Medical Journal of Trakya University / Trakya Universitesi Tip Fakultesi Dergisi (TRAK UNIV TIP FAK DE)
Trakya Universitesi Tip Fakultesi Dergisi (Medical Journal of Trakya University) is an open-access, peer-reviewed periodical that considers for publication clinical or experimental studies, original articles, case reports, invited reviews of scientific merit, letters to the editor, information on scientific meetings, and brief reports on original studies or evaluations, book reviews, and article abstracts. The Journal is published three times a year. Manuscripts may be written in English as well as in Turkish.
Current impact factor: 0.11
Impact Factor Rankings
|2016 Impact Factor||Available summer 2017|
|2012 Impact Factor||0.113|
|2011 Impact Factor||0.066|
|2010 Impact Factor||0.093|
|2009 Impact Factor||0.082|
Impact factor over time
|Website||Medical Journal of Trakya University / Trakya Universitesi Tip Fakultesi Dergisi website|
Publications in this journal
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ABSTRACT: Objective: The purpose of this study was to test the hypothesis thThis study was planned to investigate the antipneumocystis activity of terbinafine in a rat model.Material and Methods: Rats were obtained from the Hakan Çetinsaya Experimental and Clinical Research Institutions, Erciyes University, Kayseri, Turkey. Terbinafine administered orally in doses of 40, 80, 120 and 160 mg/kg/day after nine weeks of immunosuppression with dexamethasone to facilitate the development of acute Pneumocystis carinii penumoniae (PCP). Results: Untreated animals showed P. carinii infection levels with a mean (±standard deviation) log number of cysts per gram of lung tissue of 4.6±1.6 at the end of the experiment. Terbinafine administered at a dose of 160 mg/kg/day significantly reduced the log number of cysts per gram to 2.2±1.5. The therapeutic efficacy of terbinafine administered at 160 mg/kg/day (log 2.2±1.5 cysts/lung) was similar to that obtained with trimethoprim-sulfamethoxazole (TMP-SMX), 50/250 mg/kg/day (p<0.001). A reduction in the number of cysts was also observed in infected animals treated with 80, and 120 mg of terbinafine/kg/day, although the results were not statistically significant (p>0.05). Conclusion: In our model, the efficacy of terbinafine in PCP has been found to be dose dependent.
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ABSTRACT: Objective: Prion protein (PrP) expresion has previously been demonstrated in activated hepatic stellate cells (HSC), which play a key role in the development of liver fibrosis. In this study, we aimed to investigate the correlation between PrP expression and hepatic inflammation/fibrosis in patients with chronic viral hepatitis (CVH). Material and Methods: Liver specimens of 40 patients with CVH and 10 patients with metastatic liver disease having a normal liver architecture as a control group were evaluated. ThePrP staining index was calculated by counting PrP positive cells per microscopic field after immunostaining. Hepatic inflammatory activity and fibrosis scores were evaluated and compared with the number of PrP positive HSC.Results: Varying degrees of PrP expression were detected in histologic samples of the liver in patients with CVH, whereas no staining was observed in control specimens. It was also detected that the grade of inflammatory activity and stage of liver fibrosis were significantly correlated with PrP staining index (p=0.0001 for inflammation and p=0.005 for fibrosis).Conclusions: PrP is a good marker of activated HSC and correlates well with the inflammatory activity and stage of fibrosis in CVH.
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.