EMBO Reports (EMBO Rep)

Publisher: European Molecular Biology Organization; Oxford University Press; HighWire Press, EMBO Press

Journal description

EMBO Reports aims to provide high-quality scientific information in the very broadly defined area of molecular biology. EMBO Reports will have in three major sections: scientific reports reviews and science & society. The scientific reports shall be short high-quality papers of a maximum print-length of 5 pages. Papers of all areas of molecular biology will be welcome and the data presented will represent a major new insight into some aspect of molecular biology. Novelty will be a primary criterion as will the quality of the research that is reported. These papers will be reviewed and published rapidly as is in keeping with important primary scientific results. The review section will provide high-quality reviews of selected topics written by leading experts in the field. It will also report on papers of importance which are published in other scientific journals and in doing so will attempt to ensure that the material presented in EMBO Reports is appropriate for a broad readership. A particular emphasis will also be put on incisive reports of meetings at which the latest data are presented. The science & society section will be a mixture of information which is relevant to scientists working in the area of molecular biology discussion on topics which fall into the general category of the environment in which our research is performed and more in-depth articles in which specific scientific topics are dealt with in detail. By the combination of these sections EMBO Reports aims to be a leading widely read interesting journal which is synonymous with high-quality primary reports of research readable stimulating timely reviews and a forum for discussions which are of direct relevance to molecular biologists. In this way it complements the coverage to science which is provided by The EMBO Journal which has already shown the ability of EMBO to develop a journal of high quality in the area of molecular biology.

Current impact factor: 9.06

Impact Factor Rankings

2016 Impact Factor Available summer 2017
2014 / 2015 Impact Factor 9.055
2013 Impact Factor 7.858
2012 Impact Factor 7.189
2011 Impact Factor 7.355
2010 Impact Factor 7.822
2009 Impact Factor 6.907
2008 Impact Factor 7.099
2007 Impact Factor 7.45
2006 Impact Factor 8.175
2005 Impact Factor 7.663
2004 Impact Factor 7.567
2003 Impact Factor 7.39
2002 Impact Factor 7.698
2001 Impact Factor 6.046

Impact factor over time

Impact factor
Year

Additional details

5-year impact 8.04
Cited half-life 6.80
Immediacy index 2.27
Eigenfactor 0.04
Article influence 3.82
Website EMBO Reports website
Other titles EMBO reports (Online), European Molecular Biology Organization reports
ISSN 1469-3178
OCLC 46360308
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

EMBO Press

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author cannot archive a post-print version
  • Restrictions
    • 6 months embargo
  • Conditions
    • Pre-print on pre-print servers only, such as arXiv and Nature Procedings
    • Post-print on funding body's archive, author's personal website and institutional repository
    • Published source must be acknowledged
    • Must link to publisher version with DOI
    • Publisher's version/PDF cannot be used
    • Publisher will deposit on behalf of authors the accepted version to PubMed Central after 6 months embargo
  • Classification
    yellow

Publications in this journal

  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: It is striking that within a eukaryotic nucleus, the genome can assume specific spatiotemporal distributions that correlate with the cell's functional states. Cell identity itself is determined by distinct sets of genes that are expressed at a given time. On the level of the individual gene, there is a strong correlation between transcriptional activity and associated histone modifications. Histone modifications act by influencing the recruitment of non-histone proteins and by determining the level of chromatin compaction, transcription factor binding, and transcription elongation. Accumulating evidence also shows that the subnuclear position of a gene or domain correlates with its expression status. Thus, the question arises whether this spatial organization results from or determines a gene's chromatin status. Although the association of a promoter with the inner nuclear membrane (INM) is neither necessary nor sufficient for repression, the perinuclear sequestration of heterochromatin is nonetheless conserved from yeast to man. How does subnuclear localization influence gene expression? Recent work argues that the common denominator between genome organization and gene expression is the modification of histones and in some cases of histone variants. This provides an important link between local chromatin structure and long-range genome organization in interphase cells. In this review, we will evaluate how histones contribute to the latter, and discuss how this might help to regulate genes crucial for cell differentiation.
    Preview · Article · Jan 2016 · EMBO Reports
  • [Show abstract] [Hide abstract]
    ABSTRACT: Research over the past 15 years has established that defective primary cilia play a fundamental role in the pathogenesis of various genetic and acquired human diseases now termed ciliopathies. A new study, published in this issue of EMBO reports, expands the spectrum of cilia-related diseases by uncovering a role for primary cilia in preventing cardiovascular disease. Dinsmore and Reiter show that lack of endothelial cilia in the aorta results in accelerated development of atherosclerotic lesions in a mouse model of atherosclerosis on a high-fat, high-cholesterol diet. Loss of endothelial cilia further increases inflammatory gene expression and reduces vasoprotective eNOS activity . In summary, this interesting study identifies a role for aortic endothelial cilia to protect against atherosclerosis.
    No preview · Article · Jan 2016 · EMBO Reports
  • [Show abstract] [Hide abstract]
    ABSTRACT: Pattern recognition receptors (PRRs) play a key role in plant and animal innate immunity. PRR binding of their cognate ligand triggers a signaling network and activates an immune response. Activation of PRR signaling must be controlled prior to ligand binding to prevent spurious signaling and immune activation. Flagellin perception in Arabidopsis through FLAGELLIN-SENSITIVE 2 (FLS2) induces the activation of mitogen-activated protein kinases (MAPKs) and immunity. However, the precise molecular mechanism that connects activated FLS2 to downstream MAPK cascades remains unknown. Here, we report the identification of a differentially phosphorylated MAP kinase kinase kinase that also interacts with FLS2. Using targeted proteomics and functional analysis, we show that MKKK7 negatively regulates flagellin-triggered signaling and basal immunity and this requires phosphorylation of MKKK7 on specific serine residues. MKKK7 attenuates MPK6 activity and defense gene expression. Moreover, MKKK7 suppresses the reactive oxygen species burst downstream of FLS2, suggesting that MKKK7-mediated attenuation of FLS2 signaling occurs through direct modulation of the FLS2 complex.
    No preview · Article · Jan 2016 · EMBO Reports
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    ABSTRACT: Primary cilia are microtubule-based structures present on most mammalian cells that are important for intercellular signaling. Cilia are present on a subset of endothelial cells where they project into the vessel lumen and are implicated as mechanical sensors of blood flow. To test the in vivo role of endothelial cilia, we conditionally deleted Ift88, a gene required for ciliogenesis, in endothelial cells of mice. We found that endothelial primary cilia were dispensable for mammalian vascular development. Cilia were not uniformly distributed in the mouse aorta, but were enriched at vascular branch points and sites of high curvature. These same sites are predisposed to the development of atherosclerotic plaques, prompting us to investigate whether cilia participate in atherosclerosis. Removing endothelial cilia increased atherosclerosis in Apoe(-/-) mice fed a high-fat, high-cholesterol diet, indicating that cilia protect against atherosclerosis. Removing endothelial cilia increased inflammatory gene expression and decreased eNOS activity, indicating that endothelial cilia inhibit pro-atherosclerotic signaling in the aorta.
    No preview · Article · Jan 2016 · EMBO Reports

  • No preview · Article · Jan 2016 · EMBO Reports
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    ABSTRACT: Metal ion-containing macromolecules have fundamental roles in essentially all biological processes throughout the evolutionary tree. For example, iron-containing heme is a cofactor in enzyme catalysis and electron transfer and an essential hemoglobin constituent. To meet the intense demand for hemoglobin assembly in red blood cells, the cell type-specific factor GATA-1 activates transcription of Alas2, encoding the rate-limiting enzyme in heme biosynthesis, 5-aminolevulinic acid synthase-2 (ALAS-2). Using genetic editing to unravel mechanisms governing heme biosynthesis, we discovered a GATA factor- and heme-dependent circuit that establishes the erythroid cell transcriptome. CRISPR/Cas9-mediated ablation of two Alas2 intronic cis elements strongly reduces GATA-1-induced Alas2 transcription, heme biosynthesis, and surprisingly, GATA-1 regulation of other vital constituents of the erythroid cell transcriptome. Bypassing ALAS-2 function in Alas2 cis element-mutant cells by providing its catalytic product 5-aminolevulinic acid rescues heme biosynthesis and the GATA-1-dependent genetic network. Heme amplifies GATA-1 function by downregulating the heme-sensing transcriptional repressor Bach1 and via a Bach1-insensitive mechanism. Through this dual mechanism, heme and a master regulator collaborate to orchestrate a cell type-specific transcriptional program that promotes cellular differentiation.
    No preview · Article · Dec 2015 · EMBO Reports
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    ABSTRACT: Sex might be more about defending against parasites and pathogens than about love. Sexual selection has evolved to select for specific behavioural traits and might therefore have driven human social and cultural evolution.
    No preview · Article · Dec 2015 · EMBO Reports
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    ABSTRACT: With the advent of new technologies for gene editing and genetic manipulation, it becomes increasingly clear that the EU's legislation of agricultural biotechnologies is hopelessly out of date. A more rational regulatory system for GM crops should be based on the features of the product, instead of the process of engineering it.
    No preview · Article · Nov 2015 · EMBO Reports

  • No preview · Article · Nov 2015 · EMBO Reports

  • No preview · Article · Nov 2015 · EMBO Reports
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    ABSTRACT: Pluripotent embryonic stem cells (ESCs) are characterized by distinct epigenetic features including a relative enrichment of histone modifications related to active chromatin. Among these is tri-methylation of lysine 4 on histone H3 (H3K4me3). Several thousands of the H3K4me3-enriched promoters in pluripotent cells also contain a repressive histone mark, namely H3K27me3, a situation referred to as "bivalency". While bivalent promoters are not unique to pluripotent cells, they are relatively enriched in these cell types, largely marking developmental and lineage-specific genes which are silent but poised for immediate action. The H3K4me3 and H3K27me3 modifications are catalyzed by lysine methyltransferases which are usually found within, although not entirely limited to, the Trithorax group (TrxG) and Polycomb group (PcG) protein complexes, respectively, but these do not provide selective bivalent specificity. Recent studies highlight the family of ATP-dependent chromatin remodeling proteins as regulators of bivalent domains. Here, we discuss bivalency in general, describe the machineries that catalyze bivalent chromatin domains, and portray the emerging connection between bivalency and the action of different families of chromatin remodelers, namely INO80, esBAF, and NuRD, in pluripotent cells. We posit that chromatin remodeling proteins may enable "bivalent specificity", often selectively acting on, or selectively depleted from, bivalent domains.
    No preview · Article · Nov 2015 · EMBO Reports