Japanese Journal of Ophthalmology (Jpn J Ophthalmol)

Publisher: Nihon Ganka Gakkai, Springer Verlag

Journal description

The Japanese Journal of Ophthalmology, published since 1957, provides a peer-reviewed interdisciplinary forum for bimonthly publication of basic science and clinical research papers in all fields of ophthalmology. The Japanese Ophthalmological Society is dedicated to the preventive care and treatment of the eye, and to scientific research regarding all aspects of ophthalmology. To further these goals, the Society has designated the Japanese Journal of Ophthalmology its official English language publication from January 1997. The purpose of this scientific journal is to disseminate the significant results of study by ophthalmologists worldwide. To help us fulfill our purpose, we encourage you to submit your original papers concerning any area of ophthalmology, as well as Rapid Communications or Letters to the Editor. We welcome your suggestions and criticism.

Current impact factor: 1.68

Impact Factor Rankings

2016 Impact Factor Available summer 2017
2014 / 2015 Impact Factor 1.676
2013 Impact Factor 1.795
2012 Impact Factor 1.274
2011 Impact Factor 0.924
2010 Impact Factor 1.054
2009 Impact Factor 1.272
2008 Impact Factor 1.257
2007 Impact Factor 0.888
2006 Impact Factor 0.77
2005 Impact Factor 0.667
2004 Impact Factor 0.667
2003 Impact Factor 0.543
2002 Impact Factor 0.64
2001 Impact Factor 0.602
2000 Impact Factor 0.479
1999 Impact Factor 0.5
1998 Impact Factor 0.421
1997 Impact Factor 0.348
1996 Impact Factor 0.35
1995 Impact Factor 0.336
1994 Impact Factor 0.369
1993 Impact Factor 0.426
1992 Impact Factor 0.324

Impact factor over time

Impact factor

Additional details

5-year impact 1.53
Cited half-life 7.70
Immediacy index 0.27
Eigenfactor 0.00
Article influence 0.45
Website Japanese Journal of Ophthalmology website
Other titles Japanese journal of ophthalmology (Online), Japanese journal of ophthalmology, JJO
ISSN 1613-2246
OCLC 56124539
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

Springer Verlag

  • Pre-print
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  • Conditions
    • Author's pre-print on pre-print servers such as arXiv.org
    • Author's post-print on author's personal website immediately
    • Author's post-print on any open access repository after 12 months after publication
    • Publisher's version/PDF cannot be used
    • Published source must be acknowledged
    • Must link to publisher version
    • Set phrase to accompany link to published version (see policy)
    • Articles in some journals can be made Open Access on payment of additional charge
  • Classification

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: Purpose: To compare the therapeutic efficacy and safety of brimonidine/timolol fixed-combination (BTFC) and 0.5 % timolol ophthalmic solution in normal-tension glaucoma (NTG) patients. Methods: This was a multi-institution, randomized, active-controlled, open-label, parallel-group study. After a full ophthalmic and glaucoma examination, a total of 110 NTG patients-55 undergoing therapy with BTFC and 55 0.5 %, with timolol-participated in this study. Among them, 1 failed to meet the inclusion/exclusion criteria, 10 revoked their consent to participate in the study, 3 had adverse reactions, and 1 had a drug adherence rate of less than 70 %. Ultimately, a total of 95 patients-48 in the BTFC group and 47 in the 0.5 % timolol group-completed the study. The study visits took place at baseline and at 4 and 12 weeks. Diurnal IOP was measured at 9 a.m., 11 a.m., and 5 p.m. during the baseline visit and the visit at 12 weeks after eye-drop instillation. At each follow-up visit, compliance was assessed. Throughout the study, all adverse events were recorded and monitored by the investigators. Results: The average difference in IOP change measured at 11 a.m. 12 weeks after administration between the two groups was 2.10 ± 2.59 mmHg. The BTFC group had a better IOP-lowering effect at all time points than did the 0.5 % timolol group. The ratio of patients whose average IOP had decreased by >20 % after 4 and 12 weeks was 50 and 56 % in the BTFC group, respectively, whereas it was 29.41 and 23.53 % in the 0.5 % timolol group, respectively (p = 0.034, <0.001). Conclusions: BTFC has a superior IOP-lowering effect than 0.5 % timolol in NTG patients.
    No preview · Article · Nov 2015 · Japanese Journal of Ophthalmology
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    ABSTRACT: Purpose: Patients with esotropia (ET) have generally poor stereopsis; however, it is not clear whether they can see the recently developed 3-D images stereoscopically. We investigated the ability of postoperative ET patients to have stereoscopic perception of 3-D attraction images which have large crossed disparities, and also 3-D movies which have generally small uncrossed disparities. Methods: Twenty-seven ET patients (infantile ET = 12, late-onset ET = 15) were examined postoperatively. They were examined with the 4-dot test, Titmus fly test, and questionnaires to determine whether they had stereoscopic vision when observing 3-D attraction images and 3-D movies. McNemar tests were used for statistical evaluations. Results: The number of patients who passed the Titmus fly test was smaller than the number that were able to see 3-D attraction images stereoscopically (fly test 13; 48 %, 3-D attraction 22; 81 %; P = 0.016). However, the number was not significantly different from that of those who could perceive 3-D movies stereoscopically. The number of patients who passed the Titmus fly test was significantly smaller than the number who can perceive 3-D attraction images stereoscopically in the infantile ET group (fly test 2, 17 %, 3-D attraction 10, 83 %; P = 0.013) but was not different in the late-onset ET group postoperatively. The minimum angle of fusion for the 4-dot test was smaller in the Titmus fly-positive patients than in the Titmus fly-negative patients (P = 0.03). Conclusions: These results suggest that children who cannot pass the Titmus fly test might be able to experience 3-D attractions stereoscopically but not be able to see 3-D movies stereoscopically.
    No preview · Article · Nov 2015 · Japanese Journal of Ophthalmology
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    ABSTRACT: Purpose: To evaluate the effect of preservative-free (PF) tafluprost on diurnal variation of intraocular pressure (IOP) and ocular perfusion pressure (OPP), measured by use of home IOP and blood-pressure (BP) monitoring devices, for primary open angle glaucoma (POAG) patients. Methods: Twenty-two eyes from 22 patients with POAG were studied. Initially, IOP was measured at the hospital by Goldmann applanation tonometry (GAT) and Icare-ONE rebound tonometry. Each patient was then instructed how to use the Icare-ONE and BP home monitoring devices. IOP and BP were measured at home by the patients, every 4 h, before and 2 weeks after once daily treatment with PF tafluprost (0.0015 %) ophthalmic solution. Results: Intraclass correlations between different IOP measurements were greater than 0.8. PF tafluprost reduced mean diurnal IOP significantly for patients with POAG, from 15.7 ± 1.2 mmHg at baseline to 12.5 ± 0.6 mmHg 2 weeks after treatment (p < 0.001). It increased mean diurnal OPP from 48.5 ± 7.3 mmHg at baseline to 51.3 ± 7.0 mmHg post-treatment (p < 0.017). Conclusions: Icare-ONE enables glaucoma patients to measure their own diurnal IOP fluctuations. Patient-measured Icare-ONE IOP readings showed that PF tafluprost effectively reduced diurnal IOP in eyes with POAG.
    No preview · Article · Sep 2015 · Japanese Journal of Ophthalmology
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    ABSTRACT: Purpose: To determine whether water-dispersible hesperetin (WD-Hpt) can prevent degeneration of ganglion cell neurons in the ischemic retina. Methods: Ischemia reperfusion (I/R) injury was induced by increasing the intraocular pressure of mice to 110 mmHg for 40 min. Mice received daily intraperitoneal injections with either normal saline (NS, 0.3 ml/day) or WD-Hpt (0.3 ml, 200 mg/kg/day). Reactive oxygen species (ROS) was assessed by dihydroethidium and nitrotyrosine formation. Inflammation was estimated by microglial morphology in the retina. Lipopolysaccharide (LPS)-stimulated BV-2 cells were used to explore the anti-inflammatory effect of WD-Hpt on activated microglia by quantifying the expression of IL-1β using real-time quantitative reverse transcription-polymerase chain reaction. Ganglion cell loss was assessed by immunohistochemistry of NeuN. Glial activation was quantified with glial fibrillary acidic protein (GFAP) immunoreactivity. Apoptosis was evaluated with a terminal deoxynucleotidyl transferase (TUNEL) assay and immunohistochemistry of cleaved caspase-3. Phosphorylation of extracellular signal-regulated kinase (p-ERK) was surveyed by western blotting. Results: WD-Hpt decreased I/R-induced ROS formation. WD-Hpt alleviated microglial activation induced by I/R and reduced mRNA levels of IL-1β in LPS-stimulated BV-2. I/R resulted in a 37 % reduction in the number of ganglion cells in the NS-treated mice, whereas the reduction was only 5 % in the WD-Hpt-treated mice. In addition, WD-Hpt mitigated the immunoreactivity of GFAP, increased expression of cleaved caspase-3, increased number of TUNEL positive cells and p-ERK after I/R. Conclusions: WD-Hpt protected ganglion cells from I/R injury by inhibiting oxidative stress and modulating cell death signaling. Moreover, WD-Hpt had an anti-inflammatory effect through the suppression of activated microglia.
    No preview · Article · Sep 2015 · Japanese Journal of Ophthalmology
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    ABSTRACT: An understanding of the microbiome is emerging as an exciting and novel way to elucidate the regulation of the immune system. Since the immune system plays a major role in the pathogenesis of many diseases including most forms of uveitis, it is critical to clarify the relationship between our immune system and the commensal bacteria that coexist in every human being.
    No preview · Article · Sep 2015 · Japanese Journal of Ophthalmology
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    ABSTRACT: Purpose: To investigate the differences in thickness and depth of the lamina cribrosa (LC) between ocular hypertension (OH) patients and normal control subjects, using enhanced depth imaging (EDI) spectral-domain optical coherence tomography (SD-OCT). Methods: EDI-OCT data were obtained from the subjects in a cross-sectional analysis of data from a retrospective study. After IOP correction according to central corneal thickness (CCT), we divided the OH patients into two groups based on the corrected IOP (cIOP) - OH with lower IOP (OH-L; cIOP < 23 mmHg) and OH with higher IOP (OH-H; cIOP ≥ 23 mmHg). Comparisons of LC thickness and depth among three groups were performed. Results: Seventy-four OH patients and 45 normal control subjects were included in the analysis. Among the 74 OH patients, 41 were included in the OH-L group and 33 were included in the OH-H group. LC thickness was thicker in the OH-H group compared to normal controls both in superior (P = 0.02) and inferior (P = 0.01) portions. However, no difference was found in LC depth among the three groups in any portion (P = 0.36; P = 0.44; P = 0.31, respectively). Conclusion: OH patients may have a thicker LC than normal control subjects, especially in OH with definite high IOP.
    No preview · Article · Sep 2015 · Japanese Journal of Ophthalmology
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    ABSTRACT: Our aim was to investigate predictive factors associated with efficacy and recurrence after intravitreal bevacizumab (IVB) therapy for macular edema (ME) in patients with branch retinal vein occlusion (BRVO). Fifty-two eyes of 52 patients who underwent IVB as a primary treatment against ME associated with BRVO were included retrospectively. Based on the postoperative central retinal thickness (CRT), the patients were classified into two groups: an effective group in which the CRT decreased to ≤250 µm within postoperative 3 months and an ineffective group in which the CRT remained >250 µm throughout the first 3 months. The effective group was then divided into two subgroups: a recurrent group in which ME had once resolved but recurred afterward, and a nonrecurrent group in which the resolution of ME was maintained throughout the follow-up period without additional injections. Preoperative factors such as age, gender, estimated elapsed time from disease onset to IVB, visual acuity, and CRT were compared between groups. There was no significant difference between effective (n = 37) and ineffective (n = 15) groups in all preoperative factors. Between recurrent (n = 26) and nonrecurrent (n = 11) groups, elapsed time was significantly different (29.7 ± 29.5 vs. 15.7 ± 8.9 weeks, respectively; P = 0.036), and there were no significant differences in the remaining factors. Early IVB treatment against BRVO may suppress ME recurrence.
    No preview · Article · Sep 2015 · Japanese Journal of Ophthalmology
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    ABSTRACT: To determine the prevalence of and risk factors for myopia in primary school children in Chaoyang District, Beijing. This cross-sectional prevalence survey was conducted in September to October 2011 in 4 schools randomly chosen from among the 126 primary schools in Chaoyang District. Students were assessed with autorefractometry under cycloplegia and checked with retinoscopy for accuracy. Questionnaires were completed by the students' parents. Myopia was present in 36.7 ± 0.7 % of 4249 students aged 5-14 years old. The prevalence of myopia in girls (38.6 ± 1.1 %) was significantly higher than in boys (35.0 ± 1.0 %) (p = 0.015) and increased with age (p < 0.001), with the highest prevalence observed in children aged ≥11 years (67.5 ± 1.8 %). After adjustment, having a myopic parent (aOR 3.10; 95 % CI 2.49-3.86), incorrect reading posture (aOR 2.09; 95 % CI 1.75-2.50), reading a book at a distance of <20 cm (aOR 1.60; 95 % CI 1.16-2.21), studying at home for >3 h daily (aOR 1.50; 95 % CI 1.12-2.01), studying for >1 h continuously (aOR 1.21; 95 % CI 1.02-1.45), and reading extracurricular books that utilize a font larger than that used in textbooks (aOR 0.74; 95 % CI 0.59-0.94) were all significantly associated with myopia. The prevalence of myopia among primary school children in Beijing increased with age, and was significantly higher in girls ≥10 years old. Myopia was significantly associated with parental myopia, reading posture, distance between the eyes and the book being read, font size used in extracurricular reading material, time spent studying at home, and the duration of continuous study time.
    No preview · Article · Sep 2015 · Japanese Journal of Ophthalmology
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    ABSTRACT: To evaluate the changes of orbital tissue volumes and proptosis after methylprednisolone pulse therapy in thyroid-associated ophthalmopathy (TAO). The cross-sectional areas of orbital tissues and proptosis were measured with magnetic resonance imaging in 40 orbits of 20 patients with TAO before and after methylprednisolone pulse therapy. The volumes of the whole orbit, orbital fatty tissue, and extraocular muscles were calculated. The volumes and proptosis were compared before and after treatment using a paired t test. Before treatment, the mean volumes were 33.0 ± 4.8 cm(3) in the whole orbit, 19.9 ± 4.1 cm(3) in the orbital fatty tissue, and 4.6 ± 1.2 cm(3) in the total extraocular muscles. After treatment, the mean volumes were 32.5 ± 4.4 cm(3) in the whole orbit, 19.9 ± 3.7 cm(3) in the orbital fatty tissue, and 4.0 ± 1.0 cm(3) in the total extraocular muscles. The mean volumes of the whole orbit (P = 0.17) and orbital fatty tissue (P = 0.82) were not significantly decreased after treatment, while the mean volume of total extraocular muscles was significantly decreased (P < 0.001). The mean proptosis value was 18.9 ± 2.8 mm before treatment and 18.6 ± 3.4 mm after treatment. The mean proptosis value was not significantly decreased after treatment (P = 0.30). The volume of orbital fatty tissue seemed to be unchanged after methylprednisolone pulse therapy while that of total extraocular muscles was decreased. The proptosis value seemed to be unchanged after treatment.
    No preview · Article · Sep 2015 · Japanese Journal of Ophthalmology
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    ABSTRACT: To determine the prevalence of vitreous cysts in patients with retinitis pigmentosa (RP). We retrospectively reviewed the charts of 435 consecutive patients diagnosed as having typical RP. Vitreous cysts were diagnosed in 37 eyes of 28 patients with RP (13 males and 15 females; mean age 47.0 ± 19.8 years; range 15-79 years), for an overall prevalence of 6.4 %. The cysts were observed bilaterally in nine of the patients (32.1 %). Among these 28 patients, 11 (39.3 %) were younger than 40 years. In all, 81.8 % of the vitreous cysts were detected around the optic nerve head. We demonstrated that the prevalence of vitreous cysts was 6.4 % in patients with RP. These cysts were considered to be asymptomatic.
    No preview · Article · Aug 2015 · Japanese Journal of Ophthalmology
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    ABSTRACT: Our aim was to investigate whether major histocompatibility complex (MHC) polymorphisms are associated with response to infliximab therapy in Japanese patients with Behçet uveitis (BU). We retrospectively reviewed 24 patients (17 men and seven women) treated with infliximab for BU. Of them, ten patients were genotyped as HLA A*2601, and nine as HLA B*5101. Therapeutic response levels in the two groups were compared based on ocular attacks and the Behçet disease ocular attack score 24 (BOS24) over 24 months of treatment. Mean frequencies of ocular attacks at 13-18 and 19-24 months after the start of treatment were significantly higher in the HLA A*2601 group (P = 0.0392 and 0.0177, respectively). Mean BOS24-6 M values for months 1-6, 7-12, 13-18, and 19-24 were also significantly higher in the HLA A*2601 group (P = 0.0459, 0.0150, 0.0394, and 0.0178, respectively). Shortening of the infusion interval was required in eight patients in the HLA A*2601 group but in one only in the HLA B*5101 group. Behçet-disease-related adverse events occurred in eight patients in the HLA A*2601 group and two in the HLA B*5101 group. Nonocular adverse events occurred in four patients in the HLA A*2601 group and none in the HLA B*5101 group. Although mean change from baseline in the number of ocular attack scores in the HLA A26 and HLA B51 groups seemed to be similar, the HLA-A26 group had a more severe disease course under infliximab therapy for ocular/extraocular involvement. These data suggest that response to infliximab therapy in Japanese patients with BU is partly due to genetic determinants in the HLA complex.
    No preview · Article · Aug 2015 · Japanese Journal of Ophthalmology
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    ABSTRACT: To evaluate the correlation between central retinal thickness (CRT) after vitreous surgery and final visual outcome in eyes with idiopathic macular holes (MH). A prospective analysis was performed of patients who had undergone surgical treatment for MH. Best-corrected visual acuity (BCVA) and optical coherence tomography (OCT) parameters including CRT, minimum and base diameters of the MHs were analyzed pre- and postoperatively. The relationships between final visual outcome and the OCT parameters were examined by single and multiple regression analysis. Forty-one MHs cases were successfully closed postoperatively. BCVA gradually improved, and CRT decreased during the observation period following MH surgery. There were significant positive correlations between CRT at 1 month and visual acuity at 12 months after vitreous surgery (P < 0.0001). MH diameter was positively correlated with CRT at 1 month after surgery and negatively with postoperative visual acuity. CRT at 1 month after MH surgery was related to preoperative MH diameter and visual acuity at 12 months postoperatively. Our data suggest that the increased CRT at the early postoperative period may result in better visual prognosis.
    No preview · Article · Aug 2015 · Japanese Journal of Ophthalmology
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    ABSTRACT: To retrospectively assess the proportion of patients affected by a central island (CI) and its effect on visual recovery after phototherapeutic keratectomy (PTK). This retrospective study evaluated 30 eyes of 21 consecutive patients (mean age ± standard deviation, 69.6 ± 6.8 years) undergoing PTK for the treatment of band keratopathy or granular corneal dystrophy. We investigated the rate of CI formation, which was defined as a steepening area of 3 D, 1.5 mm in diameter, on each corneal videokeratograph (ATLAS 9000; Carl Zeiss Meditec), and its effect on visual recovery at 3 months and at 1 year postoperatively. A CI was found in 22 of 30 eyes (73 %) 3 months postoperatively and in 14 of 25 eyes (56 %) 1 year postoperatively. The degree of CI was significantly correlated with the change in logMAR corrected visual acuity (Spearman correlation coefficient r = 0.445, P = 0.026). The degree of CI in eyes with band keratopathy was significantly larger than that in eyes with granular dystrophy 1 year postoperatively (Mann-Whitney test, P = 0.045). The degree of CI was not significantly correlated with the ablation depth (Spearman correlation coefficient r = 0.116, P = 0.582) or the residual corneal thickness (r = -0.235, P = 0.278). CI formation was found in as many as 73 and 56 % of patients 3 months and 1 year after PTK, respectively, using the VISX Star S4 excimer laser system, and significantly affected the improvement of visual acuity. The anti-CI program should be applied by the manufacturer, not only for corneal refractive surgery but also for PTK in a clinical setting.
    No preview · Article · Aug 2015 · Japanese Journal of Ophthalmology
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    ABSTRACT: To report the results of scleral buckling (SB) with or without photocoagulation (PC) and intravitreal bevacizumab (IVB) for stage 4 retinopathy of prematurity (ROP) eyes. Forty-two eyes of 28 patients with SB and/or PC or IVB were studied. Twenty-nine eyes had stage 4A and 13 eyes had stage 4B ROP. Seventeen eyes underwent SB combined with additional intraoperative or postoperative treatments (combined group). Twenty-five eyes underwent SB without additional therapy (non-combined group). The concentrations of vascular endothelial growth factor (VEGF) in the aqueous humor determined by enzyme-linked immunosorbent assay were compared between the two groups. The initial and final reattachment rates were also compared. The gestational age and birth weight were 25.0 ± 2.0 weeks and 786 ± 222 g in the combined group, and 25.5 ± 2.1 weeks and 899 ± 315 g in the non-combined group. The postmenstrual age at the time of initial surgery was 38.0 ± 1.9 in the combined and 44.1 ± 4.0 weeks in the non-combined group (P < 0.001). The initial reattachment rate was 92 % in stage 4A and 75 % in stage 4B of ROP eyes in the combined group, and the rate was 93 % in stage 4A and 33 % in stage 4B of ROP eyes in the non-combined group. The mean VEGF concentration in aqueous humor was 1923 ± 779 pg/ml in the combined group and 985 ± 303 pg/ml in the non-combined group (P < 0.05). Our results show that the retinal reattachment rate after combined therapy was comparable to that in the non-combined group. We conclude that combined therapy may be effective even in ROP eyes with high activity.
    Preview · Article · Aug 2015 · Japanese Journal of Ophthalmology
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    ABSTRACT: To investigate the process of retinal degeneration by analyzing the functional and morphological findings in transgenic rabbits with a Pro347Leu rhodopsin mutation. Wild-type (WT) and transgenic (Tg) rabbits at ages 4, 8 and 12 months were used. We conducted functional evaluation by recording the changes in the pupil response to red and blue light stimulation and the amplitude of the electroretinography (ERG). Morphologically, rod and cone distribution was examined using light and electron microscopy. Immunostaining for the identification of retinal ganglion cells (RGCs) was also confirmed by injecting a TUJ-1 monoclonal antibody. Pupil constriction for infrared pupillography and the a- and b-waves for ERG in Tg rabbits decreased with increasing age; the differences were compared to the age-matched WT rabbits. The subnormal ERG in the Tg rabbits, especially the a-wave decrease and pupil constriction with a long latency time, was induced only during exposure to blue light stimulation at 12 months. Light and electron microscopic findings showed a progressive loss of photoreceptor cells over time manifesting by 8 months in the peripheral retina. Moreover, pyknotic nuclei of the outer nuclear layer in the center of the visual streak were observed. At 12 months, there was disappearance of the rods and ballooning degeneration of the cones. Some remaining RGCs had large cell bodies with long branching dendrites. The changes in the pupil light response and amplitude of the ERG could be used to predict the state of retinal degeneration in the Tg rabbit.
    No preview · Article · Aug 2015 · Japanese Journal of Ophthalmology
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    ABSTRACT: To investigate the surgical results for consecutive exotropia with or without insertion abnormalities on the basis of the position of the lateral rectus muscle at surgery. Patients with consecutive exotropia who had undergone medial rectus recession as a primary procedure or advancement of previously recessed medial rectus muscles from 2002 to 2012 were included in the study. The characteristics, postoperative courses, and final results were compared among 3 patient groups. The patients' characteristics including sex, refractive error, and age at the initial surgery were compared. The main outcome measures were the angles of deviation in the primary position and the average divergent drift per month after the exotropia surgery. Twenty-four eyes of 23 patients were investigated. The patients were divided into 3 groups according to insertion status: with normal muscle insertion (4 men, 4 women), slipped muscles (9 women), and stretched scars (2 men, 4 women). The preoperative angles of deviation at near differed significantly between the slipped muscle group and the normal muscle insertion group (P = 0.02). Only patients with normal insertions had significantly greater hyperopia in the nondominant eye (0.95 D) than in the dominant eye (0.53 D). The postoperative divergent shift per month was similar among the groups (0.3, 0.1, and 0.2 prism diopters per month in the slipped muscle, stretched scar, and normal muscle insertion groups, respectively; P = 0.70). Hyperopic anisometropia is an important factor in the natural course of outward drift. The postoperative course of advancement of the medial rectus muscle was equally stable in all 3 patient groups.
    No preview · Article · Aug 2015 · Japanese Journal of Ophthalmology
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    ABSTRACT: To evaluate diurnal curves of intraocular pressure (IOP) in eyes affected with unilateral acute primary angle closure (APAC) after laser peripheral iridotomy (LPI), and fellow eyes. The medical records of 22 female patients (44 eyes) with unilateral APAC and LPI performed OU were reviewed along with those of 48 normal control subjects (48 eyes). None of the subjects used glaucoma medications after LPI. IOP was measured with a Goldman applanation tonometer during waking hours and in a sitting position every 2 h between 09:00 and 23:00. IOP profiles were compared including the means, peaks, trough IOPs, and IOP fluctuations of the affected, fellow, and normal eyes. The IOPs of the affected eyes were significantly higher than those of normal eyes at every time point measured, including peak and trough IOPs. The diurnal IOPs of fellow eyes were higher than those of normal eyes, though not significantly. There were no significant differences in IOP fluctuation between the affected, fellow, and normal eyes. IOP diurnal curves for APAC affected, fellow, and normal eyes were not statistically different (repeated measures ANOVA, p = 0.865). The mean coefficient of IOP in affected and fellow eyes ranged from 0.486 to 0.604. There were no clinically significant differences among the three groups in terms of IOP diurnal curves, and thus LPI did not have a significant effect on diurnal patterns of IOP. Though the diurnal IOPs of affected eyes after LPI was significantly higher than those of normal eyes, the IOP range was not acute.
    No preview · Article · Aug 2015 · Japanese Journal of Ophthalmology
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    ABSTRACT: To verify, by use of data collected by the Japan Glaucoma Society Survey of Bleb-related Infection (JGSSBI), that bleb morphology changes within 12 months of the development of bleb-related infection. JGSSBI data from 57 eyes of 57 patients with primary open-angle glaucoma and normal tension glaucoma who developed a bleb-related infection were analyzed. Morphological features of the blebs were graded by use of a predetermined grading system. Multiple logistic regression analysis was conducted to identify factors relating to bleb morphology which were associated with poor outcome. Bleb sizes, including both circumferential and tangential lengths, were significantly smaller for stage IIIa/IIIb infections than for stage I/II bleb infections (P = 0.009 and P = 0.026 for the circumferential and tangential lengths, respectively; Fisher's direct probability test). The bleb wall also became significantly thicker during stage IIIa/IIIb infections (P = 0.003). After infection, intraocular pressure (IOP) increased significantly for all cases but was no different in the three subgroups (i.e. stage I, stage II, and stage IIIa/IIIb bleb infections). Multiple logistic regression analysis revealed that a stage III infection was significantly associated with a poor outcome for the bleb. This study revealed that the filtering bleb became smaller, both tangentially and circumferentially, and thicker, after stage III infections than after stage I or II infections.
    No preview · Article · Jul 2015 · Japanese Journal of Ophthalmology