment, and can be adapted to introduce many devices external to the endoscope into the esophagus or stomach.
    No preview · Article · Jan 2016 · Journal of Digestive Diseases
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    ABSTRACT: We report three cases of mass-forming type 1 autoimmune pancreatitis that were preoperatively suspected to be pancreatic cancer and review their clinicopathological features. Radiological findings in the present cases revealed hypoattenuating masses in the early phase or stricture of the main pancreatic duct with upstream dilatation, which is consistent with pancreatic cancer. Histopathologically, the lesions were well demarcated and met all diagnostic criteria for IgG4-related autoimmune pancreatitis, including the presence of periductal lymphoplasmacytic infiltrate, obliterative phlebitis, storiform fibrosis, and abundant IgG4-positive plasma cells. However, the adjacent uninvolved pancreatic duct and lobular structures were well preserved, and in all of the cases, none or some of the aforementioned criteria were observed. We suggest that some cases of focal autoimmune pancreatitis may progress to more severe grades and exhibit mass formation, despite remaining localized. These focal cases of autoimmune pancreatitis are difficult to distinguish from pancreatic cancer. To our knowledge, this report is the first to present a histopathological comparison of mass-forming autoimmune pancreatitis with corresponding uninvolved pancreatic tissue.
    No preview · Article · Jan 2016 · Journal of Digestive Diseases
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    ABSTRACT: Background and aim: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal system. HAO472 is a novel water-soluble synthetic derivative of oridonin, which exerts potent antitumor and anti-inflammatory effects. Methods: To confirm the potential of HAO472 as a drug against IBD, we investigated the modulatory functions of HAO472 in a mouse model of trinitrobenzene sulfonic acid (TNBS)- induced colitis. Results: HAO472 significantly ameliorated the clinical symptoms, reduced the inflammation severity, and decreased mortality in the mouse model. HAO472 also reduced TNF-α/IL-17A/IFN-γ secretion, iNOS/COX-2 expression,and lymphocyte proliferation. These changes were associated with a significant decrease of nuclear factor-kappa B (NF-κB) p65 expression and activity. Conclusions: HAO472 demonstrated positive effects onTNBS-induced colitis by modulating the subsets and functions of lymphocytes, suppressing inflammation, and inhibiting the nuclear translocation of NF-κB p65 subunits.
    No preview · Article · Dec 2015 · Journal of Digestive Diseases
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    ABSTRACT: Aim: Endoscopic transpapillary brush cytology and forceps biopsy are used widely for the pathological diagnosis of malignant biliary strictures (MBS). However, the diagnostic yield remains unclear because of the wide variation in reported values, and predictive factors for a positive diagnosis using these methods have not been established. We aimed to clarify the diagnostic yields of the two methods and predictive factors for a positive diagnosis. Methods: We reviewed 241 patients with biliary strictures who underwent transpapillary brush cytology (n=202) and/or forceps biopsy (n=208) between 2004 and 2014 at a single academic center. Results: The sensitivity of forceps biopsy for MBS was significantly higher than that of brush cytology (60.6% [97/160] vs. 36.1% [57/158]; P<0.001). The sensitivity of forceps biopsy was significantly higher in bile duct cancer than pancreatic cancer (82.0% [50/61] vs. 42.4% [28/66]; P<0.001). Multivariate analysis revealed that a serum total bilirubin level (T-Bil) ≥ 4 mg/dL (OR: 2.51, 95% CI: 1.14-5.50; p=0.022) was a significant independent predictive factor for a positive diagnosis by brush cytology, and bile duct cancer (OR: 4.93, 95% CI: 2.18-11.11; p<0.001), length of stricture ≥ 30 mm (OR: 2.94, 95% CI: 1.12-7.75; p=0.029), and T-Bil ≥ 4 mg/dL (OR: 2.25, 95% CI: 1.05-4.83; p=0.037) were significant indicators of a positive diagnosis by forceps biopsy. Conclusions: Endoscopic transpapillary forceps biopsy showed higher sensitivity than that of brush cytology for MBS. Bile duct cancer, length of stricture ≥ 30 mm and T-Bil ≥ 4 mg/dL are good indicators of a forceps biopsy. This article is protected by copyright. All rights reserved.
    No preview · Article · Dec 2015 · Journal of Digestive Diseases
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    ABSTRACT: Objective: To investigate the accuracy of cytological Ki-67 index in identifying intermediate and high-grade pancreatic neuroendocrine tumors from low-grade ones. Methods: Two investigators independently searched databases to identify eligible studies, and meta-analysis was performed to calculate the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio. Results: A total of 241 lesions from 11 studies were included. The pooled sensitivity and specificity of Ki-67 (cut-off value: 2%) in the differential diagnosis between intermediate and high-grade pancreatic neuroendocrine tumors and low-grade ones were 66% and 85% respectively. The pooled positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio were 3.71, 0.46 and 10.93, respectively. The area under the summary receiver operating characteristic curve was 0.842. When 5% was set as the cut-off value, the sensitivity and specificity were increased up to 74% and 93%, with the area under curve being improved to 0.954. Conclusion: Ki-67 cytological index is of great help in distinguishing intermediate and high-grade pancreatic neuroendocrine tumors from low-grade ones, and 5% might be a better cut-off value than 2%. This article is protected by copyright. All rights reserved.
    No preview · Article · Dec 2015 · Journal of Digestive Diseases
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    ABSTRACT: Objective: This cross-sectional study was undertaken to assess the association between spicy foods consumption and chronic uninvestigated dyspepsia (CUD) in a large sample of Iranian adults. Subjects: In this cross-sectional study, we assessed spicy foods consumption of 4763 Iranian adults living in Isfahan province using a dietary habit questionnaire. A modified validated version of the Rome III questionnaire was used to assess CUD-related symptoms. CUD was defined as having one or more of the following characteristics: bothersome postprandial fullness, early satiation and/or epigastric pain or epigastric burning at least often in the past 3 months. Information on meal regularity, meal frequency, intra-meal fluid drinking as well as other potential confounders was also collected. Results: CUD was prevalent in 15.3% (n=703) of participants. Frequent consumption of spicy foods (≥10 times/week) was associated with greater odds of having CUD (OR: 1.64; 95% CI: 1.09-2.49). This relationship was significant even after adjustment for diet-related practices and body mass index (OR: 1.66; 95% CI: 1.00-2.78). There was a significant positive association between spicy foods consumption and postprandial fullness (OR: 1.76; 95% CI: 1.29-2.40) and epigastric pain (OR: 1.78; 95% CI: 1.30-2.44). However, no significant relationship was observed between frequent spicy food consumption and early satiation. Conclusion: High consumption of spicy foods was associated with greater odds of CUD, frequent postprandial fullness and epigastric pain. Further studies, particularly of prospective nature, are needed to confirm our findings. This article is protected by copyright. All rights reserved.
    No preview · Article · Dec 2015 · Journal of Digestive Diseases
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    ABSTRACT: Drug-induced liver injury is a cause of liver disease with relative high level of morbidity and mortality. The early diagnosis is vital yet the problem remains challenging. In the absence of specific markers or tests, the diagnosis is carried out by exclusion. Steroids are usually safe drugs with regard to hepatotoxicity; moreover, they are the treatment of choice for autoimmune hepatitis. Although methylprednisolone-induced hepatotoxicity is rarely reported, it may cause severe liver injury. A timely recognition of this complication and early drug withdrawal may prevent the progression of the hepatic injury. We report a case of high-dose methylprednisolone -induced acute hepatitis and unintentional re-challenge test in a patient with multiple sclerosis and review the relevant literature. This article is protected by copyright. All rights reserved.
    No preview · Article · Dec 2015 · Journal of Digestive Diseases
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    ABSTRACT: Aim: The literature regarding clinical course of symptomatic terminal ileitis(TI) is scarce and treatment guidelines are lacking. We aimed at follow-up of a cohort of symptomatic TI patients to define an algorithm for their management. Methods: Consecutive patients with endoscopically diagnosed TI from July 2007-October 2013 were included. TI was defined as isolated involvement of terminal ileum in form of ulcers(superficial or deep) and/or nodularity without involvement of ileocaecal valve/colon. Patients were either diagnosed with Intestinal tuberculosis(ITB) or Crohn's disease(CD) (based upon standard criteria) or received only symptomatic treatment according to clinical, endoscopic, imaging and histologic(specific to ITB/CD vs non-specific) features. Based upon above findings, an algorithm was developed to differentiate non-specific terminal ileal ulcer from specific aetiology(ITB/CD). Results: Sixty three of 898(7%) patients with ulcero-constrictive intestinal disease had TI; 18 were lost to follow-up or had follow up <6 months(mean age:34.3+13.8 years, 26 males, median follow-up:14(IQR,7-27)months). Overall 31/45 patients had CD/ITB and 14 received symptomatic treatment. Significantly more patients with ITB/CD had fever, diarrhoea, weight loss, deep ulcers, ileal thickening, and either of fever/diarrhoea/GI bleed/weight loss than symptomatically treated patients. All patients with deep ulcers (n=8) and 5/6 patients with superficial ulcer and specific histology had ITB/CD. In patients with superficial ulcers/nodularity and non-specific inflammation (n=31), absence of fever/diarrhoea/GI bleed/weight loss had a negative predictive value of 91.6% in excluding ITB/CD. Conclusions: In symptomatic TI patients with superficial ulcers and non-specific histology, absence of fever/diarrhoea/GI bleed/weight loss, rules out the possibility of significant diagnoses like ITB/CD. This article is protected by copyright. All rights reserved.
    No preview · Article · Dec 2015 · Journal of Digestive Diseases
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    ABSTRACT: Lgr5 marks stem cells in digestive epithelial tissues by Lineage tracing, and in vitro ever-expansion of Lgr5 stem cells can form organoids, which can be directed to differentiate into functional somatic cells. Organoids derived from gastrointestinal epithelium even recapitulate the morphologic features of their in vivo counterpart. Culture conditions are also modified to establish cancer organoids from individual patients. With great genetic stability during derivation and expansion, organoids retain either single mutation of patient with inherited disease or multiple mutations of cancer tissues. Together with efficient gene-editing protocol, organoids are emerging as powerful in vitro disease models. This article is protected by copyright. All rights reserved.
    No preview · Article · Dec 2015 · Journal of Digestive Diseases
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    ABSTRACT: Objective: To investigate abdominal distention and stress after colonoscopy without sedation. Methods: Two hundred-five patients underwent examinations without sedation using either carbon dioxide or air insufflations. Abdominal circumference and salivary amylase activities before and after colonoscopy were measured by nurses who were blinded to insufflations. Results: In all,102 and 103 patients were randomly recruited in the CO2 insufflation and air insufflation groups, respectively. Salivary amylase activities before and after colonoscopy were not significantly different between the two groups. Abdominal circumference immediately after examination and 15 min after the examination was significantly smaller in CO2 insufflation group than that in air insufflation group (81.2 cm vs 84.0 cm, and 79.7 cm vs 83.6 cm, respectively (P <0.05). The increasing ratio of abdominal girth immediately after colonoscopy was not significantly different between the two groups. However, the increasing ratio of abdominal circumference at 15 min after colonoscopy using CO2 insufflation was significantly lower than that in the air group (1.007 vs 1.028, P <0.001). Conclusion: Salivary amylase activities after unsedated colonoscopy using CO2 insufflation were not improved, however, CO2 insufflation decreases abdominal circumference after colonoscopy compared with air insufflations. This article is protected by copyright. All rights reserved.
    No preview · Article · Dec 2015 · Journal of Digestive Diseases
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    ABSTRACT: Aim: Midodrine was found to improve systemic and renal hemodynamics in patients with cirrhotic ascites. Recently, this discovery has received research interest. Clinical trials on midodrine for this indication have demonstrated conflicting results. The aim of this study is to evaluate the effects of midodrine on cirrhotic ascites through a meta-analysis and systematic review. Methods: We searched PubMed (January 1966 to December 2014), EMBASE (January 1966- December 2014), the Cochrane Library (Issue 11, 2014), ScienceDirect (January 1966- December 2014), and the China National Knowledge Infrastructure (January 1979- December 2014) using the search terms "midodrine", "cirrhosis", "ascites" and "paracentesis" and searched for all relevant randomized controlled trials using midodrine for treatment of cirrhotic ascites. Results: Ten trials with a total of 462 patients were included. As a novel therapy for cirrhotic ascites, midodrine was not found to improve survival (OR=0.81; 95%CI 0.23 to 2.91); on the other hand, it may improve response rates (OR=3.36; 95%CI 1.47 to 7.69) and reduce plasma renin activity (MD=-3.10; 95%CI -5.37 to -0.84). When midodrine was used as an alternative to albumin in large volume paracentesis, the mortality was higher for midodrine than for albumin (OR=10.76; 95%CI 1.35 to 85.97). However, midodrine and albumin were similarly associated with the development of paracentesis-induced circulatory dysfunction (OR=1.69; 95%CI 0.43 to 6.72). Conclusions: Based on the results of the meta-analysis, midodrine may have treatment effects on cirrhotic ascites. More adequately powered and well-designed trials are required to assess the extent of the efficacy of midodrine in specifically targeted patients. This article is protected by copyright. All rights reserved.
    No preview · Article · Dec 2015 · Journal of Digestive Diseases
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    ABSTRACT: Aim: Gastric cancer is etiologically related to interactions between Helicobacter pylori infection, environmental, and host factors. Gastric carcinoma is associated with a cascade of increasing atrophic gastric mucosal damage. Prostate stem cell antigen polymorphisms have been associated with an increased risk of gastric cancer. Here, we examined the interaction between prostate stem cell antigen polymorphisms and H. pylori in the progression of H. pylori gastritis. Methods: Prostate stem cell antigen polymorphisms (TT, TC and CC) among H. pylori infected and uninfected Bhutanese were compared with the severity of H. pylori gastritis (neutrophils, monocytes, atrophy scores, H. pylori density, and the presence and extent of intestinal metaplasia) using the updated Sydney system. Results: Biopsies from 339 patients were included. The proportion of biopsies with intestinal metaplasia was also significantly (P<0.05) greater among those with the TT genotype than with either the CT or CC genotype. Despite no significant differences in inflammation or H. pylori density scores, the scores for the premalignant condition, intestinal metaplasia in both the gastric corpus and antrum, among H. pylori infected with the TT genotype was significantly (P <0.05) greater than C allele carriers. Conclusions: Prostate stem cell antigen TT genotype was associated with more than a 3-fold increase in the prevalence and extent of gastric mucosal intestinal metaplasia compared to C allele carriers among H. pylori infected Bhutanese. This article is protected by copyright. All rights reserved.
    No preview · Article · Dec 2015 · Journal of Digestive Diseases
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    ABSTRACT: Early diagnosis of colorectal cancer (CRC) would bring timely treatment and lessen the mortality. DNA methylation is assumed to be an early event in tumorigenesis and has therefore been proposed as a potential marker for early cancer detection. Accumulating evidence indicated that DNA methylation markers in the stool and blood samples would provide a minimally invasive tool for CRC screening. In addition, certain genes were more likely to have hypermethylated CpG islands in metastatic CRC patients, which may serve as prognosis markers and relapse predictors. Several commercial methylation markers have been launched in the past few years, exhibiting an attractive application prospect. Here, we will review the noninvasive methylation biomarkers used in the screening of CRC systematically, discuss the advantages of methylation assays in different remote media, including blood, stool, as well as bowel lavage fluid, and make comparison with FOBT and CEA tests. Multitarget DNA assays with combination of different methylated genes, have shown the improvement in diagnostic sensitivity. It would be very meaningful to conduct multi-center, large sample studies evaluating those methylated DNA markers systematically in the future.
    No preview · Article · Nov 2015 · Journal of Digestive Diseases
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    ABSTRACT: Objective: Pancreatic duct guidewire placement (PDGP) techniques include double guidewire technique (DGT) and trans-pancreatic sphincterotomy (TPS). DGT can be switched to TPS with ease due to the existing guidewire in the pancreatic duct. We combined DGT and TPS as a single technique, named sequential PDGP, and compared the performance of this technique with needle knife precut sphincterotomy (NKPS) in cases of difficult biliary cannulation. Methods: A total of 83 patients with difficult biliary cannulation from 1645 eligible patients were enrolled in a single endoscopy center. 63 patients underwent sequential PDGP and 20 patients underwent NKPS. Cannulation success rate, cannulation time, and ERCP-related complications were compared between the two groups. All data were recorded prospectively. Results: Successful biliary cannulation was achieved in 56 of 63 (88.9%) patients in the sequential PDGP group compared with 14 of 20 (70.0%) patients in the NKPS group (P = 0.095). Cannulation time was 7.49 ± 5.03 min in the sequential PDGP group and 10.60 ± 7.24 min in the NKPS group (P = 0.086). The incidence of post-ERCP pancreatitis was 12.7% in the sequential PDGP group and 10.0% in the NKPS group (P = 1.000). There was no significant difference in the rate of other complications (bleeding, perforation, and cholangitis) between two groups. Conclusions: Sequential PDGP is a safe and effective alternative method to NKPS in cases of difficult biliary cannulation. In patients with failed standard cannulation, sequential PDGP can be considered if the guidewire is inadvertently inserted into the pancreatic duct or can be placed in the pancreatic duct without difficulty.
    No preview · Article · Nov 2015 · Journal of Digestive Diseases
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    ABSTRACT: Inflammatory bowel disease is a chronic immune-mediated disorder of the gastrointestinal tract. It is often the result of the interaction of genetic and environmental factors. The role of endoscopy in disease surveillance is unprecedented. However, there is considerable debate in therapeutic goals in IBD patients, ranging from the resolution of clinical symptoms to mucosal healing. Furthermore, deep remission has recently been advocated for altering disease course in these patients. Additionally, neoplasia continues to be a significant cause of morbidity and mortality in IBD patients. This review discussed the role of several endoscopic techniques in assessing mucosal healing and neoplasia with emphasis on novel non-invasive endoscopic techniques. This article is protected by copyright. All rights reserved.
    No preview · Article · Nov 2015 · Journal of Digestive Diseases