Journal of B.U.ON.: official journal of the Balkan Union of Oncology (J BUON)

Publisher: Balkan Union of Oncology

Current impact factor: 0.74

Impact Factor Rankings

2016 Impact Factor Available summer 2017
2014 / 2015 Impact Factor 0.741
2013 Impact Factor 0.706
2012 Impact Factor 0.761
2011 Impact Factor 0.607
2010 Impact Factor 0.482
2009 Impact Factor 0.6

Impact factor over time

Impact factor
Year

Additional details

5-year impact 0.69
Cited half-life 3.60
Immediacy index 0.20
Eigenfactor 0.00
Article influence 0.15
Other titles Journal of BUON, Journal of Balkan Union of Oncology
ISSN 1107-0625
OCLC 42889499
Material type Periodical
Document type Journal / Magazine / Newspaper

Publications in this journal

  • Evangelos Tsiambas · Vasileios Ragos · Alicia Y Lefas · Stavros N Georgiannos · Dimitra Grapsa · Efstratios Patsouris · Konstantinos Syrigos
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    ABSTRACT: Lung cancer exhibits an increasing incidence and a high mortality rate worldwide. Non-small cell lung carcinoma (NSCLC)constitutes the majority of patients with lung cancer (about 85% of all pathologically defined lung cancer cases). A broad spectrum of genomic imbalances, including chromosome polysomy/aneuploidy or specific gene deregulation mechanisms, such as point mutations, deletions and amplifications has been already identified in the corresponding patients, modifying their response rates to novel targeted therapeutic regimens, and affecting also their life span. Among all chromosomes, chromosome 7 seems to play a critical role in NSCLC development and progression. Aberrations in significant genes located on it, such as EGFR, cMET, BRAF combined with numerical abnormalities of the whole chromosome are cytogenetic events that lead to specific molecular signatures in patients with NSCLC. Detection of these chromosome/gene imbalances based on polymerase chain reaction (PCR) and in situ hybridization provides to oncologists the right genetic substrate for handling these patients in a rational therapeutic way regarding their isolated molecular profile. In the current paper, we present the structural and functional profile of chromosome 7 focused on its alterations in NSCLC.
    No preview · Article · Feb 2016 · Journal of B.U.ON.: official journal of the Balkan Union of Oncology
  • Yingwei Zhu · Weichang Chen
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    ABSTRACT: Purpose: The most critical parameter in the evaluation of the effectiveness of minimally invasive esophagectomy for esophageal squamous cell carcinoma (SCC) is long-term outcome. In this study, patients in whom more than 5 years had elapsed since they had undergone minimally invasive esophagectomy for esophageal SCC were identified, and the 5-year overall survival (OS) rate and 5-year disease-free survival (DFS) rate were evaluated as the long-term outcomes. Methods: The stage, histology, perioperative complications, recurrence, and survival data were carefully reviewed in 49 patients who underwent minimally invasive esophagectomy for esophageal SCC between January 2008 and January 2010. Results: Postoperative 30-day complications were observed in 12 (24.5%) patients. There was no postoperative 30-day mortality. Recurrence was observed in 26 patients (53.1%): of these, 9 (18.4%) developed local recurrence and 14 (28.6%) distant metastasis. Three patients (6.1%) had both local and distant metastases. During the study period, there were 22 (44.9%) deaths, of which 20 were due to cancer and 2 were due to other causes. The patient 5-year OS and DFS rates were 58 and 45%, respectively. Conclusion: Minimally invasive esophagectomy for the treatment of esophageal SCC is as feasible and safe as open esophagectomy in terms of both very long- and short-term outcomes.
    No preview · Article · Feb 2016 · Journal of B.U.ON.: official journal of the Balkan Union of Oncology
  • Klara Pecankova · Pavel Majek · Jaroslav Cermak · Jan E Dyr

    No preview · Article · Feb 2016 · Journal of B.U.ON.: official journal of the Balkan Union of Oncology
  • Lucio Dell'Atti
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    ABSTRACT: Purpose: Digital rectal examination (DRE) is a routine part of prostate cancer Purpose: Digital rectal examination (DRE) is a routine part of prostate cancer (PCa) screening and provides important prognostic information. The purpose of this study was to analyse the potential association between obese patients and DRE findings for PCa detection. Methods: We retrospectively reviewed the medical records of patients who underwent an initial prostate needle biopsy for abnormal DRE, high prostate specific antigen (PSA) levels (≥4 ng/mL), or both at the Department of Urology. Patients with a history of biopsy, surgical treatment of prostatic disease, or incomplete clinical data were excluded from this study. A total of 1113 patients were included in the analysis. Before the biopsy procedure body mass index (BMI) was calculated. Age, PSA, BMI, DRE findings, prostate volume and Gleason score were analysed to assess the potential association between obesity and PCa detection. Results: The mean + SD BMI was 28.3 + 4.1 kg/m2. A total of 373 (33.5%) patients were classified as obese (BMI ≥30 kg/m2). No significant difference was noted in the number of biopsy cores between obese and non obese patients. The obese men were older, had a lower PSA concentration, a large prostate volume, and were less likely to have abnormal DRE findings. Patients with high grade prostate cancer (HGPCa) had higher BMI. Age, PSA and prostate volume were not significantly associated with a higher risk of cancer at biopsy. Conclusions: Our data demonstrated that obese patients have lower PSA levels, larger prostates and abundant perirectal fat. Lower PSA serum levels and large prostate size associated with high BMI, indicated a potential risk for delayed diagnosis and poor pathological outcomes.PCa) screening and provides important prognostic information. The purpose of this study was to analyse the potential association between obese patients and DRE findings for PCa detection. Methods: We retrospectively reviewed the medical records of patients who underwent an initial prostate needle biopsy for abnormal DRE, high prostate specific antigen (PSA) levels (≥4 ng/mL), or both at the Department of Urology. Patients with a history of biopsy, surgical treatment of prostatic disease, or incomplete clinical data were excluded from this study. A total of 1113 patients were included in the analysis. Before the biopsy procedure body mass index (BMI) was calculated. Age, PSA, BMI, DRE findings, prostate volume and Gleason score were analysed to assess the potential association between obesity and PCa detection. Results: The mean + SD BMI was 28.3 + 4.1 kg/m(2). A total of 373 (33.5%) patients were classified as obese (BMI ≥30 kg/m(2)). No significant difference was noted in the number of biopsy cores between obese and non obese patients. The obese men were older, had a lower PSA concentration, a large prostate volume, and were less likely to have abnormal DRE findings. Patients with high grade prostate cancer (HGPCa) had higher BMI. Age, PSA and prostate volume were not significantly associated with a higher risk of cancer at biopsy. Conclusions: Our data demonstrated that obese patients have lower PSA levels, larger prostates and abundant perirectal fat. Lower PSA serum levels and large prostate size associated with high BMI, indicated a potential risk for delayed diagnosis and poor pathological outcomes.
    No preview · Article · Feb 2016 · Journal of B.U.ON.: official journal of the Balkan Union of Oncology
  • Ioannis K Gkialas · Charalampos Fragkoulis
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    ABSTRACT: Purpose: Building on decades of research, the past few years have yielded a near expo-nential increase in treatment modalities for patients with metastatic prostate cancer. Individually, these improvements in overall survival may appear modest, however, nearly all of them have a distinct mechanism of action and the possibility of synergistic effects have yet to be established. The promise of a durable impact on the mortality from metastatic prostate cancer will likely stem from further elucidation of molecular pathways involved in prostate cancer, as well as defining the optimal sequence of treatment for patients with metastatic prostate cancer.
    No preview · Article · Feb 2016 · Journal of B.U.ON.: official journal of the Balkan Union of Oncology
  • Panagis M Lykoudis · Constantinos Nastos · Dionysis Dellaportas · Evi Kairi-Vassilatou · Christina Dastamani · Agathi Kondi-Pafiti
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    ABSTRACT: Purpose: To present series of patients with large rare primary lesions of the adrenal glands that were operated in our department. The initial indication for surgery was decided based on their impressive similarity to other more sinister adrenal pathologies. Methods: The clinical records of the department and histopathology reports, covering the 1986-2015 period were assessed. Rare adrenal pathologies that preoperatively were clinically mimicking other adrenal tumors were included. Results: In total, 8 patients (age range 20-75 years) with rare tumors of the adrenal glands were found. Seven patients had a preoperative indication for adrenalectomy due to the possibility of malignancy. In one patient surgery was undertaken due to the possible diagnosis of adrenal hemorrhagic cyst. Among these patients 4 had a histopathologic diagnosis of hemangiomas, one of a lymphangiomatous cyst and 3 of myelolipomas. Conclusion: Rare benign tumors of the adrenal glands can present as very large lesions that can be either diagnosed incidentally or due to atypical symptoms. Though unusual, they should be considered in the differential diagnostic approach of adrenal lesions, because they share common clinical and radiological characteristics with more sinister and frequent lesions such as malignant tumors and also hematomas.
    No preview · Article · Feb 2016 · Journal of B.U.ON.: official journal of the Balkan Union of Oncology
  • Meral Gunaldi · Hakan Kocoglu · Yildiz Okuturlar · Asuman Gedikbasi · Mehmet Karabulut · Halil Alis · Mehmet Hursitoglu
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    ABSTRACT: Purpose: In colorectal cancer (CRC), as in most of other malignancies, heat shock proteins (HSPs) are overexpressed and are associated with apoptosis, cancer cell proliferation, differentiation, invasion, and metastasis. HSP70 is one of the HSPs and has a promising future in cancer studies for both diagnostic and therapeutic applications. In this study, we tried to evaluate the serum levels of HSP70 in CRC patients, and to evaluate its predictive value of detecting CRC. Methods: This prospective study was consisted of 33 patients diagnosed with CRC and 31 healthy subjects who were matched for age. Enzyme-linked immunosorbent assays (ELISA) were used to evaluate the serum levels of HSP70 in patients with CRC and in the healthy control group. A cut-off value for HSP70 was also determined using receiver operating characteristic (ROC) curve analysis. Results: Patients with CRC had significantly higher HSP70 concentrations compared with the control group (4.52 ± 1.83 vs 1.22 ± 0.48 ng/ml, p=0.001), the cut-off value was ≥2.25 ng/ml (95% CI 0.993-1.003, p<0.001). The sensitivity and specificity of elevated serum HSP70 in the CRC group were 96.77 and 96.96%, respectively. Also, HSP70 levels were significantly higher with rectal disease localization (p=0.01). Conclusion: This study shows that the serum level of HSP70 is elevated in patients with CRC. HSP70 may be utilized as an adjunct to other diagnostic or screening tests.
    No preview · Article · Feb 2016 · Journal of B.U.ON.: official journal of the Balkan Union of Oncology
  • Qing Tian · Yong-Hong Zang
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    ABSTRACT: Purpose: Cervical carcinoma is the second most common malignancy in females and most of the cases are found in developing countries. The objectives of the present study were (a): to demonstrate the antiproliferative and apoptotic effects of Achillea falcata (A.falcata) extract in human cervical cancer cells (HeLa), and (b): to study the effect of the extract on cellular morphology, cell cycle phase distribution and mitochondrial membrane potential. Methods: MTT assay was used to evaluate the anticancer effect of the extract on HeLa cells. Phase contrast, fluorescence microscopy and transmission electron microscopy (TEM) were used to investigate the morphological changes in these cancer cells after extract treatment. Flow cytometry was used to evaluate the effects of the extract on cell cycle and mitochondrial membrane potential. Results: The results revealed that A. falcata extract led to a significant antiproliferative effect in HeLa cancer cells. The extract induced cellular shrinkage, chromatin condensation and appearance of apoptotic bodies which are the hallmarks of cellular apoptosis. TEM results showed that extract-treated cells had nuclear membrane which was hemispherical and the nuclear chromatin was concentrated and bundled on the inner border of karyotheca. The endoplasmic reticulum also became enlarged in the inner segment. The extract also induced G2/M phase cell cycle arrest along with loss of mitochondrial membrane potential. Conclusion: Achillea falcata extract induced potent antiproliferative and apoptotic effects in HeLa cells. This was accompanied by cellular shrinkage, chromatin condensation, G2/M phase cell cycle arrest and a loss of mitochondrial membrane potential in these cancer cells.
    No preview · Article · Feb 2016 · Journal of B.U.ON.: official journal of the Balkan Union of Oncology
  • Sinziana Cetean · Tudor Ciuleanu · Daniel-Corneliu Leucuta · Calin Cainap · Anne-Marie Constantin · Irina Cazacu · Simona Cainap · Alexandra Gherman · Luminita Oprean · Adriana Hangan · Radu Oprean
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    ABSTRACT: Purpose: Platinum derivatives play a very important role in cancer therapy. Despite their outstanding results in the treatment of tumors with different locations, the occurrence of hypersensitivity reactions raises issues when it comes to therapy decision, because the changing of chemotherapy line could influence the tumor's evolution. Over the years the scientific community has paid particular attention to the mechanism by which this occurs and to identification of predictive factors. The purpose of this case-control, retrospective study was to find new predictive markers for the occurrence of allergic reactions to platinum derivatives. Methods: We identified 59 cases of allergic reactions to platinum derivatives in the Oncology Institute "Prof. Dr. Ion Chiricuta" from Cluj-Napoca city in 2013. Blood tests data were analyzed before the administration of the cycle on which the allergic reaction occurred, along with the mandatory analyses for the patients and we focused on the values of neutrophils, lymphocytes, monocytes, eosinophils and basophils. Results: When these values were compared with the values of the control group (,which was made at a ratio of 1:2 or 1:3, matched for age, tumor location and chemotherapy cycle) we found that each increase of lymphocytes or doses of platinum and each drop in monocytes number increased the risk for allergic reactions to occur. Conclusion: These findings are of a great value for the physicians and represent a starting point for more detailed studies.
    No preview · Article · Feb 2016 · Journal of B.U.ON.: official journal of the Balkan Union of Oncology
  • Nicolae Crisan · Iulia Andras · Catalina Bungardean · Ioan Coman

    No preview · Article · Feb 2016 · Journal of B.U.ON.: official journal of the Balkan Union of Oncology
  • Dogan Yazilitas · Nuriye Ozdemir · Cemil Hocazade · Yakup Bozkaya · Ozan Yazici · Mehmet Ali Nahit Sendur · Nurullah Zengin
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    ABSTRACT: Purpose: The primary extranodal non Hodgkin's lymphoma 'EN-NHL) is a heterogeneous group of diseases with expression of different oncogenes compared to nodal NHLs. In this study, we aimed to compare the clinical and pathological findings, the prognostic factors, the treatment and the survival data in patients with stage I-II primary EN-NHL with nodal NHL 'N-NHL). Methods: Between January 1991 and January 2014, 853 patients with diagnosis of NHL were reviewed. Of 853 patients, 379 '44%) with stage I-II disease were included in the study and were divided into two groups according to involved sites as nodal and extranodal. The N-NHL group consisted of stage I-II patients without extranodal involvement, who were diagnosed by incisional or excisional lymph node biopsy. The EN-NHL group consisted of patients with a single primary extranodal involvement and/or a locoregional lymph node involvement, and who were diagnosed by means of a biopsy from the extranodal region. Results: A total of 112 patients with N-NHL and 267 with EN-NHL were enrolled in the study. About 3/4 of the N-NHL patients had stage II, while 50% of the EN-NHL patients had stage I 'p<0.01). There was no statistically significant difference between EN-NHL and NHL in terms of 5-year overall survival '0S) 'p=0.25). The median 5-year OS in the diffuse large B cell lymphoma 'DLBCL) subgroup with N-NHL was 52%, while that of the EN-NHL was 68% 'p=0.006). Conclusion: Patients with stage I-II N-NHL had a poorer prognosis than EN-NHL patients. However, 5-year OS rates were similiar between groups.
    No preview · Article · Feb 2016 · Journal of B.U.ON.: official journal of the Balkan Union of Oncology
  • Xin-Ying Gao · Xiu-Ling Wang
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    ABSTRACT: Purpose: Colon cancer is one of the most common malignancies worldwide. Cancer stem-like cells (CSCs) are a distinct subgroup of cancer cells that play a vital role in the development of cancer and also a role in the development of resistance against therapeutic agents. In this study we investigated the role of CSCs in colon cancer and evaluated the tumor-associated antigen CEP55 for targeting immunotherapeutically CSCs. Methods: Side population (SP) cells from colon cancer cell line SW480, were isolated using DNA-binding dye Hoechst 33342. The cytotoxic activity of cytotoxic T lymphocytes (CTL) clone 41 for side population (SP) cells and main population (MP) cells was evaluated using 51Cr release assay. The SP cells, MP cells and presorted cells from the colon cancer cell line were evaluated in NOD/SCID mice. Results: The isolated SP cells showed resistance to the chemotherapeutic agents irinotecan and oxaliplatin, which suggests that targeting the CSCs can be a better strategy for the treatment of chemotherapy-resistant colon cancer. HLA class I and HLA-A24 in SP cells and MP cells were expressed at the same level. We used CTL clone 41 to corroborate the sensitivity of SP cells to cytotoxic T lymphocyte response. The cytotoxic responses of SP cells were to the same extent as they were in MP cells and pre-sorted cells. Adoptive transfer of CTL clone 41 in immunodeficient mice inhibited SW480-induced tumors, suggesting that this approach can be used for colon cancer immunotherapy. Conclusion: Our novel findings suggest that colon cancer CSCs are sensitive to CTLs, and CEP55, a tumor-associated antigen, can be successfully used as active immunotherapy for targeting CSCs in colon cancer.
    No preview · Article · Feb 2016 · Journal of B.U.ON.: official journal of the Balkan Union of Oncology
  • Chen Li · Jin Yichao · Lin Jiaxin · Zhang Yueting · Lu Qin · Yang Tonghua
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    ABSTRACT: Purpose: Reported evidence supports a role for methylenetetrahydrofolate reductase (MTHFR) in the risk of chronic myelogenous leykemia (CML). However, these reports arrived at non-conclusive and even conflicting results regarding the association between two common MTHFR polymorphisms (C677T and A1298C) and CML risk. Thus, a meta-analysis was carried out to clarify a more precise association between these two polymorphisms and the CML risk by updating the available publications. Methods: Pooled odds ratios (OR) with corresponding 95% confidence interval (95% CI) and stratification analysis were performed to estimate the relationship between MTHFR polymorphisms and the risk of CML under different genetic comparison models. Results: Data from the meta-analysis showed no significant association between MTHFR C677T polymorphism and CML risk. However, significant associations were found between MTHFR A1298C variants and CML risk under homozygous comparison model (CC vs AA, OR=1.62, 95% CI=1.11-2.36, p=0.01) and dominant comparison model (CC+AC vs AA, OR=1.68, 95% CI=1.17-2.43, p=0.005) in overall population; especially more obvious impacts were noticed for Asian populations in subgroup analysis for homozygous model (CC vs AA, OR=2.00, 95% CI=1.25-3.21, p=0.004) and dominant model (CC+AC vs AA, OR=2.49, 95% CI=1.42-4.36, p=0.001), but this did not apply in Caucasian populations. Conclusion: The results of this meta-analysis suggested no significant association between MTHFR C677T polymorphism and CML risk, while an increased CML risk was noticed for 1298C variant carriers, especially in Asian populations but not in Caucasian populations, which suggested ethnicity differences between MTHFR A1298C polymorphisms and risk of CML.
    No preview · Article · Feb 2016 · Journal of B.U.ON.: official journal of the Balkan Union of Oncology
  • Cheng Yuan · Xin-Hua Xu · Zhuo Chen
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    ABSTRACT: Purpose: The objective of this study was to compare the efficacy of the conventional treatment (radiotherapy/RT and chemotherapy/CT) and the combination treatment with antiepidermal growth factor receptor (anti EGFR) monoclonal antibodies in patients with primary nasopharyngeal cancer (NPC) using meta-analysis of data retrieved from the literature. Methods: Seven databases (Pubmed, Embase, Cochrane Library, CBM, CNKI, Wanfang,VIP) were searched. Of 537 identified articles, 12 satisfied our eligibility criteria and entered this meta-analysis. A total of 821 patients in 12 randomized controlled clinical trials (RCTs) were included in the study to compare the effect in the short-term and long-term treatment. Results: The combination treatment improved the objective complete remission rate (CR) of primary NPC and the metastatic lymph nodes, and the 1-year distant metastasis-free survival (MFS) rate relative risk (RR=1.40, 95%CI:1.29-1.53, p=0.00; RR=1.29, 95%CI:1.18-1.42, p=0.00; RR%1.17, 95%CI:1.01-1.35, p=0.03, respectively). There was no difference in the 2- and 3-year MFS rate (RR=1.06, 95%CI:0.85-1.33, p=0.60 ; RR=0.87, 95%CI:0.63-1.22) p=0.43, respectively). Conclusion: The combination with anti EGFR monoclonal antibodies and conventional treatment (RT and/or CT) improved the short-term therapeutic effect, but this benefit disappeared after 1 year.
    No preview · Article · Feb 2016 · Journal of B.U.ON.: official journal of the Balkan Union of Oncology
  • Hector Chapoy-Villanueva · Ivonne Martinez-Carlin · G Lopez-Berestein · Arturo Chavez-Reyes
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    ABSTRACT: Purpose: To evaluate the effectiveness of a neutral DOPC nanoliposome system for the delivery of siRNA to tumor cells in an obese murine cervical cancer model. Methods: In vitro silencing of E6-E7 mRNA and E7 protein using siRNAE6 or siRNAE7 was analyzed in TC-1 cells by RT-PCR and Western blot. Silencing and antitumor capacities of siRNAE7-DOPC-nanoparticles (NP) were tested in vivo in both normal and obese mice using qPCR. These NPs were administered twice a week for 15 days and tumor volume and weight were recorded. Results: Levels of in vitro E6-E7 silencing were 90% for mRNA and 60% for protein when siRNAE7 was used. On the other hand when siRNAE6 was used, the levels of silencing were 50% for E6-E7 mRNA and only 20% for protein. In vivo E7 mRNA silencing by siRNAE7-DOPC-NP was similar (60%) in both non-obese and obese mouse models. The therapeutic study showed a 65% decrease in tumor volume and a 57% reduction in tumor weight as compared to the control groups. Conclusion: There was no negative impact of obesity on the antitumor activity of siRNA-DOPC-NP in obese mice.
    No preview · Article · Feb 2016 · Journal of B.U.ON.: official journal of the Balkan Union of Oncology
  • Jian Han · Shan-Shan Lu · Zhi-Jie Wang · You-Lin Li
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    ABSTRACT: Purpose: Cancer is one of the leading causes of mortality worldwide. Tumor cells circulating in the blood evidence the migration of tumor from the site of origin to another site leading to the formation of new metastatic lesion and establishment of metastatic tumors. In the present study, cultured metastatic tumor cells were injected into the C57BL/6 mice through tail-vein injection (TVI) and the anti-metastatic properties of flax seed oil (FSO) were evaluated. Methods: Pre-administration of FSO in a dose of 0.3 ml/mice/day was performed for 15 days. On 16th and 21st day, mice were challenged with 2x105 /100 μl murine B10 melanoma (YAC-1 suspended in sterile PBS) cells and continued with FSO administration until the end of the experimental period (40 days) to assess the effect on lung metastasis. At the end of experimental period, mice were sacrificed for plasma and lung tissue samples for biochemical and marker studies. Activities of marker enzymes (AST and ALT), enzymic antioxidants (superoxide dismutase/SOD and catalase/CAT), levels of non/enzymic antioxidants (glutathione), oxidation/stress marker (malondialdehyde/MDA) and cytokines (TNF-alpha, IL-2, IFN-gamma and MMP-9) were assessed. Results: Elevated marker enzyme activities in serum and altered enzymic and non-enzymic antioxidants were recovered during FSO treatment. Altered metastatic markers levels favoring the formation of metastatic lesions were observed in the disease group. FSO administration re-altered the levels of these markers in the treatment group contributing to better control of metastasis development. Conclusion: These results support the protective role of FSO against lung cancer metastasis.
    No preview · Article · Feb 2016 · Journal of B.U.ON.: official journal of the Balkan Union of Oncology
  • Yan Zhang · Tao Wang · Hua-Qiao Huang · Wei Li · Xiao-Ling Cheng · Jing Yang
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    ABSTRACT: Purpose: Long non-coding RNAs (lncRNAs) have been shown to play a crucial role in the development as well as the prognosis of various human cancers, particularly in human metastasis associated lung adenocarcinoma transcript-1 (MALAT-1), which has been shown to be upregulated in some tumors. However, the role of MALAT-1 in cervical cancer (CC) is yet to be elucidated. This study aimed to establish a correlation between MALAT-1 and its role in CC progression and prognosis. Methods: The expression of MALAT-1 was examined in tissue samples of 30 CC patients and was compared with the adjacent non-cancerous tissues. The relationship between MALAT-1 levels and clinicopathological parameters from the CC patients was analyzed. Cell migration and invasion assays were performed with quantification of the expression levels of MALAT-1 in 4 CC cell lines using RT-PCR. Results: Our results demonstrate that MALAT-1 is upregulated in CC. We found higher expression of MALAT-1 in all the 4 CC cell lines, especially in SiHa and ME-180 CC cell lines. After analysis of the relationship between MALAT-1 levels and clinicopathological parameters from CC patients, a robust correlation could be obtained between MALAT-1 overexpression with lymph node metastasis, tumor differentiation and clinical stage. Furthermore, the ectopic expression of MALAT-1 increased cell proliferation and contributed directly to invasion and migration. Conclusion: Taken together, this study suggests an indispensible role played by MALAT-1 in CC progression, which may act as a potential prognostic indicator for CC and also could be a novel potential target for diagnosis of CC.
    No preview · Article · Feb 2016 · Journal of B.U.ON.: official journal of the Balkan Union of Oncology
  • Florin Zaharie · George Ciorogar · Roxana Zaharie · Teodora Mocan · Claudiu Zdrehus · Lucian Mocan · Ioana Berindan-Neagoe · Patriciu Achimas · Cornel Iancu · Claudiu Tomus
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    ABSTRACT: Purpose: This study was carried out to compare the therapeutic outcomes and complications of the laparoscopic and the conventional open surgery technique used for treating rectal cancer. Another goal was to find the fastest and most accurate method of treatment for rectal cancer, along with establishing the advantages and disadvantages of the two surgical techniques, depending on cancer location and its stage. Methods: A total of 172 patients diagnosed with rectal cancer and hospitalized in the Department of Surgery III between January 1st 2008 and December 31st 2011 were studied. The laparoscopic approach was performed on 29 (16.8%) patients, and the remaining 143 (83.2%) underwent the conventional Miles/Lloyd-Davies abdominoperineal resection. A longitudinal study was conducted on patients with rectal resection, the used data being obtained from the database of the Department of Surgery III, hospital records, protocols and clinical charts of rectal cancer cases. Results: There were no statistically significant differences regarding symptoms, gender, age, body mass index (BMI), tumor site, TNM stage, intraoperative accidents, operative time, and postoperative mortality between the two groups. The laparoscopic group presented advantages regarding antibiotic and analgesic therapy, early mobilization, hospital stay, intraoperative blood loss, resuming oral nutrition, bowel transit resumption, postoperative complications and wound complications. Conclusion: Laparoscopic abdominoperineal resection for rectal cancer is feasible, safe and effective. It can be safely performed by an experienced team, reducing the rate of postoperative complications, the need for blood transfusions, the adminstration of antibiotics and painkillers, allowing faster bowel transit resumption, shortening hospital stay and providing superior aesthetic results.
    No preview · Article · Feb 2016 · Journal of B.U.ON.: official journal of the Balkan Union of Oncology
  • Marek Z Wojtukiewicz · Dominika Hempel · Joanna Kruszewska · Lech Zimnoch · Walter Kisiel · Ewa Sierko
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    ABSTRACT: Purpose: Erythropoiesis-stimulating agents (ESAs) are recommended for treating chemotherapy-induced anemia in breast cancer patients. Reduced survival rates in ESAs-treated patients have been reported, possibly due to thromboembolic complications, however the exact mechanism remains obscure. The principal activator of blood coagulation in cancer is tissue factor (TF). There are data that erythropoietin receptor (EPO-R) is expressed in tumor cells. The purpose of this study was to evaluate the expression of EPO-R and TF in loco in breast cancer. Methods: The expression of EPO-R and TF was investigated in 24 invasive breast carcinoma specimens. Immunohistochemical (IHC) methodologies according to ABC technique and double-staining IHC procedure were employed utilizing antibodies against EPO-R and TF. Results: Expression of EPO-R and TF was demonstrated in the tumor cells in all breast cancer specimens. No staining for EPO-R and TF was visualized in normal breast tissue. Double staining studies revealed co-expression of both EPO-R and TF in breast cancer cells and endothelial cells. Conclusions: EPO-R and TF expression and their coexpression in breast cancer cells suggest a possibility that EPO-R might be responsible for some adverse effects and reduced survival observed in ESAs-treated breast cancer patients with anemia, possibly due to the interaction with TF. Further experimental studies are warranted to determine the role of both EPO-R and TF in the treatment with ESAs of breast cancer patients with chemotherapy-induced anemia.
    No preview · Article · Feb 2016 · Journal of B.U.ON.: official journal of the Balkan Union of Oncology
  • Marianna Karamanou · Gregory Tsoucalas · Konstantinos Laios · Efthimios Deligeoroglou · Emmanouil Agapitos · George Androutsos
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    ABSTRACT: Byzantine physicians recognized uterine cancer as a distinct disease and tried to suggest a therapeutic approach. The work of Oribasius, Aetius of Amida, Paul of Aegina, Cleopatra Metrodora and Theophanes Nonnus reflects the Hippocratic-Galenic scientific ideas as well as their own concept on this malignancy. According to their writings uterine cancer was considered an incurable disease and its treatment was based mainly on palliative herbal drugs.
    No preview · Article · Feb 2016 · Journal of B.U.ON.: official journal of the Balkan Union of Oncology