Colorectal Disease (Colorectal Dis)

Publisher: Association of Coloproctology of Great Britain and Ireland, Wiley

Journal description

Colorectal Disease is a new journal publishing original research in any discipline relating to colorectal pathology. The journal will further education and inter-professional development by including regular review articles, discussions of current controversies, occasional highly selected case reports, and question and answer features.Colorectal Disease is the official organ of the Association of Coloproctology of Great Britain and Ireland. The journal will report news of the Association and take a major interest in coloproctological matters across Europe as a whole.

Current impact factor: 2.35

Impact Factor Rankings

2016 Impact Factor Available summer 2017
2014 / 2015 Impact Factor 2.351
2013 Impact Factor 2.017
2012 Impact Factor 2.081
2011 Impact Factor 2.927
2010 Impact Factor 2.728
2009 Impact Factor 2.41
2008 Impact Factor 2.293
2007 Impact Factor 2.059

Impact factor over time

Impact factor
Year

Additional details

5-year impact 2.36
Cited half-life 4.10
Immediacy index 0.74
Eigenfactor 0.02
Article influence 0.73
Website Colorectal Disease website
Other titles Colorectal disease (Online)
ISSN 1463-1318
OCLC 45907159
Material type Document, Periodical, Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

Wiley

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author cannot archive a post-print version
  • Restrictions
    • 12 months embargo
  • Conditions
    • Some journals have separate policies, please check with each journal directly
    • On author's personal website, institutional repositories, arXiv, AgEcon, PhilPapers, PubMed Central, RePEc or Social Science Research Network
    • Author's pre-print may not be updated with Publisher's Version/PDF
    • Author's pre-print must acknowledge acceptance for publication
    • Non-Commercial
    • Publisher's version/PDF cannot be used
    • Publisher source must be acknowledged with citation
    • Must link to publisher version with set statement (see policy)
    • If OnlineOpen is available, BBSRC, EPSRC, MRC, NERC and STFC authors, may self-archive after 12 months
    • If OnlineOpen is available, AHRC and ESRC authors, may self-archive after 24 months
    • Publisher last contacted on 07/08/2014
    • This policy is an exception to the default policies of 'Wiley'
  • Classification
    yellow

Publications in this journal


  • No preview · Article · Feb 2016 · Colorectal Disease

  • No preview · Article · Feb 2016 · Colorectal Disease
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    ABSTRACT: In order to improve post-operative outcome, 3mm laparoscopy has been proposed [1], but it has not achieved wide application, especially in adults, due to several limitations of the current devices such as shaft weakness, reduced size of end-effectors as well as their intrinsic fragility [2]. These factors are even more limiting during advanced surgical procedures, such as colorectal surgery in adults [3]. Furthermore standard 3mm instruments require the use of trocars that needs an incision that is always 3mm wider than the instrument itself, hence reducing the benefit. This article is protected by copyright. All rights reserved.
    No preview · Article · Jan 2016 · Colorectal Disease
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    ABSTRACT: Adverse effects of different types of medication can cause various patterns of colitis.(1) The immunosuppresive drugs Mycophenolic acid and anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) antibody Ipilimumab are known to cause a graft-versus-host disease (GVHD)-like apoptotic enteropathy (AE).(1,2) Recently, antimetabolites (Methotrexate and Capecitabine) and tumour necrosis factor-α (TNF-α) inhibitors (Etanercept and Infliximab) have also been reported to cause similar changes.(2) Adalimumab is a fully humanized anti TNF-α monoclonal antibody that has been approved by the Food and Drug Administration (FDA) for use in Crohn's disease and ulcerative colitis (UC).(3,4) Here we present a case of apoptic enteropathy (AE) in a patient with ulcerative colitis, who was being treated with Adalimumab. To best of our knowledge, this is the first such case reported in the literature. This article is protected by copyright. All rights reserved.
    No preview · Article · Jan 2016 · Colorectal Disease
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    ABSTRACT: Aim: The study used a national registry to compare the outcome after a low Hartmann's procedure (LHP), defined as removal of most of the rectum to leave a short anorectal stump and an end colostomy and low anterior resection (LA) with or without a diverting ileostomy (DI) in rectal cancer patients all of whom had received preoperative neoadjuvant radiotherapy (RT). Method: Patients who underwent LHP or LA with or without DI for rectal cancer after RT between 2009 and 2013 were identified from the Dutch Surgical Colorectal Audit. The postoperative outcome was compared between the three groups and risk of complications, reoperation and mortality were analysed in a multivariable model. Results: 4288 patients were included, of whom 27.8% underwent LHP, 20.2% LA, and 61.0% LA with DI. Thirty-day mortality was higher after LHP (3.2% vs. 1.3% and 1.3% for LA with or without DI, p<0.001), but LHP was not an independent predictor of mortality in multivariable analysis. LHP and LA with DI were associated with a lower rate of abdominal infective complications (6.5% and 10.1% vs.16.2%, p<0.001) and reoperation (7.3% and 8.1% vs.16.5%, p<0.001). In multivariable analysis, LHP (OR 0.35, 95%CI 0.26-0.47) and LA with DI (OR 0.43, 95%CI 0.33-0.54) were associated with a lower risk of reoperation than LA alone. LHP was associated with a lower risk of any postoperative complication than LA with or without DI (OR 0.81, 95%CI 0.66-0.98). Conclusion: LHP and LA with DI were associated with fewer infective complications and reoperations than LA alone. The thirty day mortality and the rate of any complication were less after LHR than LA with or without DI. This article is protected by copyright. All rights reserved.
    No preview · Article · Jan 2016 · Colorectal Disease
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    ABSTRACT: Aim: Sessile serrated adenomas/polyps (SSA/Ps) have been proposed as precursors of colorectal cancer. The aims of this investigation were to compare the endoscopic findings of SSA/Ps with those of other serrated lesions and to compare the histologic findings of SSA/Ps with those of conventional adenomas. Method: We retrospectively reviewed colonoscopy records from 1984 to 2013 at our institution and identified cases of endoscopically or surgically resected conventional adenomas and serrated lesions, including SSA/Ps, hyperplastic polyps (HPs) and traditional serrated adenomas (TSAs). The colonoscopic findings of SSA/Ps were compared with those of the other two serrated lesions and histologic findings were compared among all groups of lesions. Results: There were 79 HPs in 68 patients, 77 SSA/Ps in 63 patients, 167 TSAs in 145 patients and 6324 conventional adenomas in 4129 patients. The inverted type and flat-elevated type were more frequent among SSA/Ps than among the other two types of serrated lesions. Magnifying colonoscopy revealed that a round and open pit pattern, expanded crypt openings, and varicose microvascular vessels were more frequently observed among SSA/Ps than among the other types. The incidence of high-grade dysplasia or carcinoma among SSA/Ps (13.0%) was significantly higher than that among HPs (0%, p<0.001) and equivalent to that among conventional adenomas (12.3%). Conclusion: SSA/Ps have colonoscopic features distinct from HPs and TSAs. The malignant potential of SSA/Ps seems to be equal to that of conventional adenomas. This article is protected by copyright. All rights reserved.
    No preview · Article · Jan 2016 · Colorectal Disease
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    ABSTRACT: Background: Lipomodelling has been successfully used in reconstructive breast surgery but not yet in patients with permanent stomas. Methods: A feasibility study of six patients with permanent stomas was undertaken. Patients underwent lipomodelling of the peri-stomal area. The number of leakages and quality of life before and after the procedure for 6 months was measured. Results: All patients reported an improvement in their stoma related quality of life and a reduction in the number of leakages suffered.,)mean 2.25 leakages / 24 hours pre and 0.5 leakages / 24 hours post). Conclusions: Lipomodelling appears to be an effective method to reduce stoma leakages due to peristomal skin contour abnormalities. This article is protected by copyright. All rights reserved.
    No preview · Article · Jan 2016 · Colorectal Disease
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    ABSTRACT: Aim: Data on risk factors for portomesenteric venous thrombosis (PMVT) following abdominal surgery for ulcerative colitis (UC) are limited. The aim of this study was to investigate factors associated with PMVT after surgical treatment for UC. Method: Patients who underwent restorative proctocolectomy (RPC) and ileal pouch-anal anastomosis (IPAA) including diverting ileostomy closure for medically refractory UC were identified from a prospectively maintained data base. Patient-related, disease-related and treatment-related variables were collected. Univariable and multivariable analyses were performed to assess factors associated with PMVT. Results: Of the 521 patients completing surgical treatment for UC between 2006 and 2012, symptomatic PMVT occurred in 36 (7%), which resulted in a significantly increased hospital stay (P<0.001). Patients developing PMVT were younger (P=0.014), had a lower preoperative albumin level (P=0.037) and were more likely to have been taking steroids within one month before surgery (P=0.006). The combined incidence of PMVT was comparable between patients having a three-stage and two-stage management (6% vs. 8%, P= 0.43), but the relative incidence of PMVT after restorative proctocolectomy (RPC) + IPAA was 8%, significantly higher than 4% after total abdominal colectomy (TAC) (P=0.005) and 2% after subsequent completion proctectomy (CP) + IPAA (P=0.038). Multivariate analysis confirmed that RPC + IPAA was associated with a significantly greater risk of PMVT than CP + IPAA (OR=4.9, P=0.003) or TAC (OR=3.5, P=0.011). Preoperative steroid medication was an independent factor for PMVT (OR=5.8, P=0.006). Conclusion: Steroid use one month before surgery is associated with an increased risk of PMVT. A staged restorative proctocolectomy does not increase the overall incidence of PMVT. This article is protected by copyright. All rights reserved.
    No preview · Article · Jan 2016 · Colorectal Disease
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    ABSTRACT: Aim: Pelvic exenteration is an aggressive operation for locally advanced rectal cancer. Social deprivation has been shown to reduce life expectancy and has been linked to a poorer outcome in patients with colorectal cancer. The aim of this study was to analyse the effect of social deprivation scores on the outcome in these complex patients. Method: A retrospective review of all patients undergoing pelvic exenteration for primary rectal cancer between 2006 and 2014 was performed. Deprivation scores were calculated for all patients using the Welsh Index of Multiple Deprivation (WIMD). Patients were then grouped into quartiles, form Q1 (most deprived) to Q4 (least deprived). The primary outcome measure was 5 year survival. Results: 120 patients were included (65 female) with a median age of 64 (31-90) years. No differences between quartiles were identified for neoadjuvant therapy (p=0.687) or type of exenteration (p=0.690). The median length of stay was significantly higher in the most deprived groups (Q1-Q2; p=0.023). There was a significant difference in survival between the groups, with lowest five year survival rates (53%) in the most deprived quartile (Q1) (p=0.015). Conclusion: Social deprivation is significantly associated with postoperative length of stay and survival in patients undergoing pelvic exenteration for primary rectal cancer. This article is protected by copyright. All rights reserved.
    No preview · Article · Jan 2016 · Colorectal Disease
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    ABSTRACT: Aim: The study CEA Watch (Netherlands Trial Register 2182) has shown that an intensified follow-up schedule with more frequent CEA measurements but fewer outpatient visits detects more curable recurrences compared with the usual follow-up protocol in colorectal cancer patients. The aim of the study was to compare the cost and cost-effectiveness between various follow-up programmes. Method: 3,223 patients with stage I-III colorectal cancer (CRC) were followed between October 2010 and October 2012. Direct medical costs were calculated per patient adding the costs for all visits, CEA measurements and imaging. Productivity losses and travel expenses were calculated using answers from questionnaires. The cost-effectiveness displayed the additional costs per additional patient with recurrent disease (RD) and used an Incremental Cost Effectiveness Ratio (ICER) to compare those. Results: The mean yearly cost per patient was € 548 in the intensified protocol and €497 in the control protocol. The ICER was €94 (95% CI € 76 - € 157) per percent; to detect one additional patient with a recurrence in the intervention protocol compared with the control protocol, would require an additional €9,400. For curable recurrences, the ICER was €607 (CI: -€ 5695 to € 5728). Annual patient-reported costs were € 509 per year in the intervention protocol and € 488 in the control protocol. Conclusion: The current study demonstrates that the direct medical and patient-reported cost of a newly introduced, safe and effective way of CRC follow-up was comparable to that of standard care. The ICER per curable recurrence was considered acceptably low. This article is protected by copyright. All rights reserved.
    No preview · Article · Jan 2016 · Colorectal Disease
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    ABSTRACT: We completely agree with Mr Kelly about the necessity of an accurate preoperative staging that would allow planning the prostatic resection before surgery. However, prostatic involvement by the rectal tumour is sometimes diagnosed only intra-operatively and the decision about the best resection plane is difficult and based on the surgeon's experience. When a partial prostatectomy is performed, the urethral damage is the main intra- operative complication. In our experience, the use of a flexible urethral probe often does not prevent from urethral injuries. This article is protected by copyright. All rights reserved.
    No preview · Article · Jan 2016 · Colorectal Disease
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    ABSTRACT: Aim: The analysis of the volatile part of the metabolome (Volatile Organic Compounds (VOC)) present in the gas phase of excreted materials is a promising new research field for the identification of screening tools for several cancers, including colorectal cancer (CRC). The VOC signature can reflect the health status as a 'fingerprint', which can be modified in several diseases. Technical difficulties still limit the widespread use of VOC analysis in the clinical setting, but this approach has already been applied successfully in the diagnosis of CRC. The present study reviews the available data on VOC present in DEAR AUITHOR THE WORD 'HEADSPACE' IS NOT ENGLISH AS FAR AS I KNOW. IF YOU WANT TO INCLUDE A WORD THAT IS RECOGNISED THEN PLEASE LET ME KNOW. OTHERWISE I WILL REMOVE IT FROM THE TEXT. Headspace is the word used to identify "the gaseous constituents of a closed space above liquids or solid emitting and vapors measured using headspace gas chromatography" the headspace (the gaseous constituents of a closed space above a liquid or solid) of blood, urine, faeces and breath as a potential screening tool for CRC. Method: A systematic electronic literature search was conducted in PubMed, Scirus and Google using the keywords Metabolomic, Volatile Organic Compounds (VOC), Electronic-nose and Colorectal Cancer. Only articles published in English between 2000-2015 were selected and independently checked by two of the authors. Results: Ten papers describing the reliability of VOC analysis in breath and faeces, blood and urine were selected, all indicating good reliability in detecting colorectal cancer. The use of different substrates and different analytical platforms has led to the identification of different patterns of VOC. Conclusion: The reliability of a metabolomic approach in CRC screening as a non-invasive biomarker is supported by this review despite several limitation due to the number of patients included in each study, the different analytical platforms and the biological material used and different VOCs identified This article is protected by copyright. All rights reserved.
    No preview · Article · Jan 2016 · Colorectal Disease
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    ABSTRACT: In 2013 a group of medical students and surgical trainees in the United Kingdom (UK) founded Student Audit and Research in Surgery (STARSurg, www.starsurg.org), a national, student-driven research collaborative. STARSurg enables students to participate in high quality studies, developing skills to enable them to become research-active clinicians in the future (1). This article is protected by copyright. All rights reserved.
    No preview · Article · Jan 2016 · Colorectal Disease
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    ABSTRACT: Aim: The study investigated the value of faecal lactoferrin as a follow-up biomarker for mucosal healing of ulcerative colitis during granulocyte and monocyte adsorptive apheresis (GMA) therapy. Method: Patients with ulcerative colitis exhibiting a moderate or severe disease activity with a partial Mayo Score (pMS) of over 4 were enrolled in this study. The patients received ten courses of GMA therapy. The pMS value and faecal lactoferrin level were monitored and compared with the findings of endoscopy until 12 months after the last dose of GMA therapy. Results: Twenty patients (male: female 11: 9) were enrolled in this study. Twelve had total colitis, while six had left-sided involvement and two had distal proctitis. Thirteen (65.0%) responded to GMA therapy. The faecal lactoferrin levels were significantly decreased in patients who responsed to GMA therapy (P<0.05), whereas the levels did not change in non-responders. Moreover, the faecal lactoferrin levels correlated with the endoscopic findings (r=0.792, P<0.01) and pMS scores (r=0.529, P<0.01). The correlation coefficients between the faecal lactoferrin levels and mucosal findings were higher than those observed between the pMS score and mucosal findings. Conclusion: The faecal lactoferrin level is a useful biomarker of the mucosal findings in ulcerative colitis. Although endoscopy is the gold standard, the faecal lactoferrin level can be used as a biomarker during GMA therapy in patients with ulcerative colitis. This article is protected by copyright. All rights reserved.
    No preview · Article · Jan 2016 · Colorectal Disease
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    ABSTRACT: Aim: The study aimed to review, consolidate, and analyze the findings of studies investigating the efficacy of anal fistula plugs (AFPs) in treating fistula-in-ano in Crohn's patients. Method: A literature review was conducted via PUBMED, EMBASE, MEDLINE, SCOPUS and COCHRANE LIBRARY for the period 1995-2015. Articles were selected and reviewed based on specific inclusion and exclusion criteria. Results: A total of 16 studies were extracted, of which 12 were included in the systematic review. In total, 84 patients (n=1-20 per study), with a median age of 45 (18-72) years, and a median follow-up time of 9 (3-24) months were analyzed. The total success rate, defined as closure of the fistula track, was 49/84 (58.3%, 95% CI 47-69%). Success in patients with recurrent anal fistulas was 2/5 (40%, 95% CI 5-85%). Overall, the success rates of Surgisis(®) and GORE(®) BIO-A(®) brand plugs were 48/80 (60%, 95% CI 48-71%) and 1/4 (25%, 95% CI 1-81%). The recurrence rate of fistula-in-ano in the five studies that reported recurrence was 3/22 (13.6%). In two comparative studies, inferior overall success rates were found in patients who received pre-operative immunomodulators versus those who did not (3/11 (27.3%) v 17/23 (73.9%)). Conclusion: The studies suggest that the use of an AFP in Crohn's disease patients is a safe procedure with reasonable success, little morbidity and a low risk of incontinence. The current literature is limited by a number of factors including small study cohorts, grouping of fistulas in Crohn's disease with other types of anal fistula, short and highly variable follow-up times, and multiple confounding factors such as number of fistula tracts, use of pre-operative steroids or immunosuppressants, previous use of setons and variation in surgical technique. This article is protected by copyright. All rights reserved.
    No preview · Article · Jan 2016 · Colorectal Disease
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    ABSTRACT: Aim: Colon cancer resection in a non-elective setting is associated with high rates of morbidity and mortality. The aim of this retrospective study is to identify risk factors for overall mortality after colon cancer resection with a special focus on non-elective resection. Method: Data were obtained from the Dutch Surgical Colorectal Audit. Patients undergoing colon cancer resection in the Netherlands between January 2009 and December 2013 were included. Patient, treatment and tumour factors were analyzed in relation to the urgency of surgery. The primary outcome was the thirty day postoperative mortality. Results: The study included 30,907 patients. In 5934 (19.2%) of patients, a non-elective colon cancer resection was performed. There was a 4.4% overall mortality rate, with significantly more deaths after non-elective surgery (8.5% vs 3.4%, P<0.001). Patients of older age and male gender, and with high comorbidity, advanced tumours, perforated tumours, a tumour in the right or transverse colon and postoperative anastomotic leakage were at risk of postoperative death. In non-elective resections, a right-sided tumour and postoperative anastomotic leakage were associated with high mortality. Conclusion: Non-elective colon cancer resection is associated with high mortality. In particular, right-sided resections and patients with tumour perforation are at particularly high risk. The optimization of patients prior to surgery and expeditious operation after diagnosis might prevent the need for a non-elective resection. This article is protected by copyright. All rights reserved.
    No preview · Article · Jan 2016 · Colorectal Disease
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    ABSTRACT: Aim: Minimally invasive approaches to proctectomy for rectal cancer have not been widely adopted due to inherent technical challenges. A modification of traditional trans-abdominal mobilization termed transanal total mesorectal excision (TaTME) has the potential to improve access to the distal rectum. The aim of the current study is to assess outcomes following TaTME for rectal cancer. Methods: This is a retrospective analysis of a prospectively maintained database of consecutive patients who underwent TaTME for rectal cancer at a single institution. The study period was from March 1, 2012 to July 31, 2015. Results: During the study period 50 patients underwent TaTME. The median tumour distance from the anal verge was 4.4 (3.0-5.5) cm. The rate of conversion from a planned minimally invasive approach was 2.2%. The median operative time was 267.0 (227.0-331.0) minutes. The median lymph node yield was 18.0 (12.0-23.8), the macroscopic quality assessment of the resected specimen was incomplete in 2% and the circumferential resection margin positivity rate was 4%. Intra-operative morbidity occurred in 6% and the thirty-day morbidity rate was 36%. The median length of stay was 4.5 (4.0-8.0) days. The median follow-up was 15.1 (7.0-23.2) months, 2 patients have developed a local recurrence and 8 patients have developed distant recurrence. Conclusions: These data suggest TaTME for rectal cancer is feasible with acceptable pathological outcomes and morbidity profile. Further data on functional and long-term survival outcomes are required. This article is protected by copyright. All rights reserved.
    No preview · Article · Jan 2016 · Colorectal Disease
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    ABSTRACT: Obturator hernia is rare, including 0.073% of hernias in the western world.(1) The majority of patients are diagnosed by CT scan.(2) Traditionally, an open approach was adopted to repair such hernias, but with the advent of laparoscopic surgery there has been a shift in favour of this approach. A literature review identified 34 patients who had a laparoscopic repair of an obturator hernia. In eight cases the repair was performed as an emergency procedure. In these cases, the hernia was successfully reduced by gentle traction on the efferent limb without any complication.(3) Various techniques have been suggested to close the hernial defect. These include inversion of the sac, laparoscopic suturing and placement of polypropylene mesh.(4,5,6) (This article is protected by copyright. All rights reserved.)
    No preview · Article · Jan 2016 · Colorectal Disease