Journal of Maternal-Fetal and Neonatal Medicine (J MATERN-FETAL NEO M)

Publisher: European Association of Perinatal Medicine; Federation of Asia and Oceania Perinatal Societies; International Society of Perinatal Obstetricians, Informa Healthcare

Journal description

The official journal of The European Association of Perinatal Medicine, The Federation of Asia and Oceania Perinatal Societies, and The International Society of Perinatal Obstetricians.

Current impact factor: 1.37

Impact Factor Rankings

2016 Impact Factor Available summer 2017
2014 / 2015 Impact Factor 1.367
2013 Impact Factor 1.208
2012 Impact Factor 1.518
2011 Impact Factor 1.495
2010 Impact Factor 2.071
2009 Impact Factor 1.362
2008 Impact Factor 1.089
2007 Impact Factor 1

Impact factor over time

Impact factor
Year

Additional details

5-year impact 1.40
Cited half-life 3.80
Immediacy index 0.29
Eigenfactor 0.01
Article influence 0.44
Other titles Journal of maternal-fetal & neonatal medicine (Online), Journal of maternal-fetal and neonatal medicine
ISSN 1476-7058
OCLC 49941200
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

Informa Healthcare

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author cannot archive a post-print version
  • Restrictions
    • 12 months embargo
  • Conditions
    • On author's personal website or institution website
    • Publisher copyright and source must be acknowledged
    • Non-commercial
    • Must link to publisher version
    • Publisher's version/PDF cannot be used
    • NIH funded authors may post articles to PubMed Central for release 12 months after publication
    • Wellcome Trust authors may deposit in Europe PMC after 6 months
  • Classification
    yellow

Publications in this journal


  • No preview · Article · Feb 2016 · Journal of Maternal-Fetal and Neonatal Medicine
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    ABSTRACT: Objective: To evaluate if ultrasound variables at term are associated with the mode of delivery in women with previous cesarean section.Methods: This was a prospective study of singleton pregnant women who planned a trial of vaginal birth after cesarean delivery. Cervical length, posterior cervical angle, head-perineum distance and estimated fetal weight were measured at 37-39 weeks’ gestation.Results: 144 pregnancies were examined and vaginal delivery was achieved in 98 women (73%). Logistic regression analysis identified cervical length, head-perineum distance, age, previous vaginal delivery, previous cesarean for dystocia and Bishop score as predictors of vaginal delivery. Combining ultrasound and clinical parameters, two models for risk scoring that differ in the variable Bishop score or cervical length were constructed. The AUC of these models were 0.867 and 0.855, respectively.Conclusions: In women with a previous cesarean section, measurement of cervical length and head-perineum distance at term are associated with the mode of delivery. A combination of clinical and sonographic parameters at term can predict the likelihood of vaginal delivery.
    No preview · Article · Feb 2016 · Journal of Maternal-Fetal and Neonatal Medicine
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    ABSTRACT: Aim: To investigate the effects of severity of preeclampsia on thiol-disulphide homeostasis (TDH).Material and methods: A total of 108 participants were divided into three groups: Group 1 was composed of pregnant women with no obstretric complications, group 2 included pregnant women with mild preeclampsia, and group 3 consisted of pregnant women with severe preeclampsia. TDH parameters were determined, and comparisons of clinical and routine laboratory test findings were made in all groups.Results: The serum native thiol level was 347.9 ± 27.4 in the control group, 237.2 ± 44.2 in the mild preeclampsia group, and 227.9 ± 53.1 in the severe preeclampsia group (p < 0.001). The serum total thiol level was 376.1 ± 31.9 in the control group, 261.8 ± 49.4 in the mild pre-eclampsia group, and 248.3 ±57.4 in the severe preeclampsia group (p < 0.001). The disulphide level was 14.1 ± 5.6 in the control group, 12.3 ± 5.1 in the mild preeclampsia group, and 10.2 ± 4.8 in the severe preeclampsia group (p=0.001). A significant correlation between impairment in degree of TDH and severity of preeclampsia was observed.Conclusion: TDH was impaired in women with preeclampsia, and this impairment increased with disease severity. Therefore, impaired TDH may have a role in the etiopathogenesis of the disease.
    No preview · Article · Feb 2016 · Journal of Maternal-Fetal and Neonatal Medicine
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    ABSTRACT: Objective: Venous thromboembolism (VTE) is one of the leading causes of pregnancy-associated death in the Western world. Cancer is a known risk factor for thrombosis outside of pregnancy. The objective of this study is to evaluate the effect of cancer on the risk of VTE, including deep vein thrombosis (DVT) and pulmonary embolism (PE) in pregnancy.Methods: We conducted a retrospective population-based cohort study using the Health Care Cost and Utilization Project database from 2003 to 2011. Risk of developing DVT, PE and VTE among pregnant patients with the 10 most prevalent malignancies was measured using unconditional logistic regression analysis.Results: A total of 2826 women were identified with underlying malignancies, among our study cohort of 7917453 women. Risk of VTE was increased among pregnant patients with cervical cancer (OR 8.64, 95% CI (2.15-34.79)), ovarian cancer (OR 10.35, 95% CI (1.44-74.19)), Hodgkin's disease (OR 7.87, 95% CI (2.94-21.05)) and myeloid leukemia (OR 20.75, 95% CI (6.61-65.12)). There was no increased risk of VTE among women with brain cancer, thyroid cancer, melanoma and lymphoid leukemia.Conclusion: Many cancers may increase risk of VTE in pregnancy. Appropriate thromboprophylaxis should be considered in some of these women, particularly those with hematological malignancies and gynecologic cancers.
    No preview · Article · Feb 2016 · Journal of Maternal-Fetal and Neonatal Medicine
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    ABSTRACT: Objective. Early exposure to common anesthetic and sedative agents causes widespread brain cell degeneration and apoptosis in the developing rat brain, associated with persistent learning deficits in rats. This study was designed to determine whether the α2 adrenergic receptor agonist, dexmedetomidine, produces brain cell degeneration and apoptosis in postnatal day-7 rats in the same brain areas when compared to ketamine. Methods. Systemic saline, ketamine 20 mg/kg, or dexmedetomidine at 30 or 45 μg/kg were given six times to postnatal day 7 rats (n=6/group) every 90 minutes. Twenty-four hours after the initial injection, brain regions were processed and analyzed for cell degeneration using the silver stain and for apoptosis using activated caspase-3 immunohistochemistry. Results. Exposure to ketamine resulted in significant cellular degeneration and apoptosis in limbic brain regions, but non-significant changes in primary sensory brain regions. In contrast, dexmedetomidine produced significant cellular degeneration and apoptosis in primary sensory brain regions, but non-significant changes in limbic regions. Conclusions. These data show that ketamine and dexmedetomidine result in anatomically distinct patterns of cell degeneration and apoptosis in the brains of 7-day-old rat pups. The meaning and the clinical significance of these findings remain to be established.
    No preview · Article · Jan 2016 · Journal of Maternal-Fetal and Neonatal Medicine
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    ABSTRACT: Objective: To investigate maternal serum and neonatal umbilical cord asymmetric dimethylarginine (ADMA) levels in prediction of perinatal prognosis in pregnancies with preeclampsia (PE) and fetal intrauterine growth retardation (IUGR) accompanying PE (PE+IUGR).Methods: Maternal serum ADMA (msADMA) and neonatal umbilical cord ADMA (ucADMA) levels were studied from 34 patients with PE, 25 patients with PE+IUGR, and 30 healthy pregnant controls in this prospective case-control study. Umbilical artery Doppler indices of fetuses, birth weights, Apgar scores, umbilical artery pH measurements of neonates, and admissions to neonatal intensive care unit (NICU) were recorded.Results: Median msADMA was significantly higher in PE and PE+IUGR groups (p=0.024 and p=0.011, respectively), and ucADMA was significantly higher in PE and PE+IUGR groups than control group (p=0.029 and p=0.018, respectively). Median msADMA and ucADMA levels were significantly higher in PE+IUGR group than PE group (p=0.019 and 0.021, respectively). ucADMA levels did not correlate with fetal umbilical arterial blood flow neither in PE nor in PE+IUGR group (p=0.518 and p=0.892, respectively). None was related with neonatal umbilical artery pH or NICU admission rates.Conclusions: msADMA and ucADMA correlated with severity of PE. msADMA and ucADMA failed to predict perinatal outcome in patients with PE and PE+IUGR.
    No preview · Article · Jan 2016 · Journal of Maternal-Fetal and Neonatal Medicine
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    ABSTRACT: Objectives: This prospective, randomized study aimed to compare the analgesic effects of acetaminophen, diclofenac and hyoscine-N-butylbromide (HnBB) in cases of second trimester pregnancy termination.Methods: In sixty women with indications for second trimester pregnancy termination, three analgesic agents were randomized into three groups: group 1, acetaminophen; group 2, diclofenac; and group 3, HnBB. A visual analogue scale (VAS) used for the evaluation of pain perception. The primary outcome of the study was mean VAS score during the procedure and last VAS score before the completion of termination. The secondary outcomes were the induction-to-abortion interval, the percentage of aborted cases within the first 24 hours and finally the need for parenteral analgesia.Results: Demographic characteristics were similar among the groups. The mean VAS and last VAS scores before termination did not differ among the groups (p=0.3 and 0.2, respectively). The need for parenteral analgesia did not differ among the groups (p=0.3). Although a shorter induction-to-abortion interval and greater number of cases with successful termination before 24 hours were found in the HnBB group, the differences were not statistically significant (p=0.6 and 0.5 respectively).Conclusions: Our study did not demonstrate a difference in pain perception among second trimester pregnancy termination cases using acetaminophen, diclofenac and HnBB.
    No preview · Article · Jan 2016 · Journal of Maternal-Fetal and Neonatal Medicine
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    ABSTRACT: Objective: The aim of this study is to evaluate whether the platelet mass in the first 24 hour of life is effective on closure of patent ductus arteriosus (PDA) or not.Study design: Preterm infants with a gestational age of < 32 weeks, hospitalized at a tertiary neonatal intensive care unit (NICU) and requiring medical treatment (intravenous or oral ibuprofen) for hemodinamically significant PDA (hsPDA) were enrolled in this study. The patients were divided into two groups after first course of pharmacologic treatment according to closure of PDA (Group 1: PDA closure, Group 2: PDA without closure). Groups were compared in terms of demographics findings, morbidities, platelet measurements like counts, mean platelet volume (MPV), and platelet mass (platelet count x mean platelet volume).Results: The study included 77 preterm newborns in Group 1, and 30 preterms in Group 2. There were no differences in birth weight, gestational age, gender and maternal risk factors between the study groups. The mean platelet count in the first postnatal blood count were in Group 1: 211.3 ± 89.2X103/mm3 and in Group 2: 216.5± 26 X103/mm3, respectively (p=0.783). The mean platelet volumes (MPV) were similar in both groups (p=0.535). No statistically significant difference between platelet mass values was detected (Group 1: 1811±884 fl/nl, Group 2: 1868±717fl/nl) (p=0.753).Conclusion: Our data suggest platelet count, MPV and platelet mass did not affect the closure of hsPDA with ibuprofen.
    No preview · Article · Jan 2016 · Journal of Maternal-Fetal and Neonatal Medicine
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    ABSTRACT: Objective: To assess the prediction of delivery within 7 days in pregnant women who showed symptoms of spontaneous preterm birth (PB) by means of fetal adrenal gland biometry and to compare these predictions with the cervical length (CL) measurement.Methods: We performed a prospective cross-sectional study with 53 pregnant women between 24 and 36 weeks of gestation. An ultrasound exam was performed for each participant to obtain the CL measurement (transvaginal route) and fetal adrenal gland biometry on day 1 of their hospital admission because of symptoms of spontaneous PB. The main outcome measure was the time between the ultrasound exam and delivery, which was classified into two groups: delivery ≤7 days and delivery >7 days. A receiver operating characteristics (ROC) curve was performed to define the cutoffs for sensitivity and specificity.Results: The prevalence of delivery within 7 days was 35.8%, which showed a statistically significant difference from the depth of the central zone of the fetal adrenal gland (p = 0.036). The cutoff for the depth of the central zone of the fetal adrenal gland was 7.2 mm (sensitivity 66.7%, specificity 61.8%, and accuracy 63.5%). These values were not significantly different than the cutoffs for cervical length measurement: 20 mm (p = 0.267) and 9 mm (p = 0.118).Conclusion: The biometry for the central zone of the fetal adrenal gland predicted delivery within 7 days in pregnant women with spontaneous PB and had a predictive accuracy similar to that of CL measurement.
    No preview · Article · Jan 2016 · Journal of Maternal-Fetal and Neonatal Medicine
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    ABSTRACT: Objective: We assessed the utility of the pulse oximeter perfusion index (PI) in maternal monitoring immediately after delivery.Methods: We examined 30 pregnant women without any complications using the Rad7 device at delivery. The correlations between heart rate (HR), systolic blood pressure (BP), oxygen saturation SpO2, PI, Pleth variability index (PVI), shock index, and blood loss were assessed.Results: Blood loss at 20 min postpartum was not correlated with the difference in heart rate, systolic BP, SpO2, shock index or PVI taken immediately after delivery and at 20 min postpartum, but showed a strong negative correlation with the difference in the PI taken immediately after delivery and at 20 min postpartum (r = -0.70).Conclusion: PI changes were correlated with post-delivery blood loss and can be used for maternal monitoring at delivery.
    No preview · Article · Jan 2016 · Journal of Maternal-Fetal and Neonatal Medicine
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    ABSTRACT: Background: Gut development, function and colonisation is impaired in animal models of prematurity with intrauterine growth restriction (IUGR). The effect of Bifidobacterium breve (B. breve) supplementation on fecal bifidobacteria in small for gestational age (SGA: Birth weight <10th centile due to IUGR) preterm infants is not known.Objective: We compared B. breve M-16V supplementation effect on fecal bifidobacteria in preterm (<33 weeks) SGA vs. non-SGA infants in the two arms of our randomised controlled trial.Results: There were no baseline differences in the proportion of detectable B. breve counts between SGA vs. non-SGA infants. [Probiotic: 7 (33%) vs 22 (42%), p=0.603, Placebo: 1 (6%) vs 1 (2%), p=0.429] B. breve counts did not differ between SGA and non-SGA infants in response to treatment (p=0.589), after adjusting for baseline count (p < 0.001) and treatment allocation (p<0.001). An interaction term between growth status and treatment showed negligible change (p=0.938). Probiotic treated SGA infants reached full feeds earlier than SGA controls (HR 2.00, 95% CI 1.05-3.82, p=0.035): Median (IQR): 16 (12-26) vs 19 (11-25) days, after adjustment for age at starting feeds and gestation <28 weeks.Conclusion: Response to B. breve M-16V supplementation was not significantly different in preterm (<33 weeks) SGA vs non-SGA infants.
    No preview · Article · Jan 2016 · Journal of Maternal-Fetal and Neonatal Medicine
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    ABSTRACT: Objective: To assess the maternal complications in pregnant women with fetuses with several congenital anomaly as well as the predictor variables for the termination of pregnancy.Methods: We performed a retrospective cohort study with 94 medical records of pregnant women with fetal infeasibility confirmed in the postnatal period by clinical, radiological, or anatomopathological exams. To compare the categorical variables regarding the termination and non-termination of pregnancy, we used analysis of variance (ANOVA) and the Mann-Whitney U test. To assess the variables that were more associated with the judicial request for termination of pregnancy, we used logistic regression.Results: The termination of pregnancy was performed in 41 (43.6%) and non-termination of pregnancy in 53 (56.4%) pregnant women. Pregnant women who did not terminate the pregnancy had more complications in the gestational period (p < 0.0001) and in the postpartum period (p = 0.0088). After multiple logistic regressions, the following variables influenced the decision to terminate the pregnancy: type of congenital anomaly (OR: 18.59, CI95% 1.96; 175.87) and living children (OR: 0.45, CI 95% 0.25; 0.80).Conclusion: Most of the pregnant women with fetal infeasibility opted for non-termination of pregnancy and these patients had more obstetrical complications. The type of congenital anomaly and living children were the factors most associated with the choice for the termination of pregnancy.
    No preview · Article · Jan 2016 · Journal of Maternal-Fetal and Neonatal Medicine
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    ABSTRACT: OBJECTIVE: We examined the predictive macrosomia birthweight thresholds for adverse maternal and neonatal outcomes.STUDY DESIGN: This was a multicenter, retrospective cohort study conducted in China. We selected 178,709 singletons weighing ≥ 2,500 g with gestational age 37–44 weeks. We categorized macrosomia with two gradations (4,000–4,499 g and ≥ 4,500 g) and compared them with a normosomic reference group of infants with birthweight 2,500–3,999 g.RESULTS: The risks of obstetric and neonatal complications increased when infants had a birthweight of ≥ 4,000 g. The rates of infant mortality, Apgar score ≤ 3 at 5 min, respiratory and neurological disorders rose significantly among neonates weighing ≥ 4,500 g.CONCLUSION: A definition of macrosomia as birthweight ≥ 4,000 g could be beneficial as an indicator of obstetric and newborn complications, and birthweight ≥ 4,500 g might be predictive of severe infant morbidity and mortality risk.
    No preview · Article · Jan 2016 · Journal of Maternal-Fetal and Neonatal Medicine
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    ABSTRACT: Background: Preeclampsia (PE) is one of the most common pregnancy-related complications. We have previously reported that Gadd45α is over-expressed in trophoblasts in preeclamptic placentas, with an excessive activation of p38 mitogen-activated protein kinase (MAPK) and increased levels of soluble Fms-like tyrosine kinase 1(sFlt-1) and soluble endoglin (sEng) in maternal sera. Now we further investigate how Gadd45α regulates trophoblast functions and anti-angiogenesis factors secretions during placental development in patients with PE. Methods: Human placental villous explants were used to verify the effects of Gadd45α and p38 MAPK in placentation. Then HRT8/SVneo cells exposed to hypoxia/reoxygenation (H/R) were employed as an oxidative stress model to investigate the effects of Gadd45α on invasion and sFlt-1/sEng secretions. Through silencing Gadd45α with lentiviral vector-based short-hairpin RNA and inhibiting p38 MAPK with SB203580, we demonstrated that Gadd45α and its downstream p38 protein played roles in the pathology of preeclampsia. Results: Gadd45α was found to have increased expression in H/R-treated villous explants and HTR8/SVneo cells. Gadd45α knockdown or p38 blockage could promote trophoblast outgrowth and migration in H/R-exposed villous explants, and enhance the potentials of trophoblast migration/invasion and network formation in H/R-exposed HTR8/SVneo cells. These functional changes might be related to the increased activities of MMP2/9. Meanwhile, Gadd45α knockdown or p38 inhibition also decreases sFlt-1/sEng secretions via suppressing oxidative stress. Conclusions: Oxidative stress-induced overexpression of Gadd45α might influence the activity of MMPs through activation of p38 MAPK signaling to affect the invasion of trophoblast cells, and increase the secretions of sFlt-1/sEng, which then participate in the pathogenesis of preeclampsia.
    No preview · Article · Jan 2016 · Journal of Maternal-Fetal and Neonatal Medicine

  • No preview · Article · Jan 2016 · Journal of Maternal-Fetal and Neonatal Medicine
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    ABSTRACT: Objective: To assess the association of vaginal commensal and low grade pathogenic bacteria including Ureaplasma parvum, Ureaplasma urealyticum, Mycoplasma hominis, Mycoplasma genitalium, Group B Streptococcus (GBS), and Gardnerella vaginalis, in women who delivered preterm at less than 37 weeks gestation in the presence or absence of inflammation of the chorioamnionitic membranes.Methods: A case control study involving women who delivered before 37 weeks gestation with and without inflammation of chorioamnionitic membranes.A total of 57 placental samples were histologically examined for polymorphonuclear leukocyte infiltration of placental tissue for evidence of chorioamnionitis, and by type-specific nucleic acid amplification for evidence of infection with one or more of the target bacteria. Demographic data was collected for each mother.Results: Amongst the 57 placental samples, 42.1% had chorioamnionitis and 24.6% delivered in the second trimester of pregnancy; U. parvum, U. urealyticum, G. vaginalis and GBS were all detected in the study with respective prevalence of 19.3%, 3.5%, 17.5% and 15.8%; M.genitalium and M. hominis were not detected. U. parvum was significantly associated with chorioamnionitis (p value = 0.02; OR 5.0; (95% CI 1.2-21.5) and was more common in women who delivered in the second (35.7%) compared to the third trimester of pregnancy (13.9%). None of the other bacteria were associated with chorioamnionitis or earlier delivery and all G.vaginalis positive women delivered in the third trimester of pregnancy (p value 0.04).Conclusions: The detection of U. parvum in placental tissue was significantly associated with acute chorioamnionitis in women presenting in extreme preterm labour.
    No preview · Article · Jan 2016 · Journal of Maternal-Fetal and Neonatal Medicine

  • No preview · Article · Jan 2016 · Journal of Maternal-Fetal and Neonatal Medicine
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    ABSTRACT: Objective: Maternal obesity affects one in every five women giving birth worldwide. This condition is associated with adverse perinatal outcomes, as well as increased morbidity and mortality for mother and offspring.Methods: We carried out a prospective study at the University of Pecs Medical Center, Pecs, Hungary, between 1 January 2013 and 1 January 2014. We enrolled 60 obese (body mass index > 30 kg/m2) low-risk pregnant women and 108 age-, ethnicity- and parity-matched non-obese pregnant control subjects. The ST segment of the fetal electrocardiogram was assessed by STAN® monitoring. Neonatal outcomes and cord gas analysis of the umbilical vessels were evaluated after birth.Results: No infant with definitive metabolic acidosis was delivered in either group. We observed 32 and 106 ST events in the obese and control group, respectively, but this difference was not statistically significant. To date, none of the infants delivered as part of this study has demonstrated developmental insufficiency.Conclusions: Obesity might not influence the fetal electrocardiogram during labor as an independent risk factor for adverse pregnancy outcomes. Studies with larger cohort sizes are needed to confirm our findings.
    No preview · Article · Jan 2016 · Journal of Maternal-Fetal and Neonatal Medicine