Journal of Medical Sciences(Faisalabad) (J Med Sci)
Journal of Medical Sciences is a clinical-medicine oriented and internationally disseminated publication, the aim of which is to provide a medium of communication for physicians in the world's scientific community. The Journal will welcome original clinical research experience on prevalent diseases in the region, and analysis of various regional parameters which may modulate the incidence, course and management of disease and relevant medical problems.
Journal Impact: 0.36*
Journal impact history
|2016 Journal impact||Available summer 2017|
|2015 Journal impact||0.36|
|2014 Journal impact||0.38|
|2013 Journal impact||0.31|
|2012 Journal impact||0.61|
|2011 Journal impact||0.58|
|2010 Journal impact||0.24|
|2009 Journal impact||0.17|
|2008 Journal impact||0.13|
|2007 Journal impact||0.13|
|2006 Journal impact||0.08|
|2003 Journal impact||0.08|
|2002 Journal impact||0.08|
Journal impact over time
|Website||Journal of Medical Sciences website|
|Document type||Journal / Magazine / Newspaper, Computer File|
Publications in this journal
- [Show abstract] [Hide abstract] ABSTRACT: Administration of valporic acid, the most common medication prescribed against epilepsy produces many metabolic and morphological aberrations in liver due to the fact that liver is the main detoxifying site for these antiepileptic drugs. This experimental work was done for study of the prophylactic role of silymarin and vitamin E in hepatotoxic induced by valporic acid in albino rats. Fifty adult male albino rats weighting 150-200 g were divided into five equal groups, one control and the other four for the drugs. Group I control group is subdivided into two subgroups (IA, IB). Group II ingested valporic acid, group III ingested valporic acid+silymarin, group IV ingested valporic acid+vitamine E and finally group V ingested valporic acid+both drugs, the ingestion was done through orogastric tube for four week. After four weeks biochemical studies (ALT, AST and total bilirubin) were done for all rats in all groups, then the rats were sacrificed and histopathological studies were done for their livers. Biochemical analysis revealed significant increased in AST, ALT and total bilirubin in the group II, III, IV and V in comparison with control groups and revealed significant decrease in the group III, IV and V in comparison with group II. Histopathological examination of the group II revealed necro-inflammatory foci with infiltration of the hepatic lobules with inflammatory cells and inflammation in the portal tract. Histopathological examination of the liver section of group III, IV and V showed mild necrosis and inflammation in hepatic lobules and showedmild inflammation in the portal tract. The liver is highly affected by ingestion of valporic acid. However, ingestion of silymarin and/or vitamine E that is naturally occurring antioxidants can decrease this harmful effect of these drugs on the liver. Therefore, the patient on chronic use of valporic acid must use silymarin and/or vitamin E to protect their livers. © 2014, Asian Network for Scientific Information. All Rights Reserved.
- [Show abstract] [Hide abstract] ABSTRACT: In recent years, pericarp (peel) of Garcinia mangostana (known as mangosteen) has been used as a traditional medicine for the treatment of oral malodor, mouth apthae and chronic ulcer or as anti-inflammatory agent and antibacterial substances. This study was conducted to investigate the effect of immersion in pericarp of G. mangostana solution on tooth surface color. Fifteen premolar teeth were immersed in 1, 2 and 3% pericarp of G. mangostana solution (n = 5). Duration of immersion was 60 min (equal to 1 min day-1 gargling for 2 months), 120 min (equal to 4 month gargling) and 180 min (equal to 6-month gargling). The specimen's color were measured with CIEL*a*b* method (intraoral spectrophotometer, Vita Easyshade, USA). There were significant changes of lightness (L*) and redness (a*) of specimen after immersion in 1, 2 and 3% solution of G. mangostana pericarp for more than 60 min (p>0.05). The tooth color change (AE) was clinically perceptible and beyond clinical tolerance (AE>3.50) in all immersion time. It was concluded that G. mangostana solution can affect tooth color and was clinically unacceptable. The highest color change was in group that immersed on 2% mangosteen solution for 180 min (AE = 20.35), it was equal to gargling for 6 months/day/minutes. © 2014, Asian Network for Scientific Information. All Rights Reserved.
- [Show abstract] [Hide abstract] ABSTRACT: To evaluate the effect of timolol 0.1% gel and latanoprost 0.005% on myopic regression after myopic LASIK surgery in comparison to artificial tears as placebo. The study included 90 patients with mean age of 25.7±5.7 years; 12 patients had bilateral LASIK and both eyes were included in the study. All patients underwent complete ophthalmologic examination for determination of uncorrected and corrected distant visual acuity (UDVA and CDVA), intraocular pressure (TOP), Schrimertest, central corneal pachymetry andcorneal topography. These parameters were evaluated at time of inclusion and 3-monthly for 12 months. The percentage of change at the 12th month in comparison to the baseline measures, was calculated for assurance of randomization and accurate evaluation of outcome. Patients were randomly allocated into 3 equal groups: Control group received artificial tears; Timolol group received timolol maleate 0.1% gel once daily and Prostaglandin (PG) group received latanoprost 0.005% eye drops once daily. Topical therapy significantly improved UCDVA and CDVA at the end of follow-up period compared to control group and to their respective baseline measures with significantly higher percentage of improvement in timolol group compared to PG group. Control eyes showed non-significant deterioration of spherical error evaluation and extent of astigmatism at the end of follow-up compared to baseline measures, while both modalities of topical therapy significantly improved it compared to their respective preoperative measures and to control group. Timolol also, significantly improved extent of astigmatism compared to PG. The percentage of increase of corneal thickness and percentage of decrease of corneal diopter were significantly greater in control group compared to study groups. Topical therapy significantly reduced IOP in comparison to their respective pre-treatment IOP and to control group with non-significant difference between both groups. IOP lowering therapy is beneficial for amelioration of myopic regression after LASIK surgery manifested as improvement of DVA and lessening of spherical errors. Timolol 0.1% gel provided more efficient outcome compared to PG analogue and could be advocated for postoperative use. © 2014, Asian Network for Scientific Information. All Rights Reserved.
- [Show abstract] [Hide abstract] ABSTRACT: The aim of this study was to estimate the prevalence of IgM anti-HAV in students aged from 6-12 years old in Damietta Governorate and to identify factors associated with the prevalence of this infection. The present study included 1000 children, aged 6-12 years; selected from pediatric outpatient clinic; regardless of their vaccination history. They were selected during the period from September 2012 to September 2014. The following data related to identification and socio-demographic characteristics were documented: The individual gender, age, residence, number of household members, number of rooms, number of people sleeping together in the same room, family income, educational level of parents or guardians, availability of piped water supply, presence of sewage and the existence and number of bathrooms in the house. Then IgG and IgM were estimated. Age ranged from 6 to 12 years with a mean of 8.87±1.95 years; 56.7% of cases were males, 66.4% live in rural areas, 46.5% of cases were of low socioeconomic standard and 24.2% of middle standard; previous vaccination was reported in 2.7% of cases, active infection reported in 1.9% cases and previous (old) infection or vaccination was reported in 86.5% of cases. Finally, ALT cases ranged from 8-65 IUmL-1 with a mean of 12.53±5.40 IUmL-1 and AST ranged from 8-29 with a mean of 12.07±2.56 IU mL-1. Positive cases were younger (7.94±2.09vs. 8.89±1.94, respectively); of low socioeconomic standards (37.7%), had significantly higher ALT and AST. No case of actively infected group had previous vaccination or old infection. In old infection or vaccination, there was no significant difference between positive and negative cases as regard to age, gender or socioeconomic status. However, there was significant increase of previous vaccination in positive cases (3.1%) when compared to negative cases (0.0%) and significant increase of positive IgM in negative IgG cases. In addition, there was significant increase of liver enzymes in cases negative for IgG when compared to positive cases. There was highendemicity of hepatitis A virus infection in school age children. The active infection reported inminor percentage and the condition was self-limiting. Thus, most positive cases were not vaccinated or had active clinical infection. Seroconversion is due to subclinical infection. Thus, IgG and IgM estimation must be done before vaccination. © 2014, Asian Network for Scientific Information. All Rights Reserved.
- [Show abstract] [Hide abstract] ABSTRACT: Cancer is perceived as a disease of unregulated communication within cells of the body. Currently chemotherapy, radiation therapy, immunotherapy, photodynamic therapy, hormonal therapy and surgery have been used for cancer treatment. The therapeutic success rate for cancer can be tremendously improved by use of natural products such as Catharanthus roseus, Curcuma longa, Taxus bravifolia, Camptotheca acuminate etc. Boswellic acids are bioactive pentacyclic triterpenes derived from natural plant source (Boswellia serrata) represents one of the most promising anticancer agent. Various anticancer research studies and published data reported on safety of Boswellia serrata showed that boswellic acids can be used for treatment of colon cancer, pancreatic cancer, brain tumor, leukemia and prostate cancer etc. An attempt has been made in this review to highlight the treatment therapies, different Boswellia species, structural composition and role of boswellic acids in cancer therapy, safety/toxicological profile and interactions of boswellic acids. © 2014, Asian Network for Scientific Information. All Rights Reserved.
- [Show abstract] [Hide abstract] ABSTRACT: Demodex mites are commensals of the pilosebaceous unit in human. This study aimed to investigate possible association ofDemodex folliculorum with Basal Cell Carcinoma (BCC), Squamous Cell Carcinoma (SCC), melanoma, Discoid Lupus Erythematosus (DLE) and rosacea. In this case-control study, standardized skin surface biopsy samples were obtained from the cheeks of healthy individuals (n = 28); patients with BCC (n = 18), SCC (n = 13) and melanoma (n = 11) and patients with DLE (n = 28) and inflammatory rosacea (n = 34). Mite density (cm-2) and the rate of infestation (density >5) were compared. The rate of mite infestation (%) was comparable between the controls (21.4) and the patients with BCC (22.2, p = 0.95), SCC (18.8, p = 0.83), melanoma (9.1, p = 0.37) and DLE (17.9, p = 0.74). Infestation was significantly more frequent in the rosacea group (47.1, p = 0.04) than in the controls. While, the mean mite density (cm-2) was comparable between the control (4.07±2.06) and the groups with BCC (5.01±2.08,p= 0.68), SCC(3.17±1.29,p = 0.49)andDLE(3.26±1.04,p = 0.91); it was significantly higher in the group of rosacea (8.56±3.29, p = 0.03) and lower in the group of melanoma (1.45±0.58, p = 0.04) in comparison with the normal group. In conclusion, although Demodex folliculorum does not seem to play a role in the pathogenesis of BCC, SCC and DLE, it is apparently associated with rosacea and melanoma.
- [Show abstract] [Hide abstract] ABSTRACT: Laminectomy is a surgical treatment for lumbar stenosis. In some patients, however, back pain may recur after this operation. This study was performed to determine underlying causes of recurrent back pain after laminectomy and examine the possibility of an association between axial rotation and segmental instability after laminectomy. A total of 35 patients with previous laminectomy with and without discectomy and recurrent back pain were recruited. Etiologies of recurrent back pain were investigated. An axially rotated lumbar vertebra was reported, when at extreme parasagittal sections the posterior borders of two successive vertebral bodies were not aligned. The frequency of this image finding was compared before and after laminectomy. An axially rotated lumbar vertebra was present in two patients before operation and in four patients after it. Only two new cases with axial vertebral rotation were identified after laminectomy (p = 0.50). The underlying causes of recurrent low back pain after laminectomy were disc reherniation (57.1%), spondylolisthesis (20%), scarring (8.6%), new axial rotation (5.7%), ligamentum flavum hypertrophy (5.7%) and diastematomyelia (2.9%). According to these findings, recurrent disc herniation and spondylolisthesis are two major causes of recurrent back pain after laminectomy. Axial lumbar vertebral rotation is not associated with instability.
- [Show abstract] [Hide abstract] ABSTRACT: Segmental instability is known as an underlying mechanism of degenerative vertebral and intervertebral disc changes. Based on a new finding an axially rotated lumbar vertebra may be occasionally spotted on lumbar magnetic resonance (MR) images obtained in non-weight-bearing position. This study was performed to examine the possibility of an association between this new finding and nerve root involvement in the lumbar spine. A total of 54 lumbar MR images of patients with signs of nerve root involvement in the lumbar spine were reviewed. An axially rotated lumbar vertebra was reported when at extreme parasagittal sections the posterior borders of two successive vertebral bodies were not aligned. Association of these rotations with radiculopathy and sensory/motor involvement in the corresponding regions in the lower extremity was examined. The mean pain severity was 7.59±2.10 (min-max: 3-10). There was a significant direct correlation between VAS and the linear amount of axial rotation (r = 0.73, p<0.001). There was also a significant, reverse correlation between the linear amount of axial rotation and the mean anteroposterior diameter of the neural foramen at the side of rotation (r = -0.91, p<0.001). Radiculopathy was concordant with axial rotation of the lumbar vertebrae in 88.9% of the cases. Both the linear amount of the axial vertebral rotation and anteroposterior diameter of the neural foramen were significantly associated with deficit in tactile sensation. Axial rotation of the lumbar vertebra is possibly an underlying cause of radiculopathy/back pain and sensory deficient in the lower extremities. This association is probably mediated with the involvement of neural elements in narrowed neural foramen at the side of rotation.
- [Show abstract] [Hide abstract] ABSTRACT: Essential hypertension is a multifactorial complex trait. It affects around one billion people worldwide. Many genes have been incriminated in its onset. This study aimed to determine the association of the AGT T174M gene variant with essential hypertension in a sample of Algerian population of the Oran city. In this study, we involved 350 subjects, 180 hypertensives and 170 normotensives. Consents were obtained from all the participated subjects. Polymerase Chain Reaction (PCR) combined with Restrictive Fragment Length Polymorphism (RFLP) was used to detect the T174M variant of angiotensinogen (AGT) gene. Blood pressure, body height and weight, fasting blood glucose and serum lipid were measured in all subjects. The genotypic and allelic distribution of the T174M variant of the AGT gene did not differ in hypertensives and normotensives group (OR = 1.05; 95% CI [0.583-1.932]; X² = 5.298; p>0.05; X² = 5.692; p>0.05), where the frequency of genotypes in the patient with essential hypertension was TT: 64.4%; TM: 20.5%; MM: 15% vs. TT: 55.8%; TM: 19.4%; MM: 24.7% for the controls. The allelic frequency was 0.7 vs. 0.66 for the T allele and 0.26 vs. 0.34 for the mutant allele in hypertensives and controls, respectively. This study shows that the T174M variant of the AGT gene is not associated with essential hypertension in this sample of Algerian population of the Oran city.
- [Show abstract] [Hide abstract] ABSTRACT: Now-a-days prostate cancer is the second widespread cancer among men. It is important to use new techniques in radiation therapy of prostate cancer that make lower exposure to normal tissues. Notwithstanding the conformal radiotherapy methods with 3-dimensional treatment planning which are known as 3-D conformal radiotherapy and IMRT are using for radiotherapy of prostate cancer, the Co-60 Unit with conventional 2-dimensional treatment planning is still using for radiotherapy of prostate cancer in some of radiotherapy centers, particular in developing countries. Therefore, this study is designed to evaluate the method that with using of shielding blocks and 3-D treatment planning instead of 2-D planning for Co-60 unit therapy, is able to reduce the received dose by critical uninvolved organs such as bladder and rectum. Both treatment planning methods were done on a tissue-equivalent and anthropomorphic phantom in the way of equally weighted 4-field (Box method), that consist of two pairs of parallel-opposed anterioposterior and right and left lateral beams to deliver 200 cGy to isocenter point. TLD-100 dosimeters were used for measuring the absorbed doses of rectum and bladder. Cerrobend blocks for shaping each radiation field were constructed and used in 3-D treatment planning method. The experiments were repeated five times and absorbed dose values compared with paired student's T-test for a confidence level of 95%. The average of measured values of received dose by bladder and rectum in 2-D conventional treatment planning were 117.5±3.4, 120.5±4.6, 80.4±3.8 and 77±3.2 cGy, respectively in 3-D conformal treatment planning. The results show that use of cerrobend blocks in 3-D conformal treatment planning, significantly reduces the absorbed dose to critical uninvolved structures in proportion to 2-D conventional radiotherapy of prostate cancer with using Co-60 unit.
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