Medical Principles and Practice (Med Princ Pract)

Publisher: Karger

Journal description

Medical Principles and Practiceí is a general medical journal that focuses on recent advances made in basic medical sciences and clinical practice. It reflects the broad spectrum of work conducted by scientists and physicians from around the world at the Kuwait University faculty of medicine since its foundation in 1976. The international character of their contributions has resulted in the journal attracting original papers, reviews, reports and short communications not only from Kuwait and the Middle East, but also from the international scientific and medical communities as a whole.

Current impact factor: 1.34

Impact Factor Rankings

2016 Impact Factor Available summer 2017
2014 / 2015 Impact Factor 1.34
2013 Impact Factor 1.113
2012 Impact Factor 0.963
2011 Impact Factor 0.887
2010 Impact Factor 1.069
2009 Impact Factor 0.824
2008 Impact Factor 0.583
2007 Impact Factor 0.542
2006 Impact Factor 0.442
2005 Impact Factor 0.566
2004 Impact Factor 0.319
2003 Impact Factor 0.194
2002 Impact Factor 0.141
2001 Impact Factor 0.106
2000 Impact Factor 0.097
1999 Impact Factor 0.263
1998 Impact Factor 0.125

Impact factor over time

Impact factor
Year

Additional details

5-year impact 1.12
Cited half-life 5.30
Immediacy index 0.17
Eigenfactor 0.00
Article influence 0.26
Website Medical Principles and Practice website
ISSN 1423-0151
OCLC 164576043
Material type Internet resource
Document type Internet Resource, Computer File, Journal / Magazine / Newspaper

Publisher details

Karger

  • Pre-print
    • Author can archive a pre-print version
  • Post-print
    • Author can archive a post-print version
  • Conditions
    • On author's personal website or institutional website
    • Server must be non-commercial
    • Publisher's version/PDF may be used
    • Published source must be acknowledged
    • Must link to publisher version
    • Creative Commons Attribution Non-Commercial License 3.0
    • All titles are open access journals
    • This policy is an exception to the default policies of 'Karger'
  • Classification
    green

Publications in this journal

  • [Show abstract] [Hide abstract]
    ABSTRACT: In the majority of women, breast cancer progresses through increased transcriptional activity due to over-expressed estrogen receptor (ER). Therapeutic strategies include a) reduction of circulating ovarian estrogen or of peripherally produced estrogen (in postmenopausal women) with aromatase inhibitors and b) application of selective estrogen receptor modulators (SERMS) for receptor blockade. Success of these interventions is limited by the variable but persistent onset of acquired resistance and by intrinsic refractiveness which manifests despite adequate levels of ER in about 50% of patients with advanced metastatic disease. Loss of functional ER leads to endocrine insensitivity, loss of cellular adhesion and polarity, and increased migratory potential due to trans-differentiation of the epithelial cancer cells into a mesenchymal-like phenotype (EMT). Multiple mechanisms contributing to therapeutic failure have been proposed: a) loss or modification in ER expression including epigenetic mechanisms b) agonistic actions of SERMS that may be enhanced through increased expression of co-activators c) attenuation of tamoxifen metabolism through expression of genetic variants of P450 cytochromes that leads to more or less active metabolites d) increased growth factor signaling particularly through epidermal growth factor receptor (EGFR/erbB2) activation of pathways involving keratinocyte growth factor (KGF) platelet-derived growth factor (PDGF/abl) and nuclear factor ƙB (NFƙB). In addition, the small non-coding microRNAs, recently recognized as critical gene regulators, exhibit differential expression in tamoxifen sensitive vs resistant cell lines. Several studies suggest the potential of using these either as targets, or as therapeutic agents, to modulate EMT regulators, as a means of reversing the aggressive metastatic phenotype by reversal of EMT, with the added benefit of re-sensitisation to anti-estrogens.
    No preview · Article · Feb 2016 · Medical Principles and Practice

  • No preview · Article · Jan 2016 · Medical Principles and Practice

  • No preview · Article · Jan 2016 · Medical Principles and Practice
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    ABSTRACT: Objective: The purpose of this study was to investigate the efficiency of computed tomographic perfusion (CTP), contrast enhanced computed tomography (CECT) and 18F- fluorodeoxyglucose position emission tomography (PET/CT) in the diagnosis of esophageal cancer. Subjects and methods: This prospective study consisted of 33 patients with pathologically confirmed esophageal cancer of which and 2 had esophageal abscess. All the patients underwent CTP, CECT and PET/CT imaging and the imaging findings were evaluated. Sensitivity, specificity, positive predictive and negative predictive values were calculated for each of the three imaging modalities relative to the histological diagnosis. Results: Thirty three tumors were visualized on CTP; on CECT:29, on PET/CT:27. Six tumors were stage 1 and the two and four tumors missed by CECT and PET/CT, respectively. The significant differences were between the CTP and CECT (p:0.02), and CTP and PET/CT (p:0.04), for stage 1 tumors were found. Sensitivity, specificity, positive predictive. Corresponding values for and negative predictive value of CTP were 100%,100%,100% and 100% respectively. Corresponding values for CECT were 93.94%, 0%, 93.94% and 0% respectively, and those of PET/CT were 87.88%, 0%, 93.55% and 0% respectively. Hence the sensitivity, specificity, positive predictive and negative predictive values of CTP were better than those of CECT and PET/CT. Conclusion: The CTP had an advantage over CECT and PET/CT in the detecting small lesions. The CTP was valuable especially in stage 1 tumors.
    No preview · Article · Jan 2016 · Medical Principles and Practice
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    ABSTRACT: Staphylococcus epidermidis has emerged as the main causative agent for graft-related and nosocomial infections. Rampant use of antibiotics and biofilm formed by the organism results in poor penetration of the drug and further aggravates the antibiotic resistance, emphasizing an urgent need to explore alternative treatment modalities. Antimicrobial peptides (AMPs), produced as effector molecules of the innate immunity of living organisms, have therapeutic potential that can be used to inhibit the growth of microbes. In addition, the susceptibility of a microbe to become resistant to an AMP is relatively low. The AMPs are amphipathic peptides of 12 to 100 residues, which have a broad spectrum activity against microbes. There are scattered reports of AMPs listed against S. epidermidis and there is an urgent need to systematically study the AMPs. Various natural AMPs as well as synthetic peptides have been investigated against S. epidermidis. These peptides have shown to inhibit both planktonic culture as well as S. epidermidis biofilm effectively. The multiple modes of action in killing the organism minimize the chances for development of resistance. This review focused on various natural and synthetic peptides that demonstrate activity against S. epidermidis. .
    No preview · Article · Dec 2015 · Medical Principles and Practice
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    ABSTRACT: Objectives: The aim of this study was to investigate the elastic properties of the aorta and myocardial performance index of left ventricule in patients with Lichen Planus (LP). Subjects and methods: A total of 54 patients with lichen planus and 50 controls were enrolled to the study. Patients in the two groups were well matched regarding age, gender, body mass index, any smoking history, diabetes mellitus, systolic blood pressure, diastolic blood pressure. The echocardiographic examination was performed in study subjects and the controls. Aortic elasticity parameters and myocardial performance index of left ventricule were calculated. Student's t-test, chi-square analysis, multiple linear regression analysis were used for statistical analysis. Results: Aortic strain (AS) (4.77±1.81 vs 8.95±2.22, p<0.001) and aortic distensibility (AD) (0.25±0.009 vs 0.42±0.120, p<0.001) were significantly lower, and aortic stiffness index β (ASIβ) (3.65±1.03 vs 2.70±0.91, p<0.001) was significantly higher in the LP group compared to the controls. Also myocardial performance index was significantly higher in the LP group compared to the control group (p=0.001). Longevity of the LP was negatively correlated with AS (r=-0.364, p<0.001), AD (r=-0.279, p=0.006), and positively correlated with tei index (r=0.324, p=0.001) and ASIβ (r=0.364, p<0.001). After adjustment for relevant confounders (age, male gender, smoking, systolic blood pressure, diastolic blood pressure, diabetes mellitus, low density lipoprotein cholesterol, high density lipoprotein cholesterol) LP and longevity of the LP were still associated with of AS, AD and ASIβ. Conclusion: In this study, AS and AD were lower, and ASIβ and myocardial performance index were higher in LP patients compared to controls.
    No preview · Article · Dec 2015 · Medical Principles and Practice
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    ABSTRACT: Throughout history, natural products have played a dominant role in the treatment of human ailments. For example, the legendary discovery of penicillin transformed global existence. Presently, natural products comprise a large portion of current-day pharmaceutical agents, most notably in the area of cancer therapy. Examples include taxol, vinblastine, and camptothecin. These structurally unique agents function by novel mechanisms of action; isolation from natural sources is the only plausible method that could have led to their discovery. In addition to terrestrial plants as sources for starting materials, the marine environment (e.g., ecteinascidin 743, eribulin, dolastatins), microbes (e.g., bleomycin, doxorubicin, staurosporin), and slime molds (e.g., epothilone B) have yielded remarkable cancer chemotherapeutic agents. Irrespective of these advances, cancer remains a leading cause of death worldwide. Undoubtedly, the prevention of human cancer is highly preferable to treatment. Cancer chemoprevention, the use of vaccines or pharmaceutical agents to inhibit, retard, or reverse the process of carcinogenesis, is another important approach for easing this formidable public health burden. Similar to cancer chemotherapeutic agents, natural products play an important role in this field. There are many examples, including dietary phytochemicals such as sulforaphane and phenethylisothiocyanate (cruciferous vegetables) and resveratrol (grapes and grape products). Overall, natural product research is powerful approach for discovering biologically active compounds with unique structures and mechanisms of action. Given the unfathomable diversity of nature, it is reasonable to suggest that chemical leads can be generated that are capable of interacting with most or possibly all therapeutic targets.
    No preview · Article · Dec 2015 · Medical Principles and Practice
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    ABSTRACT: Objective: To report an unusual case of oral hyaline ring granuloma (HRG) that caused an extensive osteolytic lesion. Clinical presentation and intervention: A 22-year-old female was referred to our hospital with a large expansile cystic lesion in the left mandibular ramus associated with a clinically visible, partially erupted third molar. A diagnosis of paradental cyst was made. After marsupialization of the lesion, histopathological analysis of the surgical specimen showed an unusual exuberant HRG reaction supported by scarce fibrous stroma. Conclusion: This was a case of exuberant HRG reaction that caused extensive bone destruction.
    No preview · Article · Dec 2015 · Medical Principles and Practice
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    ABSTRACT: Objective: To present the mesalamine-induced acute exacerbation of symptoms and inflammatory markers in children with Crohn's disease (CD). Clinical Presentation and Intervention: Three children who presented with CD, had acute exacerbation of colitis symptoms or elevated inflammatory markers when mesalamine was added to treatment while tapering/ceasing steroid treatment. While on steroid treatment, the patients maintained clinical and laboratory remission, but with the initiation of mesalamine treatment.they had abdominal pain and bloody mucoid diarrhea and/or elevation of white blood cell count, C-reactive protein level and erythrocyte sedimentation rate Bacterial pathogens were exclude from the urine, throat, and blood cultures, parasites with stool examination, viral pathogens with serology. Within 3 to 7 days after the mesalamine treatment was stopped.the patients showed improvement of colitis symptoms and normalisation of white blood cell count, C-reactive protein level and erythrocyte sedimentation rate Conclusion: In this study mesalamine mimiced CD relapse in children with CD while tapering or after stopping steroid treatment. Awareness of this side effect of mesalamine could prevent a misdiagnosis of steroid dependency. .
    No preview · Article · Dec 2015 · Medical Principles and Practice

  • No preview · Article · Dec 2015 · Medical Principles and Practice
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    ABSTRACT: Objective: The aim of this paper was to report the first case of Kennedy disease misdiagnosed as polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes (POEMS) syndrome. Clinical presentation and intervention: A 58-year-old Chinese man presented with limb numbness, progressive limb proximal weakness, lymph node and thyroid enlargement, edema, pigmentation in the lower limb, and obvious gynecomastia, was initially diagnosed as POEMS syndrome and was treated with dexamethasone and small doses of cyclophosphamide without any improvement after six months. Finally, the patient diagnosis was confirmed as Kennedy disease (KD) by gene analysis. Conclusion: This case suggests that clinicians should pay more attention to the differential diagnosis between KD and POEMS syndrome and gene analysis was helpful to detect this rare confusing disease in this patient.
    No preview · Article · Nov 2015 · Medical Principles and Practice
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    ABSTRACT: Objective: To evaluate the diagnostic performance of the bedside index for severity in acute pancreatitis (BISAP) score in predicting severe acute pancreatitis (SAP). Materials and methods: A systematic search was conducted using PubMed, Cochrane library and EMBASE databases up to May 2014, and 9 related studies, including 1,972 subjects, were reviewed. Pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnosis of odds ratio (DOR) and hierarchic summary receiver-operating characteristic (HSROC) curves, as well as the area under the HSROC curve (AUC), were assessed using the HSROC and bivariate mixed effects models. Moreover, a subgroup analysis stratified by cutoff value was performed to measure the effect of the diagnostic threshold on the performance of the BISAP score. Finally, publication bias was assessed using Deeks' funnel plot asymmetry test. Statistical analyses were performed using the STATA 12.0 software. Results: The pooled sensitivity, specificity, PLR, NLR and DOR of the BISAP for predicting SAP were 64.82% (95% CI: 54.47-73.74%), 83.62% (95% CI: 70.03-91.77%), 3.96 (95% CI: 2.27-6.89), 0.42 (95% CI: 0.34-0.52) and 9.41 (95% CI: 5.38-16.45), respectively. The AUC was 0.77 (95% CI: 0.73-0.80). Moreover, the subgroup analysis results demonstrated that the BISAP cutoff point at 3 had a higher specificity and greater accuracy than at 2 to predict SAP. No significant publication bias was detected across the studies (p = 0.359). Conclusion: The BISAP score showed low sensitivity but high specificity for assessing the severity of acute pancreatitis.
    No preview · Article · Nov 2015 · Medical Principles and Practice
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    ABSTRACT: Objective: The aim of this study was to compare the health effects of shisha smoking with cigarette smoking among male college students in Kuwait. Subjects and methods: This cross-sectional study was conducted among 525 male students of Kuwait from September to October 2013. A pretested questionnaire was used for information on demographics and health complaints. Peak expiratory flow rate (PEFR) was measured using a portable peak flow meter. The outcome variables of health status were compared between smoking shisha, cigarette, or both and nonsmoking. Results: The prevalence of current smokers was 243/525 (46%): 52 (10%) were shisha smokers, 69 (13%) cigarette smokers, and 122 (23%) were both shisha and cigarette smokers. Symptoms of persistent cough (4%, 2/52 vs. 13%, 15/69, p = 0.007), chest pain (4%, 2/52 vs. 23% 16/69, p = 0.004), and rapid heart rate (12%, 6/52 vs. 28%, 19/69, p = 0.04) were significantly lower among shisha smokers compared with cigarette smokers. Other complaints, including asthma, respiratory infections, shortness of breath, high blood pressure, increased blood sugar, and sleep disturbances were similar in between the two groups. Values of PEFR were not significantly different between shisha smokers and cigarette smokers. Conclusion: This study demonstrated evidence suggesting that shisha smoking was not safer than cigarette smoking except a few complaints, such as cough, chest pain, and rapid heart rate, and that the people who smoked both had worse health effects in terms of frequent symptoms of respiratory infections, persistent cough, rapid heartbeats, and sleep disturbances.
    No preview · Article · Nov 2015 · Medical Principles and Practice
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    ABSTRACT: Objective: The purpose of this study was to evaluate the effect of atorvastatin consumption on amiodarone-induced pulmonary fibrosis in the rats. Materials and methods: Thirty six (36) male Wistar rats were randomly divided into four groups: control group (CTL): received 0.3 ml of distilled water intratracheally on days 0 and 2 and also 0.5 ml orally from day 0 for three weeks; atorvastatin group (AT): in addition to intratracheal distilled water, received atorvastatin 1mg/kg orally from day 0 for three weeks; amiodarone group (AMI): received two intratracheal instillation amiodarone (6.25 mg/ kg, in 0.3 ml of water) on days 0 and 2 and also 0.5 ml of distilled water, similar to CTL group.AMI+AT: amiodarone+ atorvastatin group (AMI+AT): received both amiodarone and atorvastatin in the same doses and methods used in AMI and AT groups. After 28 days, the rate of lung fibrosis was estimated according to pathological criteria of lung sections and measurement of hydroxyproline in pieces of left lung tissue. Results: Lung hydroxyproline content was higher in treated groups (CTL: 0.35±0.017; AT: 0.38±0.012; AMI: 0.375±0.018: AMI+AT: 0.38±0.012 unit/mg protein), however did not reached to significant level when compared with CTL group (p=0.56). Amiodarone significantly increased the score of pulmonary fibrosis (0.5) in comparison with AT (0.125) and CTL (0) groups (p<0.5). Combination of amiodarone and atorvastatin exacerbated the pulmonary fibrosis (1.5) (p<0.01 compared with the amiodarone group (0.5) and p<0.001versus AT (0.125) and CTL (0) groups). Conclusion: In this study the concomitant administration of amiodarone and atorvastatin increased the pulmonary fibrosis in rat.
    No preview · Article · Nov 2015 · Medical Principles and Practice